Staurosporine- and H-7-induced cell death in SH-SY5Y neuroblastoma cells is associated with caspase-2 and caspase-3 activation, but not with activation of the FAS/FAS-L-caspase-8 signaling pathway

Molecular Brain Research

Volumn 85, Issue 1-2, 2000, Pages 61-67

  Lopez E ^a   Ferrer, I ^a  

^a HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

Author keywords

Apoptosis; Caspase; H 7; PARP; SH SY5Y neuroblastoma; Staurosporine

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; CASPASE 2; CASPASE 3; CASPASE 8; CASPASE 9; CASPASE INHIBITOR; FAS ANTIGEN; FAS LIGAND; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN KINASE INHIBITOR; STAUROSPORINE;

APOPTOSIS; ARTICLE; CELL LINE; COLORIMETRY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; NERVE CELL NECROSIS; NEUROBLASTOMA CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; ANTIGENS, CD95; APOPTOSIS; BLOTTING, WESTERN; CASPASE 2; CASPASE 3; CASPASE 8; CASPASE 9; CASPASES; CELL SURVIVAL; ENZYME ACTIVATION; ENZYME INHIBITORS; FAS LIGAND PROTEIN; HUMANS; MEMBRANE GLYCOPROTEINS; NEUROBLASTOMA; NEURONS; PROTEINS; SIGNAL TRANSDUCTION; STAUROSPORINE; TUMOR CELLS, CULTURED;

EID: 0034727885     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(00)00235-7     Document Type: Article

References (54)

1. Human ICE/Ced-3 protease nomenclature
2. Involvement of MACH, a novel MORT1/FADD-interacting protease, in FAS/APO-1 and TNF receptor-induced cell death
3. Characterization of the cell death process induced by staurosporine in human neuroblatoma cell lines
4. Activation of DNA-dependent protein kinase may play a role in apoptosis of human neuroblastoma cells
5. Portrait of an executioner: The molecular mechanism of Fas/APO-1-induced apoptosis
6. The Fas pathway in apoptosis
7. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
8. 2+ ions
9. CPP32, a novel human apoptotic protein with homology to C elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme
10. Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family
11. Regulated targeting of Bax to mitochondria
12. Regulation of Fas-mediated apoptosis
13. Mitochondria and apoptosis
14. Differential requirement for caspase 9 in apoptotic pathways in vivo
15. Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill
16. Cytosol-to-membrane redistribution of Bax and Bcl-x(L) during apoptosis
17. Programmed cell death and Bcl-2 protection in the absence of a nucleus
18. Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade
19. The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
20. Staurosporine-induced neuronal apoptosis
21. Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9
22. Mechanisms mediating caspase activation in cell death
23. Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE
24. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
25. Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c
26. The caspase-3 precursor has a cytosolic and mitochondrial distribution: Implications for apoptotic signaling
27. Endogenous bax translocation in SH-SY5Y human neuroblastoma cells and cerebellar granule neurons undergoing apoptosis
28. The role of the caspase family of cysteine proteases in apoptosis
29. Signalling by proteolysis: Death receptors induce apoptosis
30. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (FAS/APO-1) death-inducing signaling complex
31. H-7-induced apoptosis in the cells of a Drosophila neuronal cell line though affecting unidentified H-7-sensitive substance(s)
32. Apoptosis mediated by the Fas system
33. Effects of ICE-like protease and calpain inhibitors on neuronal apoptosis
34. Caspase structure, proteolytic substrates, and function during apoptotic cell death
35. Mechanisms of CD95 (APO-1/Fas)-mediated apoptosis
36. Characterization of CPP-32-like protease activity following apoptotic challenge in SH-SY5Y neuroblastoma cells
37. 1-(5-Isoquinolinesulfonyl)-2-methylpiperazine induces apoptosis in human neuroblastoma cells, SH-SY5Y, through a p53-dependent pathway
38. Serial killers: Ordering caspase activation prevents in apoptosis
39. Autoactivation of pro-caspase-9 by Apaf-1-mediated oligomerization
40. Mitochondrial release of caspase-2 and -9 during the apoptotic process
41. Mitochondria as regulators of apoptosis: Doubt no more
42. Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly (ADP-ribose) polymerase
43. Caspases: Enemies within
44. A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis
45. Caspase-2 mediates neuronal death induced by β-amyloid
46. Targeted disruption of the mouse caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo-1, and DR3 and is lethal prenatally
47. Tumor necrosis factor receptor and Fas signaling mechanisms
48. Staurosporine induces programmed cell death in embryonic neurons and activation of the ceramide pathway
49. Apoptotic signal transduction: Emerging pathways
50. Movement of Bax from the cytosol to mitochondria during apoptosis
51. Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked
52. Redistribution of Bax from cytosol to membranes is induced by apoptotic stimuli and is an early step in the apoptotic pathway
53. Caspase knockouts: Matters of life and death
54. Apaf-1, a human protein homologous to C elegans CED-4, participates in cytochrome c-dependent activation of caspase-3