-
1
-
-
0002768765
-
Hereditary and acquired motor neuron diseases
-
L.P. Rowland, editor. Williams & Wilkins. Philadelphia, Pennsylvania, USA
-
Rowland, L.P. 1995. Hereditary and acquired motor neuron diseases. In Merritt's textbook of neurology. L.P. Rowland, editor. Williams & Wilkins. Philadelphia, Pennsylvania, USA. 742-749.
-
(1995)
Merritt's Textbook of Neurology
, pp. 742-749
-
-
Rowland, L.P.1
-
2
-
-
0028960506
-
Amyotrophic lateral sclerosis: Recent insights from genetics and transgenic mice
-
Brown, R.H., Jr. 1995. Amyotrophic lateral sclerosis: recent insights from genetics and transgenic mice. Cell. 80:687-692.
-
(1995)
Cell
, vol.80
, pp. 687-692
-
-
Brown R.H., Jr.1
-
3
-
-
0027426169
-
Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase
-
Deng, H.-X., et al. 1993. Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase. Science. 261:1047-1051.
-
(1993)
Science
, vol.261
, pp. 1047-1051
-
-
Deng, H.-X.1
-
4
-
-
0027401203
-
Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
-
Rosen, D.R., et al. 1993. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature. 362:59-62.
-
(1993)
Nature
, vol.362
, pp. 59-62
-
-
Rosen, D.R.1
-
5
-
-
0031057003
-
Epidemiology of mutations in superoxide dismutase in amyotrophic lateral sclerosis
-
Cudkowicz, M.E., et al. 1997. Epidemiology of mutations in superoxide dismutase in amyotrophic lateral sclerosis. Ann. Neurol. 41:210-221.
-
(1997)
Ann. Neurol.
, vol.41
, pp. 210-221
-
-
Cudkowicz, M.E.1
-
6
-
-
0029881166
-
Blood superoxide dismutase, catalase and glutathione peroxidase activities in familial and sporadic amyotrophic lateral sclerosis
-
Przedborski, S., et al. 1996. Blood superoxide dismutase, catalase and glutathione peroxidase activities in familial and sporadic amyotrophic lateral sclerosis. Neurodegeneration. 5:57-64.
-
(1996)
Neurodegeneration
, vol.5
, pp. 57-64
-
-
Przedborski, S.1
-
7
-
-
0028221169
-
Down-regulation of copper/zinc superoxide dismutase causes apoptotic death in PC12 neuronal cells
-
Troy, C.M., and Shelanski, M.L. 1994. Down-regulation of copper/zinc superoxide dismutase causes apoptotic death in PC12 neuronal cells. Proc. Natl. Acad. Sci. USA. 91:6384-6387.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 6384-6387
-
-
Troy, C.M.1
Shelanski, M.L.2
-
8
-
-
0028205372
-
Chronic inhibition of superoxide dismutase produces apoptotic death of spinal neurons
-
Rothstein, J.D., Bristol, L.A., Hosler, B., Brown, R.H., Jr., and Kuncl, R.W. 1994. Chronic inhibition of superoxide dismutase produces apoptotic death of spinal neurons. Proc. Natl. Acad. Sci. USA. 91:4155-4159.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 4155-4159
-
-
Rothstein, J.D.1
Bristol, L.A.2
Hosler, B.3
Brown R.H., Jr.4
Kuncl, R.W.5
-
9
-
-
15844393658
-
Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury
-
Reaume, A.G., et al. 1996. Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury. Nat. Genet. 13:43-47.
-
(1996)
Nat. Genet.
, vol.13
, pp. 43-47
-
-
Reaume, A.G.1
-
10
-
-
0028284779
-
Motor neuron degeneration in mice that express a human Cu, Zn superoxide dismutase mutation
-
Gurney, M.E., et al. 1994. Motor neuron degeneration in mice that express a human Cu, Zn superoxide dismutase mutation. Science. 264:1772-1775.
-
(1994)
Science
, vol.264
, pp. 1772-1775
-
-
Gurney, M.E.1
-
11
-
-
0029053881
-
An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria
-
Wong, P.C., et al. 1995. An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria. Neuron. 14:1105-1116.
-
(1995)
Neuron
, vol.14
, pp. 1105-1116
-
-
Wong, P.C.1
-
12
-
-
0031051485
-
ALS-linked SOD1 mutant G85R mediated damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions
-
Bruijn, L.I., et al. 1997. ALS-linked SOD1 mutant G85R mediated damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions. Neuron. 18:327-338.
