Hypermethylation of the p16 gene in nasopharyngeal carcinoma

Cancer Research

Volumn 56, Issue 12, 1996, Pages 2721-2725

  Lo, Kwok Wai ^a   Cheung, Siu Tim ^a   Leung, Sing Fai ^a   Van Hasselt, Andrew ^b   Tsang, Yuen Shan ^a   Mak, Ko Fung ^a   Chung, Yuk Fei ^a   Woo, John K S ^b   Lee, Joseph C K ^a   Huang, Dolly P ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CHROMOSOME 9P; GENE EXPRESSION; HUMAN; HUMAN CELL; METHYLATION; NASOPHARYNX CARCINOMA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SOUTHERN BLOTTING; TRANSCRIPTION REGULATION; XENOGRAFT;

CARRIER PROTEINS; CYCLIN-DEPENDENT KINASE INHIBITOR P16; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, TUMOR SUPPRESSOR; HELA CELLS; HUMANS; METHYLATION; NASOPHARYNGEAL NEOPLASMS; POLYMERASE CHAIN REACTION; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

EID: 9344271110     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Muir, C., Waterhouse, J., Mack, T., Powell, J , and Whelan, S. Cancer Incidence in Five Continents, Vol 5. IARC Scientific Publ. No 88 Lyon, France: IARC, 1987.
2. Huang, D P. Epidemiology and aetiology In: C. A van Hasselt and A. G. Gibb (eds.), Nasopharyngeal Carcinoma, pp. 23-35. Hong Kong: The Chinese University Press, 1991.
3. Lu, Q-L., Elia, G., Lucas, S., and Thoma, J. A. Bcl-2 proto-oncogene expression in Epstein-Barr-virus-associated nasopharyngeal carcinoma Int J. Cancer, 53: 29-35, 1993
4. Porter, M J., Field, J K., Leung, S. F , Lo, D , Lee, J. C., Spandidos, D. A., and van Hasselt, C. A. The detection of the c-myc and ras oncogenes in nasopharyngeal carcinoma by immunohistochemistry. Acta Otolaryngol., 114: 105-109, 1994.
5. Sun, Y., Hegamyer, G., and Colburn, N. H. Nasopharyngeal carcinoma shows no detectable retinoblastoma susceptibility gene alterations. Oncogene, 8: 791-795, 1993.
6. Sun, Y., Hildesheim, A, Li, H., Li, Y , Chen, J. Y., Hayes, R. B., Rothman, N., Bi, W F , Cao, Y., Yao, K-T., Lanier, A. P., Hegamyer, G., El-Deiry, W. S , Xiong, Y., and Colburn, N. H No point mutation but a codon 31ser > arg polymorphism of the WAF-1/CIP-I/p21 tumor suppressor gene in nasopharyngeal carcinoma (NPC): the polymorphism distinguishes Caucasians from Chinese. Cancer Epidemiol. Biomarkers & Prev., 4, 261-267, 1995.
7. Sun, Y , Hildesheim, A, Li, H., Lanier, A. P , Cao, Y , Yao, K. T., Yang, C. S., and Colburn, N H. The von Hippel-Lindau disease tumor-suppressor gene is not mutated in nasopharyngeal carcinomas. Int. J. Cancer, 60, 437-438, 1995.
8. Spruck, C. H., III, Tsao, Y C., Huang, D. P., Yang, A. S., Rideout, W M., III, Gonzalwz-Zulueta, M , Choi, P , Lo, K. W , Yu, M C., and Jones, P. A. Absence of p53 gene mutations in primary nasopharyngeal carcinomas. Cancer Res., 52: 4787-4790, 1992.
9. Chakrani, F., Armand, J., Lenoir, G., Ju, L. Y., Liang, J P., May, E., and May, P. Mutations clustered in exon 5 of the p53 gene in primary nasopharyngeal carcinomas from southeastern Asia. Int. J. Cancer, 61, 316-320, 1995.
10. Lo, K. W., Tsao, S. W., Huang, D. P , and Lee, J. C. K. Detailed deletion mapping on the short arm of chromosome 3 in nasopharyngeal carcinomas Int. J Oncol , 4: 1359-1364, 1994.
