메뉴 건너뛰기




Volumn 80, Issue 6, 1997, Pages 1034-1045

The prognostic significance of p53 and bcl-2 expression in lung adenocarcinoma and its correlation with Ki-67 growth fraction

Author keywords

bcl 2; Ki 67; Lung adenocarcinoma; p53; Poliferative activity; Survival analysis

Indexed keywords

ADULT; AGED; ARTICLE; CANCER SURVIVAL; CELL PROLIFERATION; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG ADENOCARCINOMA; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION;

EID: 0030761399     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0142(19970915)80:6<1034::AID-CNCR5>3.0.CO;2-9     Document Type: Article
Times cited : (111)

References (51)
  • 2
    • 0023120513 scopus 로고
    • Recent trends in different histological types of lung cancer in Tokyo based on pathological autopsy records
    • Tsugane S, Watanabe S, Sugimura H, Urano Y, Matsubara S. Recent trends in different histological types of lung cancer in Tokyo based on pathological autopsy records. Jpn J Cancer Res 1987;78:162-9.
    • (1987) Jpn J Cancer Res , vol.78 , pp. 162-169
    • Tsugane, S.1    Watanabe, S.2    Sugimura, H.3    Urano, Y.4    Matsubara, S.5
  • 3
    • 0023726197 scopus 로고
    • Prognosis and survival in resected lung carcinoma based on the new international staging system
    • Naruke T, Goya T, Tsuchiya R, Suemasu K. Prognosis and survival in resected lung carcinoma based on the new international staging system. J Thorac Cardiovasc Surg 1988; 96: 440-7.
    • (1988) J Thorac Cardiovasc Surg , vol.96 , pp. 440-447
    • Naruke, T.1    Goya, T.2    Tsuchiya, R.3    Suemasu, K.4
  • 4
    • 0027538035 scopus 로고
    • The molecular biology of lung cancer pathogenesis
    • Minna JD. The molecular biology of lung cancer pathogenesis. Chest 1993; 103:449S-56S.
    • (1993) Chest , vol.103
    • Minna, J.D.1
  • 7
  • 8
    • 0026649648 scopus 로고
    • The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
    • Momand J, Zambetti GP, Olson DC, George D, Levine AJ. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 1992;69:1237-45.
    • (1992) Cell , vol.69 , pp. 1237-1245
    • Momand, J.1    Zambetti, G.P.2    Olson, D.C.3    George, D.4    Levine, A.J.5
  • 9
    • 0026669469 scopus 로고
    • p53 function and dysfunction
    • Vogelstein B, Kinzler KW. p53 function and dysfunction. Cell 1992;70:523-6.
    • (1992) Cell , vol.70 , pp. 523-526
    • Vogelstein, B.1    Kinzler, K.W.2
  • 10
    • 0028071555 scopus 로고
    • Mutations in the p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis
    • Greenblatt MS, Bennet WP, Hollstein M, Harris CC. Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res 1994; 54: 4855-78.
    • (1994) Cancer Res , vol.54 , pp. 4855-4878
    • Greenblatt, M.S.1    Bennet, W.P.2    Hollstein, M.3    Harris, C.C.4
  • 11
    • 0029054396 scopus 로고
    • mdm2 gene amplification and overexpression in non-small cell lung carcinomas with accumulation of the p53 protein in the absence of p53 gene mutations
    • Marchetti A, Buttitta F, Pellegrini S, Merlo G, Chella A, Angeletti CA, et al. mdm2 gene amplification and overexpression in non-small cell lung carcinomas with accumulation of the p53 protein in the absence of p53 gene mutations. Diagn Mol Pathol 1995;4:93-7.
    • (1995) Diagn Mol Pathol , vol.4 , pp. 93-97
    • Marchetti, A.1    Buttitta, F.2    Pellegrini, S.3    Merlo, G.4    Chella, A.5    Angeletti, C.A.6
  • 12
    • 0026737950 scopus 로고
    • Accumulation of p53 protein correlates with a poor prognosis in human lung cancer
    • Quinlan DC, Davidson AG, Summers CL, Warden HE, Doshi HM. Accumulation of p53 protein correlates with a poor prognosis in human lung cancer. Cancer Res 1992;52:4828-31.
