Phe303 in TMVI of the α1B-adrenergic receptor is a key residue coupling TM helical movements to G-protein activation

Biochemistry

Volumn 41, Issue 2, 2002, Pages 588-596

  Chen, Songhai ^a,b   Lin, Fang ^a,b   Xu, Ming ^a   Graham, Robert M ^a,c  

^a ST VINCENT S HOSPITAL   (Australia)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

MUTANTS;

MUTAGENESIS; PROTEINS; THERMODYNAMIC STABILITY;

BIOCHEMISTRY;

ADRENALIN; ALPHA 1 ADRENERGIC RECEPTOR STIMULATING AGENT; ALPHA 1B ADRENERGIC RECEPTOR; CYSTEINE; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; INOSITOL PHOSPHATE; MUTANT PROTEIN; PHENYLALANINE;

ALPHA ADRENERGIC STIMULATION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL MEMBRANE; CONTROLLED STUDY; HYDROLYSIS; MOLECULAR DYNAMICS; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; RECEPTOR BINDING; SIGNAL TRANSDUCTION; THERMOSTABILITY;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CELL MEMBRANE; COS CELLS; CRICETINAE; CYSTEINE; CYTOPLASM; DOSE-RESPONSE RELATIONSHIP, DRUG; EPINEPHRINE; GTP-BINDING PROTEINS; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; LIGANDS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; PHENYLALANINE; PHOSPHATIDYLINOSITOLS; PROTEIN BINDING; RECEPTORS, ADRENERGIC, ALPHA-1; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; TEMPERATURE; TIME FACTORS; TRANSFECTION;

ANIMALIA; CHEN;

EID: 0037080007     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi011868k     Document Type: Article

References (31)