-
(1997)
Neuron
, vol.18
, pp. 327-338
-
-
Bruijn, L.I.1
-
13
-
-
0035575761
-
Rats expressing human cytosolic copper-zinc superoxide dismutase transgenes with amyotrophic lateral sclerosis: Associated mutations develop motor neuron disease
-
Nagai, M., et al. 2001. Rats expressing human cytosolic copper-zinc superoxide dismutase transgenes with amyotrophic lateral sclerosis: associated mutations develop motor neuron disease. J. Neurosci. 21:9246-9254.
-
(2001)
J. Neurosci.
, vol.21
, pp. 9246-9254
-
-
Nagai, M.1
-
14
-
-
0036212119
-
Mutant SOD1 causes motor neuron disease independent of copper chaperone-mediated copper loading
-
Subramaniam, J.R., et al. 2002. Mutant SOD1 causes motor neuron disease independent of copper chaperone-mediated copper loading. Nat. Neurosci. 5:301-307.
-
(2002)
Nat. Neurosci.
, vol.5
, pp. 301-307
-
-
Subramaniam, J.R.1
-
15
-
-
0029584941
-
Superoxide dismutase in familial amyocrophic lateral sclerosis: Models for gain of function
-
Brown, R.H., Jr. 1995. Superoxide dismutase in familial amyocrophic lateral sclerosis: models for gain of function. Curr. Opin. Neurobiol. 5:841-846.
-
(1995)
Curr. Opin. Neurobiol.
, vol.5
, pp. 841-846
-
-
Brown R.H., Jr.1
-
16
-
-
0029096114
-
Age-dependent penetrance of disease in a transgenic mouse model of familial amyotrophic lateral sclerosis
-
Chiu, A.Y., et al. 1995. Age-dependent penetrance of disease in a transgenic mouse model of familial amyotrophic lateral sclerosis. Mol. Cell. Neurosci. 6:349-362.
-
(1995)
Mol. Cell. Neurosci.
, vol.6
, pp. 349-362
-
-
Chiu, A.Y.1
-
17
-
-
0028933344
-
Neuropathological changes in two lines of mice carrying a transgene for mutant human Cu,Zn SOD, and in mice overexpressing wild type human SOD: A model of familial amyotrophic lateral sclerosis (FALS)
-
Dal Canto, M.C., and Gurney, M.E. 1995. Neuropathological changes in two lines of mice carrying a transgene for mutant human Cu,Zn SOD, and in mice overexpressing wild type human SOD: a model of familial amyotrophic lateral sclerosis (FALS). Brain Res. 676:25-40.
-
(1995)
Brain Res.
, vol.676
, pp. 25-40
-
-
Dal Canto, M.C.1
Gurney, M.E.2
-
18
-
-
0033018506
-
Inducible nitric oxide synthase upregulation in a transgenic mouse model of familial amyotrophic lateral sclerosis
-
Almer, G., Vukosavic, S., Romero, N., and Przedborski, S. 1999. Inducible nitric oxide synthase upregulation in a transgenic mouse model of familial amyotrophic lateral sclerosis. J. Neurochem. 72:2415-2425.
-
(1999)
J. Neurochem.
, vol.72
, pp. 2415-2425
-
-
Almer, G.1
Vukosavic, S.2
Romero, N.3
Przedborski, S.4
-
19
-
-
0029966363
-
Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions
-
Tu, P.H., et al. 1996. Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions. Proc. Natl. Acad. Sci. USA. 93:3155-3160.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 3155-3160
-
-
Tu, P.H.1
-
20
-
-
0035516124
-
From Charcor to Lou Gehrig: Deciphering selective motor neuron death in ALS
-
Cleveland, D.W., and Rothstein, J.D. 2001. From Charcor to Lou Gehrig: deciphering selective motor neuron death in ALS. Nat. Rev. Neurosci. 2:806-819.
-
(2001)
Nat. Rev. Neurosci.
, vol.2
, pp. 806-819
-
-
Cleveland, D.W.1
Rothstein, J.D.2
-
21
-
-
0027293275
-
ALS, SOD and peroxynitrite
-
Beckman, J.S., Carson, M., Smith, C.D., and Koppenol, W.H. 1993. ALS, SOD and peroxynitrite. Nature. 364:584.
-
(1993)
Nature
, vol.364
, pp. 584
-
-
Beckman, J.S.1
Carson, M.2
Smith, C.D.3
Koppenol, W.H.4
-
22
-
-
0029671220
-
Altered reactivity of superoxide dismutase in familial amyotrophic lateral sclerosis
-
Wiedau-Pazos, M., et al. 1996. Altered reactivity of superoxide dismutase in familial amyotrophic lateral sclerosis. Science. 271:515-518.
