Targeting Rho in cardiovascular disease

Circulation Research

Volumn 87, Issue 7, 2000, Pages 526-528

  Laufs, Ulrich ^b   Liao, James K ^a,c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b SAARLAND UNIVERSITY   (Germany)

^c Vascular Medicine Unit   (United States)

Author keywords

Cholesterol; Cytoskeleton; Gene regulation; GTP binding proteins; Isoprenoids

Indexed keywords

CHOLESTEROL; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ISOPRENOID; MESSENGER RNA; RAS PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; RHO FACTOR; TRANSCRIPTION FACTOR;

ANIMAL MODEL; ARTERIOSCLEROSIS; CARDIOVASCULAR DISEASE; CHOLESTEROL SYNTHESIS; CYTOSKELETON; EDITORIAL; GENE EXPRESSION REGULATION; HEART MUSCLE CELL; NONHUMAN; PRIORITY JOURNAL; RAT; VASCULAR SMOOTH MUSCLE;

EID: 0034730812     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.87.7.526     Document Type: Editorial

References (20)

1. Rho GTPases and the actin cytoskeleton
2. Influence of pravastatin and plasma lipids on clinical events in the West of Scotland Coronary Prevention Study (WOSCOPS)
3. Regulation of the mevalonate pathway
4. Involvement of Rho GTPases in the transcriptional inhibition of preproendothelin-1 gene expression by simvastatin in vascular endothelial cells
5. Endothelins
6. Neuroprotection mediated by changes in the endothelial actin cytoskeleton
7. HMG CoA reductase inhibitors reduce plasminogen activator inhibitor-1 expression by human vascular smooth muscle and endothelial cells
8. Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase
9. Rho GTPases and signaling networks
10. 3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors attenuate vascular smooth muscle proliferation by preventing rho GTPase-induced down-regulation of p27(Kipl)
11. The IL-1 receptor and Rho directly associate to drive cell activation in inflammation
12. Stimulation of bone formation in vitro and in rodents by statins
13. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension
14. Enhanced myosin light chain phosphorylations as a central mechanism for coronary artery spasm in a swine model with interleukin-1β
15. Small guanine nucleotide-binding proteins and myocardial hypertrophy
16. Translational control of p27Kip1 accumulation during the cell cycle
17. Effect of pravastatin on outcomes after cardiac transplantation
18. Simvastatin inhibits leukocyte-endothelial cell interactions and protects against inflammatory processes in normocholesterolemic rats
19. Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation
20. Improvement of nitric oxide-dependent vasodilatation by HMG-CoA reductase inhibitors through attenuation of endothelial superoxide anion formation