-
4
-
-
0020470466
-
Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes
-
(1982)
Nature
, vol.300
, pp. 611-615
-
-
Palmiter, R.D.1
-
7
-
-
0034989658
-
Developmental roles of platelet-derived growth factors
-
(2001)
BioEssays
, vol.23
, pp. 494-507
-
-
Betsholtz, C.1
-
10
-
-
0031758635
-
The application of high-throughput screening to novel lead discovery
-
(1998)
Prog. Drug Res.
, vol.51
, pp. 245-269
-
-
Kenny, B.A.1
-
16
-
-
2042437650
-
Initial sequencing and analysis of the human genome
-
(2001)
Nature
, vol.409
, pp. 860-921
-
-
Lander, E.S.1
-
17
-
-
0028073794
-
BRCA1 mutations in primary breast and ovarian carcinomas
-
(1994)
Science
, vol.266
, pp. 120-122
-
-
Futreal, P.A.1
-
18
-
-
0027933150
-
A physical map and candidate genes in the BRCA1 region on chromosome 17q12-21
-
(1994)
Nat. Genet.
, vol.7
, pp. 472-479
-
-
Albertsen, H.M.1
-
19
-
-
0027480960
-
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group
-
(1993)
Cell
, vol.72
, pp. 971-983
-
-
Group, T.H.D.C.R.1
-
20
-
-
0028113345
-
A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1
-
(1994)
Science
, vol.266
, pp. 66-71
-
-
Miki, Y.1
-
21
-
-
0028006563
-
Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13
-
(1994)
Science
, vol.265
, pp. 2088-2090
-
-
Wooster, R.1
-
22
-
-
0024424270
-
Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA
-
(1989)
Science
, vol.245
, pp. 1066-1073
-
-
Riordan, J.R.1
-
23
-
-
0035978651
-
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
-
(2001)
Nature
, vol.411
, pp. 599-603
-
-
Hugot, J.P.1
-
24
-
-
0035140274
-
Concordance of murine quantitative trait loci for salt-induced hypertension with rat and human loci
-
(2001)
Genomics
, vol.71
, pp. 70-77
-
-
Sugiyama, F.1
-
26
-
-
17644442703
-
Correction of deafness in shaker-2 mice by an unconventional myosin in a BAC transgene
-
(1998)
Science
, vol.280
, pp. 1444-1447
-
-
Probst, F.J.1
-
27
-
-
0028241271
-
Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior
-
(1994)
Science
, vol.264
, pp. 719-725
-
-
Vitaterna, M.H.1
-
28
-
-
0034425410
-
A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse
-
(2000)
Nat. Genet.
, vol.25
, pp. 440-443
-
-
Nolan, P.M.1
-
30
-
-
0035903241
-
Elevated blood pressure in transgenic mice with brain-specific expression of human angiotensinogen driven by the glial fibrillary acidic protein promoter
-
(2001)
Circ. Res.
, vol.89
, pp. 365-372
-
-
Morimoto, S.1
-
31
-
-
0035903243
-
Targeted alpha(1A)-adrenergic receptor overexpression induces enhanced cardiac contractility but not hypertrophy
-
(2001)
Circ. Res.
, vol.89
, pp. 343-350
-
-
Lin, F.1
-
32
-
-
0028263498
-
Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor
-
(1994)
Science
, vol.264
, pp. 582-586
-
-
Milano, C.A.1
-
33
-
-
0025259637
-
A promoter that drives transgene expression in cerebellar Purkinje and retinal bipolar neurons
-
(1990)
Science
, vol.248
, pp. 223-226
-
-
Oberdick, J.1
-
34
-
-
0023938061
-
Atrial natriuretic factor-SV40 T antigen transgenes produce tumors and cardiac arrhythmias in mice
-
(1988)
Science
, vol.239
, pp. 1029-1033
-
-
Field, L.J.1
-
35
-
-
0028806218
-
A targeted glucocorticoid receptor antisense transgene increases thymocyte apoptosis and alters thymocyte development
-
(1995)
Immunity
, vol.3
, pp. 647-656
-
-
King, L.B.1
-
37
-
-
0025318633
-
High level, regulated expression of the chimeric P-enolpyruvate carboxykinase (GTP)-bacterial O6-alkylguanine-DNA alkyltransferase (ada) gene in transgenic mice
-
(1990)
Cancer Res.