-
(1996)
Science
, vol.271
, pp. 515-518
-
-
Wiedau-Pazos, M.1
-
23
-
-
0030833449
-
Decreased zinc affinity of amyotrophic lateral sclerosis-associated superoxide dismutase mutants leads to enhanced catalysis of tyrosine nitration by peroxynitrite
-
Crow, J.P., Sampson, J.B., Zhuang, Y.X., Thompson, J.A., and Beckman, J.S. 1997. Decreased zinc affinity of amyotrophic lateral sclerosis-associated superoxide dismutase mutants leads to enhanced catalysis of tyrosine nitration by peroxynitrite. J. Neurochem. 69:1936-1944.
-
(1997)
J. Neurochem.
, vol.69
, pp. 1936-1944
-
-
Crow, J.P.1
Sampson, J.B.2
Zhuang, Y.X.3
Thompson, J.A.4
Beckman, J.S.5
-
24
-
-
0039251419
-
Induction of nitric oxide-dependent apoptosis in motor neurons by zinc-deficient superoxide dismutase
-
Estevez, A.G., et al. 1999. Induction of nitric oxide-dependent apoptosis in motor neurons by zinc-deficient superoxide dismutase. Science. 286:2498-2500.
-
(1999)
Science
, vol.286
, pp. 2498-2500
-
-
Estevez, A.G.1
-
25
-
-
0032544674
-
Aggregation and motor neuron toxicity of an ALS-linked SOD1 mutant independent from wild-type SOD1
-
Bruijn, L.I., et al. 1998. Aggregation and motor neuron toxicity of an ALS-linked SOD1 mutant independent from wild-type SOD1. Science. 281:1851-1854.
-
(1998)
Science
, vol.281
, pp. 1851-1854
-
-
Bruijn, L.I.1
-
26
-
-
0030777650
-
Aggregation of mutant Cu/Zn superoxide dismutase proteins in a culture model of ALS
-
Durham, H.D., Roy, J., Dong, L., and Figlewicz, D.A. 1997. Aggregation of mutant Cu/Zn superoxide dismutase proteins in a culture model of ALS: J. Neuropathol. Exp. Neurol. 56:523-530.
-
(1997)
J. Neuropathol. Exp. Neurol.
, vol.56
, pp. 523-530
-
-
Durham, H.D.1
Roy, J.2
Dong, L.3
Figlewicz, D.A.4
-
27
-
-
0033940437
-
Late-onset neurodegenerative diseases: The role of protein insolubility
-
Johnson, W.G. 2000. Late-onset neurodegenerative diseases: the role of protein insolubility. J. Anat. 196:609-616.
-
(2000)
J. Anat.
, vol.196
, pp. 609-616
-
-
Johnson, W.G.1
-
28
-
-
0028915976
-
Mutations associated with amyotrophic lateral sclerosis convert superoxide dismutase from an antiapoptotic gene to a proapoptotic gene: Studies in yeast and neural cells
-
Rabizadeh, S., et al. 1995. Mutations associated with amyotrophic lateral sclerosis convert superoxide dismutase from an antiapoptotic gene to a proapoptotic gene: studies in yeast and neural cells. Proc. Natl. Acad. Sci. USA. 92:3024-3028.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 3024-3028
-
-
Rabizadeh, S.1
-
29
-
-
0030831352
-
Mutant superoxide dismutase-1-linked familial amyotrophic lateral sclerosis: Molecular mechanisms of neuronal death and protection
-
Ghadge, G.D., et al. 1997. Mutant superoxide dismutase-1-linked familial amyotrophic lateral sclerosis: molecular mechanisms of neuronal death and protection. J. Neurosci. 17:8756-8766.
-
(1997)
J. Neurosci.
, vol.17
, pp. 8756-8766
-
-
Ghadge, G.D.1
-
30
-
-
0030943110
-
Effects of wild-type and mutated copper/zinc superoxide dismutase on neuronal survival and L-DOPA-induced toxicity in postnatal midbrain culture
-
Mena, M.A., et al. 1997. Effects of wild-type and mutated copper/zinc superoxide dismutase on neuronal survival and L-DOPA-induced toxicity in postnatal midbrain culture. J. Neurochem. 69:21-33.
-
(1997)
J. Neurochem.
, vol.69
, pp. 21-33
-
-
Mena, M.A.1
-
31
-
-
0028896092
-
The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy
-
Roy, N., et al. 1995. The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy. Cell. 80:167-178.
