A transgenic mouse expressing human CYP4B1 in the liver

Biochemical and Biophysical Research Communications

Volumn 284, Issue 3, 2001, Pages 757-762

  Imaoka, Susumu ^a   Hayashi, Koji ^b   Hiroi, Toyoko ^a   Yabusaki, Yoshiyasu ^b   Kamataki, Tetsuya ^c   Funae, Yoshihiko ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b SUMITOMO CHEMICAL CO LTD   (Japan)

^c HOKKAIDO UNIVERSITY   (Japan)

Author keywords

2 aminofluorene; CYP4B; Cytochrome P450; Lauric acid hydroxylation; Transgenic mouse

Indexed keywords

2 FLUORENYLAMINE; CYTOCHROME P450 4B1; CYTOCHROME P450 ISOENZYME; ENZYME ANTIBODY; LAURIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CATALYSIS; CONTROLLED STUDY; FATTY ACID METABOLISM; HYDROLYSIS; LIVER MICROSOME METABOLISM; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSGENE; TRANSGENIC MOUSE;

EID: 0034810603     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2001.5055     Document Type: Article

References (26)

1. P450 superfamily: Update on new sequences, gene mapping, accession numbers, and nomenclature
2. Roles of cytochrome P-450 enzymes in chemical carcinogenesis and cancer chemotherapy
3. CYP4B1 activates 4-ipomeanol in rat lung
4. The rabbit pulmonary monooxygenase system. Partial structural characterization of the cytochrome P-450 components and comparison to the hepatic cytochrome P-450
5. Primary structures of cytochrome P-450 isozyme 5 from rabbit and rat and regulation of species-dependent expression and induction in lung and liver: Identification of cytochrome P-450 gene subfamily IVB
6. Bovine bladder mucosa microsomal cytochrome P-450 and 4-amino-biphenyl N-hydroxylase activity
7. The cytochrome P-450 monooxygenase system of rabbit bladder mucosa: Enzyme components and isozyme 5-dependent metabolism of 2-aminofluorene
8. Mutagenic activation of 3-methoxy-4-aminoazobenzene by mouse renal cytochrome P450 CYP4B1: Cloning and characterization of mouse CYP4B1
9. Mutagenic activation of urinary bladder carcinogens by CYP4B1 and the presence of CYP4B1 in bladder mucosa
10. Identification of a new P450 expressed in human lung: Complete cDNA sequence, cDNA-directed expression, and chromosome mapping
11. Identification of a meander region proline residue critical for heme binding to cytochrome P450: Implications for the catalytic function of human CYP4B1
12. CYP4B1 is a possible risk factor for bladder cancer in humans
13. Establishment of transgenic mice carrying human fetus-specific CYP3A7
14. Gene expression of a novel cytochrome P450 of the CYP4F subfamily in human seminal vesicles
15. Apolipoprotein B mRNA-editing protein induces hepatocellular carcinoma and dysplasia in transgenic animals
16. Multiple forms of human P450 expressed in Saccharomyces cerevisiae. Systematic characterization and comparison with those of the rat
17. Expression of bovine cytochrome P450c21 and its fused enzymes with yeast NADPH-cytochrome P450 reductase in Saccharomyces cerevisiae
18. Artificial P450/reductase fusion enzymes: What can we learn from their structures?
19. Characterization of three cytochrome P450s purified from renal microsomes of untreated male rats and comparison with human renal cytochrome P450
20. Changes in the amount of cytochrome P450s in rat hepatic microsomes with starvation
21. Effects of human cytochrome b5 on CYP3A4 activity and stability in vivo
22. Metabolic activation of 4-ipomeanol by complementary DNA-expressed human cytochromes P-450: Evidence for species-specific metabolism
23. Molecular basis of the Dark Agouti rat drug oxidation polymorphism: Importance of CYP2D1 and CYP2D2
24. Expression of four rat CYP2D isoforms in Saccharomyces cerevisiae and their catalytic specificity
25. Hypoxia-induced production of 12-hydroxyeicosanoids in the corneal epithelium: Involvement of a cytochrome P-4504B1 isoform
26. Regulation of cyclooxygenase-2 by hypoxia and peroxisome proliferators in the corneal epithelium