, vol.50
, pp. 1701-1708
-
-
Lim, I.K.1
-
38
-
-
0029818753
-
Time-sensitive reversal of hyperplasia in transgenic mice expressing SV40 T antigen
-
(1996)
Science
, vol.273
, pp. 1384-1386
-
-
Ewald, D.1
-
41
-
-
0035816681
-
Use of the tetracycline-controlled transcriptional silencer (tTS) to eliminate transgene leak in inducible overexpression transgenic mice
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 25222-25229
-
-
Zhu, Z.1
-
42
-
-
0035339043
-
Induced myelination and demyelination in a conditional mouse model of Charcot-Marie-Tooth disease type 1A
-
(2001)
Hum. Mol. Genet.
, vol.10
, pp. 1007-1018
-
-
Perea, J.1
-
43
-
-
0032144128
-
Inducible and reversible gene expression with the rtTA system for the study of memory
-
(1998)
Neuron
, vol.21
, pp. 257-265
-
-
Mansuy, I.M.1
-
46
-
-
0027135790
-
Disruption of Krox-20 results in alteration of rhombomeres 3 and 5 in the developing hindbrain
-
(1993)
Cell
, vol.75
, pp. 1199-1214
-
-
Schneider-Maunoury, S.1
-
47
-
-
0030447736
-
Altered segmental identity and abnormal migration of motor neurons in mice lacking Hoxb-1
-
(1996)
Nature
, vol.384
, pp. 630-634
-
-
Studer, M.1
-
48
-
-
15844370315
-
PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis
-
(1996)
Cell
, vol.85
, pp. 863-873
-
-
Bostrom, H.1
-
49
-
-
0030756325
-
Pericyte loss and microaneurysm formation in PDGF-B-deficient mice
-
(1997)
Science
, vol.277
, pp. 242-245
-
-
Lindahl, P.1
-
50
-
-
0027496895
-
Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)
-
(1993)
Cell
, vol.75
, pp. 59-72
-
-
Liu, J.P.1
-
51
-
-
0033575885
-
EPS8 and E3B1 transduce signals from Ras to Rac
-
(1999)
Nature
, vol.401
, pp. 290-293
-
-
Scita, G.1
-
53
-
-
0030597357
-
An Escherichia coli system for assay of F1p site-specific recombination on substrate plasmids
-
(1996)
Gene
, vol.180
, pp. 225-227
-
-
Snaith, M.R.1
-
54
-
-
0025847620
-
Recombinase-mediated gene activation and site-specific integration in mammalian cells
-
(1991)
Science
, vol.251
, pp. 1351-1355
-
-
O'Gorman, S.1
-
55
-
-
0028059099
-
Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting
-
(1994)
Science
, vol.265
, pp. 103-106
-
-
Gu, H.1
-
56
-
-
0034234894
-
Conditional biallelic Nf2 mutation in the mouse promotes manifestations of human neurofibromatosis type 2
-
(2000)
Genes Dev.
, vol.14
, pp. 1617-1630
-
-
Giovannini, M.1
-
57
-
-
0029155706
-
Inducible gene targeting in mice
-
(1995)
Science
, vol.269
, pp. 1427-1429
-
-
Kuhn, R.1
-
58
-
-
0035408211
-
Liver-derived IGF-I is of importance for normal carbohydrate and lipid metabolism
-
(2001)
Diabetes
, vol.50
, pp. 1539-1545
-
-
Sjogren, K.1
-
59
-
-
13044294029
-
Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice
-
(1999)
Proc. Natl. Acad. Sci. U. S. A.
, vol.96
, pp. 7088-7092
-
-
Sjogren, K.1
-
61
-
-
0035793045
-
Impaired adipogenesis and lipolysis in the mouse upon selective ablation of the retinoid X receptor alpha mediated by a tamoxifen-inducible chimeric Cre recombinase (Cre-ERT2) in adipocytes
-
(2001)
Proc. Natl. Acad. Sci. U. S. A.
