Effects of wild-type and mutated copper/zinc superoxide dismutase on neuronal survival and L-DOPA-induced toxicity in postnatal midbrain culture

Journal of Neurochemistry

Volumn 69, Issue 1, 1997, Pages 21-33

  Mena, Maria A ^a,d   Khan, Uzma ^a   Togasaki, Daniel M ^a   Sulzer, David ^a,b   Epstein, Charles J ^c   Przedborski, Serge ^a  

^a Columbia University ^*  (United States)

^b NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d HOSPITAL RAMÓN Y CAJAL   (Spain)

Author keywords

Amyotrophic lateral sclerosis; Apoptosis; L DOPA; Necrosis; Oxidative stress; Parkinson's disease; Postnatal midbrain neurons; Superoxide dismutase; Transgenic mouse

Indexed keywords

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ARTICLE; CELL PROTECTION; CELL SURVIVAL; ENZYME ACTIVITY; MALE; MESENCEPHALON; MOUSE; NEUROTOXICITY; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PARKINSONISM; POSTNATAL GROWTH; PRIORITY JOURNAL; PROTEIN DETERMINATION; TRANSGENIC MOUSE;

ANIMALIA; MUS MUSCULUS;

EID: 0030943110     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1997.69010021.x     Document Type: Article

References (47)

1. Basma A. N., Morris E. J., Nicklas W. J., and Geller H. M. (1995) L-DOPA cytotoxicity to PC12 cells in culture is via its autoxidation. J. Neurochem. 64, 825-832.
2. Beal M. F. (1995) Aging, energy, and oxidative stress in neurodegenerative diseases. Ann. Neurol. 38, 357-366.
3. Beal M. F., Ferrante R. J., Henshaw R., Matthews R. T., Chan P. H., Kowall N. W., Epstein C. J., and Schulz J. B. (1995) 3-Nitropropionic acid neurotoxicity is attenuated in copper/zinc superoxide dismutase transgenic mice. J. Neurochem. 65, 919-922.
4. Brown R. H. Jr. (1995) Superoxide dismutase in familial amyotrophic lateral sclerosis: models for gain of function. Curr. Opin. Neurobiol. 5, 841-846.
5. Cabelli D. E., Allen D., and Bielski H. J. (1989) The interaction between Cu(I) Superoxide dismutase and hydrogen peroxide. J. Biol Chem. 264, 9967-9971.
6. Ceballos-Picot I., Nicole A., Briand P., Grimber G., Delacourte A., Defossez A., Javoy-Agid F., Lafon M., Blouin J. L., and Sinet P. M. (1991) Neuronal-specific expression of human copper-zinc superoxide dismutase gene in transgenic mice: animal model of gene dosage effects in Down's syndrome. Brain Res. 552, 198-214.
7. Chan P. H., Yang G. Y., Chen S. F., Carslon E., and Epstein C. J. (1991) Cold-induced brain edema and infarction are reduced in transgenic mice overexpressing CuZn-superoxide dismutase. Ann. Neurol. 29, 482-486.
8. Cohen G. and Werner P. (1994) Free radicals, oxidative stress, and neurodegeneration, in Neurodegenerative Diseases (Calne D. B., ed), pp. 139-161. W. B. Saunders, Philadelphia.
9. Coyle J. T. and Puttfarcken P. (1993) Oxidative stress, glutamate, and neurodegenerative disorders. Science 262, 689-694.
10. Cubells J. F., Rayport S., Rajendran G., and Sulzer D. (1994) Methamphetamine neurotoxicity involves vacuolation of endocytic organelles and dopamine-dependent intracellular oxidative stress. J. Neurosci. 14, 2260-2271.
11. Deng H.-X., Hentati A., Tainer J. A., Iqbal Z., Cayabyab A., Hung W.-Y., Getzoff E. D., Hu P., Herzfeldt B., Roos R. P., Warner C., Deng G., Soriano E., Smyth C., Parge H. E., Ahmed A., Roses A. D., Hallewell R. A., Pericak-Vance M. A., and Siddique T. (1993) Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase. Science 261, 1047-1051.
12. Du X. and Iacovitti L. (1995) Synergy between growth factors and transmitters required for catecholamine differentiation in brain neurons. J. Neurosci. 15, 5420-5427.
13. Elroy-Stein O. and Groner Y. (1988) Impaired neurotransmitter up-take in PC12 cells overexpressing human Cu/Zn-superoxide dismutase - implications for gene dosage effects in Down syndrome. Cell 52, 259-267.
14. Elroy-Stein O., Bernstein E., and Groner Y. (1986) Overproduction of human Cu/Zn-superoxide dismutase in transfected cells: extenuation of paraquat-mediated cytotoxicity and enhancement of lipid peroxidation. EMBO J. 5, 615-622.
15. Epstein C. J., Avraham K. B., Lovett M., Smith S., Elroy-Stein O., Rotman G., Bry C., and Groner Y. (1987) Transgenic mice with increased Cu/Zn-superoxide dismutase activity: animal model of dosage effects in Down syndrome. Proc. Natl. Acad. Sci. USA 84, 8044-8048.
16. Fahn S. and Cohen G. (1992) The oxidant stress hypothesis in Parkinson's disease: evidence supporting it. Ann. Neurol. 32, 804-812.
17. Graham D. G. (1978) Oxidative pathways for catecholamines in the genesis of neuromelanin and cytotoxic quinones. Mol. Pharmacol. 14, 633-643.
18. Greenlund L. J. S., Deckwerth T. L., and Johnson E. M. Jr. (1995) Superoxide dismutase delays neuronal apoptosis: a role for reactive oxygen species in programmed neuronal death. Neuron 14, 303-315.
19. Gurney M. E., Pu H., Chiu A. Y., Dal Canto M. C., Polchow C. Y., Alexander D. D., Caliendo J., Hentati A., Kwon Y. W., Deng H.-X., Chen W., Zhai P., Sufit R. L., and Siddique T. (1994) Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation. Science 264, 1772-1775.
20. Halliwell B. and Gutteridge J. M. (1991) Free Radicals in Biology and Medicine, 2nd edit. Clarendon Press, Oxford.
21. Han S.-K., Mytilineou C., and Cohen G. (1996) L-DOPA up-regulates glutathione and protects mesencephalic cultures against oxidative stress. J. Neurochem. 66, 501-510.
22. Hartley A., Stone J. M., Heron C., Cooper J. M., and Schapira A. H. V. (1994) Complex I inhibitors induce dose-dependent apoptosis in PC12 cells: relevance to Parkinson's disease. J. Neurochem. 63, 1987-1990.
23. Heikkila R. E. and Cohen G. (1973) 6-Hydroxydopamine: evidence for superoxide radical as an oxidative intermediate. Science 181, 456-457.
24. Huang T.-T., Carlson E., Leadon S. A., and Epstein C. J. (1992) Relationship of resistance to oxygen free radicals to CuZn-superoxide dismutase activity in transgenic, transfected, and trisomie cells. FASEB J. 6, 903-910.
