Determinants of aminoglycoside-binding specificity for rRNA by using mass spectrometry

Proceedings of the National Academy of Sciences of the United States of America

Volumn 96, Issue 18, 1999, Pages 10129-10133

  Griffey, Richard H ^a   Hofstadler, Steven A ^a   Sannes Lowery, Kristin A ^a   Ecker, David J ^a   Crooke, Stanley T ^a  

^a ISIS PHARMACEUTICALS   (United States)

Author keywords

16S RNA; 18S RNA; Aminoglycoside; Fourier transform ion cyclotron resonance MS

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; APRAMYCIN; KANAMYCIN B; LIVIDOMYCIN; PAROMOMYCIN; PROTEIN SYNTHESIS INHIBITOR; RIBOSOME RNA; RIBOSTAMYCIN; RNA; TOBRAMYCIN;

ARTICLE; BINDING AFFINITY; BINDING SITE; DRUG STRUCTURE; MASS SPECTROMETRY; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; RNA BINDING;

AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; BASE SEQUENCE; BINDING SITES; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; KINETICS; NUCLEIC ACID CONFORMATION; RNA, RIBOSOMAL, 16S; RNA, RIBOSOMAL, 18S; SENSITIVITY AND SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EUKARYOTA; PROKARYOTA;

EID: 0033621114     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.96.18.10129     Document Type: Article

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