Randomized, double-blind placebo-controlled trial of coenzyme Q10 in patients with acute myocardial infarction

Cardiovascular Drugs and Therapy

Volumn 12, Issue 4, 1998, Pages 347-353

  Singh, Ram B ^a,b   Wander, Gurpreet S ^a   Rastogi, Amit ^a   Shukla, Pradeep K ^a   Mittal, Adarsh ^a   Sharma, Jagdish P ^a   Mehrotra, Shiv K ^a   Kapoor, Raj ^a   Chopra, Raj K ^a  

^a Medical Hospital and Research Centre Moradabad   (India)

^b MHRC   (India)

Author keywords

Antioxidant vitamins; Infarction; Ischemia; Oxidative stress; Ubiquinone

Indexed keywords

ALKADIENE; ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; BETA CAROTENE; HEART ENZYME; LIPID PEROXIDE; MALONALDEHYDE; Q GEL; RETINOL; UBIDECARENONE; UNCLASSIFIED DRUG;

ACUTE HEART INFARCTION; ADULT; ANGINA PECTORIS; ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; EPIGASTRIC PAIN; FEMALE; FOLLOW UP; HEADACHE; HEART ARRHYTHMIA; HEART DEATH; HEART LEFT VENTRICLE FUNCTION; HUMAN; HYPOTENSION; MAJOR CLINICAL STUDY; MALE; NAUSEA; ORAL DRUG ADMINISTRATION; OXIDATIVE STRESS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SYMPTOM; TIME; VOMITING;

ANGINA PECTORIS; ANTIOXIDANTS; ARRHYTHMIA; DOUBLE-BLIND METHOD; HEART VENTRICLES; HUMANS; MALE; MYOCARDIAL INFARCTION; MYOCARDIUM; OXIDATIVE STRESS; PLACEBOS; TIME FACTORS; UBIQUINONE;

EID: 0031785608     PISSN: 09203206     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1007764616025     Document Type: Article

References (35)

