Differential inactivation of caspase-8 in lung cancers

Cancer Biology and Therapy

Volumn 1, Issue 1, 2002, Pages 65-69

  Shivapurkar, Narayan ^a,b   Toyooka, Shinichi ^a   Eby, Michael T ^a   Huang, Chun Xian ^a   Sathyanarayana, Ubaradka G ^a,b   Cunningham, H Thomas ^a   Reddy, Jyotsna L ^a   Brambilla, Elizabeth ^c   Takahashi, Takashi ^d   Minna, John D ^a,b   Chaudhary, Preet M ^a,b   Gazdar, Adi F ^b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c GRENOBLE UNIVERSITY HOSPITAL   (France)

^d AICHI CANCER CENTER HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CASP8 PROTEIN, HUMAN; CASP9 PROTEIN, HUMAN; CASPASE; CASPASE 8; CASPASE 9; DNA; TUMOR PROTEIN;

APOPTOSIS; ARTICLE; BIOSYNTHESIS; BRONCHUS TUMOR; CARCINOID; CHEMISTRY; CHROMOSOME 2; COMPARATIVE STUDY; DNA METHYLATION; ENZYME INDUCTION; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; HETEROZYGOSITY LOSS; HUMAN; LUNG NON SMALL CELL CANCER; LUNG TUMOR; PHYSIOLOGY; SMALL CELL CARCINOMA; TUMOR SUPPRESSOR GENE;

APOPTOSIS; BRONCHIAL NEOPLASMS; CARCINOID TUMOR; CARCINOMA, NON-SMALL-CELL LUNG; CARCINOMA, SMALL CELL; CASPASE 8; CASPASE 9; CASPASES; CHROMOSOMES, HUMAN, PAIR 2; DNA METHYLATION; DNA, NEOPLASM; ENZYME INDUCTION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; GENES, TUMOR SUPPRESSOR; HUMANS; LOSS OF HETEROZYGOSITY; LUNG NEOPLASMS; NEOPLASM PROTEINS;

EID: 85047687948     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.1.1.45     Document Type: Article

References (44)