-
(1995)
Cell
, vol.80
, pp. 167-178
-
-
Roy, N.1
-
32
-
-
0032863462
-
Lack ofapoptosis in mice with ALS
-
Migheli, A., et al. 1999. Lack ofapoptosis in mice with ALS. Nat. Med. 5:966-967.
-
(1999)
Nat. Med.
, vol.5
, pp. 966-967
-
-
Migheli, A.1
-
33
-
-
0034610328
-
Caspase-1 and -3 are sequentially activated in motor neuron death in Cu,Zn superoxide dismutase-mediated familial amyotrophic lateral sclerosis
-
Pasinelli, P., Houseweart, M.K., Brown, R.H., Jr., and Cleveland, D.W. 2000. Caspase-1 and -3 are sequentially activated in motor neuron death in Cu,Zn superoxide dismutase-mediated familial amyotrophic lateral sclerosis. Proc. Natl. Acad. Sci. USA. 97:13901-13906.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 13901-13906
-
-
Pasinelli, P.1
Houseweart, M.K.2
Brown R.H., Jr.3
Cleveland, D.W.4
-
34
-
-
0034671376
-
Delaying caspase activation by Bcl-2: A clue to disease retardation in a transgenic mouse model of amyotrophic lateral sclerosis
-
Vukosavic, S., et al. 2000. Delaying caspase activation by Bcl-2: a clue to disease retardation in a transgenic mouse model of amyotrophic lateral sclerosis. J. Neurosci. 20:9119-9125.
-
(2000)
J. Neurosci.
, vol.20
, pp. 9119-9125
-
-
Vukosavic, S.1
-
35
-
-
0002023977
-
Apoptosis versus necrosis
-
V.E. Koliatsos and R.R. Ratan, editors. Humana Press. Totowa, New Jersey, USA
-
Clarke, P.G.H. 1999. Apoptosis versus necrosis. In Cell death and diseases of the nervous system. V.E. Koliatsos and R.R. Ratan, editors. Humana Press. Totowa, New Jersey, USA. 3-28.
-
(1999)
Cell Death and Diseases of the Nervous System
, pp. 3-28
-
-
Clarke, P.G.H.1
-
36
-
-
0029981892
-
A novel type of programmed neuronal death in the cervical spinal cord of the chick embryo
-
Yaginuma, H., et al. 1996. A novel type of programmed neuronal death in the cervical spinal cord of the chick embryo. J. Neurosci. 16:3685-3703.
-
(1996)
J. Neurosci.
, vol.16
, pp. 3685-3703
-
-
Yaginuma, H.1
-
37
-
-
0034687754
-
An alternative, nonapoptotic form of programmed cell death
-
Sperandio, S., de Belle, I., and Bredesen, D.E. 2000. An alternative, nonapoptotic form of programmed cell death. Proc. Natl. Acad. Sci. USA. 97:14376-14381.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 14376-14381
-
-
Sperandio, S.1
De Belle, I.2
Bredesen, D.E.3
-
38
-
-
0032896327
-
Neuronal death in amyotrophic lateral sclerosis is apoptosis: Possible contribution of a programmed cell death mechanism
-
Martin, L.J. 1999. Neuronal death in amyotrophic lateral sclerosis is apoptosis: possible contribution of a programmed cell death mechanism. J. Neuropathol. Exp. Neurol. 58:459-471.
-
(1999)
J. Neuropathol. Exp. Neurol.
, vol.58
, pp. 459-471
-
-
Martin, L.J.1
-
39
-
-
0028101227
-
Apoptosis related antigen, Le(Y) and nick-end labeling are positive in spinal motor neurons in amyotrophic lateral sclerosis
-
Yoshiyama, Y., Yamada, T., Asanuma, K., and Asahi, T. 1994. Apoptosis related antigen, Le(Y) and nick-end labeling are positive in spinal motor neurons in amyotrophic lateral sclerosis. Acta Neuropathol. (Berl.) 88:207-211.
-
(1994)
Acta Neuropathol. (Berl.)
, vol.88
, pp. 207-211
-
-
Yoshiyama, Y.1
Yamada, T.2
Asanuma, K.3
Asahi, T.4
-
40
-
-
0032862513
-
Upregulation of Bax protein and increased DNA degradation in ALS spinal cord motor neurons
-
Ekegren, T., Grundstrom, E., Lindholm, D., and Aquilonius, S.M. 1999. Upregulation of Bax protein and increased DNA degradation in ALS spinal cord motor neurons. Acta Neurol. Scand. 100:317-321.
-
(1999)
Acta Neurol. Scand.
