Insulin-stimulated Activation of eNOS Is Independent of Ca2+ but Requires Phosphorylation by Akt at Ser1179

Journal of Biological Chemistry

Volumn 276, Issue 32, 2001, Pages 30392-30398

  Montagnani, Monica ^c   Chen, Hui ^c   Barr, Valarie A ^a   Quon, Michael J ^b  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; CHELATION; CHEMICAL ACTIVATION; ETHANE; GROWTH KINETICS; INSULIN;

SIGNALING PATHWAYS;

BIOCHEMISTRY;

4,5 DIAMINOFLUORESCEIN; CALCIUM CHELATING AGENT; CALCIUM ION; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; FLUORESCENT DYE; INSULIN; LYSOPHOSPHATIDIC ACID; MUTANT PROTEIN; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHOSPHATIDYLINOSITOL 3 KINASE; PLATELET DERIVED GROWTH FACTOR; PROTEIN KINASE B; PROTEIN S1179A; SERINE; UNCLASSIFIED DRUG; 1,2-BIS(2-AMINOPHENOXY)ETHANE-N,N,N',N'-TETRAACETIC ACID; AKT1 PROTEIN, HUMAN; CALCIUM; DRUG DERIVATIVE; EGTAZIC ACID; INDUCIBLE NITRIC OXIDE SYNTHASE; LYSOPHOSPHOLIPID; NOS3 PROTEIN, HUMAN; NOS3 PROTEIN, MOUSE; ONCOPROTEIN; PROTEIN SERINE THREONINE KINASE;

ANIMAL CELL; ARTICLE; CELL STRAIN 3T3; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; INSULIN RELEASE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; VASCULAR ENDOTHELIUM; VASODILATATION; ANIMAL; BIOSYNTHESIS; CATTLE; CELL LINE; CHEMISTRY; DOSE RESPONSE; ENZYMOLOGY; GENETIC TRANSFECTION; IMMUNOBLOTTING; METABOLISM; PHOSPHORYLATION; PLASMID; TIME;

ANIMALIA;

1-PHOSPHATIDYLINOSITOL 3-KINASE; 3T3 CELLS; ANIMALS; CALCIUM; CATTLE; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; EGTAZIC ACID; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; HUMANS; IMMUNOBLOTTING; INSULIN; LYSOPHOSPHOLIPIDS; MICE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHORYLATION; PLASMIDS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; SERINE; TIME FACTORS; TRANSFECTION;

EID: 0035839532     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M103702200     Document Type: Article

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