메뉴 건너뛰기




Volumn 59, Issue 3, 2002, Pages 268-279

Policosanol safely down-regulates HMG-CoA reductase - Potential as a component of the Esselstyn regimen

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE TRIPHOSPHATASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; POLICOSANOL; STATIN;

EID: 0036734326     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-9877(02)00226-8     Document Type: Article
Times cited : (40)

References (169)
  • 1
    • 0027987849 scopus 로고
    • Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study (4S)
    • (1994) Lancet , vol.344 , pp. 1383-1389
  • 2
    • 0028883828 scopus 로고
    • Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia
    • West of Scotland Coronary Prevention Study Group
    • (1995) N Engl J Med , vol.333 , pp. 1301-1307
    • Shepherd, J.1    Cobbe, S.M.2    Ford, I.3
  • 3
    • 0342981862 scopus 로고    scopus 로고
    • The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels
    • Cholesterol and Recurrent Events Trial investigators
    • (1996) N Engl J Med , vol.335 , pp. 1001-1009
    • Sacks, F.M.1    Pfeifer, M.A.2    Moye, L.A.3
  • 4
    • 0029948598 scopus 로고    scopus 로고
    • Can the clinical efficacy of the HMG CoA reductase inhibit effects on LDL-cholesterol?
    • (1996) Atherosclerosis , vol.125 , pp. 267-269
    • Gaw, A.1
  • 15
    • 0032508533 scopus 로고    scopus 로고
    • Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase
    • (1998) J Biol Chem , vol.273 , pp. 24266-24271
    • Laufs, U.1    Liao, J.K.2
  • 16
    • 0033800718 scopus 로고    scopus 로고
    • Atorvastatin upregulates type III nitric oxide synthase in thrombocytes, decreases platelet activation, and protects from cerebral ischemia in normocholesterolemic mice
    • (2000) Stroke , vol.31 , pp. 2442-2449
    • Laufs, U.1    Gertz, K.2    Huang, P.3
  • 18
    • 0035122832 scopus 로고    scopus 로고
    • Inhibition of geranylgeranylation reduces angiotensin II-mediated free radical production in vascular smooth muscle cells: Involvement of angiotensin AT1 receptor expression and Rac1 GTPase
    • (2001) Mol Pharmacol , vol.59 , pp. 646-654
    • Wassmann, S.1    Laufs, U.2    Baumer, A.T.3
  • 20
    • 0033618378 scopus 로고    scopus 로고
    • 3-Hydroxy-3- methylglutaryl-CoA reductase inhibitors attenuate vascular smooth muscle proliferation by preventing rho GTPase-induced down-regulation of p27(Kip1)
    • (1999) J Biol Chem , vol.274 , pp. 21926-21931
    • Laufs, U.1    Marra, D.2    Node, K.3    Liao, J.K.4
  • 30
    • 0033657002 scopus 로고    scopus 로고
    • Modulation of vascular cell activation, function, and apoptosis: Role of antioxidants and nuclear factor-kappa B
    • (2000) Curr Top Cell Regul , vol.36 , pp. 217-235
    • Weber, C.1    Erl, W.2
  • 36
    • 0030582956 scopus 로고    scopus 로고
    • Alzheimer's disease A radical vascular connection
    • (1996) Nature , vol.380 , pp. 108-111
    • Stamler, J.S.1
  • 38
    • 0032730094 scopus 로고    scopus 로고
    • Vascular nitric oxide, sex hormone replacement, and fish oil may help to prevent Alzheimer's disease by suppressing synthesis of acute-phase cytokines
    • (1999) Med Hypotheses , vol.53 , pp. 369-374
    • McCarty, M.F.1
  • 48
    • 0032508516 scopus 로고    scopus 로고
    • Effect of insulin on farnesyltfransferase. Specificity of insulin action and potentiation of nuclear effects of insulin-like growth factor-1, epidermal growth factor, and platelet-derived growth factor
    • (1998) J Biol Chem , vol.273 , pp. 23892-23896
    • Goalstone, M.L.1    Leitner, J.W.2    Wall, K.3
  • 58
    • 0036619294 scopus 로고    scopus 로고
    • Insulin's stimulation of endothelial superoxide generation may reflect up-regulation of isoprenyl transferase activity that promotes Rac translocation
    • (2002) Med Hypotheses , vol.58 , pp. 472-475
    • McCarty, M.F.1
  • 85
  • 101
    • 17444436621 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled study of the effects of policosanol in patients with intermittent claudication
    • (1999) Angiology , vol.50 , pp. 123-130
    • Castano, G.1    Mas, R.2    Roca, J.3
  • 105
    • 0033813254 scopus 로고    scopus 로고
    • Effects of policosanol treatment on the susceptibility of low density lipoprotein (LDL) isolated from healthy volunteers to oxidative modification in vitro
    • (2000) Br J Clin Pharmacol , vol.50 , pp. 255-262
    • Menendez, R.1    Mas, R.2    Amor, A.M.3
  • 108
    • 0034968683 scopus 로고    scopus 로고
    • A comparative study of policosanol vs lovastatin on intimal thickening in rabbit cuffed carotid artery
    • (2001) Pharmacol Res , vol.43 , pp. 31-37
    • Noa, M.1    Mas, R.2    Mesa, R.3
  • 118
    • 0026659873 scopus 로고
    • Effects of dietary cholesterol on serum cholesterol: A meta-analysis and review
    • (1992) Am J Clin Nutr , vol.55 , pp. 1060-1070
    • Hopkins, P.N.1
  • 119
    • 0020451477 scopus 로고
    • Hypercholesterolemia and atherosclerosis: Effects of dietary protein
    • (1982) Fed Proc , vol.41 , pp. 2792-2796
    • Carroll, K.K.1
  • 123
    • 0344132034 scopus 로고    scopus 로고
    • Updating a 12-year experience with arrest and reversal therapy for coronary heart (disease an overdue requiem for palliative cardiology)
    • (1999) Am J Cardiol , vol.84 , pp. 339-341
    • Esselstyn, C.B.1
  • 129
    • 0036618839 scopus 로고    scopus 로고
    • Favorable impact of a vegan diet with exercise on hemorheology - Implications for control of diabetic neuropathy
    • (2002) Med Hypotheses , vol.58 , pp. 476-486
    • McCarty, M.F.1
  • 132
    • 0035010067 scopus 로고    scopus 로고
    • Effects of individual risk factors on the incidence of cardiovascular events in the treated hypertensive patients of the Hypertension Optimal Treatment Study
    • HOT Study Group
    • (2001) J Hypertens , vol.19 , pp. 1149-1159
    • Zanchetti, A.1    Hansson, L.2    Dahlof, B.3
  • 133
    • 0023276302 scopus 로고
    • Failure to reduce cholesterol as explanation for the limited efficacy of antihypertensive treatment in the reduction of CHD. Examination of the evidence from six hypertension intervention trials
    • (1987) Klin Wochenschr , vol.65 , pp. 828-832
    • Heyden, S.1    Schneider, K.A.2    Fodor, G.J.3
  • 144
    • 0345109256 scopus 로고    scopus 로고
    • Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: Results of the GISSI-Prevenzione trial
    • Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico
    • (1999) Lancet , vol.354 , pp. 447-455
  • 148
    • 0028028101 scopus 로고
    • Long-term effect of taurine in congestive heart failure: Preliminary report
    • Heart Failure Research with Taurine Group
    • (1994) Adv Exp Med Biol , vol.359 , pp. 425-433
    • Azuma, J.1
  • 165
    • 0033675223 scopus 로고    scopus 로고
    • Is there a potential therapeutic role for vitamin E or other antioxidants in atherosclerosis?
    • (2000) Curr Opin Lipidol , vol.11 , pp. 603-607
    • Steinberg, D.1
  • 166
    • 0032732007 scopus 로고    scopus 로고
    • Oxidants downstream from superoxide inhibit nitric oxide production by vascular endothelium - A key role for selenium-dependent enzymes in vascular health
    • (1999) Med Hypotheses , vol.53 , pp. 315-325
    • McCarty, M.F.1
  • 169
    • 0033658651 scopus 로고    scopus 로고
    • Up-regulation of endothelial nitric oxide activity as a central strategy for prevention of ischemic stroke - Just say NO to stroke!
    • (2000) Med Hypotheses , vol.55 , pp. 386-403
    • McCarty, M.F.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.