Primary human hepatocytes as a tool for the evaluation of structure- activity relationship in cytochrome P450 induction potential of xenobiotics: Evaluation of rifampin, rifapentine and rifabutin

Chemico-Biological Interactions

Volumn 107, Issue 1-2, 1997, Pages 17-30

  Li, Albert P ^a   Reith, M Kelly ^b   Rasmussen, Asenath ^c   Gorski, J Chris ^d   Hall, Stephen D ^d   Xu, Lilly ^c   Kaminski, Donald L ^c   Cheng, Lawrence K ^b  

^a In Vitro Technologies Inc   (United States)

^b SANOFI   (France)

^c SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cytochrome P450; Drug interactions; Enzyme induction; Hepatocytes; Human drug metabolism; Liver; Rifabutin; Rifampin; Rifamycins; Rifapentine; Xenobiotic metabolism

Indexed keywords

CYTOCHROME P450 ISOENZYME; DEXTROMETHORPHAN; ETHOXYRESORUFIN DEETHYLASE; MIDAZOLAM; RIFABUTIN; RIFAMPICIN; RIFAPENTINE; TESTOSTERONE; TOLBUTAMIDE; XENOBIOTIC AGENT; ZIDOVUDINE;

CONFERENCE PAPER; DEMETHYLATION; DRUG GLUCURONIDATION; DRUG HYDROXYLATION; ENZYME ACTIVITY; ENZYME INDUCTION; HUMAN; HUMAN CELL; LIVER CELL; STRUCTURE ACTIVITY RELATION;

ANTIBIOTICS, ANTITUBERCULAR; ANTITUBERCULAR AGENTS; CYTOCHROME P-450 ENZYME SYSTEM; DRUG EVALUATION, PRECLINICAL; ENZYME INDUCTION; GLUCURONATES; HUMANS; HYDROXYLATION; ISOENZYMES; LIVER; RIFABUTIN; RIFAMPIN; STRUCTURE-ACTIVITY RELATIONSHIP; TESTOSTERONE; TIME FACTORS; ZIDOVUDINE;

STAPHYLOCOCCUS PHAGE 3A;

EID: 0030665109     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2797(97)00071-9     Document Type: Conference Paper

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