, vol.100
, pp. 317-321
-
-
Ekegren, T.1
Grundstrom, E.2
Lindholm, D.3
Aquilonius, S.M.4
-
41
-
-
0027985477
-
A study of apoptosis in normal and pathologic nervous tissue after in situ endlabeling of DNA strand breaks
-
Migheli, A., Cavalla, P., Marino, S., and Schiffer, D. 1994. A study of apoptosis in normal and pathologic nervous tissue after in situ endlabeling of DNA strand breaks. J. Neuropathol. Exp. Neurol. 53:606-616.
-
(1994)
J. Neuropathol. Exp. Neurol.
, vol.53
, pp. 606-616
-
-
Migheli, A.1
Cavalla, P.2
Marino, S.3
Schiffer, D.4
-
42
-
-
0033625507
-
Motor neuronal death in sporadic amyotrophic lateral sclerosis (ALS) is not apoptotic. A comparative study of ALS and chronic aluminium chloride neurotoxicity in New Zealand white rabbits
-
He, B.P., and Strong, M.J. 2000. Motor neuronal death in sporadic amyotrophic lateral sclerosis (ALS) is not apoptotic. A comparative study of ALS and chronic aluminium chloride neurotoxicity in New Zealand white rabbits. Neuropathol. Appl. Neurobiol. 26:150-160.
-
(2000)
Neuropathol. Appl. Neurobiol.
, vol.26
, pp. 150-160
-
-
He, B.P.1
Strong, M.J.2
-
43
-
-
0027338125
-
Le(y) antigen expression is correlated with apoptosis (programmed cell death)
-
Hiraishi, K., Suzuki, K., Hakomori, S., and Adachi, M. 1993. Le(y) antigen expression is correlated with apoptosis (programmed cell death). Glycobiology. 3:381-390.
-
(1993)
Glycobiology
, vol.3
, pp. 381-390
-
-
Hiraishi, K.1
Suzuki, K.2
Hakomori, S.3
Adachi, M.4
-
44
-
-
0032963464
-
Fractin immunostaining for the detection of apoptotic cells and apoptotic bodies in formalin-fixed and paraffin-embedded tissue
-
Suurmeijer, A.J., van der Wijk, J., van Veldhuisen, D.J., Yang, F., and Cole, G.M. 1999. Fractin immunostaining for the detection of apoptotic cells and apoptotic bodies in formalin-fixed and paraffin-embedded tissue. Lab. Invest. 79:619-620.
-
(1999)
Lab. Invest.
, vol.79
, pp. 619-620
-
-
Suurmeijer, A.J.1
Van der Wijk, J.2
Van Veldhuisen, D.J.3
Yang, F.4
Cole, G.M.5
-
45
-
-
0002571491
-
Apoptosis mediated by a novel leucine zipper protein Par-4
-
Rangnekar, V.M. 1998. Apoptosis mediated by a novel leucine zipper protein Par-4. Apoptosis. 3:61-66.
-
(1998)
Apoptosis
, vol.3
, pp. 61-66
-
-
Rangnekar, V.M.1
-
46
-
-
0034012013
-
The prostate apoptosis response-4 protein participates in motor neuron degeneration in amyotrophic lateral sclerosis
-
Pedersen, W.A., Luo, H., Kruman, I., Kasarskis, E., and Mattson, M.P. 2000. The prostate apoptosis response-4 protein participates in motor neuron degeneration in amyotrophic lateral sclerosis. FASEB J. 14:913-924.
-
(2000)
FASEB J.
, vol.14
, pp. 913-924
-
-
Pedersen, W.A.1
Luo, H.2
Kruman, I.3
Kasarskis, E.4
Mattson, M.P.5
-
47
-
-
0035033952
-
Signaling for survival and death in neurones. The role of stress-activated kinases, JNK and p38
-
Harper, S.J., and LoGrasso, P. 2001. Signaling for survival and death in neurones. The role of stress-activated kinases, JNK and p38. Cell. Signal. 13:299-310.
-
(2001)
Cell. Signal
, vol.13
, pp. 299-310
-
-
Harper, S.J.1
LoGrasso, P.2
-
48
-
-
0035834279
-
Molecular steps of death receptor and mitochondrial pathways of apoptosis
-
Gupta, S. 2001. Molecular steps of death receptor and mitochondrial pathways of apoptosis. Life Sci. 69:2957-2964.
-
(2001)
Life Sci.
, vol.69
, pp. 2957-2964
-
-
Gupta, S.1
-
49
-
-
0037068836
-
Motoneuron death triggered by a specific pathway downstream of Fas. Potentiation by ALS-Linked SOD1 mutations
-
Raoul, C., et al. 2002. Motoneuron death triggered by a specific pathway downstream of Fas. Potentiation by ALS-Linked SOD1 mutations. Neuron. 35:1067-1083.
