DAP kinase - A proapoptotic gene that functions as a tumor suppressor

Experimental Cell Research

Volumn 264, Issue 1, 2001, Pages 185-192

  Raveh, Tal ^a   Kimchi, Adi ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

DEATH ASSOCIATED PROTEIN KINASE; GENE PRODUCT; PROTEIN KINASE; PROTEIN P53; UNCLASSIFIED DRUG;

APOPTOSIS; CARCINOGENESIS; CHROMOSOME ABERRATION; GENE ACTIVATION; GENE FUNCTION; HUMAN; MALIGNANT TRANSFORMATION; METASTASIS; NICK END LABELING; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; TUMOR CELL LINE; TUMOR SUPPRESSOR GENE;

EID: 0035835823     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2000.5134     Document Type: Article

References (37)

1. p14ARF links the tumour suppressors RB and p53
2. 2+/calmodulin-dependent, cytoskeletal-associated protein kinase, with cell death-inducing functions that depend on its catalytic activity
3. DAP-kinase participates in TNF-alpha- and Fas-induced apoptosis and its function requires the death domain
4. E1A signaling to p53 involves the p19(ARF) tumor suppressor
5. Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death
6. A genetic tool used to identify thioredoxin as a mediator of a growth inhibitory signal
7. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
8. Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients
9. The death domain: A module shared by proteins with diverse cellular functions
10. Cancer metastasis
11. p53 and apoptosis
12. Protein kinase catalytic domain sequence database: Identification of conserved features of primary structure and classification of family members
13. DAP kinase links the control of apoptosis to metastasis
14. Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF
15. Hypermethylation of the DAP-kinase CpG island is a common alteration in B-cell malignancies
16. Apoptosis in cancer: Cause and cure
17. DAP-kinase loss of expression in various carcinoma and B-cell lymphoma cell lines: Possible implications for role as tumor suppressor gene
18. Oncogenic mechanisms mediated by DNA methylation
19. The c-myc oncogene perturbs B lymphocyte development in Eμ-myc transgenic mice
20. Activation of p53 by oncogenes
21. Apoptosis in cancer
22. bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation
23. Apoptotic membrane blebbing is regulated by myosin light chain phosphorylation
24. The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53
25. Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
26. A functional genetic screen identifies regions at the C-terminal tail and death-domain of death-associated protein kinase that are critical for its proapoptotic activity
27. DAP-kinase activates a p19ARF/p53-mediated apoptotic checkpoint to suppress oncogenic transformation
28. Gene promoter hypermethylation in tumors and serum of head and neck cancer patients
29. The INK4A/ARF locus and its two gene products
30. Tumor surveillance via the ARF-p53 pathway
31. Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2
32. Hypermethylation of the death-associated protein (DAP) kinase promoter and aggressiveness in stage I non-small-cell lung cancer
33. Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation
34. Apoptosis and carcinogenesis
35. Developmental changes in distribution of death-associated protein kinase mRNAs
36. Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6
37. Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization