Induction of resistance to active experimental allergic encephalomyelitis by myelin basic protein-specific Th2 cell lines generated in the presence of glucocorticoids and IL-4

European Journal of Immunology

Volumn 30, Issue 3, 2000, Pages 747-758

  Ramírez, Francisco ^a,b,c   Mason, Don ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

Autoimmunity; Cytokine experimental allergic encephalomyelitis; Neuroimmunology; Th2

Indexed keywords

ANTIBODY; CD8 ANTIGEN; CYTOKINE; DEXAMETHASONE; GLUCOCORTICOID; INTERLEUKIN 4; MYELIN BASIC PROTEIN;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ARTICLE; CELL LINE; CELLULAR IMMUNITY; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; HUMORAL IMMUNITY; IMMUNIZATION; LYMPHOCYTIC INFILTRATION; MALE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RAT; TH2 CELL;

ADOPTIVE TRANSFER; ANIMALS; AUTOANTIBODIES; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE; DEXAMETHASONE; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; GLUCOCORTICOIDS; IMMUNITY, CELLULAR; IMMUNOGLOBULIN G; INTERFERON TYPE II; INTERLEUKIN-4; MALE; MYELIN BASIC PROTEINS; NEUROIMMUNOMODULATION; RATS; RATS, INBRED LEW; SPINAL CORD; TH1 CELLS; TH2 CELLS;

EID: 0343570506     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200003)30:3<747::AID-IMMU747>3.0.CO;2-Y     Document Type: Article

References (53)

