Corticosteroids Inhibit IL-12 Production in Human Monocytes and Enhance Their Capacity to Induce IL-4 Synthesis in CD4+ Lymphocytes

Journal of Immunology

Volumn 158, Issue 12, 1997, Pages 5589-5595

  Blotta, M Heloisa ^a,b   DeKruyff, Rosemarie H ^a   Umetsu, Dale T ^a  

^a STANFORD UNIVERSITY   (United States)

^b UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 4;

ADULT; ARTICLE; BIOSYNTHESIS; CD4+ T LYMPHOCYTE; CELL ADHESION; CELL CULTURE; DRUG EFFECT; HUMAN; IMMUNOLOGY; MONOCYTE;

ADULT; CD4-POSITIVE T-LYMPHOCYTES; CELL ADHESION; CELLS, CULTURED; DEXAMETHASONE; HUMANS; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-12; INTERLEUKIN-4; MONOCYTES;

EID: 0031570475     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Goulding, N. J., and P. M. Guyre. 1993. Glucocorticoids, lipocortins and the immune response. Curr. Opin. Immunol. 5:108.
2. Gillis, S., G. R. Crabtree, and K. A. Smith. 1979. Glucocorticoid-induced inhibition of T cell growth factor production. I. The effect on mitogen-induced lymphocyte proliferation. J. Immunol. 123:1624.
3. Arya, S. K., F. Wong-Staal, and R. C. Gallo. 1984. Dexamethasone-mediated inhibition of human T cell growth factor and γ-interferon messenger RNA. J. Immunol. 133:273.
4. Schleimer, R. P., and B. S. Bochner. 1994. The effects of glucocorticoids on human eosinophils. J. Allergy Clin. Immunol. 94:1202.
5. U.S. Department of Health and Human Services. 1992. International Consensus Report on Diagnosis and Management of Asthma. U.S. Public Health Service, Washington, DC.
6. Robinson, D. S., Q. Hamid, S. Ying, A. Tsicopoulos, J. Barkans, A. M. Bentley, C. Corrigan, S. R. Durham, and A. B. Kay. 1992. Predominant Th2-like bronchoalveolar T-lymphocyte population in atopic asthma. N. Engl. J. Med. 326:298.
7. Busse, W. W., R. L. Coffman, E. W. Gelfand, A. B. Kay, and L. J. Rosenwasser. 1995. Mechanisms of persistent airway inflammation in asthma: a role for T cells and T-cell products. Am. J. Respir. Crit. Care Med. 152:388.
8. + helper T cells: new insights into the regulation of IgE synthesis and into the pathogenesis of allergic disease. Pediatr. Asthma Allergy Immunol. 6:1.
9. Romagnani, S. 1994. Lymphokine production by human T cells in disease states. Annu. Rev. Immunol. 12:227.
10. Bousquet, J., P. Chanez, J. Y. Lacoste, G. Barneon, N. Ghavanian, I. Enander, P. Venge, S. Ahlstedt, J. Simony-Lafontaine, and P. Godard. 1990. Eosinophilic inflammation in asthma. N. Engl. J. Med. 323:1033.
11. Gundel, R. H., L. G. Letts, and G. J. Gleich. 1991. Human eosinophil major basic-protein induces airway constriction and airway hyperresponsiveness in primates. J. Clin. Invest. 87:1470.
12. Scheinman, R. I., P. C. Cogswell, A. K. Lofquist, and A. S. Baldwin, Jr. 1995. Role of transcriptional activation of IκB alpha in mediation of immunosuppression by glucocorticoids. Science 270:283.
13. Auphan, N., J. A. DiDonato, C. Rosette, A. Helmberg, and M. Karin. 1995. Immunosuppression by glucocorticoids: inhibition of NF-κB activity through induction of I kappa B synthesis. Science 270:286.
14. Barnes, P. J. 1996. Molecular mechanisms of steroid action in asthma. J. Allergy Clin. Immunol. 97:159.
15. Wu, C. Y., C. Fargeas, T. Nakajima, and G. Delespesse. 1991. Glucocorticoids supress the production of interleukin 4 by human lymphocytes. Eur. J. Immunol. 21:2645.
16. Leung, D. Y., R. J. Martin, S. J. Szefler, E. R. Sher, S. Ying, A. B. Kay, and Q. Hamid. 1995. Dysregulation of interleukin 4, interleukin 5, and interferon γ gene expression in steroid-resistant asthma. J. Exp. Med. 181:33.
17. + T cells in vitro. J. Immunol. 156:2406.
18. Daynes, R. A., and B. A. Araneo. 1989. Contrasting effects of glucocorticoids on the capacity of T cells to produce the growth factors interleukin 2 and interleukin 4. Eur. J. Immunol. 19:2319.
19. Zieg, G., G. Lack, R. J. Harbeck, E. W. Gelfand, and D. Y. Leung. 1994. In vivo effects of glucocorticoids on IgE production. J. Allergy Clin. Immunol. 94:222.
20. Trinchieri, G. 1995. InterIeukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 13:251.
21. + T lymphocytes. J. Immunol. 155:111.
22. + cells from allergic individuals is modulated by allergen concentration and antigen-presenting cell type. J. Exp. Med. 181:1081.
23. + T cells requires repeated antigenic stimulation. Cell. Immunol. 152:18.
24. Li, Y., N. Ito, T. Suzuki, D. J. Stechschulte, and K. N. Dileepan. 1995. Dexamethasone inhibits nitric oxide-mediated cytotoxicity via effects on both macrophages and target cells. Immunopharmacology 30:177.
