Role for granulocyte colony-stimulating factor in the generation of human T regulatory type 1 cells

Blood

Volumn 100, Issue 7, 2002, Pages 2562-2571

  Rutella, Sergio ^a,b   Pierelli, Luca ^a,b   Bonanno, Giuseppina ^a,b   Sica, Simona ^a,b   Ameglio, Franco ^a,b   Capoluongo, Ettore ^a,b   Mariotti, Andrea ^a,b   Scambia, Giovanni ^a,b   D'Onofrio, Giuseppe ^a,b   Leone, Giuseppe ^a,b  

^a CATHOLIC UNIVERSITY   (Italy)

^b SAN GALLICANO DERMATOLOGICAL INSTITUTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOANTIGEN; CD28 ANTIGEN; CD4 ANTIGEN; CYCLOSPORIN A; DEXAMETHASONE; IMMUNOMODULATING AGENT; IMMUNOSUPPRESSIVE AGENT; INFLIXIMAB; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; METHOTREXATE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; NEUTRALIZING ANTIBODY; PADGEM PROTEIN; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; T LYMPHOCYTE RECEPTOR; TACROLIMUS; TRANSFORMING GROWTH FACTOR BETA1;

ADULT; ANTIGEN SPECIFICITY; APOPTOSIS; ARTICLE; CELL CONTACT; CELL FUNCTION; CELL SURFACE; CELL TYPE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DRUG EFFECT; DRUG MECHANISM; FEMALE; HELPER CELL; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTE ACTIVATION; LYMPHOCYTE PROLIFERATION; MALE; MEMORY CELL; NORMAL HUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TRANSPLANTATION;

EID: 0036786347     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2001-12-0291     Document Type: Article

References (56)