    • (1992) Cancer Res , vol.52 , pp. 4828-4831
    • Quinlan, D.C.1    Davidson, A.G.2    Summers, C.L.3    Warden, H.E.4    Doshi, H.M.5
  • 13
    • 0028884881 scopus 로고
    • Prognostic significance of p53 and ras p-21 expression in nonsmall cell lung cancer
    • Fujino M, Dosaka-Akita H, Harada M, Hiroumi H, Kinoshita I, Akie K, et al. Prognostic significance of p53 and ras p-21 expression in nonsmall cell lung cancer. Cancer 1995;76: 2457-63.
    • (1995) Cancer , vol.76 , pp. 2457-2463
    • Fujino, M.1    Dosaka-Akita, H.2    Harada, M.3    Hiroumi, H.4    Kinoshita, I.5    Akie, K.6
  • 14
    • 0026698080 scopus 로고
    • The relationship of p53 immunostaining to survival in carcinoma of the lung
    • McLaren R, Kuzu I, Dunnill M, Harris A, Lane D, Gatter KC. The relationship of p53 immunostaining to survival in carcinoma of the lung. Br J Cancer 1992;66:735-8.
    • (1992) Br J Cancer , vol.66 , pp. 735-738
    • McLaren, R.1    Kuzu, I.2    Dunnill, M.3    Harris, A.4    Lane, D.5    Gatter, K.C.6
  • 16
    • 0021270716 scopus 로고
    • Molecular cloning of the chromosomal breakpoint of B-cell lymphomas and leukemias with the t(11;14) chromosome translocation
    • Tsujimoto Y, Yunis J, Onorato SL, Erikson J, Nowell PC, Croce CM. Molecular cloning of the chromosomal breakpoint of B-cell lymphomas and leukemias with the t(11;14) chromosome translocation. Science 1984;224: 1403-6.
    • (1984) Science , vol.224 , pp. 1403-1406
    • Tsujimoto, Y.1    Yunis, J.2    Onorato, S.L.3    Erikson, J.4    Nowell, P.C.5    Croce, C.M.6
  • 17
    • 0025341687 scopus 로고
    • Expression of the bcl-2 oncogene protein is not specific for the 14;18 chromosomal translocation
    • Pezzella F, Tse AG, Cordell JL, Pulford KA, Gatter KC, Mason DY. Expression of the bcl-2 oncogene protein is not specific for the 14;18 chromosomal translocation. Am J Pathol 1990;137:225-32.
    • (1990) Am J Pathol , vol.137 , pp. 225-232
    • Pezzella, F.1    Tse, A.G.2    Cordell, J.L.3    Pulford, K.A.4    Gatter, K.C.5    Mason, D.Y.6
  • 18
    • 0025204548 scopus 로고
    • Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
    • Hockenbery D, Nunez G, Milliman C, Schreiber RD, Korsmeyer SJ. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 1990;348:334-6.
    • (1990) Nature , vol.348 , pp. 334-336
    • Hockenbery, D.1    Nunez, G.2    Milliman, C.3    Schreiber, R.D.4    Korsmeyer, S.J.5
  • 20
    • 0029035891 scopus 로고
    • Bcl-2 protein: A prognostic factor inversely correlated to p53 in non-small-cell lung cancer
    • Fontanini G, Vignati S, Bigini D, Mussi A, Lucchi M, Angeletti CA, et al. Bcl-2 protein: a prognostic factor inversely correlated to p53 in non-small-cell lung cancer. Br J Cancer 1995;71:1003-7.
    • (1995) Br J Cancer , vol.71 , pp. 1003-1007
    • Fontanini, G.1    Vignati, S.2    Bigini, D.3    Mussi, A.4    Lucchi, M.5    Angeletti, C.A.6
  • 21
    • 0027944957 scopus 로고
    • Bcl-2 protein expression and long-term survival in breast cancer
    • Joensuu H, Pylkkänen L, Toikkanen S. Bcl-2 protein expression and long-term survival in breast cancer. Am J Pathol 1994;145:1191-8.