25. Jordan J., Ghadge G. D., Prehn J. H. M., Toth P. T., Roos R. P., and Miller R. J. (1995) Expression of human copper/zinc-superoxide dismutase inhibits the death of rat sympathetic neurons caused by withdrawal of nerve growth factor. Mol. Pharmacol. 47, 1095-1100.
26. Kostic V., Gurney M. E., Deng H.-X., Siddique T., Epstein C. J., and Przedborski S. (1997) Midbrain dopaminergic neuronal degeneration in a transgenic mouse model of familial amyotrophic lateral sclerosis. Ann. Neurol. 41, 497-504.
27. Lowry O. H., Rosebrough N. J., Farr A. L., and Randall R. J. (1951) Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265-275.
28. Mena M. A., Pardo B., Paino C. L., and Garcia de Yebenes J. (1993) Levodopa toxicity in foetal rat midbrain neurones in culture: modulation by ascorbic acid. Neuroreport 4, 438-440.
29. Mytilineou C., Han S.-K., and Cohen G. (1993) Toxic and protective effects of L-DOPA on mesencephalic cell cultures. J. Neurochem. 61, 1470-1478.
30. Nakao N., Frodl E. M., Widner H., Carlson E., Eggerding F. A., Epstein C. J., and Brundin P. (1995) Overexpressing Cu/Zn superoxide dismutase enhances survival of transplanted neurons in a rat model of Parkinson's disease. Nat. Med. 1, 226-231.
31. Pardo B., Mena M. A., Casarejos M. J., Paíno C. L., and Garcia de Yébenes J. (1995) Toxic effects of L-DOPA on mesencephalic cell cultures: protection with antioxidants. Brain Res. 682, 133-143.
32. Przedborski S., Kostic V., Jackson-Lewis V., Naini A. B., Simonetti S., Fahn S., Carlson E., Epstein C. J., and Cadet J. L. (1992) Transgenic mice with increased Cu/Zn-superoxide dismutase activity are resistant to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity. J. Neurosci. 12, 1658-1667.
33. Przedborski S., Jackson-Lewis V., Muthane U., Jiang H., Ferreira M., Naini A. B., and Fahn S. (1993) Chronic levodopa administration alters cerebral mitochondrial respiratory chain activity. Ann. Neurol. 34, 715-723.
34. Przedborski S., Donaldson D., Jakowec M., Kish S. J., Guttman M., Rosoklija G., and Hays A. P. (1996a) Brain superoxide dismutase, catalase and glutathione peroxidase activities in amyotrophic lateral sclerosis. Ann. Neurol. 39, 158-165.
35. Przedborski S., Jackson-Lewis V., Yokoyama R., Shibata T., Dawson V. L., and Dawson T. M. (1996b) Role of neuronal nitric oxide in MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)-induced dopaminergic neurotoxicity. Proc. Natl. Acad. Sci. USA 93, 4565-4571.
36. Przedborski S., Khan U., Kostic V., Carlson E., Epstein C. J., and Sulzer D. (1996c) Increased superoxide dismutase activity improves survival of cultured postnatal midbrain neurons. J. Neurochem. 67, 1383-1392.
37. Rabizadeh S., Gralla E. B., Borchelt D. R., Gwinn R., Valentine J. S., Sisodia S., Wong P., Lee M., Hahn H., and Bredesen D. E. (1995) Mutations associated with amyotrophic lateral sclerosis convert superoxide dismutase from an antiapoptotic gene to a proapoptotic gene: studies in yeast and neural cells. Proc. Natl. Acad. Sci. USA 92, 3024-3028.
38. Rosen D. R., Siddique T., Patterson D., Figlewicz D. A., Sapp P., Hentati A., Donaldson D., Goto J., O'Regan J. P., Deng H.-X., Rahmani Z., Krizus A., McKenna-Yasek D., Cayabyab A., Gaston S. M., Berger R., Tanzi R. E., Halperin J. J., Herzfeldt B., Van den Bergh R., Hung W.-Y., Bird T., Deng G., and Mulder D. W. (1993) Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 362, 59-62.
39. Rowland L. P. (1995) Amyotrophic lateral sclerosis: human challenge for neuroscience. Proc. Natl. Acad. Sci. USA 92, 1251-1253.
40. Takeshima T., Johnston J. M., and Commissiong J. W. (1994) Mesencephalic type 1 astrocytes rescue dopaminergic neurons from death induced by serum deprivation. J. Neurosci. 14, 4769-4779.
41. Troy C. M. and Shelanski M. L. (1994) Down-regulation of copper/ zinc superoxide dismutase causes apoptotic death in PC12 neuronal cells. Proc. Natl. Acad. Sci. USA 91, 6384-6387.
42. Walkinshaw G. and Waters C. M. (1994) Neurotoxin-induced cell death in neuronal PC12 cells is mediated by induction of apoptosis. Neuroscience 63, 975-987.
43. Wiedau-Pazos M., Goto J. J., Rabizadeh S., Gralla E. B., Roe J. A., Lee M. K., Valentine J. S., and Bredesen D. E. (1996) Altered reactivity of superoxide dismutase in familial amyotrophic lateral sclerosis. Science 271, 515-518.
44. Yang G., Chan P. H., Chen J., Carlson E., Chen S. F., Weinstein P., Epstein C. J., and Kamii H. (1994) Human copper-zinc superoxide dismutase transgenic mice are highly resistant to reperfusion injury after focal cerebral ischemia. Stroke 25, 165-170.
45. Yim M. B., Chock P. B., and Stadtman E. R. (1990) Copper,zinc superoxide dismutase catalyzes hydroxyl radical production from hydrogen peroxide. Proc. Natl. Acad. Sci. USA 87, 5006-5010.
46. Yim M. B., Chock P. B., and Stadtman E. R. (1993) Enzyme function of copper,zinc superoxide dismutase as a free radical generator. J. Biol. Chem. 268, 4099-4105.
47. m for hydrogen peroxide. Proc. Natl. Acad. Sci. USA 93, 5709-5714.