5 Inhibitors of Hepatitis C Virus NS3•4A Protease: An Overdue Line of Therapy

Progress in Medicinal Chemistry

Volumn 39, Issue C, 2002, Pages 215-255

  Perni, Robert B ^a   Kwong, Ann D ^a  

^a VERTEX PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; NS3 PROTEIN, HEPATITIS C VIRUS; NS4 PROTEIN, HEPATITIS C VIRUS; SERINE PROTEINASE INHIBITOR; VIRUS PROTEIN;

ANIMAL; CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; HEPATITIS C; HUMAN; REVIEW; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIVIRAL AGENTS; DRUG DESIGN; HEPATITIS C; HUMANS; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL NONSTRUCTURAL PROTEINS;

EID: 0036982198     PISSN: 00796468     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0079-6468(08)70072-9     Document Type: Article

References (152)

1. Alberti A., Chemello L., and Benvegnu L. J. Hepatol. 31 Suppl, 1 (1999) 17-24
2. Hagedorn C.H., and Rice C.M. Curr. Top. Microbiol. Immunol. 242 (2000), Springer Berlin, New York
3. Lavanchy D. J. Viral Hep. 6 (1999) 35-47
4. Steedman A., Sarbah M.D., and Younossi Z.M. J. Clin. Gastroenterol. 30 (2000) 125-143
5. Feinstone S.M., Kapikian A.Z., Purcell R.H., Alter M.J., and Holland P.V. New Engl. J. Med. 292 (1975) 767-770
6. Schreiber G.B., Busch M.P., Fcleinman S.H., and Korelitz J.T. New Engl. J. Med. 334 (1996) 1685-1690
7. Alter M.J., Kruszon-Moran D., and Nainan O.V. N. Engl. J. Med. 341 (1999) 556-562
8. Lam N.P. Am. J. Health-Syst. Pharm. 56 (1999) 961-973
9. MacDonald M., Crofts N., and Kaldor J. Epidemiologic Rev. 18 (1996) 137-148
10. Niederau C., Lange S., Heintges T., Erhardt A., Buschkamp M., Hurter D., Nawrocki M., Kruska L., Hensel F., Petry W., and Haussinger D. Hepatology 28 (1998) 1687-1695
11. Seef L.B. Hepatology 26 Suppl. 1 (1997) 21S-28S
12. Huang L., and Koziel M. Curr. Opin. Immun. 16 (2000) 558-564
13. Kew M.C. FEMS Microbiol. Rev. 14 (1994) 211-220
14. National Institutes of Health Consensus Development Statement. Management of Hepatitis C. Hepatology 26 Supplement 1 (1997) 2S-10S
15. Koff R.S. Am. J. Gastroenter. 95 (2000) 1392-1393
16. Malone D.C. Formulatory 35 (2000) 681
17. Wong J.B., Poynard T., Ling M.H., Albrecht J.K., and Pauker S.G. Am. J. Gastroenter. 95 (2000) 1524-1530
18. Radkowski M., Kubicka J., Kisiel E., Cianciara J., Nowicki M., Rakela J., and Laskus T. Blood 95 (2000) 3986-3989
19. Crovatto M., Pozzato G., Zorat F., Pussini E., Nascimben F., Baracetti S., Grando M.G., Mazzaro C., Reitano M., Modolo M.L., Martelli P., Spada A., and Santini G. Haematologica 85 (2000) 356-361
20. Neumann A.U., Lam N.P., Dahari H., Gretch D.H., Wiley T.E., Layden T.J., and Perelson A.S. Science (Washington, D.C.) 282 (1998) 103-107
21. Neumann A.U. Antiviral Ther. 5 (2000) 85-90
22. Zeuzam S. J. Hepatol. 31 (1999) 61-64
23. Mabee C.L., Crippin J.S., and Lee W.M. Aliment. Pharmacol. Ther. 12 (1998) 509-518
24. Morapadour D., and Blum H.E. Europ. J. Gastro. Enterol. 11 (1999) 1199-1202
25. Lino S. Intervirology 4 (1999) 166-172
