Alteration of the Bcl-x/Bax ratio in a transgenic mouse model of amyotrophic lateral sclerosis: Evidence for the implication of the p53 signaling pathway

Neurobiology of Disease

Volumn 7, Issue 4, 2000, Pages 406-415

  González De Aguilar, José Luis ^a   Gordon, Jon W ^b   René, Frédérique ^a   De Tapia, Marc ^a   Lutz Bucher, Bernadette ^a   Gaiddon, Christian ^a   Loeffler, Jean Philippe ^a  

^a CNRS   (France)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN BCL X; PROTEIN P53; TRANSCRIPTION FACTOR;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL TISSUE; APOPTOSIS; ARTICLE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

EID: 0033826143     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1006/nbdi.2000.0295     Document Type: Article

References (40)

1. p53 Is essential for developmental neuron death as regulated by the TrkA and p75 neurotrophin receptors
2. Gene regulation analysis by lipopolyamine-mediated DNA transfer in primary neurons
3. Bcl-xL protects adult septal cholinergic neurons from axotomized cell death
4. Bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death
5. ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions
6. Induction of the growth inhibitor IGF-binding protein 3 by p53
7. p53 And CD95-associated apoptosis in neurodegenerative disease
8. p73 Function is inhibited by tumor-derived p53 mutants in mammalian cells
9. Upregulation of Bax protein and increased DNA degradation in ALS spinal cord motor neurons
10. Protein synthesis required to anchor a mutant p53 protein which is temperature-sensitive for nuclear transport
11. Expression pattern of candidate cell death effector proteins Bax, Bcl-2, Bcl-x and c-jun in sensory and motor neurons following sciatic nerve transection in the rat
12. Motor neuron degeneration in mice that express a human Cu, Zn superoxide dismutase mutation
13. Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: A comparison between ABC and unlabeled antibody (PAP) procedures
14. A biological role for Egr-1 in cell survival following ultra-violet irradiation
15. Bcl-2: Prolonging life in a transgenic mouse model of familial amyotrophic lateral sclerosis
16. Bcl-2, Bax and Bcl-x expression following kainic acid administration at convulsant doses in the rat
17. Neuronal death in amyotrophic lateral sclerosis is apoptosis: Possible contribution of a programmed cell death mechanism
18. Expression of wild-type p53 stimulates an increase in both Bax and Bcl-xL protein content in HT29 cells
19. Bcl-2 gene family in the nervous system
20. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo
21. Identification of a p53-dependent negative response element in the bcl-2 gene
22. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
23. Time course of neuropathology in the spinal cord of G86R superoxide dismutase transgenic mice
24. Altered expression of bcl-2 and bax mRNA in amyotrophic lateral sclerosis spinal cord motor neurons
25. Familial adult motor neuron disease: Amyotrophic lateral sclerosis
26. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death
27. The p53 pathway
28. Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis
29. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
30. Bcl-xL protects cancer cells from p53-mediated apoptosis
31. Nuclear localization is essential for the activity of p53 protein
32. DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
33. Bax deficiency prevents the increased cell death of immature neurons in bcl-x-deficient mice
34. Molecular genetics of familial amyotrophic lateral sclerosis
35. Adenovirus-mediated gene transfer of the tumor suppressor p53 induces apoptosis in postmitotic neurons
36. Bax promotes neuronal cell death and is down-regulated during the development of the nervous system
37. Bax and Bcl-2 interaction in a transgenic mouse model of familial amyotrophic lateral sclerosis
38. An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria
39. Involvement of p85 in p53-dependent apoptotic response to oxidative stress
40. The apoptosis-associated gamma-ray response of Bcl-x(L) depends on normal p53 function