    • (1994) Am J Pathol , vol.145 , pp. 1191-1198
    • Joensuu, H.1    Pylkkänen, L.2    Toikkanen, S.3
  • 22
    • 0028214472 scopus 로고
    • The Bcl-2 protein: A prognostic indicator strongly related to p53 protein in lymph node-negative breast cancer patients
    • Silvestrini R, Veneroni S, Daidone MG, Benini E, Boracchi P, Mezzetti M, et al. The Bcl-2 protein: a prognostic indicator strongly related to p53 protein in lymph node-negative breast cancer patients. J Natl Cancer Inst 1994;86:499-504.
    • (1994) J Natl Cancer Inst , vol.86 , pp. 499-504
    • Silvestrini, R.1    Veneroni, S.2    Daidone, M.G.3    Benini, E.4    Boracchi, P.5    Mezzetti, M.6
  • 23
    • 0029065973 scopus 로고
    • bcl-2 protein in invasive ductal breast carcinomas
    • Hurlimann J, Larrinaga B, Vala DL. bcl-2 protein in invasive ductal breast carcinomas. Virchows Arch 1995;426: 163-8.
    • (1995) Virchows Arch , vol.426 , pp. 163-168
    • Hurlimann, J.1    Larrinaga, B.2    Vala, D.L.3
  • 24
    • 0029071016 scopus 로고
    • Immunohistochemical analysis of bcl-2 and p53 expression in breast carcinomas: Their correlation with Ki-67 growth fraction
    • Gorczyca W, Markiewski M, Kram A, Tuziak T, Domagala W. Immunohistochemical analysis of bcl-2 and p53 expression in breast carcinomas: their correlation with Ki-67 growth fraction. Virchows Arch 1995;426:229-33.
    • (1995) Virchows Arch , vol.426 , pp. 229-233
    • Gorczyca, W.1    Markiewski, M.2    Kram, A.3    Tuziak, T.4    Domagala, W.5
  • 25
    • 0028174254 scopus 로고
    • Bcl-2 protein expression in carcinomas originating from the follicular epithelium of the thyroid gland
    • Pilotti S, Collini P, Rilke F, Cattoretti G, Del Bo R, Pierotti MA. Bcl-2 protein expression in carcinomas originating from the follicular epithelium of the thyroid gland. J Pathol 1994; 172:337-42.
    • (1994) J Pathol , vol.172 , pp. 337-342
    • Pilotti, S.1    Collini, P.2    Rilke, F.3    Cattoretti, G.4    Del Bo, R.5    Pierotti, M.A.6
  • 26
    • 0028862440 scopus 로고
    • Expression and prognostic significance of Bcl-2 in ovarian tumours
    • Henriksen R, Wilander E, Öberg K. Expression and prognostic significance of Bcl-2 in ovarian tumours. Br J Cancer 1995;72:1324-9.
    • (1995) Br J Cancer , vol.72 , pp. 1324-1329
    • Henriksen, R.1    Wilander, E.2    Öberg, K.3
  • 27
    • 0027093255 scopus 로고
    • Expression of the protooncogene bcl-2 in the prostate and its association with emergence of androgen-independent prostate cancer
    • McDonnell TJ, Troncoso P, Brisbay SM, Logothetis C, Chung LW, Hsieh JT, et al. Expression of the protooncogene bcl-2 in the prostate and its association with emergence of androgen-independent prostate cancer. Cancer Res 1992;52:6940-4.
    • (1992) Cancer Res , vol.52 , pp. 6940-6944
    • McDonnell, T.J.1    Troncoso, P.2    Brisbay, S.M.3    Logothetis, C.4    Chung, L.W.5    Hsieh, J.T.6
  • 29
    • 0029066597 scopus 로고
    • Bcl-2 expression and its association with cell kinetics in human gastric carcinomas and intestinal metaplasia
    • Saegusa M, Takano Y, Okayasu I. Bcl-2 expression and its association with cell kinetics in human gastric carcinomas and intestinal metaplasia. J Cancer Res Clin Oncol 1995; 121:357-63.