26. Pol S., Nalpas B., Bourliere M., Couzigou P., Tran A., Aberrgel A., Zarski J.P., Ber-thelot P., and Brechot C. Hepatology 31 (2000) 1338-1344
27. Heathcote E.J., Shiftman M.L., Cooksley G.E., Dushieko G.M., Lee S.S., Balart L., Reindollar R., Reddy R.K., Wright T.L., Lin A., Hoffman J., and De Pamphilis J. New Engl. J. Med. 343 (2000) 1673-1680
28. Zeuzem S., Feinman S.V., Rasenack J., Heathcote E.J., Lai M.-Y., Gane E., O'Grady J., Reichen J., Diago M., Lin A., Hoffman J., and Brunda M.J. N. Engl. J. Med. 343 (2000) 1666-1672
29. Sulkowski M., Reindollar R., and Yu J. Hepatol. 30 4 (1999) 197a Pt., 2
30. Craxi A., Camma C., and Giunta M. J. Hepatol. 31 Suppl. 1 (1999) 160-167
31. Nagamine T., Tagaki H., Takayama H., Kojima A., Kakizaki S., Mori M., and Nakajima K. Biol. Trace. Elem. Res. 75 (2000) 53-63
32. Dymock B.W., Jones P.S., and Wilson F.X. Antivir. Chem. Chemother. 11 (2000) 79-96
33. Walker M.A. Drug Discovery Today 4 (1999) 518-529
34. Smith J.P. Digestive Dis. Sci. 42 (1997) 1681-1687
35. Welch P., Yei S., and Barber J.R. Clin. Diag. Virol. 10 (1998) 163-171
36. Turik, M.A., DeSante, K.A., Hillgren, K.M., Braun, D.K., Sandberg, J.A., Gonzales, C.R., LaBell, E.S., Ernest, C.S., Brown-Augsberger, P.L. and Blatt, L.M.; (2000) 51st Annual Meeting, AASLD, Dallas, TX, 1136.
37. Wang W., Preville P., Morin N., Mounir S., Cai W., and Siddiqui M.A. Bioorg. Med. Chem. Lett. 10 (2000) 1151-1154
38. Damen M., and Bresters D. Curr. Stud. Hematol. Blood Trans. 62 (1998) 181-207
39. Marcellin P. J. Hepatol. 31 Suppl. 1 (1999) 9-16
40. Choo Q.L., Kuo G., Weiner A.J., Overby L.R., Bradley D.W., and Houghton M. Science (Washington, D.C.) 244 (1989) 359-362
41. Major M.E., and Feinstone S.M. Hepatology 25 (1997) 1527-1538
42. Blight K., Kolykhalov A.A., Reed K.E., Agapov E.V., and Rice C.M. Antiviral Ther. 3 (1998) 71-81
43. Drazan K.E. Liver Transplant. 6 (2000) 396-406
44. Bartenschlager R., Ahlborn L., Mous J., and Jacobsen H. J. Virol. 68 (1994) 5045-5055
45. Satoh S., Tanji Y., Hijikata M., Kimura K., and Shimotohno K. J. Virol. 69 (1995) 4255-4260
46. De Francesco R., Neddermann P., Tomei L., Steinkuhler C., Gallinari P., and Folgori A. Sem. Liver Disease 20 (2000) 69-83
47. Failla C., Tomei L., and De Francesco R. J. Virol. 68 (1994) 3753-3760
48. Gallinari P., Paoline C., Brennan D., Nardi C., Steinkuhler C., and De Francesco R. Biochemistry 38 (1999) 5620-5632
49. Tanji Y., Hijikata M., Satoh S., Kaneko T., and Shimotohno K. J. Virol. 69 (1995) 1575-1581
50. Grakoui A., McCourt D.W., Wychowski C., Feinstone S.M., and Rice C.M. J. Virol. 67 (1993) 2832-2843
51. Han D.S., Hahm B., Rho H.-M., and Jang S.K. J. Gen. Virol. 76 (1995) 985-993
52. Kim J.L., Morgenstern K.A., Lin C., Fox T., Dwyer M.D., Landro J.A., Chambers S.P., Markland W., Lepre C., O'Malley E., Harbeson S.L., Rice C.M., Murcko M.A., Caron P.R., and Thomson J.A. Cell 87 (1996) 343-355
53. Love R.A., Parge H.E., Wickersham J.A., Hostomsky Z., Habuka N., Noomaw E.W., Adachi T., and Hostomska Z. Cell 87 (1996) 331-342
