Repertoire requirements of CD4+ T cells that prevent spontaneous autoimmune encephalomyelitis

Journal of Immunology

Volumn 164, Issue 10, 2000, Pages 5499-5507

  Olivares Villagómez, Danyvid ^a,b   Wensky, Allen K ^a,b   Wang, Yijie ^a   Lafaille, Juan J ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; OVALBUMIN; T LYMPHOCYTE RECEPTOR;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; IMMUNOPATHOGENESIS; IMMUNOREGULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; TRANSGENIC MOUSE;

EID: 0034657835     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.10.5499     Document Type: Article

References (68)

1. Ben-Nun, A., S. Eisenstein, and I. R. Cohen. 1982. Experimental autoimmune encephalomyelitis (EAE) in genetically resistant rats: PVG rats resist active induction of EAE but are susceptible to and can generate EAE effector T cell lines. J. Immunol. 129:918.
2. Cohen, I. R. 1986. Regulation of autoimmune disease physiological and therapeutic. Immunol. Rev. 94:5.
3. + T cell subset that inhibits this autoimmune potential. J. Exp. Med. 177:627.
4. Hafler, D. A., and H. L. Weiner. 1995. Immunologic mechanisms and therapy in multiple sclerosis. Immunol. Rev. 144:75.
5. Ota, K., M. Matsui, E. L. Milford, G. A. Mackin, H. L. Weiner, and D. A. Hafler. 1990. T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis. Nature 346:183.
6. Goverman, J., A. Woods, L. Larson, L. P. Weiner, L. Hood, and D. M. Zaller. 1993. Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity. Cell 72:551.
7. Lafaille, J. J., K. Nagashima, M. Katsuki, and S. Tonegawa. 1994. High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice. Cell 78:399.
8. Scott, B., R. Liblau, S. Degermann, L. A. Marconi, L. Ogata, A. J. Caton, H. O. McDevitt, and D. Lo. 1994. A role for non-MHC genetic polymorphism in susceptibility to spontaneous autoimmunity. Immunity 1:73.
9. + T cells induce or protect from chronic intestinal inflammation in CB-17 scid mice. Int. Immunol. 5:1461.
10. + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 389:737.
11. Asano, M., M. Toda, N. Sakaguchi, and S. Sakaguchi. 1996. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulalinn. J. Exp. Med. 184:387.
12. + T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells. J. Immunol. 160: 1212.
13. Saoudi, A., B. Seddon, D. Fowell, and D. Mason. 1996. The thymus contains a high frequency of cells that prevent autoimmune diabetes on transfer into prediabetic recipients. J. Exp. Med. 184:2393.
14. + helper/ inducer T lymphocytes prevent spontaneous diabetes in the BB/W rat. Diabetologia 30:22.
15. Boitard, C., R. Yasunami, M. Dardenne, and J. F. Bach. 1989. T cell-mediated inhibition of the transfer of autoimmune diabetes in NOD mice. J. Exp. Med. 169:1669.
16. + T cells expressing endogenous T cell receptor chains protect myelin basic protein-specific transgenic mice from spontaneous autoimmune encephalomyelitis. J. Exp. Med. 188:1883.
17. + T cells prevent spontaneous experimental autoimmune encephalomyelitis in anti-myelin basic protein T cell receptor transgenic mice. J. Exp. Med. 188:1875.
18. Qin, S., S. P. Cobbold, H. Pope, J. Elliott, D. Kioussis, J. Davies, and H. Waldmann. 1993. "Infectious" transplantation tolerance. Science 259:974.
19. Modigliani, Y., V. Thomas-Vaslin, A. Bandeira, M. Coltey, N. M. Le Douarin, A. Coutinho, and J. Salaun. 1995. Lymphocytes selected in allogeneic thymic epithelium mediate dominant tolerance toward tissue grafts of the thymic epithelium haplotype. Proc. Natl. Acad. Sci. USA 92:7555.
20. Modigliani, Y., A. Coutinho, P. Pereira, N. Le Douarin, V. Thomas-Vaslin, O. Burlen-Defranoux, J. Salaun, and A. Bandeira. 1996. Establishment of tissue-specific tolerance is driven by regulatory T cells selected by thymic epithelium. Eur. J. Immunol. 26:1807.
21. + T cells in recovery from antigen-induced autoimmune disease. J. Exp. Med. 178:909.
22. Kumar, V., K. Stellrecht, and E. Sercarz. 1996. Inactivation of T cell receptor peptide-specific CD4 regulatory T cells induces chronic experimental autoimmune encephalomyelitis (EAE). J. Exp. Med. 184:1609.
23. + T cells. Curr. Opin. Immunol. 7:367.
24. + NK T cells associated with disease development in autoimmune-prone mice. J. Immunol. 156:4035.
25. +-like thymocytes in the NOD mouse. Eur. J. Immunol. 26:2989.
26. - T-cell deficiency and IDDM in NOD/Lt mice. Diabetes 46:572.
27. - (NKT) thymocytes prevent insulin-dependent diabetes mellitus in nonobese diabetic (NOD)/Lt mice by the influence of interleukin (IL)-4 and/or IL-10. J. Exp. Med. 187:1047.
28. Lehuen, A., O. Lantz, L. Beaudoin, V. Laloux, C. Carnaud, A. Bendelac, J. F. Bach, and R. C. Monteiro. 1998. Overexpression of natural killer T cells protects Vα14-Jα281 transgenic nonobese diabetic mice against diabetes. J. Exp. Med. 188:1831.
29. + thymocytes expressing L-selectin mediate "active tolerance" in the nonobese diabetic mouse. J. Immunol. 161:2620.
30. lo thymocytes in vivo. Science 250: 1720.
31. Mombaerts, P., J. Iacomini, R. S. Johnson, K. Herrup, S. Tonegawa, and V. E. Papaioannou. 1992. RAG-1-deficient mice have no mature B and T lymphocytes. Cell 68:869.
32. Gilfillan, S., A. Dierich, M. Lemeur, C. Benoist, and D. Mathis. 1993. Mice lacking TdT: mature animals with an immature lymphocyte repertoire. Science 261:1175.
33. Mombaerts, P., A. R. Clarke, M. A. Rudnicki, J. Iacomini, S. Itohara, J. J. Lafaille, L. Wang, Y. Ichikawa, R. Jaenisch, M. L. Hooper, and et al. 1992. Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages. Nature 360:225.
34. Baron, J. L., J. A. Madri, N. H. Ruddle, G. Hashim, and C. A. Janeway, Jr. 1993. Surface expression of α4 integrin by CD4 T cells is required for their entry into brain parenchyma. J. Exp. Med. 177:57.
35. Lafaille, J. J., F. V. Keere, A. L. Hsu, J. L. Baron, W. Haas, C. S. Raine, and S. Tonegawa. 1997. Myelin basic protein-specific T helper 2 (Th2) cells cause experimental autoimmune encephalomyelitis in immunodeficient hosts rather than protect them from the disease. J. Exp. Med. 186:307.
36. Hsieh, C. S., A. B. Heimberger, J. S. Gold, A. O'Garra, and K. M. Murphy. 1992. Differential regulation of T helper phenotype development by interleukins 4 and 10 in an αβ T-cell-receptor transgenic system. Proc. Natl. Acad. Sci. USA 89: 6065.
37. + T cells from T cell receptor transgenic mice. J. Exp. Med. 176:1091.
38. Hickey, W. F., B. L. Hsu, and H. Kimura. 1991. T-lymphocyte entry into the central nervous system. J. Neurosci. Res 28:254.
39. Bauer, J., M. Bradl, W. F. Hickley, S. Forss-Petter, H. Breitschopf, C. Linington, H. Wekerle, and H. Lassmann. 1998. T-cell apoptosis in inflammatory brain lesions: destruction of T cells does not depend on antigen recognition. Am. J. Pathol. 153:715.
40. Ikuta, K., T. Kina, I. MacNeil, N. Uchida, B. Peault, Y. H. Chien, and I. L. Weissman. 1990. A developmental switch in thymic lymphocyte maturation potential occurs at the level of hematopoietic stem cells. Cell 62:863.
41. Herzenberg, L. A., and A. B. Kantor. 1993. B-cell lineages exist in the mouse. Immunol. Today 14:79.
42. Revoltella, R., and Z. Ovary. 1969. Reaginic antibody production in different mouse strains. Immunology 17:45.
43. Grun, J. L., and P. H. Maurer. 1989. Different T helper cell subsets elicited in mice utilizing two different adjuvant vehicles: the role of endogenous interleukin 1 in proliferative responses. Cell. Immunol. 121:134.
44. Beck, L., and H. L. Spiegelberg. 1989. The polyclonal and antigen-specific IgE and IgG subclass response of mice injected with ovalbumin in alum or complete Freund's adjuvant. Cell. Immunol. 123:1.
