Human hepatocytes in primary culture predict lack of cytochrome P-450 3A4 induction by eletriptan in vivo

Drug Metabolism and Disposition

Volumn 28, Issue 1, 2000, Pages 51-57

  Pichard Garcia, Lydiane ^a   Hyland, Ruth ^b   Baulieu, Jean ^c   Fabre, Jean Michel ^a,d   Milton, Ashley ^b   Maurel, Patrick ^a  

^a CNRS   (France)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^c CROIX ROUSSE HOSPITAL   (France)

^d HÔPITAL SAINT ELOI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

6BETA HYDROXYHYDROCORTISONE; CYCLOSPORIN A; CYTOCHROME P450 3A4; ELETRIPTAN; RIFAMPICIN; SEROTONIN AGONIST;

ARTICLE; CELL CULTURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG METABOLISM; DRUG SCREENING; DRUG URINE LEVEL; HUMAN; HUMAN EXPERIMENT; LIVER CELL; MALE; MIGRAINE; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

ADULT; AGED; CELLS, CULTURED; CYTOCHROME P-450 ENZYME SYSTEM; DNA FRAGMENTATION; DNA PRIMERS; ENZYME INDUCTION; FEMALE; HUMANS; HYDROCORTISONE; INDOLES; LIVER; MALE; MICROSOMES, LIVER; MIDDLE AGED; MIGRAINE DISORDERS; MIXED FUNCTION OXYGENASES; PYRROLIDINES; SEROTONIN AGONISTS; TRYPTAMINES;

EID: 0033985434     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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