The application of high-throughput screening to novel lead discovery

Progress in Drug Research

Volumn 51, Issue , 1998, Pages 245-269

  Kenny, Barry A ^a,b   Bushfield, Mark ^a,b   Parry Smith, David J ^a,b   Fogarty, Simon ^a,d,e   Treherne, J Mark ^a,b,c  

^a Cambridge Drug Discovery   (United Kingdom)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^c UNIVERSITY OF BASEL   (Switzerland)

^d Cambridge Drug Discovery ^*  (United Kingdom)

^e GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Automation; Drug discovery; G proteins; High throughput screening; Informatics; Ion channels; Kinases; Orphan receptors; Receptors

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; LEAD; POTASSIUM CHANNEL;

ACCURACY; AUTOMATION; CHEMICAL STRUCTURE; DATA ANALYSIS; DATA BASE; DRUG DELIVERY SYSTEM; DRUG SCREENING; DRUG TARGETING; ENERGY TRANSFER; ENZYME LINKED IMMUNOSORBENT ASSAY; INFORMATION SCIENCE; MELANOCYTE; MULTIGENE FAMILY; PREDICTION; PRIORITY JOURNAL; REVIEW; SCINTILLATION;

EID: 0031758635     PISSN: 0071786X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-0348-8845-5_7     Document Type: Review

References (52)

