Incorporation of beta cell redifferentiation therapy into a lipoprivic strategy for reversing type 2 diabetes

Medical Hypotheses

Volumn 58, Issue 6, 2002, Pages 462-471

  McCarty, Mark F ^a  

^a Pantox Laboratories   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOTIN; FATTY ACID; GLUCAGON LIKE PEPTIDE 1; INSULIN; TRANSCRIPTION FACTOR;

CELL DIFFERENTIATION; EXERCISE; FATTY ACID OXIDATION; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; HUMAN; HYPERGLYCEMIA; INSULIN RELEASE; INSULIN RESISTANCE; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; REVIEW;

EID: 0036619311     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1054/mehy.2001.1454     Document Type: Article

References (144)

1. Epidemiology of diabetes and its macrovascular manifestations in Pacific populations: The medical effects of social progress
2. Diabetes mellitus and dietary fiber of starchy foods
3. Epidemiology of diabetes mellitus in the Asia-Pacific region
4. Westernisation, insulin resistance and diabetes in Australian aborigines
5. Epidemiology of type II diabetes: An international perspective
6. Overview of non-insulin-dependent diabetes mellitus (NIDDM) in different population groups
7. Globalization, coca-colonization and the chronic disease epidemic: Can the Doomsday scenario be averted?
8. Contribution of intra-abdominal fat accumulation to the impairment of glucose and lipid metabolism in human obesity
9. Regional fat distribution-implications for type II diabetes
10. Pathophysiology and molecular mechanisms of visceral fat syndrome: The Japanese experience
11. Phenotypic characteristics associated with insulin resistance in metabolically obese but normal-weight young women
12. Effects of weight loss and reduced hyperglycemia on the kinetics of insulin secretion in obese non-insulin dependent diabetes mellitus
13. Benefits and limitations of very-low-calorie diet therapy in obese NIDDM
14. A review of long-term studies evaluating the efficacy of weight loss in ameliorating disorders associated with obesity
15. Aggressive weight reduction treatment in the management of type 2 diabetes
16. Effects of caloric restriction and weight loss on glycemic control, insulin release and resistance, and atherosclerotic risk in obese patients with type II diabetes mellitus
17. Beneficial effects of a high carbohydrate, high fiber diet on hyperglycemic diabetic men
18. Long-term effects of high-carbohydrate, high-fiber diets on glucose and lipid metabolism: A preliminary report on patients with diabetes
19. High-carbohydrate, high-fiber diets for insulin-treated men with diabetes mellitus
20. A high carbohydrate leguminous fibre diet improves all aspects of diabetic control
21. High-fibre and low-fat diets in diabetes mellitus
22. Response of non-insulin-dependent diabetic patients to an intensive program of diet and exercise
23. Long-term use of a high-complex-carbohydrate, high-fiber, low-fat diet and exercise in the treatment of NIDDM patients
24. Diet and exercise in the treatment of NIDDM: The need for early emphasis
25. Marked improvement in carbohydrate and lipid metabolism in diabetic Australian aborigines after temporary reversion to traditional lifestyle
26. Toward improved management of NIDDM: A randomized, controlled, pilot intervention using a lowfat, vegetarian diet
27. Metabolic implications of body fat distribution
28. The glucoregulatory and antilipolytic actions of insulin in abdominal obesity with normal or impaired glucose tolerance: An in vivo and in vitro study
29. Insulin resistance in adipocytes of obese women: Effects of body fat distribution and race
30. Insulin-resistant lipolysis in abdominally obese hypertensive individuals: Role of the renin-angiotensin system
31. Tumor necrosis factor alpha inhibits signaling from the insulin receptor
32. The expression of tumor necrosis factor in human adipose tissue: Regulation by obesity, weight loss, and relationship to lipoprotein lipase
33. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance
34. Inhibition of insulin receptor signaling by TNF: Potential role in obesity and non-insulin-dependent diabetes mellitus
35. Measurement of plasma glucose, free fatty acid, lactate, and insulin for 24 h in patients with NIDDM
36. Regulation of non-esterified fatty acid and glycerol concentration by insulin in normal individuals and patients with type 2 diabetes
37. Carbohydrate and lipid metabolism of skeletal muscle in type 2 diabetic patients
38. Intramuscular triglyceride and muscle insulin sensitivity: Evidence for a relationship in nondiabetic subjects
39. Skeletal muscle triglyceride levels are inversely related to insulin action
40. Subcutaneous abdominal fat and thigh muscle composition predict insulin sensitivity independently of visceral fat
41. Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects
42. Lipoprotein lipase hydrolyzes endogenous triacylglycerols in muscle of exercised rats
43. Lipase regulation of muscle triglyceride hydrolysis
44. Mechanisms of fatty acid-induced inhibition of glucose uptake
45. Effects of fat on glucose uptake and utilization in patients with non-insulin-dependent diabetes
46. Role of fatty acids in the pathogenesis of insulin resistance and NIDDM