54. Yan Y., Li Y., Munshi S., Sardana V., Cole J.L., Sardana M., Steinkuhler C., Tomei L., De Francesco R., Kuo K.C., and Chen Z. Protein Science 7 (1998) 837-847
55. Pasquo A., Nardi M.C., Dimasi N., Tomei L., Steinkuhler C., Delmastro P., Tramontano A., and De Francesco R. Fold. Des. 3 (1998) 433-441
56. Taremi S.S., Beyer B., Maher M., Yao N., Prosise W., Weber P.C., and Malcolm B.A. Protein Science 7 (1998) 2143-2149
57. Barbato G., Cicero D.O., Chira M., Nardi C., Steinkuhler C., Cortese R., and De Francesco R. J. Mol. Biol. 289 (1999) 371-384
58. Errington W., Wardell A.D., McDonald S., Goldin R.D., and McGarvey M.J. J. Med. Virol. 59 (1999) 456-462
59. Wolk B., Sansonno D., Krausslich H.-G., Dammacco F., Rice C.M., Blum H.E., and Mor-adpour D. J. Virol. 74 (2000) 2293-2304
60. Landro J.A., Raybuck S.A., Luong Y.P.C., O'Malley E.T., Harbeson S.L., Morgenstern K.A., Rao B.G., and Livingston D. Biochemistry 36 (1997) 9340-9348
61. Tomei L., Failla C., Vitale R.L., Bianchi E., and De Francesco R. J. Gen. Virol. 77 (1995) 1065-1070
62. Bianchi E., Ingenito R., Simon R.J., and Pessi A. J. Am. Chem. Soc. 121 (1999) 7698-7699
63. Love R.A., Parge H.E., Wickersham J.A., Hostomsky Z., Habuka N., Noomaw E.W., Adachi T., Margosiak S., Dagostina E., and Hostomska Z. Clinical Diag. Virol. 10 (1998) 151-156
64. Love R.A., Parge H.E., Wickersham J.A., Hostomsky Z., Habuka N., Moomaw E.W., Adachi T., Margosiak S., Dagosino E., and Hostomska Z. In: Schinazi R.F., Sommadossi J.-P., and Thomas H.C. (Eds). Therapies for Viral Hepatitis (1998), International Medical, Press, London 247-254
65. Bartenschlager R. J. Viral. Hep. 6 (1999) 165-181
66. De Francesco R., and Steinkuhler C. Curr. Top. Microb. Immunol. 242 (2000) 149-169
67. Kwong A.D., Kim J.L., Rao B.G., Lipovsek D., and Raybuck S.A. Antiviral Res. 40 (1998) 1-18
68. Butkiewicz N.J., Yao N., Wright-Minogue J., Zhang R., Ramanathan L., Lau J.Y.N., Hong Z., and Dasmahapatra B. Biochem. Biophys. Res. Commun. 267 (2000) 278-282
69. Wright-Minogue J., Yao N., Zhang R., Butkiewicz N.J., Baroudy B.M., Lau J.Y.N., and Hong Z. J. Hepatol. 32 (2000) 497-504
70. Fattori D., Urbani A., Brunetti M., Ingenito R., Pessi A., Pendergast K., Narjes F., Matassa V.G., De Francesco R., and Steinkuhler C. J. Biol. Chem. 275 (2000) 15106-15113
71. Bianchi E., Orru S., Dal Piaz F., Ingenito R., Casbarra A., Biasiol G., Koch U., Puchi P., and Pessi A. Biochemistry 38 (1999) 13844-13852
72. Matassa V., Narjes F., Koehler K., Ontoria J., Poma M., and Marchetti A. PCT Int. Appl. (1999) WO 99/64442
73. Chem., Abstr. 132 (2000) 36034x
74. Zhang R., Beyer B.M., Durkin J., Ingram R., Njoroge F.G., Windsor W.T., and Malcolm B.A. Anal. Biochem. 270 (1999) 268-275
75. Sudo K., Inoue H., Shimizu Y., Yamaji K., Konno K., Shigeta S., Kaneko T., Yokota T., and Shimotohno K. Antiviral Res. 32 (1996) 9-18
76. Sali D.L., Ingram R., Wendel M., Gupta D., McNemar C., Tsarbopoulos A., Chen J.W., Hong Z., Chase R., Risano C., Zhang R., Yao N., Kwong A.D., Ramanathan L., Le H.V., and Weber P.C. Biochemistry 37 (1998) 3392-3401
