FKBP12 is the only FK506 binding protein mediating T-cell inhibition by the immunosuppressant FK506

Transplantation

Volumn 73, Issue 11, 2002, Pages 1835-1838

  Xu, Xuehong ^a   Su, Bing ^a   Barndt, Robert J ^a   Chen, Hanying ^a   Xin, Hongbo ^a   Yan, Guifan ^a   Chen, Linyuan ^a   Cheng, Dongsheng ^a   Heitman, Joseph ^a   Zhuang, Yuan ^a   Fleischer, Sidney ^a   Shou, Weinian ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FK 506 BINDING PROTEIN; FK 506 BINDING PROTEIN 12; FK 506 BINDING PROTEIN 12.6; FK 506 BINDING PROTEIN 5; IMMUNOPHILIN; IMMUNOSUPPRESSIVE AGENT; RAPAMYCIN; TACROLIMUS; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL GROWTH; CELL ISOLATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG PROTEIN BINDING; GENE INACTIVATION; GENE MUTATION; GENETIC ENGINEERING; GROWTH INHIBITION; IMMUNOSUPPRESSIVE TREATMENT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; T LYMPHOCYTE ACTIVATION;

EID: 0037096607     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-200206150-00023     Document Type: Article

References (10)

1. Chemistry and biology of the immunophilins and their immunosuppressive ligands
2. Immunopharmacology of rapamycin
3. Structure of FKBP12.6 on complex with rapamycin
4. Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast
5. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
6. Rapamicin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinase
7. A novel FK506 binding protein can mediate the immunosuppressive effects of FK506 and is associated with the cardiac ryanodine receptor
8. FKBP51, a novel T-cell-specific immunophilin capable of calcineurin inhibition
9. Cardiac defects and altered ryanodine receptor function in mice lacking FKBP12
10. Estrogen protects FKBP12.6 null mice from cardiac hypertrophy