47. Free fatty acid as a link in the regulation of hepatic glucose output by peripheral insulin
48. Causal linkage between insulin suppression of lipolysis and suppression of liver glucose output in dogs
49. Central role of the adipocyte in insulin resistance
50. Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: Impairment in adipocyte-beta-cell relationships
51. Lipotoxicity in the pathogenesis of obesity-dependent NIDDM: Genetic and clinical implications
52. Prolonged elevation of plasma free fatty acids desensitizes the insulin secretory response to glucose in vivo in rats
53. Prolonged elevation of plasma free fatty acids impairs pancreatic beta-cell function in obese nondiabetic humans but not in individuals with type 2 diabetes
54. Glucokinase as glucose sensor and metabolic signal generator in pancreatic beta-cells and hepatocytes
55. The pancreatic beta-cell glucose sensor
56. PDX-1 induces insulin and glucokinase gene expressions in alpha TC1 clone 6 cells in the presence of betacellulin
57. Fatty acids decrease IDX-1 expression in rat pancreatic islets and reduce GLUT2, glucokinase, insulin, and somatostatin levels
58. Elevated circulating free fatty acid levels impair endothelium-dependent vasodilation
59. Obesity/insulin resistance is associated with endothelial dysfunction: Implications for the syndrome of insulin resistance
60. Vascular effects of non-esterified fatty acids: Implications for the cardiovascular risk factor cluster
61. Plasma free fatty acids and endothelium-dependent vasodilation: Effect of chain-length and cyclooxygenase inhibition
62. Free fatty acid elevation impairs insulin-mediated vasodilation and nitric oxide production
63. Insulin and the vasculature - Old actors, new roles
64. Beta-cell dysfunction induced by chronic hyperglycemia: Current ideas on mechanism of impaired glucose-induced insulin secretion
65. Reduced insulin, GLUT2, and IDX-1 in beta-cells after partial pancreatectomy
66. Transcription factor abnormalities as a cause of beta cell dysfunction in diabetes: A hypothesis
67. Differential expression of the insulin gene transcriptional repressor CCAAT/enhancer-binding protein beta and transactivator islet duodenum homeobox-1 in rat pancreatic beta cells during the development of diabetes mellitus
68. Effect of chronic hyperglycemia on in vivo insulin secretion in partially pancreatectomized rats
69. Chronic hyperglycemia is associated with impaired glucose influence on insulin secretion: A study in normal rats using chronic in vivo glucose infusions
70. In vivo effects of glucosamine on insulin secretion and insulin sensitivity in the rat: Possible relevance to the maladaptive responses to chronic hyperglycaemia
71. In vivo glucosamine infusion induces insulin resistance in normoglycemic but not in hyperglycemic conscious rats
72. Different aetiologies of type 2 (non-insulin-dependent) diabetes mellitus in obese and non-obese subjects
73. Insulin action in black Americans with NIDDM
74. Insulin-sensitive and insulin-resistant variants in nonobese Japanese type 2 diabetic patients: The role of triglycerides in insulin resistance
75. Promotion of hepatic lipid oxidation and gluconeogenesis as a strategy for appetite control
76. Eicosapentaenoic acid as an adjuvant to dieting strategies that disinhibit hepatic fatty acid oxidation
77. Pyruvare and hydroxycitrate/carnitine may synergize to promote reverse electron transport in hepatocyte mitochondria, effectively 'uncoupling' the oxidation of fatty acids
78. Hepatothermic therapy of obesity: Rationale and an inventory of resources
79. Optimizing exercise for fat loss
80. Contribution of a sedentary lifestyle and inactivity to the etiology of overweight and obesity: Current evidence and research issues
81. Exercise and obesity
82. Physical activity and weight maintenance
83. Weight loss on a low-fat diet: Consequence of the imprecision of the control of food intake in humans
84. Weight loss in women participating in a randomized trial of low-fat diets
85. Behavioral strategies of individuals who have maintained long-term weight losses
86. The role of dietary fat in body fatness: Evidence from a preliminary meta-analysis of ad libitum low-fat dietary intervention studies
87. Effects of a low-insulin-response, energy-restricted diet on weight loss and plasma insulin concentrations in hyperinsulinemic obese females
88. High glycemic index foods, overeating, and obesity
89. Dietary glycemic index and obesity
90. Role of diet and exercise in the management of hyperinsulinemia and associated atherosclerotic risk factors
91. Induction of human skeletal muscle lipoprotein lipase gene expression by short-term exercise is transient
92. Physical training increases muscle GLUT4 protein and mRNA in patients with NIDDM
93. Exercise, glucose transport, and insulin sensitivity
94. Exercise-induced overexpression of key regulatory proteins involved in glucose uptake and metabolism in tetraplegic persons: Molecular mechanism for improved glucose homeostasis
95. Effect of long-term exercise on gene expression of insulin signaling pathway intermediates in skeletal muscle
96. Role of exercise training in the prevention and treatment of insulin resistance and non-insulin-dependent diabetes mellitus
97. Exercise and the treatment of type 2 diabetes mellitus: An update