1. Grech ED, Jackson M, Ramsdale DR. Reperfusion injury after acute myocardial infarction. Br Med J 1995;310:477-478.
2. Bernier M, Hearse DJ, Manning AS. Reperfusion induced arrhythmias and oxygen derived free radicals. Circ Res 1986;58:331-340.
3. Ceremuzynski L. Hormonal and metabolic reactions evoked by acute myocardial infarction. Circ Res 1981;48:765-776.
4. Singh RB, Niaz MA, Rastogi S, Sharma JP, Kumar R, Bishnoi I, Beegom R. Plasma levels of antioxidant vitamins and oxidative stress in patients with suspected acute myocardial infarction. Acta Cardiol 1994;49:441-452.
5. Wilkinson P, Sayer J, Laji K, Grundy C, Marchant B, Kopelman P, Timmis AD. Comparison of case fatality in South Asian and white patients after acute myocardial infarction: Observational study. Br Med J 1996;312:1330-1333.
6. Beyer RE, The participation of coenzyme Q10 in free radical production and antioxidation. Free Radic Biol Med 1990;8: 545-565.
7. Lenaz G, Battino M. Studies on the role of ubiquinone in the control of the mitochondrial respiratory chain. Free Radic Res Commun. 1990;8:317-327.
8. Atar D, Mortensen SA, Flachs H, Herzog WR. Coenzyme Q10 protects ischemic myocardium in an open-chest swine model. Clin Investig 1993;71:S 103-111.
9. Herzog WR, Schlossberg ML, Mortensen SA, Serebruany VL. Dietary supplementation with coenzyme Q10 reduces platelet aggregability in swine Coenzyme Q. Res Biol Med 1995;3:5-8.
10. Serebruany VL, Ordonez JV, Herzog WR, Morten R, Mortensen SA, Folkers K, Gurbel PA. Dietary coenzyme Q10 supplementation alters platelet size and inhibits human Vitronectin (CDSI/CD61) receptor expression. J Cardiovasc Pharmacol 1997;29:16-22.
11. Battino M, Fato R, Lenaz G. Coenzyme Q10 can control the efficiency of oxidative phosphorylation. Int J Tissue React 1990;12:137-144.
12. Singh RB, Niaz MA, Rastogi V, Rastogi SS. Coenzyme Q in cardiovascular disease. J Assoc Physiol India 1998;46: 299-306.
13. Kamikawa T, Kobayashi A, Yamashita T, Hayashi H, Yamasaki N. Effects of coenzyme Q10 on exercise tolerance in chronic stable angina pectoris. Am J Cardiol 1985;56:247-257.
14. Mazzola C, Guffanti EE, Vaccarella A, Meregalli M, Colmago R, Ferrario N, Cantoni V, Marcherri G. Noninvasive assessment of coenzyme Q10 in patients with chronic stable effort angina and moderate heart failure. Curr Ther Res 1987;41:923-930.
15. Hofman-Bang C, Rehnqvist N, Swedberg K, Astrom H. Coenzyme Q10 as an adjunctive in treatment of congestive heart failure. J Am Coll Cardiol 1992;19(Suppl.):774-776.
16. Takasawa K, Fuse K, Konishi T, Watanabe Y. Prevention of premature ventricular contractions with coenzyme Q10 after coronary artery bypass grafting. In: Folkers K, Littami GP, Yamagami T, eds. Biomedical and Clinical Aspects of Coenzyme Q. Vol. 6, Amsterdam: Elsevier 1991:357-359.
17. World Health Organization Myocardial Infarction Community Registers Copenhagen. World Health Organization, 1976.
18. Brubacher G, Vuillenmier JP, Incurtis HC, Roth M, eds. Vitamin C: Clinical Biochemistry, Principles and Methods, Vol. 2. Berlin: de Gruyter, 1974:989-997.
19. Vuilleumier JP, Keller HE, Gysel D, Hunziker F. Clinical chemical methods for the routine assessment of the vitamin status in human population. Part 1. The fat soluble vitamins A, E and beta-carotene. Int J Vit Nutr Res 1983;58:265-272.
20. Esterbauer H, Cheeseman KH. Determination of aldehyde peroxidation products malonyldialdehyde and 4 hydroxynonenal. Method Enzymol 1990;186:407-421.
21. Niato C, Kawamura M, Yamamoto Y. Lipid peroxides as the initiating factor of atherosclerosis. Am NY Acad Sci 1993; 676:27-45.
22. Lunec J, Hallovan SP, White AG, Dormandy TL. Free radical oxidation (peroxidation) products in serum and synovial fluids in rheumatoid arthritis. J Rheumatol 1981:8:233-245.
23. Schardr F, Welzel D, Schess W, Toda K. Effect of coenzyme Q10 on ischemia-induced ST-segment depression: A double blind, placebo controlled crossover study. In: Folkers K, Yamamura Y, eds. Biomedical and Clinical Aspects of Coenzyme Q10, Vol. 5. Amsterdam: Elsevier, 1986:385-394.
24. Rosi E, Lombardo A, Testa M, et al. Coenzyme Q10 in ischaemic cardiopathy. In: Folkers K, Littarru GP, Yamagami T, eds. Biomedical and Clinical Aspects of Coenzyme Q, Vol. 6. Amsterdam: Elsevier, 1991:321-326.
25. Wilson MF, Frishman WH, Giles T, Sethi G, Greenberg SM, Brackett DJ. Coenzyme Q10 therapy and exercise duration in stable angina. In: Folkers K, Littami GP, Yamagami T, eds. Biomedical and Clinical Aspects of Coenzyme Q, Vol. 6. Amsterdam: Elsevier, 1991:339-348.
26. Kuklinski B, Weissenbacher E, Fahnrich A. Coenzyme Q10 and antioxidants in acute myocardial infarction. Mol Aspect Med 1994:15(Suppl.):143-147.
27. Barbiroli B, Frassineti C, Martinelli P, Iotti S, Lodi R, Cortelli P, Montagna P. Coenzyme Q10 improves mitochondrial respiration in patients with mitrochondrial cytopathies. An in vivo study on brain and skeletal muscle by phosphorous magnetic resonance spectroscopy. Cell Mol Biol 1997:43:741-749.
28. Yoshida T, Maulik G, Bagchi D, Dash SK, Engelman RM, Das DK. Increased myocardial tolerance to ischemia-reperfusion injury by feeding pigs with coenzyme Q10. In: Das DK, Engelman R, Cherian KM, eds. Myocardial Preservation, Preconditioning and Adaptation. Ann NY Acad Sci 1996:793:414-419.
29. Kontush A, Reich A, Baum K, Spranger T, Finckh B, Kohlschutter A, Beisiegel U. Plasma ubiquinol is decreased in patients with hyperlipidemia. Atherosclerosis 1997:129:119-126.
30. Yokoyama H, Lingle DM, Crestanello JA, et al. Coenzyme Q10 protects coronary endothelial function from ischaemia reperfusion injury via an antioxidant effect. Surgery 1996; 120:189-196.
31. Kagan V, Packer L. Electron transport regenerates vitamin E in mitochandria and microsomes via ubiquinone: An antioxidant aduct. In: Corogni F, Banni S, Desai MA, Rice-Evans C, eds. Free Radicals and Antioxidants and Nutrition. London: Richelieu Press, 1993:27-36.
32. Baggio G, Gandini R, Plancher AC, Passeri M, Carmosino G. Italian multicenter study on the safety and efficacy of coenzyme Q10 as adjunctive therapy in heart failure. Mol Aspects Med 1994;15(Suppl.):287-294.
33. Karlsson J, Lin L, Gunnes S, Sylven C, Astrom H, Jansson E, Semb B. Muscle characteristics in effort angina before and after CABG. Can J Cardiol 1997;13:577-582.
34. Soja AM, Mortensen SA. Treatment of congestive heart failure with coenzyme Q10 illuminated by meta-analyses of clinical trials. Mol Aspects Med 1997:18(Suppl.):159-168.
35. Chopra RK, Goldman R, Sinatra ST, Bhagvan HN. Relative bioavailability of coenzyme Q10 formulations in human subjects. Int J Vit Nutr Res 1998;68:109-113.