The identification of α-ketoamides as potent inhibitors of hepatitis C virus NS3-4A proteinase

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 3, 2001, Pages 355-357

  Bennett, J M ^a   Campbell, A D ^a   Campbell, A J ^a   Carr, M G ^a   Dunsdon, R M ^a   Greening, J R ^a   Hurst, D N ^a   Jennings, N S ^a   Jones, P S ^a   Jordan, S ^a   Kay, P B ^a   O'Brien, M A ^a   King Underwood, J ^a   Raynham, T M ^a   Wilkinson, C S ^a   Wilkinson, T C I ^a   Wilson, F X ^a  

^a Roche Discovery Welwyn ^*  (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA KETOAMIDE; AMIDE; KETONE DERIVATIVE; PROTEINASE; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; ENZYME INHIBITION; HEPATITIS C VIRUS; HUMAN; NONHUMAN; PROTEIN DEGRADATION;

AMIDES; ANTIVIRAL AGENTS; COMBINATORIAL CHEMISTRY TECHNIQUES; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR MIMICRY; PEPTIDES; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL NONSTRUCTURAL PROTEINS;

EID: 0035847669     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)00654-5     Document Type: Article

References (17)