, vol.98
, pp. 224-228
-
-
Imai, T.1
-
63
-
-
0032510494
-
A causal role for E-cadherin in the transition from adenoma to carcinoma
-
(1998)
Nature
, vol.392
, pp. 190-193
-
-
Perl, A.K.1
-
64
-
-
0032978138
-
Reduced expression of neural cell adhesion molecule induces metastatic dissemination of pancreatic beta tumor cells
-
(1999)
Nat. Med.
, vol.5
, pp. 286-291
-
-
Perl, A.K.1
-
65
-
-
0033617532
-
Effects of angiogenesis inhibitors on multistage carcinogenesis in mice
-
(1999)
Science
, vol.284
, pp. 808-812
-
-
Bergers, G.1
-
66
-
-
0033614962
-
Essential role for oncogenic Ras in tumour maintenance
-
(1999)
Nature
, vol.400
, pp. 468-472
-
-
Chin, L.1
-
67
-
-
0026725757
-
Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells
-
(1992)
Cell
, vol.71
, pp. 343-353
-
-
Plump, A.S.1
-
68
-
-
0027258140
-
Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery
-
(1993)
J. Clin. Invest.
, vol.92
, pp. 883-893
-
-
Ishibashi, S.1
-
69
-
-
0028268018
-
The two-receptor model of lipoprotein clearance: tests of the hypothesis in 'knockout' mice lacking the low density lipoprotein receptor, apolipoprotein E, or both proteins
-
(1994)
Proc. Natl. Acad. Sci. U. S. A.
, vol.91
, pp. 4431-4435
-
-
Ishibashi, S.1
-
70
-
-
0031927755
-
A mouse model of human familial hypercholesterolemia: markedly elevated low density lipoprotein cholesterol levels and severe atherosclerosis on a low-fat chow diet
-
(1998)
Nat. Med.
, vol.4
, pp. 934-938
-
-
Powell-Braxton, L.1
-
71
-
-
0033536163
-
Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse
-
(1999)
Nature
, vol.400
, pp. 173-177
-
-
Schenk, D.1
-
75
-
-
15844419997
-
Role of CYP2E1 in the hepatotoxicity of acetaminophen
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 12063-12067
-
-
Lee, S.S.1
-
76
-
-
0032520017
-
Uroporphyria produced in mice by iron and 5-aminolaevulinic acid does not occur in Cyp1a2(-/-) null mutant mice
-
(1998)
Biochem. J.
, vol.330
, pp. 149-153
-
-
Sinclair, P.R.1
-
78
-
-
0034234231
-
Cytochrome P4501B1 mediates induction of bone marrow cytotoxicity and preleukemia cells in mice treated with 7,12-dimethylbenz[a]anthracene
-
(2000)
Cancer Res.
, vol.60
, pp. 3454-3460
-
-
Heidel, S.M.1
-
80
-
-
0032826035
-
Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failure
-
(1999)
Nat. Med.
, vol.5
, pp. 1135-1142
-
-
Heymans, S.1
-
81
-
-
0032518922
-
Abnormal heart rate and body temperature in mice lacking thyroid hormone receptor alpha 1
-
(1998)
EMBO J.
, vol.17
, pp. 455-461
-
-
Wikstrom, L.1
-
82
-
-
0032416664
-
Using genetic mutations to study the neural basis of behavior
-
(1998)
Cell
, vol.95
, pp. 879-882
-
-
Steele, P.M.1
-
83
-
-
0030852513
-
Postnatal lung function and morphology in transgenic mice expressing transforming growth factor-alpha
-
(1997)
Am. J. Pathol.
, vol.151
, pp. 1075-1083
-
-
Hardie, W.D.1
-
85
-
-
0032861562
-
Normal feeding behavior, body weight and leptin response require the neuropeptide Y Y2 receptor
-
(1999)
Nat. Med.
, vol.5
, pp. 1188-1193
-
-
Naveilhan, P.1
|