Two distinct mechanisms are involved in 6-hydroxydopamine- and MPP+- induced dopaminergic neuronal cell death: Role of caspases, ROS, and JNK

Journal of Neuroscience Research

Volumn 57, Issue 1, 1999, Pages 86-94

  Choi, Won Seok ^a   Yoon, So Young ^a   Oh, Tae H ^b,c   Choi, Eui Ju ^d   O'Malley, Karen L ^e   Oh, Young J ^a  

^a Yonsei University   (South Korea)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c Korea Institute of Science and Technology   (South Korea)

^d Korea University   (South Korea)

^e WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Caspase; JNK; Parkinson's disease; Reactive oxygen species

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; 1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; ACETYLCYSTEINE; CASPASE; CASPASE INHIBITOR; CATALASE; N(G) NITROARGININE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; OXIDOPAMINE; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; DOPAMINERGIC NERVE CELL; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; MOUSE; NERVE CELL CULTURE; NERVE CELL NECROSIS; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION;

1-METHYL-4-PHENYLPYRIDINIUM; ANIMALS; APOPTOSIS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CASPASES; CELL LINE; DOPAMINE; DOPAMINE AGENTS; ENZYME ACTIVATION; IMMUNOBLOTTING; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; NEURONS; OXIDOPAMINE; REACTIVE OXYGEN SPECIES;

EID: 0033168508     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(19990701)57:1<86::AID-JNR9>3.0.CO;2-E     Document Type: Article

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