77. Fowler A., Price-Jones M., Hughes K., Anson J., Lingham R., and Schulman M. J. Biomol. Screen. 5 (2000) 153-158
78. Hirowatari Y., Hijikata M., and Shimitohno K. Analyt. Biochem. 225 (1995) 113-120
79. Song O., Cho O.H., Hahm B., and Jang S.K. Molecules and Cells 6 (1996) 183-189
80. Cho Y.G., Moon H.-S., and Sung Y.-C. J. Virol. Methods 65 (1997) 201-207
81. Germann, U? Hoock, T. and Kwong, A.D.; (2000) U.S.A. Patent 6 117 639.
82. Filocamo G., Pacini L., and Migliaccio G. J. Virol. 71 (1997) 1417-1427
83. Hahm B., Back S.H., Lee T.G., Wimmer E., and Jang S.K. Virology 226 (1996) 318-326
84. Lai V.C., Zhong W., Skelton A., Ingravallo P., Vassilev V., Donis R.O., Hong Z., and Lau J.Y.N. J. Virol. 74 (2000) 6339-6347
85. Beames B., Chavez D., Guerra B., Notvall L., Brasky K.M., and Lanford R.E. J. Virol. 74 (2000) 11764-11772
86. Schinazi R.F., Ilan E., Black P.L., Yao X., and Dagan S. Antiviral Chem. Che-mother. 10 (1999) 99-114
87. Kato N., Nakazawa T., Mizutani T., and Shimotohno K. Biochem. Biophys. Res. Commun. 206 (1995) 863-869
88. Mizutani T., Kato N., Ikeda M., Sugiyama K., and Shimotohno K. Biochem. Biophys. Res. Commun. 227 (1996) 822-826
89. Nakajima N., Hijikata M., Yoshikura H., and Shimizu Y.K. J. Virol. 70 (1996) 3325-3329
90. Shimizu Y.K., and Yoshikura H. J. Virol. 68 (1994) 8406-8408
91. Shimizu Y.K., Purcell R.H., and Yoshikura H. Proc. Nat. Acad. Sci. U.S.A. 90 (1993) 6037-6041
92. Shimizu Y.K., Lgarashi H., Kiyoohara T., Shapiro M., Wong D.C., Purcell R.H., and Yoshikura H. J. Gen. Virol. 79 (1998) 1381-1386
93. Tagawa M., Kato N., Yokosuka O., Ishikawa T., Ohto M., and Omata M. J. Gastroenterol. Hepatol. 10 (1995) 523-527
94. Seipp S., Mueller H.M., Pfaff E., Stremmel W., Theilmann L., and Goeser T. J. Gen. Virol. 78 (1997) 2467-2476
95. Fornier C., Sureau C., Coste J., and Ducos J. J. Gen. Virol. 79 (1998) 2367-2374
96. Ito I., Mukaigawa J., Zuo J., Hirabayashi Y., Mitamura K., and Yasui K. J. Gen. Virol. 77 (1996) 1043-1054
97. Iacovacci S., Manzin A., Barca S., Sargiacomo M., Serafino A., Valli M.B., Macioce G., Hassan H.J., Ponzetto A., Clementi M., Peschle C., and Carloni G. Hepatology 26 (1997) 1328-1337
98. Carloni G., Locovacci S., Sargiacomo M., Ravagnan G., Ponzetto A., Peschle C., and Battaglia R. Arch. Virol. (Suppl) 8 (1993) 31-39
99. Lohmann V., Korner F., Koch J.-O., Herian U., Theilmann L., and Bartenschlager R. Science (Washington, D.C.) 285 (1999) 110-113
100. Bartenschlager R., and Lohmann V. J. Gen. Virology 81 (2000) 1631-1648
101. Pietschmann T., Lohmann V., Rutter G., Kurpanek K., and Bartenschlager R. J. Virol. 75 (2001) 1252-1264
102. Lohmann V., Korner F., Dobierzewska A., and Bartenschlager R. J. Virol. 75 (2001) 1437-1449
103. Blight K.E., Kolykhalov A.A., and Rice C.M. Science (Washington, D.C.) 290 (2000) 1972-1974
104. Bukh, J., Teilier, R., Feinstone, S., Eder, G., Krawczynski, K., Govindarajan, S., Apgar, C, Johnson, R., Lesniewski, R.R., Farci, P., Kew, M.C., Mayumi, M., Simmonds, P., Miller, R.H., Elkins, R. and Purcell, R.H.; (1999) 6th Int. Symp. on Hepatitis C and Related Viruses, Bethesda, MD, U.S.A., Poster 4.3.
105. Major M.E., Mihalik K., Fernandez J., Seidman J., Kleiner D., Kolyhalov A.A., Rice C.M., and Feinstone S.M. J. Virol. 73 (1999) 3317-3325
106. Yanagi M., Purcell R.H., Emerson S.U., and Bukh J. Proc. Nat. Acad. Sci. U.S.A. 94 (1997) 8738-8743
107. Zauberman, A., Nussbaum, O., llan E., Eren, R., Ben-Moshe, O., Arazi, Y., Berre, S., Lubin, I., Shouval, D., Galun, E., Reisner, Y. and Dagan, S.; (1999) 6th Int. Symp. on Hepatitis C and Related Viruses, Bethesda, MD, U.S.A., Oral 4.3.
