Is Atherosclerosis an Arginine Deficiency Disease?

Journal of Investigative Medicine

Volumn 46, Issue 8, 1998, Pages 377-380

  Cooke, John P ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ANIMAL; ARTERIOSCLEROSIS; HUMAN; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; REVIEW; VASCULAR ENDOTHELIUM; VASODILATATION;

ANIMALS; ARGININE; ARTERIOSCLEROSIS; ENDOTHELIUM, VASCULAR; HUMANS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; VASODILATION;

EID: 0032185604     PISSN: 17088267     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Ross R. Cellular and molecular studies of atherosclerosis. Atherosclerosis 1997;131(suppl):S3-4.
2. Moncada S, Higgs EA. Molecular mechanisms and therapeutic strategies related to nitric oxide. FASEB J 1995;9:1319-30.
3. Kubes P, Suzuki M, et al. Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc Natl Acad Sci USA 1991;88:4651-85.
4. Stamler JS, Mendelsohn ME, Amarante P, Smick D, Andon N, Davies PF, Cooke JP, Loscalzo J. N-acetylcysteine potentiates platelet inhibition by endothelium-derived relaxing factor. Circ Res 1989;65:789-95.
5. Garg UC, Hassid A, et al. Nitric oxide-generating vasodilators and 8-bromocyclic guanosine monophosphate inhibit mitrogenesis and proliferation of cultured rat vascular smooth muscle cells. J Clin Invest 1989;83:1774-7.
6. Cohen RA, Zitnay KM, Haudenschild CC, Cunningham LD. Loss of selective endothelial cell vasoactive functions in pig coronary arteries caused by hypercholesterolemia. Circ Res 1988;63:903-10.
7. Jacobs M, Plane F, Bruckdorfer KR. Native and oxidized low-density lipoproteins have different inhibitory effects on endothelium-derived relaxing factor in the rabbit aorta. Br J Pharmacol 1990;100:21-6.
8. Kugiyama K, Kerns SA, Morrisett JD, Roberts R, Henry PD. Impairment of endothelium-dependent arterial relaxation by lysolecithin in modified low-density lipoproteins. Nature 1990;344:160-2.
9. Creager MA, Gallagher SJ, Girerd XJ, Coleman SM, Dzau VJ, Cooke JP. L-arginine improves endothelium-dependent vasodilation in hypercholesterolemic humans. J Clin Invest 1992;90:1248-53.
10. Clarkson P, Adams MR, Powe AJ, Donald AE, McCredie R, Robinson J, McCarthy SN, Keech A, Celermajer DS, Deanfield JE. Oral L-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults. J Clin Invest 1996:5;97:1989-94.
11. Drexler H, Zeiher AM, Meinzer K, Just H. Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolaemic patients by L-arginine. Lancet 1991;338(8782-8783): 1546-50.
12. Böger RH, Bode-Böger SM, Thiele W, et al. Biochemical evidence for impaired nitric oxide synthesis in patients with peripheral arterial occlusive disease. Circulation 1997;95:2068-74.
13. Bode- Böger SM, Böger RH, Alfke H, Heinzel D, Tsikas D, Creutzig A, et al. L-arginine induces nitric oxide-dependent vasodilation in patients with critical limb ischemia. A randomized controlled study. Circulation 1996;93:85-90.
14. Lerman A, Burnett JC Jr, Higano ST, McKinley LJ, Holmes DR Jr. Long-term L-arginine supplementation improves small-vessel coronary endothelial function in humans. Circulation 1998;97(21):2123-8.
15. Pollock JS, Försterman U, Mitchell JA et al. Purification and characterization of paniculate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells. Proc Natl Acad USA 1991;88:10480-4.
16. Vallance P, Leone A, Calver A, Collier J, Moncada S: I Endogenous dimethylarginine as an inhibitor of nitric oxide synthesis. J Cardiovasc Pharmacol 1992;20(12 Suppl):S60-2.
17. Bode-Böger SM, Böger RH, Kienke S, Junker W, Frölich JC. Elevated L-arginine/ dimethylarginine ratio contributes to enhanced systemic NO production by dietary L-arginine in hypercholesterolemic rabbits. Biochem Biophys Res Comm 1996;219:598-603.
18. Boger RH, Bode-Boger SM, Sxuba A, Tsao PS, Chan JR, Tangphao O, Blaschke TF, Cooke JP. ADMA: a novel risk factor for endothelial dysfunction: its role in hypercholesterolemia [abstract]. Circulation 1998;96s:A173.
19. Matsuoka H, Itoh S, Kimoto M, Kohno K, Tamai O, Wada Y, et al. Asymmetrical dimethlyarginine, an endogenous nitric oxide synthase inhibitor, in experimental hypertension. Hypertension 1997;29:242-7.
20. Faraci FM, Brian JE, Heistad DD. Response of cerebral blood vessels to an endogenous inhibitor of nitric oxide synthase. Am J Physiol 1995;269:H1522-7.
21. Kurose I, Wolf R, Grisham MB, Granger DN. Effects of an endogenous inhibitor of nitric oxide synthesis on postcapillary venules. Am J Physiol 1995;268:H2224-31.
