The DAP kinase family of pro-apoptotic proteins: Novel players in the apoptotic game

BioEssays

Volumn 23, Issue 4, 2001, Pages 352-358

  Kögel, Donat ^a   Prehn, Jochen H M ^a   Scheidtmann, Karl Heinz ^b  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS REGULATORY PROTEIN; DEATH ASSOCIATED PROTEIN KINASE; PROTEIN KINASE (CALCIUM,CALMODULIN); PROTEIN SERINE THREONINE KINASE;

AMINO ACID SEQUENCE; ANIMAL; APOPTOSIS; CELL FRACTIONATION; ENZYME ACTIVATION; HUMAN; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGY; REVIEW; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; ENZYME ACTIVATION; HUMANS; MOLECULAR SEQUENCE DATA; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; SUBCELLULAR FRACTIONS;

EID: 0035074343     PISSN: 02659247     EISSN: None     Source Type: Journal    
DOI: 10.1002/bies.1050     Document Type: Review

References (47)

1. Cellular survival: A play in three Akts
2. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
3. The beginning of the end: IkappaB kinase (IKK) and NF-kappaB activation
4. NAK is an IkappaB kinase-activating kinase
5. Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways
6. Signal transduction pathways regulated by mitogen- activated/extracellular response kinase kinase kinase induce cell death
7. Serine/threonine protein kinases and apoptosis
8. Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death
9. RIP: A novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death
10. RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase
11. Identification of RIP3, a RIP-like kinase that activates apoptosis and NFkappaB
12. Proteolytic activation of protein kinase C delta by an ICE-like protease in apoptotic cells
13. Caspase-3-mediated cleavage of protein kinase C theta in induction of apoptosis
14. Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death
15. Death-associated protein kinase 2 is a new calcium/calmodulin-dependent protein kinase that signals apoptosis through its catalytic activity
16. Death-associated protein kinase-related protein 1, a novel sedne/threonine kinase involved in apoptosis
17. Cloning and characterization of Dlk, a novel serine/threonine kinase that is tightly associated with chromatin and phosphorylates core histones
18. ZIP kinase, a novel serine/threonine kinase which mediates apoptosis
19. DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis
20. 2+/calmodulin-dependent, cytoskeletal-associated protein kinase, with cell death-inducing functions that depend on its catalytic activity
21. C-terminal truncation of Dlk/ZIP kinase leads to abrogation of nuclear transport and high apoptotic activity
22. Developmental changes in distribution of death-associated protein kinase mRNAs
23. DAP-kinase loss of expression in various carcinoma and B-cell lymphoma cell lines: Possible implications for role as tumor suppressor gene
24. DAP kinase links the control of apoptosis to metastasis
25. AATF, a novel transcription factor that interacts with Dlk/ZIP kinase and interferes with apoptosis
26. DAP-kinase participates in TNF-alpha- and Fas-induced apoptosis and its function requires the death domain
27. DAP kinase activates a p19ARF/p53-mediated apoptotic checkpoint to suppress oncogenic transformation
28. Apoptosis induced by withdrawal of interleukin-3 (IL-3) from an IL-3-dependent hematopoietic cell line is associated with repartitioning of intracellular calcium and is blocked by enforced Bcl-2 oncoprotein production
29. Reduced loading of intracellular Ca(2+) stores and downregulation of capacitative Ca(2+) influx in bcl-2-overexpressing cells
30. A functional genetic screen identifies regions at the C-terminal tail and death-domain of death-associated protein kinase that are critical for its proapoptotic activity
31. Interaction partners of Dlk/ZIP kinase: Co-expression of Dlk/ZIP kinase and Par-4 results in cytoplasmic retention and apoptosis
32. Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease
33. Par-4: An emerging pivotal player in neuronal apoptosis and neurodegenerative disorders
34. The role of calcium in apoptosis
35. The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53
36. p53: Death star
37. Caspases: Key mediators of apoptosis
38. Extranuclear apoptosis. The role of the cytoplasm in the execution phase
39. Inhibition of Ced-3/ICE-related proteases does not prevent cell death induced by oncogenes, DNA damage, or the Bcl-2 homologue Bak
40. Apoptotic membrane blebbing is regulated by myosin light chain phosphorylation
41. Anti-apoptotic versus pro-apoptotic signal transduction: Checkpoints and stop signs along the road to death
42. The catalytic subunit of DNA-dependent protein kinase selectively regulates p53-dependent apoptosis but not cell-cycle arrest
43. Life and death decisions: Regulation of apoptosis by proteolysis of signaling molecules
44. MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1
45. Activation of IkappaB kinase beta by protein kinase C isoforms
46. Control of adhesion-dependent cell survival by focal adhesion kinase
47. Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase