Chemical agents that promote chromatin compaction radiosensitize tumour cells

International Journal of Radiation Biology

Volumn 77, Issue 10, 2001, Pages 1033-1042

  Biade, S ^a   Stobbe, C C ^a   Boyd, J T ^a   Chapman, J D ^a  

^a FOX CHASE CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CESIUM 137; FOSTRIECIN; GYRASE INHIBITOR; HISTONE DEACETYLASE INHIBITOR; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE INHIBITOR; RADIOSENSITIZING AGENT; TRICHOSTATIN A;

ARTICLE; CARCINOMA CELL; CHROMATIN CONDENSATION; CHROMATIN STRUCTURE; COLON CARCINOMA; CONTROLLED STUDY; DRUG EFFECT; HUMAN; HUMAN CELL; INTERPHASE; PRIORITY JOURNAL; RADIATION INJURY; RADIOSENSITIVITY; RADIOSENSITIZATION; TUMOR CELL;

ALKENES; CELL SURVIVAL; CHROMATIN; HISTONES; HT29 CELLS; HUMANS; HYDROXAMIC ACIDS; IMMUNOHISTOCHEMISTRY; NEOPLASMS; OKADAIC ACID; PYRONES; RADIATION TOLERANCE;

MAMMALIA;

EID: 0034769471     PISSN: 09553002     EISSN: None     Source Type: Journal    
DOI: 10.1080/09553000110066068     Document Type: Article

References (48)

1. Alteration of cell cycle-dependent histone phosphorylations by okadaic acid
2. The intrinsic radiosensitivity of human tumor cells throughout their cell cycles
3. Inhibition of type II topoisomerase by fostriecin
4. Protamine-induced condensation and decondensation of the same DNA molecule
5. Biophysical models of mammalian cell inactivation by radiation
6. Radioprotection by DMSO of mammalian cells exposed to x-rays and to heavy charged-particle beams
7. Condensed chromatin and cell inactivation by single-hit kinetics
8. Chromatin compaction and tumor cell radiosensitivity at 2 Gray
9. 2-M-phase growth arrest correlates with abnormal centrosome replication, the formation of aberrant mitotic spindles, and the inhibition of serine/threonine protein phosphatase activity
10. Radioprotection of cellular chromatin by the polyamines spermine and putrescine: Preferential action against formation of DNA-protein crosslinks
11. Silencing of p16/CDKN2 expression in human gliomas by methylation and chromatin condensation
12. Phase I and pharmacokinetic study of the topoisomerase II catalytic inhibitor fostriecin
13. Enhancement of X-ray damage in synchronous Chinese hamster cells by hypertonic treatments
14. Changes in radiosensitivity and dispersion of chromatin during the cell cycle of synchronous Chinese hamster cells
15. Influence of chromatin structure on the induction of DNA double strand breaks by ionizing radiation
16. The inactivation of Chinese hamster cells by X-rays: Synchronized and exponential cell populations
17. Radiation tracks in biological materials: Initial damage in cells, DNA and associated structures
18. cdc2 kinase activity and histone H1 hyperphosphorylation, but is associated with enhanced histone H2A and H3 phosphorylation
19. Histone phosphorylation and chromatin structure in synchronized mammalian cells
20. Condensins, chromosome condensation protein complexes containing XCAP-C, XCAP-E and a Xenopus homolog of the Drosophila Barren protein
21. Higher-order chromatin structure-dependent repair of DNA double-strand breaks: Modeling the elution of DNA from nucleoids
22. Selective induction of cyclin-dependent kinase inhibitors and their roles in cell cycle arrest caused by trichostatin A, an inhibitor of histone deacetylase
23. Mitotic chromosome condensation
24. Structure and function in the nucleus
25. Cantharidin-binding protein: Identification as protein phosphatase 2A
26. Radiation sensitivity correlates with changes in DNA supercoiling and nucleoid content in cells of three Chinese hamster cell lines
27. Scaffold attachment of DNA loops in metaphase chromosomes
28. Chromatin decondensed by acetylation shows an elevated radiation response
29. Enhancement of X-ray cell killing in cultured mammalian cells by the protein phosphatase inhibitor Calyculin A
30. Universal control mechanism regulating onset of M-phase
31. Initial chromosome damage but not DNA damage is greater in ataxia telangiectasia cells
32. Functional interaction between GCN5 and polyamines: A new role for core histone acetylation
33. Response of murine small intestine to combined treatment with fostriecin and X rays
34. Antitumor drug fostriecin inhibits the mitotic entry checkpoint and protein phosphatases 1 and 2A
35. Identification of two distinct human SMC protein complexes involved in mitotic chromosome dynamics
36. The language of covalent histone modifications
37. Okadaic acid: An additional non-phorbol-12-tetradecanoate-13-acetate-type rumor promoter
38. Fission yeast condensin complex: Essential roles of non-SMC subunits for condensation and Cdc2 phosphorylation of Cut3/SMC4
39. Conversion of DNA damage into chromosome damage in response to cell cycle regulation of chromatin condensation after irradiation
40. Calyculin A induces contractile ring-like apparatus formation and condensation of chromosomes in unfertilized sea urchin eggs
41. DNA topoisomerase II is required for condensation and separation of mitotic chromosomes in S. pombe
42. Mitotic spindle pulls but fails to separate chromosomes in type II DNA topoisomerase mutants: Uncoordinated mitosis
43. Cell cycle-dependent distribution of telomeres, centromeres, and chromosome-specific subsatellite domains in the interphase nucleus of mouse lymphocytes
44. Some biochemical consequences of the spatial distribution of ionizing radiation-produced free radicals
45. Detection of ionizing radiation-induced DNA double-strand breaks by filter elution is affected by nuclear chromatin structure
46. Intrinsic radiosensitivity and prediction of patient response to radiotherapy for carcinoma of the cervix
47. Okadaic acid, a potent inhibitor of type 1 type 2A protein phosphatases, activates cdc2/H1 kinase and transiently induces a premature mitosis-like state in BHK21 cells