-
(2002)
Neuron
, vol.35
, pp. 1067-1083
-
-
Raoul, C.1
-
50
-
-
0037088793
-
Mutant Cu, Zn superoxide dismutase that causes motoneuron degeneration is present in mitochondria in the CNS
-
Higgins, C.M., Jung, C., Ding, H., and Xu, Z. 2002. Mutant Cu, Zn superoxide dismutase that causes motoneuron degeneration is present in mitochondria in the CNS. J. Neurosci. 22:RC215.
-
(2002)
J. Neurosci.
, vol.22
-
-
Higgins, C.M.1
Jung, C.2
Ding, H.3
Xu, Z.4
-
51
-
-
0032079517
-
Massive mitochondrial degeneration in motor neurons triggers the onset of amyotrophic lateral sclerosis in mice expressing a mutant SOD1
-
Kong, J.M., and Xu, Z.S. 1998. Massive mitochondrial degeneration in motor neurons triggers the onset of amyotrophic lateral sclerosis in mice expressing a mutant SOD1. J. Neurosci. 18:3241-3250.
-
(1998)
J. Neurosci.
, vol.18
, pp. 3241-3250
-
-
Kong, J.M.1
Xu, Z.S.2
-
52
-
-
0031865772
-
Metabolic dysfunction in familial, but not sporadic, amyotrophic lateral sclerosis
-
Browne, S.E., et al. 1998. Metabolic dysfunction in familial, but not sporadic, amyotrophic lateral sclerosis. J. Neurochem. 71:281-287.
-
(1998)
J. Neurochem.
, vol.71
, pp. 281-287
-
-
Browne, S.E.1
-
53
-
-
0034068601
-
Mitochondrial control of cell death
-
Kroemer, G., and Reed, J.C. 2000. Mitochondrial control of cell death. Nat. Med. 6:513-519.
-
(2000)
Nat. Med.
, vol.6
, pp. 513-519
-
-
Kroemer, G.1
Reed, J.C.2
-
54
-
-
0034811953
-
Early decrease of survival signal-related proteins in spinal motor neurons of presymptomatic transgenic mice with a mutant SOD1 gene
-
Warita, H., et al. 2001. Early decrease of survival signal-related proteins in spinal motor neurons of presymptomatic transgenic mice with a mutant SOD1 gene. Apoptosis. 6:345-352.
-
(2001)
Apoptosis
, vol.6
, pp. 345-352
-
-
Warita, H.1
-
55
-
-
0035833937
-
Immune reactivity in a mouse model of familial ALS correlates with disease progression
-
Alexianu, M.E., Kozovska, M., and Appel, S.H. 2001. Immune reactivity in a mouse model of familial ALS correlates with disease progression. Neurology. 57:1282-1289.
-
(2001)
Neurology
, vol.57
, pp. 1282-1289
-
-
Alexianu, M.E.1
Kozovska, M.2
Appel, S.H.3
-
56
-
-
0034765498
-
Induction of proinflammatory molecules in mice with amyotrophic lateral sclerosis: No requirement for proapoptotic interleukin-1beta in neurodegeneration
-
Nguyen, M.D., Julien, J.P., and Rivest, S. 2001. Induction of proinflammatory molecules in mice with amyotrophic lateral sclerosis: no requirement for proapoptotic interleukin-1beta in neurodegeneration. Ann. Neurol. 50:630-639.
-
(2001)
Ann. Neurol.
, vol.50
, pp. 630-639
-
-
Nguyen, M.D.1
Julien, J.P.2
Rivest, S.3
-
57
-
-
0034647003
-
Functional role of caspase-1 and caspase-3 in an ALS transgenic mouse model
-
Li, M., et al. 2000. Functional role of caspase-1 and caspase-3 in an ALS transgenic mouse model. Science. 288:335-339.
-
(2000)
Science
, vol.288
, pp. 335-339
-
-
Li, M.1
-
58
-
-
0031918223
-
BCL-2 family: Regulators of cell death
-
Chao, D.T., and Korsmeyer, S.J. 1998. BCL-2 family: regulators of cell death. Annu. Rev. Immunol. 16:395-419.
-
(1998)
Annu. Rev. Immunol.
, vol.16
, pp. 395-419
-
-
Chao, D.T.1
Korsmeyer, S.J.2
-
59
-
-
0029787513
-
Altered expression of bcl-2 and bax mRNA in amyotrophic lateral sclerosis spinal cord motor neurons
-
Mu, X., He, J., Anderson, D.W., Trojanowski, J.Q., and Springer, J. E. 1996. Altered expression of bcl-2 and bax mRNA in amyotrophic lateral sclerosis spinal cord motor neurons. Ann. Neurol. 40:379-386.