108. Goettge, K., Rijnbrand, R., Lanford, R., Sangar, R. and Lemon, S.; (2000) 7th International Meeting on Hepatitis C and Related Viruses, Gold Coast, Queensland, Australia, P 097.
109. Schechter I., and Berger A. Biochem. Biophys. Res. Commun. 27 (1967) 157-162
110. Leung D., Abbenante G., and Fairlie D.P. J. Med. Chem. 43 (2000) 305-341
111. Perni R. Drug News Perspect. 13 (2000) 69-77
112. Cicero D.O., Barbato G., Kock U., Ingallinella P., Bianchi E., Nardi M.C., Steinkuhler C., Cortese R., Matassa V., De Francesco R., Pessi A., and Bazzo R. J. Mol. Biol. 289 (1999) 385-396
113. Barbato G., Cicero D.O., Cordier F., Narjes F., Gerlach B., Sambucini S., Grzesiek S., Matassa V.G., De Francesco R., and Bazzo R. EMBO J. 289 (2000) 385-396
114. LaPlante S.R., Cameron D.R., Aubry N., Lefebvre S., Kukolj G., Maurice R., Thibeault D., Lamarre D., and Llinas-Brunet M. J. Biol. Chem. 274 (1999) 18618-18624
115. Martin F., Dimasi N., Volpari C., Perrera C., Di Marco S., Brunetti M., Steinkuhler C., De Francesco R., and Sollazo M. Biochemistry 37 (1998) 11459-11468
116. Martin F., Steinkuhler C., Brunetti M., Pessi A., Cortese R., De Francesco R., and Sol-lazzo M. Protein Eng. 12 (1999) 1005-1011
117. Ueno T., Misawa S., Ohba Y., Matsumoto M., Mizunuma M., Kasai N., Tsumoto K., Kumagai I., and Hayashi H. J. Virol. 74 (2000) 6300-6308
118. Tung R.D., Harbeson S.L., Deininger D.D., Murcko M.A., Rao B.G., and Farmer L.F. PCT Int Appl. (1998) WO 98/17679/
119. Chem. Abstr. 128 (1998) 321945u
120. Llinas-Brunet M., Bailey M.D., Cameron D., Ghiro E., Goudreau N., Poupart M.-A., Rancourt J., and Tsantrizos Y.S. PCT Int. Appl. (2000) WO 00/09558
121. Chem. Abstr. 132 (2000) 175808r
122. Llinas-Brunet M., Bailey M., Fazal G., Ghiro E., Gorys V., Goulet S., Halmos T., Maurice R., Poirier M., Poupart M.-A., Rancourt J., Thibeault D., Wernic D., and Lamarre D. Bioorg. Med. Chem. Lett. 10 (2000) 2267-2270
123. Steinkuhler C., Basiol G., Brunetti M., Urbani A., Koch U., Cortese R., Pessi A., and De Francesco R. Biochemistry 37 (1998) 8899-8905
124. Ingallinella P., Altamura S., Bianchi E., Taliani M., Ingenito R., Cortese R., De Francesco R., Steinkuhler C., and Pessi A. Biochemistry 37 (1998) 8906-8914
125. Llinas-Brunet M., Bailey M., Deziel R., Fazal G., Gorys V., Goulet S., Halmos T., Maurice R., Poirier M., Poupart M.-A., Rancourt J., Thibeault D., Wernic D., and Lamarre D. Bioorg. Med. Chem. Lett. 8 (1998) 2719-2724
126. Han W., Hu Z., Jiang X., and Decicco C.P. Bioorg. Med. Chem. Lett. 10 (2000) 711-713
127. Narjes, F., Colarusso, S., Gerlach, B., Koelher, K., Koch, U., Steinkuhler, C, Bazzo, R., Sollazzo, M., Altamura, S., De Francesco, R. and Matassa, V.G.; (2000) 220th American Chemical Society National Meeting, Washington, DC, MEDI 17.