1. Banks, M., Binnie, A. and Fogarty, S.: J. Biomol. Screening 2, 133-135 (1997).
2. Mellor, G.W., Fogarty, S., O'Brian, S., Congreve, M., Banks, M.N., Mills, K.M., Jeffries, B. and Houston, J.G.: J. Biomol. Screening 2, 153-158 (1997).
3. McCaffrey C., Powers G., Talbot MK.: J. Biomolec. Screening 1, 187-190 (1996).
4. Fogarty, S.J., Mellor, G.W., Bank, M.N., Mills, K.M., O'Brien, M.S., Jefferies, B. and Houston, J.G.: Proximity News, issue 29 (1996).
5. Lemmo T., Rose D. and Tisone T.: Society for Biomolecular Screening, 3rd Annual Conference, 1997.
6. Cook, N.O.: Drug Discovery Today 7, 287-294 (1996).
7. Chen, W., Shields, T.S., Stork, P.J. and Cone, R.D.: Anal. Biochem. 226, 349-354 (1995).
8. Messier, T.L., Dorman, M., Brauner-Osbourne, H., Eubanks, D. and Brann, M.R.: Pharmacol. Toxicol. 76, 308-311 (1995).
9. Stratowa, C., Machat, H., Burger, E., Himmler, A., Schafer, R., Spevak., W., Weyer, U., Wiche-Castanon, M. and Czernilofsky, A.P.: J. Recep. Sig. Trans. Res. 15, 617-630 (1995).
10. Migeon, J.C. and Nathanson, N.M.:. J. Biol. Chem. 269, 9767-9773 (1994).
11. George, S.E., Bungay, P.J. and Naylor, L.H.: J. Biomolec. Screening 2, 235-240 (1997).
12. Berger, J., Hauber, J., Hauber, R., Greiger, R. and Cullen, B.R.: Gene 66, 1-10 (1994).
13. King, K., Dohlman, H.G., Thorner, J., Caron, M.G. and Lefkovitz, R.J.: Science 250, 120-123 (1990).
14. Hemmila, I. and Webb, S.: Drug Disc. Today 2, 373-381 (1997).
15. Kolb, A.J., Burke, J.W. and Mathis, G., in: J.P. Devlin (ed.): High throughput screening. Marcel Dekker Inc. 1997.
16. Dietrich, B. and Sauvage, J.P.: New J. Chem. 12, 8-9 (1988).
17. Mathis, G.: Clin. Chem. 39, 1953-1972 (1993).
18. Milligan, G., Bond, R.A. and Lee, M.: Trend Pharmacol. Sci. 16, 10-13 (1995).
19. Stables, J., Green, A., Marshall, F., Fraser, N., Knight, E., Sautel, M., Milligan, G., Lee, M. and Rees, S.: Analyt. Biochem. 252, 115-126 (1997).
20. Lerner, M.R.: Trends Neurosci. 17, 1420-147 (1994).
21. Alajoka, M.L., Baxter, G.T., Bemiss, W.R., Blau, D., Bousse, L.J., Chan, S.D.H., Dawes, T.D. and Hahnenberger, K.M., in: J.P. Devlin (ed.): High throughput screening. Marcel Dekker Inc. 1997.
22. Gilman, A.G.: Ann. Rev. Biochem. 56, 615 (1987).
23. Neer, E.: Cell 80, 249-257 (1995).
24. Clapham, D.E. and Neer, E.J.: Nature 365, 403-406 (1993).
25. Faure, M., Voyno-Yasenetskaya, A. and Bourne, H.R.: J. Biol. Chem. 269, 7851-7854 (1994).
26. Duzic, E. and Lanier, S.M.: J. Biol. Chem. 267, 24045-24052 (1992).
27. Eason, M.G., Kurose, H., Holt, B.D., Raymond, J.R. and Liggett, S.B.: J. Biol. Chem. 267, 15795-15804 (1992).
28. Perez, D.M., Deyoung, M.B. and Graham, R.M.: Mol. Pharmacol. 44, 784-795 (1993).
29. Adham, N., Tamm, J.A., Salon, J.A., Vaysee, P.J., Weinshank, R.L. and Branchek, T.: Neuropharmacology 33, 403-410 (1994).
30. Kenakin, T.: Physiol. Rev. 48, 413-463 (1996).
31. Cotecchia, S., Lattion, A.L., Diviani, D. and Cavalli, A.: Biochem. Soc. Trans. 23, 121-125 (1995).
32. DeLean, A., Kilpatrich, B.F. and Caron, M.C.: Mol. Pharmacol. 22, 290-297 (1982).
33. Herz, J.M., Thomsen, W.J. and Yarbrough, G.G.: J. Recep. Sig. Trans. Res. 17, 671-776 (1997).
34. Heldin, C.H.: FEBS Lett. 410, 17-21 (1997).
35. Cohen, G.B., Ren, R. and Baltimore, D.: Cell 80, 237-248 (1995).
36. Heldin, C.H.: Cell 80, 213-223 (1995).
37. Yarden, Y. and Schlessinger, J.: Biochemistry 26, 1443-1451 (1987).
38. Herbert, S.C.: Am. J. Med. 104, 87-98 (1998).
39. Catterall, W.A.: Curr. Opinion Cell Biol. 6, 607-615 (1994).
40. Sather, W.A. et al.: Curr Opinion Neurobiol. 4, 313-323 (1994).
41. Armstrong, C.M. et al.: Neuron 20, 371-380 (1998).
42. Ashcroft, F.M. and Roper, J.: Curr. Opinion Cell Biol. 5, 677-683 (1993).
43. Jain, K.K.: Scrip Report, P.J. Publications Ltd. 1995.
44. Liu, Q.Y. et al.: Can. J. Physiol. 14, 275-280 (1998).
45. Bezanilla, F. and Stefani, E.: Biomolec. Structures 23, 819-846 (1994).
46. Dolly, O.: Biochem. Soc. Trans. 23, 473-478 (1994).
47. Conley, E.C, in: The Ion Channel Facts Book. Vol 1. Extracellular ligand-gated channels. Academic Press, London 1995.
48. Conley, E.C., in: The Ion Channel Facts Book. Vol 2. Intracellular ligand-gated channels. Academic Press, London 1996.
49. Neher, E. and Sackmann, B.: Scientific American 266, 44-51 (1992).
50. Liem, L.K et al.: Neurosurgery 36, 382-292 (1995).
51. Epps, D.E.: Chem. Phys. Lipids 69, 137-150 (1994).
52. Houston, J. G. and Banks, M.V.: Current Opinion in Biotechnology 8, No 6, 734-740 (1997).