    • (1995) J Cancer Res Clin Oncol , vol.121 , pp. 357-363
    • Saegusa, M.1    Takano, Y.2    Okayasu, I.3
  • 30
    • 0030024253 scopus 로고    scopus 로고
    • Apoptosis and immunohistochemical bcl-2 expression in colorectal adenoma and carcinomas
    • Baretton GB, Diebold J, Christoforis G, Vogt M, Müller C, Dopfer K, et al. Apoptosis and immunohistochemical bcl-2 expression in colorectal adenoma and carcinomas. Cancer 1996;77:255-64.
    • (1996) Cancer , vol.77 , pp. 255-264
    • Baretton, G.B.1    Diebold, J.2    Christoforis, G.3    Vogt, M.4    Müller, C.5    Dopfer, K.6
  • 34
    • 0028007561 scopus 로고
    • p53 immunostaining positivity is associated with reduced survival and is imperfectly correlated with gene mutations in resected non-small cell lung cancer. a preliminary report of LCSG 871
    • Carbone DP, Mitsudomi T, Chiba I, Piantadosi S, Rusch V, Nowak JA, et al. p53 immunostaining positivity is associated with reduced survival and is imperfectly correlated with gene mutations in resected non-small cell lung cancer. A preliminary report of LCSG 871. Chest 1994;106(Suppl 6):377S-81S.
    • (1994) Chest , vol.106 , Issue.6 SUPPL.
    • Carbone, D.P.1    Mitsudomi, T.2    Chiba, I.3    Piantadosi, S.4    Rusch, V.5    Nowak, J.A.6
  • 35
    • 0029113707 scopus 로고
    • Expression of p53 oncoprotein in non-small-cell lung cancer: A favorable prognostic factor
    • Lee JS, Yoon A, Kalapurakal SK, Ro JY, Lee J, Tu N, et al. Expression of p53 oncoprotein in non-small-cell lung cancer: a favorable prognostic factor. J Clin Oncol 1995;13:1893-903.
    • (1995) J Clin Oncol , vol.13 , pp. 1893-1903
    • Lee, J.S.1    Yoon, A.2    Kalapurakal, S.K.3    Ro, J.Y.4    Lee, J.5    Tu, N.6
  • 36
    • 0023203482 scopus 로고
    • Inhibition of cell growth mediated by plasmids encoding p53 antisense
    • Shohat O, Greenberg M, Reisman D, Oren M, Rotter V. Inhibition of cell growth mediated by plasmids encoding p53 antisense. Oncogene 1987;1:277-85.
    • (1987) Oncogene , vol.1 , pp. 277-285
    • Shohat, O.1    Greenberg, M.2    Reisman, D.3    Oren, M.4    Rotter, V.5
  • 39
    • 0027440644 scopus 로고
    • Prognostic significance of the proliferation index in surgically resected non-small-cell lung cancer
    • Pence JC, Kerns BJ, Dodge RK, Iglehart JD. Prognostic significance of the proliferation index in surgically resected non-small-cell lung cancer. Arch Surg 1993;128; 1382-90.
    • (1993) Arch Surg , vol.128 , pp. 1382-1390
    • Pence, J.C.1    Kerns, B.J.2    Dodge, R.K.3    Iglehart, J.D.4
  • 41
    • 0028966055 scopus 로고
    • A prognostic model of recurrence and death in stage I non-small cell lung cancer utilizing presentation, histopathology, and oncoprotein expression
    • Harpole DH Jr., Herndon JE II, Wolfe WG, Iglehart JD, Marks JR. A prognostic model of recurrence and death in stage I non-small cell lung cancer utilizing presentation, histopathology, and oncoprotein expression. Cancer Res 1995;55: 51-6.
