DAP kinase links the control of apoptosis to metastasis

Nature

Volumn 390, Issue 6656, 1997, Pages 180-184

  Inbal, Boaz ^a   Cohen, Ofer ^a   Polak Charcon, Sylvie ^b   Kopolovic, Juri ^b   Vadai, Ezra ^a   Eisenbach, Lea ^a   Kimchi, Adi ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b SHEBA MEDICAL CENTER   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; ANKYRIN; CYCLOHEXIMIDE; DNA; GAMMA INTERFERON; MESSENGER RNA; PROTEIN KINASE (CALCIUM,CALMODULIN); SERINE; THREONINE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DNA METHYLATION; FEMALE; METASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SOUTHERN BLOTTING; TRANSGENE; TUMOR GROWTH;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; FEMALE; GENES, TUMOR SUPPRESSOR; LUNG NEOPLASMS; MICE; MICE, INBRED C57BL; NEOPLASM METASTASIS; NEOPLASM TRANSPLANTATION; TRANSFECTION; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA; MURINAE;

EID: 0030664814     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/36599     Document Type: Article

References (30)

1. Deiss, L. P., Feinstein, E., Berissi, H., Cohen, O. & Kimchi, A. Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death. Genes Dev. 9, 15-30 (1995).
2. +/calmodulin-dependent, cytoskeletal-assodated protein kinase, with cell death-inducing functions that depend on its catalytic activity. EMBO J. 16, 998-1008 (1997).
3. Feinstain, E., Wallach, D., Boldin, M., Varfolomeev, E. & Kimchi, A. The death domain: a module shared by proteins with diverse cellular functions. Trends Biochem. Sci. 20, 342-344 (1995).
4. Deiss, L. P. & Kimchi, A. A genetic tool used to identify thioredoxin as a mediator of a growth inhibitory signal. Science 252, 117-120 (1991).
5. Clarke, A. R. et al. Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature 362, 849-852 (1993).
6. Lowe, S. W., Schmitt, E. M., Smith, S. W., Osborne, B. A. & Jacks, T. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 362, 847-849 (1993).
7. Haffner, R. & Oren, M. Biochemical properties and biological effects of p53. Curr. Opin. Genet. Dev. 5, 84-90 (1995).
8. Graeber, T. G. et al. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumors. Nature 379, 88-91 (1996).
9. Morin, P. J., Vogenstein, B. & Kinzler, K. W. Apoptosis and APC in colorectal tumorigenesis. Proc. Natl Acad. Sci. USA 93, 7950-7954 (1996).
10. Bakhshi, A. et al. Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on 18. Cell 41, 899-906 (1985).
11. Tsujimoto, Y. et al. Clustering of breakpoints on chromosome 11 in human B-cell neoplasms with the t(11;14) chromosome translocation. Nature 315, 340-343 (1985).
12. Reed, J. C. Regulation of apoptosis by bcl-2 family proteins and its role in cancer and chemoresistance. Curr. Opin. Oncol. 7, 541-546 (1995).
13. Naik, P., Karrim, J. & Hanahan, D. The rise and fall of apoptosis during multistage tumorigenesis: down-modulation contributes to tumor progression from angiogenic progenitors. Genes Dev. 10, 2105-2116 (1996).
14. Kissil, J. L. et al. DAP-kinase loss of expression in B-cell leukemia and bladder carcinoma cell lines: possible implications for role as tumor suppressor gene. Oncogene 15, 403-407 (1997).
15. Eisenbach, L., Segal, S. & Feldman, M. MHC imbalance and metastatic spread in Lewis lung carcinoma clones. Int. J. Cancer 32, 113-120 (1983).
16. Layton, M. G. & Franks, L. M. Heterogeneity in a spontaneous mouse lung carcinoma: selection and characterization of stable metastatic variants. Br. J. Cancer 49, 415-421 (1984).
17. Laird, P. W. Oncogenic mechanisms mediated by DNA methylation. Mol. Med. Today 3, 223-229 (1997).
18. Bursch, W., Paffe, S., Putz, B., Barthel, G. & Schulte-Hermann, R. Determination of the length of the histological stages of apoptosis in normal liver and in altered hepatic foci of rats. Carcinogenesis 11, 847-853 (1990).
19. Meredith, J. E. Jr, Fazeli, B. & Schwartz, M. A. The extracellular matrix as a well survival factor. Mol. Biol. Cell 4, 953-961 (1993).
20. Meredith, J. E. Jr & Schwartz, M. A. Integrins, adhesion and apoptosis. Trends Cell Biol. 7, 146-150 (1997).
21. Frisch, S. M. & Francis, H. Disruption of epithelial cell-matrix interactions induces apoptosis. J. Cell Biol. 124, 619-626 (1994).
22. Boudreau, N., Sympson, C. J., Werb, Z. & Bissell, M. J. Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix. Science 267, 891-893 (1995).
23. Plaksin, S., Gelber, C., Feldman, M. & Eisenbach, L. Reversal of the metastatic phenotype in Lewis lung carcinoma cells after transfection with syngeneic H-2Kb gene. Proc. Natl Acad. Sci. USA 85, 4463-4467 (1988).
24. Holmgren, L., O'Reilly, M. S. & Folkman, J. Dormancy of micrometastases: balanced proliferation and apoptosis in the presence of angiogenesis suppression. Nature Med. 1, 149-153 (1995).
25. Nikiforov, M. A. et al. p53 modulation of anchorage independent growth and experimental metastasis. Oncogene 13, 1710-1720 (1996).
26. Shtivelman, E. A link betwen metastasis and resistance to apoptosis of variant small-cell lung carcinoma. Oncogene 14, 2167-2173 (1997).
27. Fidler, I. J. & Balch, C. M. The biology of cancer metastasis and implications for therapy. Curr. Prob. Surg. 24, 129-209 (1987).
28. Weiss, L. Biochemical interactions of cancer cells with the microvasculature during hematogenous metastatis. Cancer Metastasis Rev. 11, 227-235 (1992).
29. Xie, K. P., Dong, Z. Y. & Fidler, I. J. Activation of nitric oxide synthase gene for inhibition of cancer metastasis. J. Leuk. Biol. 59, 797-803 (1996).
30. Yamauchi, A., Taga, K., Mostowski, H. S. & Bloom, E. T. Target cell-induced apoptosis of interleukin-2-activated human natural killer cells: roles of cell surface molecules and intracellular events. Blood 87, 5127-5135 (1996).