22. Böger RH, Bode-Böger SM, Tsao PS, Lin PS, Chan JR, Cooke JP. An endogenous inhibitor of nitric oxide synthase regulates endothelial adhesiveness for monocytes [abstract]. Circulation 1997;96s:A1588.
23. MacAllister RJ, Parry H, Kimoto M et al. Regulation of nitric oxide synthesis by dimethylarginine dimethylaminohydrolase. Br J Pharmacol 1996;119:1533-40.
24. Maxwell AJ, Cooke JP. Cardiovascular effects of L-arginine. Nephrology and Hypertension 1998;7:63-70.
25. Adams MR, Jessup W, McCredie R, Robinson J, Sullivan D, Celermajer DS. Oral L-arginine improves endothelium-dependent dilation and reduces monocyte adhesion to endothelial cells in young men with cornorary artery disease, [abstract]. J Am Coll Cardiol 1997;29:387A.
26. Chauhan A, More RS, Mullins PA, Taylor G, Petch C, Schofield PM. Aging associated endothelial dysfunction in humans is reversed by L-arginine. J Am Coll Cardiol 1996;28:1796-1804.
27. Vallance P, Leone A, Calver A, Collier J, Moncada S. Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet 1992;339(8793):572-5.
28. Flavahan NA. Lysophosphatidylcholine modified G protein-dependent signaling in porcine endothelial cells. Am J Physiol 1993;264:H722-7.
29. Giaid A, Saleh D. Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension. N Engl J Med 1995;333:214-6.
30. Pieper GM, Siebenich W, Dondinger LA. Short-term oral administration of L-arginine reverses defective endothelium-dependent relaxation and cGMP generation in diabetes. Eur J Pharmacol 1996;317:317-20.
31. Pedlli R, Ebel M, Catapano G, Dell'Omo G, Ducci M, Del Chicca M, et al. Pressor, renal, and endocrine effects of L-arginine in essential hypertensives. Eur J Clin Pharmacol 1995;48:195-201.
32. Casino PR, Kilcoyne CM, Quyyumi AA, Hoeg JM, Panza JA. The role of nitric oxide in endothelium-dependent vasodilation of hypercholesterolemic patients. Circulation 1993;88:2541-7.
33. Cooke JP, Singer AH, Tsao P et al. Anti-atherogenic effects of L-arginine in the hypercholesterolemic rabbit. J Clin Invest 1992;90:1168-72.
34. Wang B, Singer A, Tsao P, et al. Dietary arginine prevents atherogenesis in the coronary artery of the hypercholesterolemic rabbit. J Am Coll Cardiol 1994;23:452-8.
35. Böger RH, Bode-Böger SM, Mügge A et al. Supplementation of hypercholesterolaemic rabbits with L-arginine reduces the vascular release of superoxide anions and restores NO production. Atherosclerosis 1995;117:273-84.
36. Marui N, Offerman MK, Swerlick R, et al. Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells. J Clin Invest 1993;92:1866-72.
37. Li H, Cybulsky MI, Gimbrone MA Jr, Libby PA. An atherogenic diet rapidly induces VCAM-1, a cytokine regulatable mononuclear leukocyte adhesion molecule, in rabbit aortic endothelium. Arterioscler Thromb 1993;13:197-204.
38. Berliner, JA, Navab M, Fogelman AM, Frank JS, Demee LL, Edwards PA, Watson AD, Lusis AJ. Atherosclerosis: basic mechanisms: oxidation, inflammation and genetics. Circulation, 1995;91:2488-96.
39. Clancy RM, Leszczynska P, Piziak J, Abramson SB. Nitric oxide, an endothelial cell relaxation factor, inhibits neutrophil superoxide anion production via a direct action on NADPH oxidase. J Clin Invest 1992;90:1116-21.
40. Peng HB, Libby P, Liao JK: Induction and stabilization of I kappa B alpha by nitric oxide mediates inhibition of NF-kappa B. J Biol Chem 1995;270:14214-9.
41. Spiecker M, Peng H-B, Liao JK. Inhibition of endothelial vascular cell adhesion molecule-1 expression by nitric oxide involves the induction and nuclear translocation of IKBα. J Biol Chem 1997;272:30969-74.
42. Pritchard KA Jr, Groszek L, Smalley DM, Sessa WC, Wu M, Villalon P, Wolin MS, Stemerman MB. Native low-density lipoprotein increases endothelial cell nitric oxide synthase generation of superoxide anion. Circ Res 1995;77(3):510-8.
43. Stroes ES, Kastelein JJ, Cosenfino F, Keenans HA, Luscher TF, Rabelink TJ. Tetrahydrobiopterin ameliorates in vivo endothelial function in hypercholesterolemic patients. Circulation 1996;94:1-220.
44. Tsao PS, Buitrago R, Chan JR, Cooke JP. Fluid flow inhibits endothelial adhesiveness: nitric oxide and transcriptional regulation of VCAM-1. Circulation 1996;94:1682-9.
45. Tsao PS, Wang BY, Buitrago R, et al. Nitric oxide regulates monocyte chemotactic protein-1. Circulation 1997;96:934-40.
46. Candipan RC, Wang B, Buitrago R, et al. Regression or progression: dependency upon vascular nitric oxide. Arterioscler Thromb Vasc Biol 1996;16:44-50.