128. Kettner C.A., and Shenvi A.B. J. Biol. Chem. 259 (1984) 15106-15112
129. Dunsdon R.M., Greening J.R., Jones P.S., Jordon S., and Wilson F.X. Bioorg. Med. Chem. Lett. 10 (2000) 1577-1579
130. Attwood. M.R., Hurst, D.N., Jones, P.S., Kay, P.B., Raynham, M. and Wilson, F.X.; (1999) U.S.A., Patent 5,866.684. See WO 98/22496 A2.
131. Chem. Abstr. 129 (1998) 54603z
132. Priestley E.S., and Decicco C.P. Organic Lett. 2 (2000) 3095-3097
133. Attwood M.R., Bennet J.M., Campbell A.D., Canning G.G.M., Carr M.G., Conway E., Dunsdon R.M., Greening J.R., Jones P.S., Kay P.B., Handa B.K., Hurst D.N., Jennings N.S., Jordon S., Keech E., O'Brien M.A., Overton H.A., King-Underwood J., and Raynham T.M. Antiviral Chem. Chemother. 10 (1999) 259-273
134. Narjes F., Brunetti M., Colarusso S., Gerlach B., Koch E., Biasol G., Fattori D., De Francesco R., Matassa V.G., and Steinkuhler C. Biochemistry 39 (2000) 1849-1861
135. Di Marco S., Rizzi M., Volpari C., Walsh M.A., Narjes F., Colarusso S., De Francesco R., Matassa V.G., and Sollazzo M. J. Biol. Chem. 275 (2000) 7152-7157
136. Bennett J.M., Campbell A.D., Campbell A.J., Car M.G., Dunsdon R.M., Greening J.R., Hurst D.N., Jennings N.S., Jones P.S., Jordon S., Kay P.B., O'Brien M.A., King-Underwood J., Raynham T.M., Wilkinson C.S., Wilkinson T.C.I., and Wilson F.X. Bioorg. Med, Chem. Lett. 11 (2001) 355-357
137. Llinas-Brunet M., Bailey M., Fazal G., Goulet S., Halmos T., Laplante S., Maurice R., Poirer M., Poupart M.-A., Thibeault D., Wernic D., and Lamarre D. Biorg. Med. Chem. Lett. 8 (1998) 1713-1718
138. Llinas-Brunet M., Bailey M.D., Cameron D., Faucher A.-M., Ghiro E., Goudreau N., Halmos T., Poupart M.-A., Rancourt J., Tsantrizoa Y.S., and Simoneau B. PCT Int. Appl. (2000) WO 00/09543
139. Chem. Abstr. 132 (2000) 180871k
140. Llinas-Brunet M., Poupart M.-A., Rancourt J., Simoneau B., and Tsantrizos Y. PCT Int. Appl. (1999) WO 99/07733
141. Chem. Abstr. 130 (1999) 168665x
142. Llinas-Brunet M., Bailey M.D., Halmos T., Poupart M.-A., and Tsantrizos Y. PCT Int. Appl. (1999) WO 99/07734
143. Chem. Abstr. 130 (1999) 168666y
144. Stansfield, I., Ontoria, J., Poma, M., Harper, S., Koch, U., DiMarco, S., Steinkuhler, C. and Matassa, V.; (2000) 220th American Chemical Society National Meeting, Washington, DC, MED1 16.
145. Tsantrizos Y.S., Cameron D., Faucher A.-M., Ghiro E., Goudreau N., Halmos T., and Llina-Bnmet M. PCT Int. Appl. (2000) WO 00/59929
146. Chem. Abstr. 133 (2000) 296659x
147. Ingallinella P., Bianchi E., Ingenito R., Koch U., Steinkuhler C., Altamura S., and Pessi A. Biochemistry 39 (2000) 12898-12906
148. Kakiuchi R., Komoda Y., Komoda K., Takeshita N., Okada S., Tani T., and Shimitohno K. FEBS Lett. 421 (1998) 217-220
149. Sudo K., Matsumoto Y., Matsushima M., Fujiwara M., Konno K., Shimitohno K., Shi-geta S., and Yokota T. Biochem. Biophys. Res. Commun. 238 (1997) 643-647
150. Sing W.T., Lee C.L., Yeo S.L., Lim S.P., and Sim M.M. Bioorg. Med. Chem. Lett. 11 (2001) 91-94
151. Chu M., Mierzwa R., He L., King A., Patel M., Pichardo J., Hart A., Butkiewicz N., and Puar M.S. Bioorg. Med. Chem. Lett. 9 (1999) 1949-1952
152. Ede N.J., Eagle S.N., Wickham G., Bray A.M., Warnes B., Shoemaker K., and Rosenberg S. J. Pept. Sci. 6 (2000) 11-18