-
(1996)
Ann. Neurol.
, vol.40
, pp. 379-386
-
-
Mu, X.1
He, J.2
Anderson, D.W.3
Trojanowski, J.Q.4
Springer, J.E.5
-
60
-
-
0032750753
-
Bax and Bcl-2 interaction in a transgenic mouse model of familial amyotrophic lateral sclerosis
-
Vukosavic, S., Dubois-Dauphin, M., Romero, N., and Przedborski, S. 1999. Bax and Bcl-2 interaction in a transgenic mouse model of familial amyotrophic lateral sclerosis. J. Neurochem. 73:2460-2468.
-
(1999)
J. Neurochem.
, vol.73
, pp. 2460-2468
-
-
Vukosavic, S.1
Dubois-Dauphin, M.2
Romero, N.3
Przedborski, S.4
-
61
-
-
0029563461
-
Apoptosis in amyotrophic lateral sclerosis is not restricted to motor neurons. Bcl-2 expression is increased in unaffected post-central gyrus
-
Troost, D., Aten, J., Morsink, F., and De Jong, J.M.B.V. 1995. Apoptosis in amyotrophic lateral sclerosis is not restricted to motor neurons. Bcl-2 expression is increased in unaffected post-central gyrus. Neuropathol. Appl. Neurobiol. 21:498-504.
-
(1995)
Neuropathol. Appl. Neurobiol.
, vol.21
, pp. 498-504
-
-
Troost, D.1
Aten, J.2
Morsink, F.3
De Jong, J.M.B.V.4
-
62
-
-
0033826143
-
Alteration of the Bcl-x/Bax ratio in a transgenic mouse model ofamyotrophic lateral sclerosis: Evidence for the implication of the p53 signaling pathway
-
Gonzalez de Aguilar, J.L., et al. 2000. Alteration of the Bcl-x/Bax ratio in a transgenic mouse model ofamyotrophic lateral sclerosis: evidence for the implication of the p53 signaling pathway. Neurobiol. Dis. 7:406-415.
-
(2000)
Neurobiol. Dis.
, vol.7
, pp. 406-415
-
-
Gonzalez de Aguilar, J.L.1
-
63
-
-
0035437866
-
Recruitment of the mitochondrial-dependent apoptotic pathway in amyotrophic lateral sclerosis
-
Guégan, C., Vila, M., Rosoklija, G., Hays, A.P., and Przedborski, S. 2001. Recruitment of the mitochondrial-dependent apoptotic pathway in amyotrophic lateral sclerosis. J. Neurosci. 21:6569-6576.
-
(2001)
J. Neurosci.
, vol.21
, pp. 6569-6576
-
-
Guégan, C.1
Vila, M.2
Rosoklija, G.3
Hays, A.P.4
Przedborski, S.5
-
64
-
-
0030756459
-
Bcl-2: Prolonging life in a transgenic mouse model of familial amyotrophic lateral sclerosis
-
Kostic, V., Jackson-Lewis, V., De Bilbao, F., Dubois-Dauphin, M., and Przedborski, S. 1997. Bcl-2: prolonging life in a transgenic mouse model of familial amyotrophic lateral sclerosis. Science. 277:559-562.
-
(1997)
Science
, vol.277
, pp. 559-562
-
-
Kostic, V.1
Jackson-Lewis, V.2
De Bilbao, F.3
Dubois-Dauphin, M.4
Przedborski, S.5
-
65
-
-
0036385720
-
Instrumental activation of Bid by caspase-1 in a transgenic mouse model of ALS
-
Guégan, C., et al. 2002. Instrumental activation of Bid by caspase-1 in a transgenic mouse model of ALS. Mol. Cell. Neurosci. 20:553-562.
-
(2002)
Mol. Cell. Neurosci.
, vol.20
, pp. 553-562
-
-
Guégan, C.1
-
66
-
-
0035834274
-
Upregulation of the pro-apoptotic BH3-only peptide harakiri in spinal neurons of amyotrophic lateral sclerosis patients
-
Shinoe, T., et al. 2001. Upregulation of the pro-apoptotic BH3-only peptide harakiri in spinal neurons of amyotrophic lateral sclerosis patients. Neurosci. Lett. 313:153-157.
-
(2001)
Neurosci. Lett.