11. Huang, D P , Lo, K. W., van Hasselt, C A., Woo, J. K. S., Choi, P. H K., Leung, S. F., Cheung, S. T , Cairns, P , Sidransky, D., and Lee, J. C. K. A region of homozygous deletion on chromosome 9p21-22 in primary nasopharyngeal carcinoma. Cancer Res , 54. 4003-4006, 1994.
12. Lo, K W , Huang, D. P., and Lau, K. M. p16 gene alterations in nasopharyngeal carcinoma. Cancer Res , 55. 2039-2043, 1995
13. Sun, Y , Hildesheim, A., Lanier, A. E. P., Cao, Y , Yao, K. T., Raab-Traub, N., and Yang C. S No point mutation but decreased expression of the p16/MTSI tumor suppressor gene in nasopharyngeal carcinoimas. Oncogene, 10, 785-788, 1995.
14. Merlo, A., Herman, J. G., Mao, L., Lee, D. J., Gabrielson, E. , Burger, P. C., Baylin, S. B , and Sidransky, D 5′ CpG island methyladon is associated with transcriptional silencing of the tumor suppressor p16/CDKN2/MTSI in human cancers. Nat. Med , I: 686-692, 1995.
15. Herman, J G., Merlo, A., Mao, L , Lapidus, R. G., Issa, J-P J., Davidson, N. E., Sidransky, D., and Baylin, S. B. Inactivation of the CDKN2/p16/MTSI gene is frequently associated with aberrant DNA methylation in all common human cancers. Cancer Res , 55: 4525-4530, 1995
16. Gonzalez-Zulueta, M., Bender, C. M., Yang, A. S , Nguyen, T., Beart, R. W., Von Tomout, J. M., and Jones, P A. Methylation of the 5′CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing Cancer Res., 55: 4531-4535, 1995.
17. Kamb, A., Gruis, N. A., Weaver-Feldhaus, J , Liu, Q., Harshman, K., Tavtigian, S. V., Stockert, E., Day III, R. S., Johnson, B. E., and Skolnick, M. H A cell cycle regulator potentially involved in genesis of many tumor types. Science (Washington DC), 264: 436-439, 1994.
18. Ritter, M., de Kant, E., and Neubauer, A. Detection of DNA methylation in the calcitonin gene in human leukemias using differential polymerase chain reaction. Leukemia (Baltimore), 9: 915-921, 1995
19. Gnarra, J R , Tory, K., Weng, Y., Schmid, L., Wei, M. H., Li, H., Latif, F , Liu, S., Chen, F., Duh. F.-M , Lubensky, I., Duan, D. R., Florence, C., Pozzatti, R., Walther, M. M., Bander, N. H., Grossman, H. B., Brauch, H., Pomer, S., Brooks, J. D., Isaacs, W. B., Lerman, M. I., Zbar, B., and Linehan, W M. Mutations of the VHL tumor suppressor gene in renal carcinoma. Nat. Genet., 7: 85-90, 1994.
20. Jen, J., Harper, J. W , Bigner, S H., Bigner, D. D., Papadopoulos, N., Markowitz, S., Willson, J. K. V., Kinzler, K. W., and Vogelstein, B. Deletion of p16 and p15 genes in brains tumors. Cancer Res., 54: 6353-6358, 1994.
21. INK4A transcript. Cancer Res , 55: 2995-2997, 1995.
22. Hussussian, C. J., Struewing, J. P., Goldstein, A. M., Higgins, P A. T., Ally, D. S., Sheahan, M. D., Clark, W. H., Jr., Turker, M. A., and Dracopoli, N. C Germline p16 mutations in familial melanoma. Nat. Genet., 8: 15-21, 1994
23. Naitoh, H., Shibata, J., Kawaguchi, A., Kodama, M., and Hatton, T. Overexpression and localization of cyclin DI mRNA and antigen in esophageal cancer. Am. J. Pathol., 146, 1161-1169, 1995