A Shift from Negative to Positive Selection of Autoreactive T Cells by the Reduced Level of TCR Signal in TCR-Transgenic CD3ζ-Deficient Mice

Journal of Immunology

Volumn 158, Issue 4, 1997, Pages 1634-1640

  Yamazaki, Tetsuo ^a   Arase, Hisashi ^a   Ono, Satoru ^a   Ohno, Hiroshi ^a   Watanabe, Hiroyuki ^a   Saito, Takashi ^a  

^a CHIBA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN T CELL RECEPTOR, ZETA CHAIN; AUTOANTIGEN; CD8 ANTIGEN; HY ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR; MEMBRANE PROTEIN;

ANIMAL; ARTICLE; BIOSYNTHESIS; C57BL MOUSE; CELL DIFFERENTIATION; CLONAL ANERGY; CYTOLOGY; FEMALE; GENETICS; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; MALE; METABOLISM; MOUSE; SIGNAL TRANSDUCTION; SPLEEN; T LYMPHOCYTE; THYMUS; TRANSGENIC MOUSE;

ANIMALS; ANTIGENS, CD8; AUTOANTIGENS; CELL DIFFERENTIATION; CLONAL ANERGY; FEMALE; H-Y ANTIGEN; LYMPHOCYTE ACTIVATION; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; SPLEEN; T-LYMPHOCYTES; THYMUS GLAND;

EID: 0031568407     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. von Boehmer, H. 1994. Positive selection of lymphocytes. Cell 76:219.
2. Nossal, G. J. V. 1994. Negative selection of lymphocytes. Cell 76:229.
3. Hogquist, K. A., S. C. Jameson, W. R. Heath, J. L. Howard, M. J. Bevan, and F. R. Carbone. 1994. T cell receptor antagonist peptides induce positive selection. Cell 76:17.
4. + T cells. Immunity 3:79.
5. Sebzda, E., V. Wallace, J. Mayer, R. S. M. Yeung, T. W. Mak., and P. S. Ohashi. 1994. Positive and negative thymocyte selection induced by different concentration of a single peptide. Science 263:1615.
6. Ashton-Rickardt, P. G., A. Bandeira, J. R. Delaney, L. Van Kaer, H.-P. Pircher, R. M. Zinkernagel, and S. Tonegawa. 1994. Evidence for a differential avidity model of T cell selection in the thymus. Cell 76:651.
7. Lyons, D. S., S. A. Lieberman, J. Hampl, J. J. Boniface, Y.-H. Chien, L. J. Berg, and M. M. Davis. 1996. A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists. Immunity 5:53.
8. Alam, S. M., P. J. Travers, J. L. Wung, W. Nasholds, S. Redpath, S. C. Jameson, and N. R. Gascoigne. 1996. T-cell-receptor affinity and thymocyte positive selection. Nature 381:616.
9. Ohno, H., T. Aoe, S. Taki, D. Kitamura, Y. Ishida, K. Rajewsky, and T. Saito. 1993. Developmental and functional impairment of T cells in mice lacking CD3ζ chains. EMBO J. 12:4357.
10. + thymocytes. Nature 333:742.
11. Yamashita, I., T. Nagata, T. Tada, and T. Nakayama. 1993. CD69 cell surface expression identifies developing thymocytes which audition for T cell antigen receptor-mediated positive selection. Int. Immunol. 9:1139.
12. Teh, H.-S., H. Kishi, B. Scott, and H. von Boehmer. 1989. Deletion of autospecific T cells in T cell receptor transgenic mice spares cells with normal TCR levels and low levels of CD8 molecules. J. Exp. Med. 169:795.
13. Koyasu, S., R. E. Hussey, L. K. Clayton, A. Lerner, R. Pederson, P. Delany-Heiken, F. Chau, and E. L. Reinhertz. 1994. Targeted disruption within the CD3ζ/η/θ/Oct-1 locus in mouse. EMBO J. 13:784.
14. Ohno, H., S. Goto, S. Taki, T. Shirasawa, H. Nakano, S. Miyatake, T. Aoe, Y. Ishida, H. Maeda, T. Shirai, K. Rajewsky, and T. Saito. 1994. Targeted disruption of the CD3η locus causes high lethality in mice: modulation of Oct-1 transcription on the opposite strand. EMBO J. 13:1157.
15. Aoe, T., S. Goto, H. Ohno, and T. Saito. 1994. Different cytoplasmic structure of the CD3ζ family dimer modulates the activation signal and function of T cells. Int Immunol. 6:1671.
16. 2 isoforms. Proc. Narl. Acad. Sci. USA 88:3842.
17. Lefrancois, L. 1991. Phenotypic complexity of intraepithelial lymphocytes of the small intestine. J. Immunol. 147:1746.
18. Rocha, B., P. Vassalli, and D. Guy-Grand. 1992. The extrathymic T-cell development pathway. Immunol. Today 13:449.
19. Scollay, R., and D. I. Godfrey. 1995. Thymic emigration: conveyor belts or lucky dips? Immunol. Today 16:268.
20. Lee, N. A., D. Y. Loh, and E. Lacy. 1992. CD8 surface levels alter the fate of α/β T cell receptor-expressing thymocytes in transgenic mice. J. Exp. Med. 175:1013.
21. Robey, E. A., F. Ramsdell, D. Kioussis, W. Sha, D. Loh, R. Axel, and B. J. Fowlkes. 1992. The level of CD8 expression can determine the outcome of thymic selection. Cell 69:1089.
22. Robey, E. A., B. J. Fowlkes, J. W. Gordon, D. Kioussis, H. von Boehmer, F. Ramsdell, and R. Axel. 1991. Thymic selection in CD8 transgenic mice supports an instructive model for commitment to CD4 or CD8 lineage. Cell 64:99.
23. Janeway, C. A., Jr. 1995. Ligands for the T-cell receptor: hard times for avidity models. Immunol. Today 16:223.
24. Chervonsky, A. V., T. V. Golovkina, S. R. Ross, and C. A. Janeway, Jr. 1995. Differences in the avidity of TCR interactions with a superantigenic ligand affect negative selection but do not allow positive selection. J. Immunol. 155:5115.
25. Spain, L. M., J. L. Jorgensen, M. M. Davis, and L. J. Berg. 1994. A peptide antigen antagonist prevents the differentiation of T cell receptor transgenic thymocytes. J. Immunol. 152:1709.
26. Klenerman, P., S. Rowland-Jones, S. McAdam, J. Edwards, S. Daenke, D. Lalloo, B. Koppe, W. Rosenberg, D. Boyd, A. Edwards, P. Giangrande, R. E. Phillips, and A. J. McMichael. 1994. Cytotoxic T-cell activity antagonized by naturally occurring HIV-1 gag variants. Nature 369:403.
27. Beroletti, A., A. Sette, F. V. Chisari, A. Penna, M. Levrero, M. D. Carli, F. Fiaccadori, and C. Ferrari. 1994. Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells. Nature 369:407.
28. Madrenas, J., R. L. Wange, J. L. Wang, N. Isakov, L. E. Samelson, and R. N. Germain. 1995. ζ phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists. Science 267:515.
29. Sloan-Lancaster, J., A. S. Shaw, J. B. Rothbard, and P. M. Allen. 1994. Partial T cell signaling; altered phospho-ζ and lacking of Zap70 recruitment in APL-induced T cell anergy. Cell 79:913.
30. Gordon, R. D., E. Simpson, and L. E. Samelson. 1975. In vitro cell-mediated immune responses to the male specific (H-Y) antigen in mice. J. Exp. Med. 142:1108.
31. Wang, W., L. R. Meadows, J. M. M. den Haan, N. E. Sherman, Y. Chen, E. Blokland, J. Shabanowitz, A. I. Agulnik, R. C. Hendrickson, C. E. Bishop, D. F. Hunt, E. Goulmy, and V. H. Engelhard. 1995. Human H-Y: a male-specific histocompatibility antigen derived from the SMCY protein. Science 269:1588.
32. Scott, D. M., I. E. Ehrmann, P. S. Ellis, C. E. Bishop, A. I. Agulnik, E. Simpson, and M. J. Mitchell. 1995. Identification of a mouse male-specific transplantation antigen. H-Y. Nature 376:695.