Conformational changes in human hepatitis C virus NS3 protease upon binding of product-based inhibitors

Biochemistry

Volumn 38, Issue 42, 1999, Pages 13844-13852

  Bianchi, Elisabetta ^a   Orrù, Stefania ^a,b   Dal Piaz, Fabrizio ^b   Ingenito, Raffaele ^a   Casbarra, Annarita ^b   Biasiol, Gabriella ^a   Koch, Uwe ^a   Pucci, Piero ^b   Pessi, Antonello ^a  

^a IRBM   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; CONFORMATIONS; DRUG INTERACTIONS; DRUG PRODUCTS; ENZYME INHIBITION; NATURAL POLYMERS; PROTEINS; SPECTROSCOPY;

CIRCULAR DICHROISM SPECTROSCOPY; CONFORMATIONAL CHANGES; HEPATITIS C VIRUS; INHIBITOR BINDING; PRODUCT BASED INHIBITORS; PROTEASE; PROTEOLYSIS; VIRAL POLYPROTEIN;

VIRUSES;

ENZYME INHIBITOR; PROTEINASE; VIRUS ENZYME;

ARTICLE; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; ENZYME BINDING; ENZYME CONFORMATION; ENZYME SUBSTRATE COMPLEX; HEPATITIS C VIRUS; PRIORITY JOURNAL; SPECTROSCOPY;

AMINO ACID SEQUENCE; CIRCULAR DICHROISM; HEPACIVIRUS; HUMANS; HYDROLYSIS; MACROMOLECULAR SUBSTANCES; MASS SPECTROMETRY; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; SUBSTRATE SPECIFICITY; VIRAL NONSTRUCTURAL PROTEINS;

EID: 0345583700     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi991220w     Document Type: Article

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