1. Zamvil, S. S. and Steinman, L., The T lymphocyte in experimental allergic encephalomyelitis. Annu. Rev. Immunol. 1990. 8: 579-621.
2. MacPhee, I. A. M. and Mason, D. W., Studies on the refractoriness to reinduction of experimental allergic encephalomyelitis in Lewis rats that have recovered from one episode of the disease. J. Neuroimmunol. 1990. 27: 9-19.
3. MacPhee, I. A. M., Antoni, F. A. and Mason, D. W., Spontaneous recovery of rats from experimental allergic encephalomyelitis is dependent on regulation of the immune system by endogenous adrenal corticosteroids. J. Exp. Med. 1989. 169: 431-445.
4. + T cells in vitro. J. Immunol. 1996. 156: 2406-2412.
5. Ramírez, F., Glucocorticoids induce a Th2 response in vitro. Dev. Immunol. 1998. 6: 233-243.
6. + T cell clones in the rat. Cloning methodology and interferon-γ secretion. J. Immunol. Methods 1989. 121: 185-196.
7. Mason, D., Genetic variation in the stress response: susceptibility to experimental allergic encephalomyelitis and implications for human inflammatory disease, Immunol. Today 1991. 12: 57-60.
8. Scott, P., IL-12: Initiation cytokine for cell-mediated immunity. Science 1993. 260: 496-497.
9. Swain, S. L., Weinberg, A. D., English, M. and Huston, G., IL-4 directs the development of Th2-like helper effectors. J. Immunol. 1990. 145: 3796-3806.
10. Baron, J. L., Madri, J. A., Ruddle, N. H., Hashim, G. and Janeway, C. A., Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma. J. Exp. Med. 1993. 177: 57-68.
11. + T line cells. Eur. J. Immunol. 1988. 18: 1993-1999.
12. Sun, D., Qin, Y., Chluba, J., Epplen, J. T. and Wekerle, H., Suppression of experimentally induced autoimmune encephalomyelitis by cytolytic T-T interactions. Nature 1988. 332: 843-845.
13. Herkel, J., Brunner, S., Meyer zum Buschenfelde, K. H. and Lohse, A. W., Humoral mechanisms in T cell vaccination: induction and functional characterization of anti-lymphocytic autoantibodies. J. Neuroimmunol. 1997. 10: 137-146.
14. MacPhee, I. A., Day, M. J. and Mason, D. W., The role of serum factors in the suppression of experimental allergic encephalomyelitis: evidence for immunoregulation by antibody to the encephalitogenic peptide. Immunology 1990. 70: 527-534.
15. Wolf, S. D., Dittel, B. N., Hardardottir, F. and Janeway, C. A., Experimental autoimmune encephalomyelitis induction in genetically B cell-deficient mice. J. Exp. Med. 1996. 184: 2271-2278.
16. Gracie, J. A. and Bradley, J. A., lnterleukin-12 induces interferon-gamma-dependent switching of IgG alloantibody sub-class. Eur. J. Immunol. 1996. 26: 1217-1221.
17. 2. Proc. Natl. Acad. Sci. USA 1989. 86: 3803-3807.
18. Peleman, R., Wu, J., Fargeas, C. and Delespesse, G., Recombinant interleukin 4 suppresses the production of interferon γ by human mononuclear cells. J. Exp. Med. 1989. 170: 1751-1756.
19. Sedgwick, J., Brostoff, S. and Mason, D., Experimental allergic encephalomyelitis in the absence of a classical delayed-type hypersensitivity reaction. Severe paralytic disease correlates with the presence of interleukin 2 receptor-positive cells infiltrating the central nervous system. J. Exp. Med. 1987. 165: 1058-1075.
20. Wong, G. H. W., Bartlett, P. F., Clark-Lewis, I., Battye, F. and Schrader, J. W., lnducible expression of H-2 and la antigens on brain cells. Nature 1984. 310: 688-691.
21. Khoruts, A., Miller, S. D. and Jenkins, M. K., Neuroantigen-specific Th2 cells are inefficient suppressors of experimental allergic encephalomyelitis induced by effector Th1 cells. J. Immunol. 1995. 155: 5011-5017.
22. Katz, J. D., Benoist, C. and Mathis, D., T helper cell subsets in insulin-dependent diabetes. Science 1995. 268: 1185-1188.
23. Chen, Y., Kuchroo, V. K., Inobe, J., Hafler, D. A. and Weiner, H. L., Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science 1994. 265: 1237-1240.
24. Cua, D. J., Hinton, D. R. and Stohlman, S. A., Self-antigen-induced Th2 responses in experimental allergic encephalomyelitis (EAE)-resistant mice. Th2-mediated suppression of autoimmune disease. J. Immunol. 1995. 155: 4052-4059.
25. Kuchroo, V. K., Das, M. P., Brown, J. A., Ranger, A. M., Zamvil, S. S., Sobel, R. A., Weiner, H. L., Nabavi, N. and Glimcher, L. H., B7-1 and B7-2 costimulatory molecules active differentially the Th1/Th2 developmental pathways: application to autoimmune disase therapy. Cell 1995. 80: 707-718.
26. Ben-Nun, A., Wekerle, H. and Cohen, I. R., Vaccination against autoimmune encephalomyelitis with T-lymphocyte line cells reactive against myelin basic protein. Nature 1981. 292: 60-61.
27. Lider, O., Reshef, T., Beraud, E., Ben-Nun, A. and Cohen, I. R., Anti-idiotypic network induced by T cell vaccination against experimental allergic encephalomyelitis. Science 1988. 239: 181-183.
28. Cohen, I. R., Regulation of autoimmune disease: physiological and therapeutic. Immunol. Rev. 1986. 94: 5-21.
29. Vandenbark, A. A., Hashim, G. and Offner, H., Immunization with a synthetic T-cell receptor peptide protects against experimental allergic encephalomyelitis. Nature 1989. 341: 541-544.
