Role of apoptosis in the response of lung carcinomas to anti-cancer treatment

Annals of the New York Academy of Sciences

Volumn 926, Issue , 2000, Pages 204-216

  Joseph, Bertrand ^a   Lewensohn, Rolf ^b   Zhivotovsky, Boris ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b Cancer Center Karolinska   (Sweden)

Author keywords

Apoptosis; Bcl 2 family; c Myc; Cancer therapy; Caspases; Cyclin D1; Fas FasL; IAP family; Lung carcinoma; p16INK4; p53; Ras family; Rb

Indexed keywords

CASPASE; CYCLIN D1; FAS ANTIBODY; FAS LIGAND; PROTEIN BCL 2; PROTEIN P53; RAS PROTEIN; SURVIVIN;

APOPTOSIS; CANCER CELL; CANCER CHEMOTHERAPY; CANCER GRADING; CANCER RADIOTHERAPY; CANCER STAGING; CELL CYCLE; CELL DEATH; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONFERENCE PAPER; DNA REPAIR; DRUG RESPONSE; HISTOLOGY; HUMAN; HUMAN CELL; LUNG CARCINOMA; ONCOGENE C MYC; TREATMENT FAILURE; TUMOR CELL DESTRUCTION;

EID: 0034508668     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2000.tb05613.x     Document Type: Conference Paper

References (65)

1. Epidemiology of lung cancer
2. Classification, histology, cytology and electron microscopy
3. Small-cell lung cancer: A perspective on the past and a preview of the future
4. Neoplasms of the lung
5. Radiation biology of lung cancer
6. Single-dose and fractionated irradiation of four human lung cancer cell lines in vitro
7. Tumor radiosensitivity and apoptosis
8. Histopathological evaluation of apoptosis in cancer
9. Apoptosis and mitotic cell death: Their relative contributions to normal-tissue and tumor radiation response
10. Prognostic biomarker study in pathologically staged N1 non-small cell lung cancer
11. Higher spontaneous apoptotic index in small cell compared with non small cell lung carcinoma cell lines; lack of correlation with Bcl-2/Bax
12. Spontaneous and radiation-induced apoptosis in lung carcinoma cells with different intrinsic radiosensitivities
13. Differences in expression of procaspases in small cell and non-small cell lung carcinoma
14. Apoptosis in operated small cell lung carcinoma is inversely related to tumor necrosis and p53 immunoreactivity
15. Defective caspase-3 relocalization in non small cell lung carcinoma: Mechanism for a nuclear apoptosis resistance
16. Apoptosis induced by etoposide in small-cell lung cancer cell lines
17. Evaluation of apoptosis and necrosis induction in cultured cells of lung carcinomas under effect of cytostatic drugs in vitro
18. Apoptosis in human disease: A new skin for the old ceremony?
19. The p53 gene as a modifier of intrinsic radiosensitivity: Implications for radiotherapy
20. Role of p53 mutations in the radiosensitivity status of tumor cells
21. Mutations in the p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis
22. p53 mutations do not predict response to paclitaxel/radiation for nonsmall cell lung carcinoma
23. Bcl-2 family proteins
24. Bcl-2 protects murine erythroleukemia cells from p53-dependent and -independent radiation-induced cell death
25. High expression of bcl-2 protein in acute myeloid leukemia cells is associated with poor response to chemotherapy
26. Apoptosis of lung cancer cells caused by some anti-cancer agents (MMC, CPT-11, ADM) is inhibited by bcl-2
27. Antisense bcl-2 treatment increases programmed cell death in non-small cell lung cancer cell lines
28. Bcl-2 protein and prognosis in patients with potentially curable non-small-cell lung cancer
29. Accelerated apoptosis and low bcl-2 expression associated with neuroendocrine differentiation predict shortened survival in operated large cell carcinoma of the lung
30. Apoptosis occurs independently of bcl-2 and p53 over-expression in non-small cell lung carcinoma
31. Survival in small cell lung carcinoma is independent of Bcl-2 expression
32. Absence of prognostic significance of bcl-2 immunopositivity in non-small cell lung cancer: Analysis of 427 cases
33. Frequent high expression of bax pro-apoptotic protein in non-small cell lung cancer
34. Overexpression of bax associated with mutations in the loop-sheet-helix motif of p53
35. p53 mutant immunopheno-type and deregulation of p53 transcription pathway (Bcl2, Bax, and Waf1) in precursor bronchial lesions of lung cancer
36. Expression of apoptosis-regulatory genes in lung tumor cell lines: Relationship to p53 expression and relevance to acquired drug resistance
37. Signal transduction via Ras
38. Co-amplification of a novel cyclophilin-like gene (PPIE) with L-myc in small cell lung cancer cell lines
39. Predictive survival markers in patients with surgically resected non-small cell lung carcinoma
40. Overexpression of oncoproteins in non-small cell lung carcinomas of smokers
41. Correlation between K-ras gene mutation and prognosis of patients with nonsmall cell lung carcinoma
42. Function of the c-Myc oncogenic transcription factor
43. The biology of lung cancer
44. Effects of c-myc oncogene modulation on differentiation of human small cell lung carcinoma cell lines
45. Prognostic relevance of c-Myc and caspase-3 for patients with non-small cell lung cancer
46. Radiosensitivity of small-cell lung cancer xenografts compared with activity of c-myc, N-myc, L-myc, c-raf-1 and K-ras proto-oncogenes
47. INK4-cyclin D1) in preinvasive bronchial lesions
48. Differential retinoblastoma and p16(INK4A) protein expression in neuroendocrine tumors of the lung
49. INK4A, retinoblastoma and p53 proteins for the prognosis of nonsmall-cell lung cancers
50. Radiation-induced apoptosis in human lymphocytes and lymphoma cells critically relies on the up-regulation of CD95/Fas/APO-1 ligand
51. Human lung carcinomas express Fas ligand
52. Expression of Fas (CD95/APO-1) and Fas ligand in lung cancer, its prognostic and predictive relevance
53. Lack of cell surface Fas/APO-1 expression in pulmonary adenocarcinomas
54. Fas expression in non-small cell lung cancer: Its prognostic effect in completely resected stage III patients
55. Alterations of Fas (Apo-1/CD95) gene in non-small cell lung cancer
56. Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer
57. Drug-induced apoptosis in lung cancer cells is not mediated by the Fas/FasL (CD95/APO1) signaling pathway
58. Apoptosis: The germs of death
59. Paclitaxel-induced apoptosis in non-small cell lung cancer cell lines is associated with increased caspase-3 activity
60. Caspase-3 activation is not responsible for vinblastine-induced Bcl-2 phosphorylation and G2/M arrest in human small cell lung carcinoma Ms-1 cells
61. Escaping cell death: Survival proteins in cancer
62. IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs
63. Anti-apoptosis gene, survivin, and prognosis of neuroblastoma
64. A novel anti-apoptosis gene: Re-expression of survivin messenger RNA as a prognosis marker in non-small-cell lung cancers