1. Champlin RE, Schmitz N, Horowitz. MM, et al. Blood stem cells compared with bone marrow as a source of hematopoietic cells for allogeneic transplantation. Blood. 2000;95:3702-3709.
2. Weissman IL. Translating stem and progenitor cell biology to the clinic: barriers and opportunities. Science. 2000;287:1442-1446.
3. Rutella S, Rumi C, Sica S, Leone G. Recombinant human granulocyte colony-stimulating factor (rhG-CSF): effects on lymphocyte phenotype and function. J Interferon Cytokine Res. 1999;19:989-994.
4. Mielcarek M, Graf L, Johnson G, Torok-Storb B. Production of interieukin-10 by granulocyte colony-stimulating factor-mobilized blood products: a mechanism for monocyte-mediated suppression of T-cell proliferation. Blood. 1998;92:215-222.
5. Boneberg EM, Hareng L, Gantner F, Wendel A, Hartung T. Human monocytes express functional receptors for granulocyte colony-stimulating factor that mediate suppression of monokines and interferon-γ. Blood. 2000;95:270-276.
6. Sloand EM, Kim S, Maciejewski JP, et al. Pharmacologic doses of granulocyte colony-stimulating factor affect cytokine production by lymphocytes in vitro and in vivo. Blood. 2000;95:2269-2274.
7. Tayebi H, Kuttler F, Saas P, et al. Effect of granulocyte colony-stimulating factor mobilization on phenotypical and functional properties of immune cells. Exp Hematol. 2001;29:458-470.
8. Nawa Y, Teshima T, Sunami K, et al. G-CSF reduces IFN-γ and IL-4 production by T cells after allogeneic stimulation by indirectly modulating monocyte function. Bone Marrow Transplant. 2000;25:1035-1040.
9. Rutella S, Rumi C, Lucia MB, Sica S, Cauda R, Leone G. Serum of healthy donors receiving recombinant human granulocyte colony-stimulating factor (rhG-CSF) induces T-cell unresponsiveness. Exp Hematol. 1998;26:1024-1033.
10. Rutella S, Rumi C, Pierelli L, et al. Granulocyte colony-stimulating factor perturbs lymphocyte mitochondrial function and inhibits cell cycle progression. Exp Hematol. 2000;28:612-625.
11. Rutella S, Pierelli L, Rumi C, et al. T-cell apoptosis induced by granulocyte colony-stimulating factor (G-CSF) is associated with retinoblastoma protein phosphorylation and reduced expression of cyclin-dependent kinase inhibitors. Exp Hematol. 2001;29:401-415.
12. Roncarolo MG, Levings MK. The role of different subsets of T regulatory cells in controlling autoimmunity. Curr Opin Immunol. 2000;12:676-683.
13. + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature. 1997;389:737-742.
14. - subset of recent thymic emigrants. J Immunol. 2001;166:7158-7164.
15. Letterio JL, Roberts AB. Regulation of immune responses by TGF-β. Annu Rev Immunol. 1998;16:137-161.
16. Prud'homme GJ, Piccirillo CA. The inhibitory effects of transforming growth factor-beta-1 (TGF-β1) in autoimmune diseases. J Autoimmun. 2000;14:23-42.
17. Joss A, Akdis M, Faith A, Blaser K, Akdis CA. IL-10 directly acts on T cells by specifically altering the CD28 co-stimulation pathway. Eur J Immunol. 2000;30:1683-1690.
18. D'Orazio TJ, Niederkorn JY. A novel role for TGF-β and IL-10 in the induction of immune privilege. J Immunol. 1998;160:2089-2098.
19. + T cell alloantigen-specific hyporesponsiveness by IL-10 and TGF-β. J Immunol. 1999;163:3684-3691.
20. Boussiotis VA, Chen ZM, Zeller JC, et al. Altered T-cell receptor + CD28-mediated signaling and blocked cell cycle progression in intedeukin 10 and transforming growth factor-β-treated alloreactive T cells that do not induce graft-versus-host disease. Blood. 2001;97:565-571.
21. Maino VC, Picker LJ. Identification of functional subsets by flow cytometry: intracellular detection of cytokine expression, Cytometry. 1998;34:207-215.
22. Testa U, Martucci R, Rutella S, et al. Autologous stem cell transplantation: release of early- and lateacting growth factors relates with hematopoietic ablation and recovery. Blood. 1994;84:3532-3539.
23. Rutella S, Pierelli L, Bonanno G, et al. Immune reconstitution after autologous peripheral blood progenitor cell transplantation: effect of interleukin-15 on T-cell survival and effector functions. Exp Hematol. 2001;29:1503-1516.
24. Pierelli L, Marone M, Bonanno G, et al. Modulation of Bcl-2 RNA/protein and p27 protein in human primitive hematopoietic progenitors by autocdne TGF-β is a cell cycle independent effect and influences their hematopoietic potential. Blood. 2000;95:3001-3009.
25. De Candia E, Hall SA, Rutella S, Landolfi R, Andrews RK, De Cristofaro R. Binding of α-thrombin to glycoprotein Ibα accelerates the hydrolysis of PAR-1 on intact platelets. J Biol Chem. 2001;276:4692-4698.
26. Sakaguchi S. Regulatory T cells: key controllers of immunologic self-tolerance. Cell. 2000;101:455-458.
27. Volpi I, Perruccio K, Tosti A, et al. Postgrafting administration of granulocyte colony-stimulating factor impairs functional immune recovery in recipients of human leukocyte antigen haplotype-mismatched hematopoietic transplants. Blood. 2001;97:2514-2521.
28. high regulatory cells in human peripheral blood. J Immunol. 2001;167:1245-1253.
29. + T cells with regulatory properties isolated from peripheral blood. J Exp Med. 2001;193:1285-1294.
30. + regulatory T cells is mediated by cell surface-bound transforming growth factor-β. J Exp Med. 2001;194:629-644.
31. - regulatory T cells from human peripheral blood. J Immunol. 2001;166:7282-7289.
32. + T cells with regulatory properties from human blood. J Exp Med. 2001;193:1303-1310.
33. + immuno-regulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J Exp Med. 1996;188:287-296.
34. Maloy KJ, Powde F. Regulatory T cells in the control of immune pathology. Nat Immunol. 2001;2:816-822.
35. + suppressor T cells. J Exp Med. 2001;193:F41-F45.
36. + regulatory cells? Immunity, 2001;14:399-406.
37. + T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10. J Immunol. 2001;166:3008-3018.
38. Asseman C, Mauze S, Leach MW, Coffman RL, Powrie F. An essential role for intedeukin-10 in the function of regulatory T cells that inhibit intestinal inflammation. J Exp Med. 1999;190:995-1003.
39. Suchin EJ, Langmuir PB, Palmer E, Sayegh MH, Wells AD, Turka LA. Quantifying the frequency of alloreactive T cells in vivo: new answers to an old question. J Immunol. 2001;166:973-981.
40. Hendriks RW, Nawijn MC, Engel JD, Van Doominck H, Grosveld F, Karis A. Expression of the transcription factor GATA-3 is required for the development of the earliest T cell progenitors and correlates with stages of cellular proliferation in the thymus. Eur J Immunol. 1999;29:1912-1918.
41. Pan L, Delmonte J, Jalonen CK, Ferrara JLM. Pre-treatment of donor mice with granulocyte colonystimulating factor polarizes donor T lymphocytes toward type-2 cytokine production and reduces severity of experimental graft-versus-host disease. Blood. 1995;86:4422-4429.
42. - T cells. Bone Marrow Transplant. 1999;23:119-124.
43. Tanaka J, Mielcarek M, Torok-Storb B. Impaired induction of the CD28-responsive complex in granulocyte colony-stimulating factor mobilized CD4 T cells. Blood. 1998;91:347-352.
44. Moser B, Loetscher P. Lymphocyte traffic control by chemokines. Nat Immunol. 2001;2:123-128.
45. + cells [letter]. Blood. 2000;95:4015-4016.
46. - regulatory T cells. J Exp Med. 2001;194:847-853.
47. Sallusto F, Lenig D, Forster R, Lipp M, Lanzavecchia A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature. 1999;401:708-712.
48. Murdoch C, Finn A. Chemokine receptors and their role in inflammation and infectious diseases. Blood. 2000;95:3032-3043.
49. + T regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function. J Exp Med. 2001;193:1295-1301.
50. + T cells is induced by immunosuppressive drugs and inhibited by T helper 1 (Th1)- and Th2-inducing cytokines. J Exp Med. 2002;195:603-616.
51. Gregori S, Casorati M, Amuchastegui S, Smiroldo S, Davalli AM, Adorini L. Regulatory T cells induced by 1α,25-dihydroxyvitamin D3 and mycophenolate mofetil treatment mediate transplantation tolerance. J Immunol. 2001;167:1945-1953.
52. Sanchez-Fueyo A, Weber M, Domenig C, Strom TB, Zheng XX. Tracking the immunoregulatory mechanisms active during allograft tolerance. J Immunol. 2002;168:2274-2281.
53. Bacchetta R, Bigler M, Touraine JL, et al. High levels of interleukin 10 production in vivo are associated with tolerance in SCID patients transplanted with HLA mismatched hematopoietic stem cells. J Exp Med. 1994;179:493-502.
54. Levings MK, Sangregorio R, Galbiati F, Squadrone S, de Waal Malefyt R, Roncarolo MG. IFN-α and IL-10 induce the differentiation of human type 1 T regulatory cells. J Immunol. 2001;166:5530-5539.
55. + T-regulatory cells and systemic collapse of antitumor immunity. Immunology. 2001;103:449-457.
56. + T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer. Cancer Res. 2001;61:4766-4772.