The use of neamine as a molecular template: Inactivation of bacterial antibiotic resistance enzyme aminoglycoside 3'-phosphotransferase type IIa

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 24, 1998, Pages 3483-3488

  Roestamadji, Juliatiek ^a   Mobashery, Shahriar ^a  

^a WAYNE STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE 3' PHOSPHOTRANSFERASE 2A; AMINOGLYCOSIDE ANTIBIOTIC AGENT; BACTERIAL ENZYME; ENZYME INHIBITOR; NEAMINE; PHOSPHOTRANSFERASE; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ARTICLE; ENZYME INACTIVATION; ENZYME INHIBITOR INTERACTION; INHIBITION KINETICS; MOLECULAR DYNAMICS; STRUCTURE ACTIVITY RELATION;

BACTERIA; DRUG RESISTANCE, MICROBIAL; KANAMYCIN KINASE; MOLECULAR PROBES; MOLECULAR STRUCTURE; NEOMYCIN;

BACTERIA (MICROORGANISMS);

EID: 0032534816     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00633-7     Document Type: Article

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18. 2O to make 100 mL, pH 0.5), 50 μL NBT (nitroblue tetrazolium) and 37.5 μL BCIP (5-bromo-4-chloro-3-indolylphosphate). This solution was used to immerse the membrane without agitation at room temperature to allow the blue-brown color to develop in the desired intensity (approximately 3-60 minutes), and then the membrane was rinsed several times in water and allowed to air dry. Ovalbumin was used as a positive control in this test.
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