30. Desquenne-Clark, L., Esch, T. R., Otvos, L. and Hebert-Katz, E., T-cell receptor peptide immunization leads to enhanced and chronic experimental allergic encephalomyelitis. Proc. Natl. Acad. Sci. USA 1991. 88: 7219-7223.
31. Jung, S., Schluesener, H. J., Toyka, K. V. and Hartung, H. P., Modulation of EAE by vaccination with T cell receptor peptides: Vβ8 T cell receptor peptide-specific CD4 + lymphocytes lack direct immunoregulatory activity. J. Neuroimmunol. 1993. 45: 15-22.
32. Bouwer, H. G. and Hinrichs, D. L., Adoptive transfer of experimental allergic encephalomyelitis: recipient response to myelin basic protein-reactive lymphocytes. J. Neuroimmunol. 1994. 54: 87-98.
33. Sun, D., Synthetic peptide representing sequences 39 to 59 of rat Vβ8 TcR fail to elicit regulatory T cells reactive with Vβ8 TcR on rat encephalitogenic T cells. Cell. Immunol. 1992. 141: 200-210.
34. Ben-Nun, A. and Cohen, I. R., Vaccination against autoimmune encephalomyelitis (EAE): Attenuated autoimmune T lymphocytes confer resistance to induction of active EAE but not to EAE mediated by the intact T lymphocyte line. Eur. J. Immunol. 1981. 11: 949-952.
35. + T cell-mediated granulomatous pathology in schistosomiasis is downregulated by a B cell-dependent mechanism requiring Fc receptor signalling. J. Exp. Med. 1998. 187: 619-629.
36. Brostoff, S. W. and Mason, D. W., Experimental allergic encephalomyelitis: successful treatment in vivo with a monoclonal antibody that recognizes T helper cells. J. Immunol. 1984. 133: 1938-1942.
37. McKnight, A. and Classon, B. J., Biochemical and immunological properties of rat recombinant interleukin 2 and interleukin 4. Immunology 1992. 75: 286-292.
38. Sunderland, C. A., McMaster, W. R. and Williams, A. F., Purification with monoclonal antibody of a predominant leukocyte-common antigen and glycoprotein from rat thymocytes. Eur. J. Immunol. 1979. 9: 155-159.
39. McMaster, W. R. and Williams, A. F., Identification of la glyco-proteins in rat thymus and purification from rat spleen. Eur. J. Immunol. 1979. 9: 426-433.
40. Brideau, R. J., Carter, P. B., McMaster, W. R., Mason, D. W. and Williams, A. F., Two subsets of rat T lymphocytes defined with monoclonal antibodies. Eur. J. Immunol. 1980. 10: 609-615.
41. Hunt, S. V. and Fowler, M. H., A repopulation assay for B and T lymphocytes stem cells employing radiation chimeras. Cell Tissue Kinet. 1981. 14: 445-464.
42. Hsiung, L. M., Barclay, A. N., Brandon, M. R., Sim, E. and Porter, R. R., Purification of human C3b inactivator by monoclonal-antibody affinity chromatography. Biochem. J. 1982. 203: 293.
43. Paterson, D. J., Jefferies, W. A., Green, J. R., Brandon, M. R., Corthesy, P., Puklavec, M. and Williams, A. F., Antigens of activated rat T lymphocytes including a molecule of 50,000 Mr detected only on CD4 positive T blast. Mol. Immunol. 1987. 24: 1281-1290.
44. - thymocytes that express L-Selectin protects rats from diabetes upon adoptive transfer. Eur. J. Immunol. 1996. 26: 2702-2708.
45. Ramírez, F., Stumbles, P., Puklavec, M. and Mason, D., Rat interleukin-4 assays. J. Immunol. Methods 1998. 221: 141-150.
46. Hunig, T., Wallny, H. J., Hartley, J. K., Lawetzky, A. and Tiefenthaler, G., A monoclonal antibody to a constant determinant of the rat T cell antigen receptor that induces T cell activation. Differential reactivity with subsets of immature and mature T lymphocytes. J. Exp. Med. 1989. 169: 73-86.
47. Tamatoni, T. and Miyasaka, M., Identification of monoclonal antibodies reactive with the rat homolog of ICAM-1, and evidence for differential involvement of ICAM-1 in the adherence of resting versus activated lymphocytes to high endothelial cells. Int. Immunol. 1990. 2: 165-171.
48. Tamatoni, T., Kotani, M. and Miyasaka, M., Characterization of the rat leukocyte integrin, CD11/CD18, by the use of LFA-1 subunit-specific monoclonal antibodies. Eur. J. Immunol. 1991. 21: 627-633.
49. Issekutz, T. B. and Wykretowicz, A., Effect of a new monoclonal antibody, TA-2, that inhibits lymphocyte adherence to cytokine stimulated endothelium in the rat. J. Immunol. 1991. 147: 109-116.
50. Van der Meide, P. H., Dubbeld, M., Vijverberg, K., Kos, T. and Schellekens, H., The purification and characterization of rat gamma interferon by use of two monoclonal antibodies. J. Gen. Virol. 1986. 67: 1059-1071.
51. Van der Meide, P. H., Borman, A. H., Beljaars, H. G., Dubbeld, M. A., Botman, C. A. and Schellekens, H., Isolation and characterization of monoclonal antibodies directed to rat interferon-gamma. Lymphokine Res. 1989. 8: 439-449.
52. + T cells in the presence of a non-depleting monoclonal antibody to CD4 induces a Th2-type response in vitro. J. Exp. Med. 1995. 182: 5-13.
53. Barclay, A. N., The localisation of populations of lymphocytes defined by monoclonal antibodies in rat lymphoid tissues. Immunology 1981. 42: 593-600.