25. + T cells. J. Exp. Med. 182:1591.
26. Viola, A., and A. Lanzavecchia. 1996. T cell activation determined by T cell receptor number and tunable thresholds. Science 273:104.
27. Snijdewint, F. G., M. L. Kapsenberg, P. J. Wauben-Penris, and J. D. Bos. 1995. Corticosteroids class-dependently inhibit in vitro Th1-and Th2-type cytokine production. Immunopharmacology 29:93.
28. Masuyama, K., M. R. Jacobson, S. Rak, Q. Meng, R. M. Sudderick, A. Kay, and O. Lowhagen. 1994. Topical glucocorticosteroid (fluticasone propionate) inhibits cells expressing cytokine mRNA for inlerleukin-4 in the nasal mucosa in allergen-induced rhinitis. Immunology 82:192.
29. Culpepper, J. A., and F. Lee. 1985. Regulation of IL-3 expression by glucocorticoids in cloned murine T lymphocytes. J. Immunol. 135:3191.
30. Beutler, B., N. Krochin, I. W. Milsark, C. Luedke, and A. Cerami. 1986. Control of cachectin synthesis: mechanisms of endotoxin resistance. Science 232:977.
31. Truss, M., and M. Beato. 1993. Steroid hormone receptors: interaction with deoxyribonucleic acid and transcription factors. Endocrinol. Rev. 14:459.
32. Yang-Yen, H. F., J. C. Chambard, and Y. S. Sun. 1990. Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction. Cell 62:1205.
33. Adcock, I. M., C. R. Brown, C. M. Gelder, H. Shirasaki, M. J. Peters, and P. J. Barnes. 1995. The effects of glucocorticoids on transcription factor activation in human peripheral blood mononuclear cells. Am. J. Physiol. 37:C331.
34. Ray, A., and K. E. Prefontaine. 1994. Physical association and functional antagonism between the p65 subunit of transcription factor NF-κB and the glucocorticoid receptor. Proc. Natl. Acad. Sci. USA 91:752.
35. Scheinman, R. I., P. C. Cogswell, A. K. Lofquist, and A. S. Baldwin, Jr. 1995. Role of transcriptional activation of IκBα in mediation of immunosuppression by glucocorticoids. Science 270:283.
36. Auphan, N., J. A. DiDonato, C. Rosette, A. Helmberg, and M. Karin. 1995. Immunosuppression by glucocorticoids: inhibition of NF-κB activity through induction of IκB synthesis. Science 270:286.
37. Zembowicz, A., and J. R. Vane. 1992. Induction of nitric oxide synthase activity by toxic shock syndrome toxin 1 in a macrophage-monocyte cell line. Proc. Natl. Acad. Sci. USA 89:2051.
38. Breuninger, L. M., W. L. Dempsey, J. Uhl, and D. M. Murasko. 1993. Hydrocortisone regulation of interleukin-6 protein production by a purified population of human peripheral blood monocytes. Clin. Immunol. Immunopathol. 69:205.
39. Heidenreich, S., T. Kubis, M. Schmidt, and W. Fegeler. 1994. Glucocorticoid-induced alterations of monocyte defense mechanisms against Candida albicans. Cell. Immunol. 157:320.
40. Murphy, T. L., M. G. Cleveland, P. Kulesza, J. Magram, and K. M. Murphy. 1995. Regulation of interleukin 12 p40 expression through an NF-κB half-site. Mol. Cell. Biol. 15:5258.
41. Manetti, R., F. Gerosa, M. G. Giudizi, R. Biagiotti, P. Parronchi, M. Piccinni, S. Sampognaro, E. Maggi, S. Romagnani, and G. Trinchieri. 1994. Interleukin 12 induces stable priming for interferon γ (IFN-γ) production during differentiation of human T helper (Th) cells and transient IFN-γ production in established Th2 cell clones. J. Exp. Med. 179:1273.
42. + T cells through an effect on antigen-presenting cells. J. Immunol. 154:2578.
43. Murphy, E., K. Shibuya, N. Hosken, P. Openshaw, V. Maino, K. Davis, K. Murphy, and A. O'Garra. 1996. Reversibility of T helper 1 and 2 populations is lost after long-term stimulation. J. Exp. Med. 183:901.
44. Jeannin, P., Y. Delneste, M. Seveso, P. Life, and J. Y. Bonnefoy. 1996. IL-12 synergizes with IL-2 and other stimuli in inducing IL-10 production by human T cells. J. Immunol. 156:3159.
45. Windhagen, A., D. E. Anderson, A. Carrizosa, R. E. Williams, and D. A. Hafler. 1996. IL-12 induces human T cells secreting IL-10 with IFN-γ. J. Immunol. 157:1127.
46. Magram, J., S. E. Connaughton, R. R. Warrier, D. M. Carvajal, C. Y. Wu. J. Ferrante, C. Stewart, U. Sarmiento, D. A. Faherty, and M. K. Gately. 1996. IL-12-deficient mice are defective in IFN-γ production and type 1 cytokine responses. Immunity 4:471.
47. Snyder, D. S., and E. R. Unanue. 1982. Corticosteroids inhibit murine macrophage Ia expression and interleukin 1 production. J. Immunol. 129:1803.
48. Moser, M., T. De Smedt, T. Somasse, F. Tielemans, A. A. Chentoun, E. Muraille, M. Van Mechelen, J. Urbain, and O. Leo. 1995. Glucocorticoids down-regulate dendritic cell function in vitro and in vivo. Eur. J. Immunol. 25:2818.