, vol.313
, pp. 153-157
-
-
Shinoe, T.1
-
67
-
-
0028335717
-
Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo
-
Miyashita, T., et al. 1994. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene. 9:1799-1805.
-
(1994)
Oncogene
, vol.9
, pp. 1799-1805
-
-
Miyashita, T.1
-
68
-
-
0034818446
-
Post-translational modifications and activation of p53 by genotoxic stresses
-
Appella, E., and Anderson, C.W. 2001. Post-translational modifications and activation of p53 by genotoxic stresses. Eur. J. Biochem. 268:2764-2772.
-
(2001)
Eur. J. Biochem.
, vol.268
, pp. 2764-2772
-
-
Appella, E.1
Anderson, C.W.2
-
69
-
-
0034517935
-
p53 is abnormally elevated and active in the CNS of patients with amyotrophic lateral sclerosis
-
Martin, L.J. 2000. p53 is abnormally elevated and active in the CNS of patients with amyotrophic lateral sclerosis. Neurobiol. Dis. 7:613-622.
-
(2000)
Neurobiol. Dis.
, vol.7
, pp. 613-622
-
-
Martin, L.J.1
-
70
-
-
0034613225
-
Motor neuron cell death in a mouse model of FALS is not mediated by the p53 cell survival regulator
-
Prudlo, J., et al. 2000. Motor neuron cell death in a mouse model of FALS is not mediated by the p53 cell survival regulator. Brain Res. 879:183-187.
-
(2000)
Brain Res.
, vol.879
, pp. 183-187
-
-
Prudlo, J.1
-
71
-
-
0033834503
-
Absence of p53: No effect in a transgenic mouse model of familial amyotrophic lateral sclerosis
-
Kuntz, C., Kinoshita, Y., Beal, M.F., Donehower, L.A., and Morrison, R.S. 2000. Absence of p53: no effect in a transgenic mouse model of familial amyotrophic lateral sclerosis. Exp. Neurol. 165:184-190.
-
(2000)
Exp. Neurol.
, vol.165
, pp. 184-190
-
-
Kuntz, C.1
Kinoshita, Y.2
Beal, M.F.3
Donehower, L.A.4
Morrison, R.S.5
-
72
-
-
0032430185
-
Caspase-1 is activated in neural cells and tissue with amyotrophic lateral sclerosis-associated mutations in copper-zinc superoxide dismutase
-
Pasinelli, P., Borchelt, D.R., Houseweart, M.K., Cleveland, D.W., and Brown, R.H.J. 1998. Caspase-1 is activated in neural cells and tissue with amyotrophic lateral sclerosis-associated mutations in copper-zinc superoxide dismutase. Proc. Natl. Acad Sci. USA. 95:15763-15768.
-
(1998)
Proc. Natl. Acad Sci. USA
, vol.95
, pp. 15763-15768
-
-
Pasinelli, P.1
Borchelt, D.R.2
Houseweart, M.K.3
Cleveland, D.W.4
Brown, R.H.J.5
-
73
-
-
1842407161
-
Inhibition of ICE slows ALS in mice
-
Friedlander, R.M., Brown, R.H., Gagliardini, V., Wang, J., and Yuan, J. 1997. Inhibition of ICE slows ALS in mice. Nature. 388:31.
-
(1997)
Nature
, vol.388
, pp. 31
-
-
Friedlander, R.M.1
Brown, R.H.2
Gagliardini, V.3
Wang, J.4
Yuan, J.5
-
74
-
-
0034610743
-
Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta
-
Nakagawa, T., et al. 2000. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature. 403:98-103.
-
(2000)
Nature
, vol.403
, pp. 98-103
-
-
Nakagawa, T.1
-
75
-
-
0032080197
-
Defects in regulation of apoptosis in caspase-2-deficient mice
-
Bergeron, L., et al. 1998. Defects in regulation of apoptosis in caspase-2-deficient mice. Genes Dev. 12:1304-1314.
-
(1998)
Genes Dev.
, vol.12
, pp. 1304-1314
-
-
Bergeron, L.1
-
76
-
-
0037007645
-
Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice
-
Zhu, S., et al. 2002. Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice. Nature. 417:74-78.
-
(2002)
Nature
, vol.417
, pp. 74-78
-
-
Zhu, S.1
-
77
-
-
0033709907
-
Deficiency in caspase-9 or caspase-3 induces compensatory caspase activation
-
Zheng, T.S., et al. 2000. Deficiency in caspase-9 or caspase-3 induces compensatory caspase activation. Nat. Med. 6:1241-1247.
-
(2000)
Nat. Med.
, vol.6
, pp. 1241-1247
-
-
Zheng, T.S.1
|