    • (1995) Cancer Res , vol.55 , pp. 51-56
    • Harpole Jr., D.H.1    Herndon II, J.E.2    Wolfe, W.G.3    Iglehart, J.D.4    Marks, J.R.5
  • 43
    • 0029969414 scopus 로고    scopus 로고
    • Inverse correlation between the expression of bcl-2 and p53 proteins in primary gastric lymphoma
    • Nakamura S, Akazawa K, Kinukawa N, Yao T, Tsuneyoshi M. Inverse correlation between the expression of bcl-2 and p53 proteins in primary gastric lymphoma. Hum Pathol 1996;27:225-33.
    • (1996) Hum Pathol , vol.27 , pp. 225-233
    • Nakamura, S.1    Akazawa, K.2    Kinukawa, N.3    Yao, T.4    Tsuneyoshi, M.5
  • 44
    • 0028115802 scopus 로고
    • bcl-2 in normal human breast and carcinoma, association with oestrogen receptor-positive, epidermal growth factor receptor-negative tumours and in situ cancer
    • Leek RD, Kaklamanis L, Pezzella F, Gatter KC, Harris AL. bcl-2 in normal human breast and carcinoma, association with oestrogen receptor-positive, epidermal growth factor receptor-negative tumours and in situ cancer. Br J Cancer 1994;69:135-9.
    • (1994) Br J Cancer , vol.69 , pp. 135-139
    • Leek, R.D.1    Kaklamanis, L.2    Pezzella, F.3    Gatter, K.C.4    Harris, A.L.5
  • 46
    • 0026597191 scopus 로고
    • p53 mutations in non-small cell lung cancer in Japan: Association between mutations and smoking
    • Suzuki H, Takahashi T, Kuroishi T, Suyama M, Ariyoshi Y, Takahashi T, et al. p53 mutations in non-small cell lung cancer in Japan: association between mutations and smoking. Cancer Res 1992;52:734-7.
    • (1992) Cancer Res , vol.52 , pp. 734-737
    • Suzuki, H.1    Takahashi, T.2    Kuroishi, T.3    Suyama, M.4    Ariyoshi, Y.5    Takahashi, T.6
  • 47
    • 0029022584 scopus 로고
    • Gender comparisons in human lung cancer: Analysis of p53 mutations, anti-p53 serum antibodies and c-erb B-2 expression
    • Guinee DG Jr., Travis WD, Trivers GE, De Benedetti VMG, Cawley H, Welsh JA, et al. Gender comparisons in human lung cancer: analysis of p53 mutations, anti-p53 serum antibodies and c-erb B-2 expression. Carcinogenesis 1995;16: 993-1002.
    • (1995) Carcinogenesis , vol.16 , pp. 993-1002
    • Guinee Jr., D.G.1    Travis, W.D.2    Trivers, G.E.3    De Benedetti, V.M.G.4    Cawley, H.5    Welsh, J.A.6
  • 48
    • 0028841327 scopus 로고
    • p53 nuclear immunostaining and gene mutations in non-small-cell lung cancer and their effects on patient survival
    • Mitsudomi T, Oyama T, Nishida K, Ogami A, Osaki T, Nakanishi R, et al. p53 nuclear immunostaining and gene mutations in non-small-cell lung cancer and their effects on patient survival. Ann Oncol 1995;6:S9-S13.
    • (1995) Ann Oncol , vol.6
    • Mitsudomi, T.1    Oyama, T.2    Nishida, K.3    Ogami, A.4    Osaki, T.5    Nakanishi, R.6
  • 49
    • 16044375068 scopus 로고    scopus 로고
    • Concordance between p53 protein overexpression and gene mutation in a large series of common human carcinomas
    • Soong R, Robbins PD, Dix BR, Grieu F, Lim B, Knowles S, et al. Concordance between p53 protein overexpression and gene mutation in a large series of common human carcinomas. Hum Pathol 1996;27:1050-5.
    • (1996) Hum Pathol , vol.27 , pp. 1050-1055
    • Soong, R.1    Robbins, P.D.2    Dix, B.R.3    Grieu, F.4    Lim, B.5    Knowles, S.6
  • 51
    • 0027109075 scopus 로고
    • p53: Guardian of the genome
    • Lane DP. p53: guardian of the genome. Nature 1992;358:15-6.
    • (1992) Nature , vol.358 , pp. 15-16
    • Lane, D.P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.