1. Golstein P. Controlling cell death. Science 1997; 275:1081-1082. (Pubitemid 27097300)
2. Cryns V, Yuan J. Proteases to die for. Genes Dev 1998; 12:1551-1570. (Pubitemid 28299508)
3. Wyllie AH. Apoptosis: An overview. Br Med Bull 1997; 53:451-465. (Pubitemid 27397303)
4. Aravind L, Dixit VM, Koonin EV. Apoptotic molecular machinery: Vastly increased complexity in vertebrates revealed by genome comparisons. Science 2001; 291:1279-1284. (Pubitemid 32173085)
5. Nicholson DW. Caspase structure, proteolytic substrates, and function during apoptotic cell death. Cell Death Differ 1999; 6:1028-1042.
6. Ashkenazi A, Dixit VM. Apoptosis control by death and decoy receptors. Curr Opin Cell Biol 1999; 11:255-260. (Pubitemid 29164042)
7. Schneider P, Tschopp J. Apoptosis induced by death receptors. Pharm Acta Helv 2000; 74:281-286. (Pubitemid 30182582)
8. Bodmer JL, Holler N, Reynard S, et al. TRAIL receptor-2 signals apoptosis through FADD and caspase-8. Nat Cell Biol 2000; 2:241-243.
9. Slee EA, Adrain C, Martin SJ. Executioner caspases-3, -6 and -7 perform distinct, nonredundant, roles during the demolition phase of apoptosis. J Biol Chem 2000; 10:7320-7326.
10. Kohno T, Morishita K, Takano H, et al. Homozygous deletion at chromosome 2q33 in human small-cell lung carcinoma identified by arbitrarily primed PCR genomic finger-printing. Oncogene 1994; 9:103-108. (Pubitemid 24020939)
11. Phelps RM, Johnson BE, Ihde DC, et al. NCI-Navy Medical Oncology Branch cell line data base. J Cell Biochem Suppl 1996; 24:32-91.
12. Merlo A, Herman JG, Mao L, et al. 5¢ CpG island methylation is associated with transcriptional silencing of the tumor suppressor p16/CDKN2/MTS1 in human cancers. Nat Med 1995; 1:686-692.
13. Baylin SB, Herman JG, Graff JR, et al. Alterations in DNA methylation: A fundamental aspect of neoplasia. Adv Cancer Res, 1998; 72:141-196. (Pubitemid 27435555)
14. Belinsky SA, Nikula KJ, Palmisano WA, et al. Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis. Proc Natl Acad Sci USA 1998; 95:11891-11896.
15. Herman JG, Merlo A, Mao L, et al. Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers. Cancer Res 1995; 55:4525-4530.
16. Herman JG, Jen J, Merlo A, et al. Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B. Cancer Res 1996; 56:722-727.
17. Toyooka KO, Toyooka S, Virmani AK, et al. Loss of expression and aberrant methylation of the CDH13 (H-cadherin) gene in breast and lung carcinomas. Cancer Res 2001; 61:4556-4560. (Pubitemid 32685789)
18. Zochbauer-Muller S, Fong KM, Maitra A, et al. 5¢ CpG island methylation of the FHIT gene is correlated with loss of gene expression in lung and breast cancer. Cancer Res 2001; 61:3581-3585.
19. Teitz T, Wei T, Valentine MB, et al. Caspase-8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN. Nat Med 2000; 6:529-535. (Pubitemid 30305902)
20. Virmani AK, Fong KM, Kodagoda D, et al. Allelotyping demonstrates common and distinct patterns of chromosomal loss in human lung cancer types. Genes Chrom Cancer 1998; 21:308-319. (Pubitemid 28165038)
21. Herman JG, Graff JR, Myohanen S, et al. Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci USA 1996; 93:9821-9826. (Pubitemid 26296693)
22. Cameron EE, Bachman KE, Myohanen S, et al. Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer. Nat Genet 1999; 21:103-107. (Pubitemid 29036293)
23. Shivapurkar N, Sood S, Wistuba II, et al. Multiple regions of chromosome 4 demonstrating allelic losses in breast carcinomas. Cancer Res 1999; 59:3576-3580. (Pubitemid 29381855)
24. Shivapurkar N, Virmani AK, Wistuba II, et al. Deletions of chromosome 4 at multiple sites are frequent in malignant mesothelioma and small cell lung carcinoma. Clin Cancer Res 1999; 5:17-23. (Pubitemid 29045173)
25. Grenet J, Teitz T, Wei T, et al. Structure and chromosome localization of the human CASP8 gene. Gene 1999; 226:225-232. (Pubitemid 29087103)
26. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000; 100:57-70. (Pubitemid 30046295)
27. Sirzen F, Zhivotovsky B, Nilsson A, et al. Higher spontaneous apoptotic index in small cell compared with non- small cell lung carcinoma cell lines: Lack of correlation with Bcl-2/Bax. Lung Cancer 1998; 22:1-13. (Pubitemid 28526438)
28. Eerola AK, Tormanen U, Rainio P, et al. Apoptosis in operated small cell lung carcinoma is inversely related to tumour necrosis and p53 immunoreactivity. J Pathol 1997; 181:172-177. (Pubitemid 27087281)
29. Borner MM, Brousset P, Pfanner-Meyer B, et al. Expression of apoptosis regulatory proteins of the Bcl-2 family and p53 in primary resected non-small-cell lung cancer. Br J Cancer 1999; 79:952-958.
30. Brambilla E, Negoescu A, Gazzeri S, et al. Apoptosis-related factors p53, Bcl2, and Bax in neuroendocrine lung tumors. Am J Pathol 1996; 149:1941-1952. (Pubitemid 26415213)
31. Kim DH, Nelson HH, Wiencke JK, et al. Promoter methylation of DAP-kinase: Association with advanced stage in non-small cell lung cancer. Oncogene 2001; 20:1765-1770. (Pubitemid 32368022)
32. Joseph B, Ekedahl J, Sirzen F, et al. Differences in expression of pro-caspases in small cell and non-small cell lung carcinoma. Biochem Biophys Res Commun 1999; 262:381-387. (Pubitemid 29429877)
33. Takita J, Yang HW, Bessho F, et al. Absent or reduced expression of the Caspase-8 gene occurs frequently in neuroblastoma, but not commonly in ewing sarcoma or rhabdomyosarcoma. Med Pediatr Oncol 2000; 35:541-543.
34. Takita J, Yang HW, Chen YY, et al. Allelic imbalance on chromosome 2q and alterations of the Caspase-8 gene in neuroblastoma. Oncogene 2001; 20:4424-4432. (Pubitemid 32726887)
35. Gardiner-Garden M, Frommer M. CpG islands in vertebrate genomes. J Mol Biol 1987; 196:261-282. (Pubitemid 17122132)
36. Shapiro GI, Park JE., Edwards CD, et al. Multiple mechanisms of p16INK4A inactivation in non-small cell lung cancer cell lines. Cancer Res 1995; 55:6200-6209.
37. Girard L, Zochbauer-Muller S, Virmani AK, et al. Genome-wide allelotyping of lung cancer identifies new regions of allelic loss, differences between small cell lung cancer and nonsmall cell lung cancer, and loci clustering. Cancer Res 2000; 60:4894-4906.
38. Kohno T, Otsuka T, Takano H et al. Identification of a novel phospholipase C family gene at chromosome 2q33 that is homozygously deleted in human small cell lung carcinoma. Hum Mol Genet 1995; 4:667-674.
39. Kischkel FC, Lawrence DA, Tinel A, et al. Death receptor recruitment of endogenous caspase-10 and apoptosis initiation in the absence of caspase-8. J Biol Chem 2001; In Press.
40. Gazdar AF, Helman LJ, Israel MA, et al. Expression of neuroendocrine cell markers L-dopa decarboxylase, chromogranin A, and dense core granules in human tumors of endocrine and nonendocrine origin. Cancer Res 1988; 48:4078-4082.
41. Linnoila RI, Mulshine JL, Steinberg SM, et al. Neuroendocrine differentiation in endocrine and non-endocrine lung carcinomas. Am J Clin Pathol 1988; 90:641-652. (Pubitemid 19006256)
42. Debelenko LV, Brambilla E, Agarwal SK, et al. Identification of MEN1 gene mutations in sporadic carcinoid tumors of the lung. Hum Mol Genet 1997; 6:2285-2290. (Pubitemid 27501081)
43. Haruki N, Yatabe Y, Travis WD, et al. Characterization of high-grade neuroendocrine tumors of the lung in relation to menin mutations. Jpn J Cancer Res 2000; 91:317-323. (Pubitemid 30198172)
44. Fisher MJ, Virmani AK, Wu L, et al. Nucleotide substitution in the ectodomain of trail receptor dr4 is associated with lung cancer and head and neck cancer. Clin Cancer Res 2001; 7:1688-1697. (Pubitemid 32708637)