98. American College of Sports Medicine position stand: Exercise and type 2 diabetes
99. Resistance training in the treatment of non-insulin-dependent diabetes mellitus
100. Resistance training improves the metabolic profile in individuals with type 2 diabetes
101. Physical activity and incidence of non-insulin-dependent diabetes mellitus in women
102. A prospective study of exercise and incidence of diabetes among US male physicians
103. Walking compared with vigorous physical activity and risk of type 2 diabetes in women: A prospective study
104. Elevated intakes of supplemental chromium improve glucose and insulin variables in individuals with type 2 diabetes
105. Chromium in the prevention and control of diabetes
106. Therapeutic evaluation of the effect of biotin on hyperglycemia in patients with non-insulin-dependent diabetes mellitus
107. High-dose biotin, an inducer of glucokinase expression, may synergize with chromium picolinate to enable a definitive nutritional therapy for type II diabetes
108. Effects of biotin upon the intracellular level of cGMP and the activity of glucokinase in cultured rat hepatocytes
109. Biotin administration improves the impaired glucose tolerance of streptozotocin-induced diabetic Wistar rats
110. Effect of dihydroxyacetone and pyruvate on plasma glucose concentration and turnover in noninsulin-dependent diabetes mellitus
111. Glucomannan minimizes the postprandial insulin surge - A potential adjuvant for hepatothermic therapy
112. Treatment of diabetes with glucomannan (konjac mannan)
113. Konjac-mannan (glucomannan) improves glycemia and other associated risk factors for coronary heart disease in type 2 diabetes: A randomized controlled metabolic trial
114. Effects of weight loss on mechanisms of hyperglycemia in obese non-insulin-dependent diabetes mellitus
115. Overnight lowering of free fatty acids with acipimox improves insulin resistance and glucose tolerance in obese diabetic and nondiabetic subjects
116. Comparison of obese NIDDM and nondiabetic women: Short- and long-term weight loss
117. Limitations of diet therapy in patients with non-insulin-dependent diabetes mellitus
118. Increase in insulin response after treatment of overt maturity-onset diabetes is independent of the mode of treatment
119. The defective glucose sensitivity of the B cell in non insulin dependent diabetes: Improvement after twenty hours of normoglycaemia
120. Glycemic control with an artificial pancreas improves insulin responses to both oral and glucose in nonobese noninsulin-dependent diabetic subjects
121. One month's insulin treatment of type II diabetes: The early and medium-term effects following insulin withdrawal
122. Improved beta-cell function after intensive insulin treatment in severe non-insulin-dependent diabetes
123. Type II diabetes, glucose 'non-sense,' and islet desensitization
124. Effect of intensive therapy on residual beta-cell function in patients with type 1 diabetes in the diabetes control and complications trial: A randomized, controlled trial
125. Very low calorie diet therapy in obese non-insulin dependent diabetes patients
126. Effects of VLCD in obese NIDDM (non-insulin dependent diabetes) on glucose, insulin and C-peptide dynamics
127. Effects of very-low-calorie diet weight reduction on glucose tolerance, insulin secretion, and insulin resistance in obese non-insulin-dependent diabetics
128. Effects of a very-low-calorie diet on long-term glycemic control in obese type 2 diabetic subjects
129. Benefits and limitations of very-low-calorie diet therapy in obese NIDDM
130. Caloric restriction per se is a significant factor in improvements in glycemic control and insulin sensitivity during weight loss in obese NIDDM patients
131. Very low calorie diet (VLCD): A useful alternative in the treatment of the obese NIDDM patient
132. The effect of short periods of caloric restriction on weight loss and glycemic control in type 2 diabetes
133. Who would have thought it? An operation proves to be the most effective therapy for adult-onset diabetes mellitus
134. The incretin notion and its relevance to diabetes
135. Molecular cloning, functional expression, and signal transduction of the GIP-receptor cloned from a human insulinoma
136. The glucagon-like peptides
137. Glucagon-like peptide-1(7-36)-amide confers glucose sensitivity to previously glucose-incompetent beta-cells in diabetic rats: In vivo and in vitro studies
138. Glucose-lowering and insulin-sensitizing actions of exendin-4: Studies in obese diabetic (ob/ob, db/db) mice, diabetic fatty Zucker rats, and diabetic rhesus monkeys (Macaca mulatta)
139. Once daily injection of exendin-4 to diabetic mice achieves long-term beneficial effects on blood glucose concentrations
140. Glucagon-like peptide-1 regulates the beta cell transcription factor, PDX-1, in insulinoma cells
141. Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas
142. Utility of metformin as an adjunct to hydroxycitrate/carnitine for reducing body fat in diabetics
143. Effect of biotin on glucokinase activity, mRNA expression and insulin release in cultured beta-cells
144. Biotin regulation of pancreatic glucokinase and insulin in primary cultured rat islets and in biotin-deficient rats