45. Nicholson, L. B., and V. K. Kuchroo. 1996. Manipulation of the Th1/Th2 balance in autoimmune disease. Curr. Opin. Immunol. 8:837.
46. Abbas, A. K., K. M. Murphy, and A. Sher. 1996. Functional diversity of helper T lymphocytes. Nature 383:787.
47. + T-cell subsets in autoimmunity. Curr. Opin. Immunol. 9:872.
48. Mason, D., and F. Powrie. 1998. Control of immune pathology by regulatory T cells. Curr. Opin. Immunol. 10:649.
49. Lafaille, J. J. 1998. The role of helper T cell subsets in autoimmune diseases. Cytokine Growth Factor Rev. 9:139.
50. Hardardottir, F., J. L. Baron, and C. A. Janeway, Jr. 1995. T cells with two functional antigen-specific receptors. Proc. Natl. Acad. Sci. USA 92:354.
51. Falcone, M., and B. R. Bloom. 1997. A T helper cell 2 (Th2) immune response against non-self antigens modifies the cytokine profile of autoimmune T cells and protects against experimental allergic encephalomyelitis. J. Exp. Med. 185:901.
52. Modigliani, Y., A. Bandeira, and A. Coutinho. 1996. A model for developmentally acquired thymus-dependent tolerance to central and peripheral antigens. Immunol. Rev. 149:155.
53. Nicholson, L. B., and V. K. Kuchroo. 1997. T cell recognition of self and altered self antigens. Crit. Rev. Immunol. 17:449.
54. Sloan-Lancaster, J., and P. M. Allen. 1996. Altered peptide ligand-induced partial T cell activation: molecular mechanisms and role in T cell biology. Annu. Rev. Immunol. 14:1.
55. Locksley, R. M., S. L. Reiner, F. Hatam, D. R. Littman, and N. Killeen. 1993. Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice. Science 261:1448.
56. Brown, D. R., N. H. Moskowitz, N. Killeen, and S. L. Reiner. 1997. A role for CD4 in peripheral T cell differentiation. J. Exp. Med. 186:101.
57. Fowell, D. J., K. Shinkai, X. C. Liao, A. M. Beebe, R. L. Coffman, D. R. Littman, and R. M. Locksley. 1999. Impaired NFATc translocation and failure of Th2 development in Itk-deficient CD4+ T cells. Immunity 11:399.
58. Heath, W. R., and J. F. Miller. 1993. Expression of two a chains on the surface of T cells in T cell receptor transgenic mice. J. Exp. Med. 178:1807.
59. Padovan, E., G. Casorati, P. Dellabona, S. Meyer, M. Brockhaus, and A. Lanzavecchia. 1993. Expression of two T cell receptor α chains: dual receptor T cells. Science 262:422.
60. Zal, T., S. Weiss, A. Mellor, and B. Stockinger. 1996. Expression of a second receptor rescues self-specific T cells from thymic deletion and allows activation of autoreactive effector function. Proc. Natl. Acad. Sci. USA 93:9102.
61. Sarukhan, A., C. Garcia, A. Lanoue, and H. von Boehmer. 1998. Allelic inclusion of T cell receptor α genes poses an autoimmune hazard due to low-level expression of autospecific receptors. Immunity 8:563.
62. Elliott, J. I., and D. M. Altmann. 1995. Dual T cell receptor α chain T cells in autoimmunity. J. Exp. Med. 182:953.
63. Fossati, G., A. Cooke, R. Q. Papafio, K. Haskins, and B. Stockinger. 1999. Triggering a second T cell receptor on diabetogenic T cells can prevent induction of diabetes. J. Exp. Med. 190:577.
64. Davis, M. M., and P. J. Bjorkman. 1988. T-cell antigen receptor genes and T-cell recognition. Nature 334:395.
65. + naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J. Immunol. 162:5317.
66. Sakaguchi, S., T. Takahashi, and Y. Nishizuka. 1982. Study on cellular events in post-thymectomy autoimmune oophoritis in mice. II. Requirement of Lyt-1 cells in normal female mice for the prevention of oophoritis. J. Exp. Med. 156:1577.
67. Seddon, B., and D. Mason. 1999. Peripheral autoantigen induces regulatory T cells that prevent autoimmunity. J. Exp. Med. 189:877.
68. Smith, H., Y. Sakamoto, K. Kasai, and K. S. Tung. 1991. Effector and regulatory cells in autoimmune oophoritis elicited by neonatal thymectomy. J. Immunol. 147:2928.