Insulin and the vasculature - Old actors, new roles

Journal of Investigative Medicine

Volumn 44, Issue 8, 1996, Pages 406-412

  Baron, Alain D ^a  

^a INDIANA UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDIABETIC AGENT; GLUCOSE; INSULIN; NITRIC OXIDE;

BIOSYNTHESIS; BLOOD VESSEL; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; ENDOTHELIUM; HUMAN; LESIONS AND DEFECTS; METABOLISM; PATHOPHYSIOLOGY; PERFUSION; PHYSIOLOGY; REVIEW; SKELETAL MUSCLE; VASCULAR DISEASE;

BLOOD VESSELS; DILATATION, PATHOLOGIC; ENDOTHELIUM; GLUCOSE; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; MUSCLE, SKELETAL; NITRIC OXIDE; PERFUSION; VASCULAR DISEASES;

EID: 0030256275     PISSN: 17088267     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Baron AD, Brechtel G, Wallace P, Edelman SV. Rates and tissue sites of non-insulin- and insulin-mediated glucose uptake in humans. Am J Physiol 1988;255:E769-74.
2. Ferrannini E, Buzzigoli RD, Giorico MA, Oleggini L, Graziadei L, Pedrinelli R, Brandi L, Bevilacqua S. Insulin resistance in essential hypertension. N Engl J Med 1987;317:350-7.
3. Reaven GM. Role of insulin resistance in human disease. Diabetes 1988;37:1595-607.
4. Laws A, Reaven GM. Insulin resistance and risk factors for coronary heart disease. In: Ferrannini E, ed. Clinical endocrinology and metabolism. London: Bailliere Tindall, 1993:1063-78.
5. Reaven GM, Chen Y-D I, Jeppesen J, Maheux P, Krauss RM. Insulin resistance and hyperinsulinemia in individuals with small, dense, low density lipoprotein particles. J Clin Invest 1992;92:141-6.
6. ZierlerKL. Theory of the use of arterioverious concentration differences for measuring metabolism in steady and nonsteady state. J Clin Invest 1961;40:2111-25.
7. Cushman S, Wardzala L. Potential mechanism of insulin action on glucose transport in the isolated rat adipose cell: apparent translocation of intracellular transport systems to the plasma membrane. J Biol Chem 1980;255:4728-62.
8. Birnbaum MJ. The insulin-sensitive glucose transporter. Int Rev Cytol 1992;137A:239-97.
9. Laakso M, Edelman SV, Brechtel G, Baron AD. Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man: a novel mechanism for insulin resistance. J Clin Invest 1990;85:1844-52.
10. Laakso M, Edelman SV, Brechtel G, Baron AD. Impaired insulin-mediated skeletal muscle blood flow in patients with NIDDM. Diabetes 1992;41:1076-83.
11. Baron AD, Brechtel G. Insulin differentially regulates systemic and skeletal muscle vascular resistance. Am J Physiol 1993;265:E61-7.
12. Moncada S, Palmer RMJ, Higgs EA. The discovery of nitric oxide as the endogenous nitrovasodilator. Hypertension 1988;12:365-72.
13. Furchgott RF, Zawadski JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980;288:373-6.
14. Rees DD, Palmer MJ, Moncada S. Role of endothelium-derived nitric oxide in the regulation of blood pressure. Proc Natl Acad Sci USA 1989;86:3375-8.
15. Vallance P, Collier J, Moncada S. Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man. Lancet 1989;ii:997-1000.
16. Steinberg HO, Brechtel G, Johnson A, Fineberg N, Baron AD. Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release. J Clin Invest 1994;94:1172-9.
17. Scherrer U, Randin D, Vollenweinder P, Vollenweinder L, Nicod P. Nitric oxide release accounts for insulin's vascular effects in humans. J Clin Invest 1994;94:2511-5.
18. Baron AD, Steinberg HO, Chaker H, Learning R, Johnson A, Brechtel G. Insulin-mediated skeletal muscle vasodilation contributes to both insulin sensitivity and responsiveness in lean humans. J Clin Invest 1995;96:786-92.
19. Baron AD, Brechtel-Hook G, Johnson A, Hardin D. Skeletal muscle blood flow. A possible link between insulin resistance and blood pressure. Hypertension 1993;21:129-35.
20. Baron AD. Hemodynamic actions of insulin. Am J Physiol 1994;267:E187-202.
21. Steinberg H, Chaker H, Learning R, Johnson A, Brechtel G, Baron AD. Obesity/insulin resistance is associates with endothelial dysfunction. Implications for the syndrome of insulin resistance. J Clin Invest. In press.
22. Panza JA, Quyyumi AA, Brush JE Jr, Epstein SE. Abnormal endothelium-dependent vascular relaxation in patients with essential hypertension. N Engl J Med 1990;323(1):227.
23. Creager MA, Cooke JP, Mendelsohn ME, Gallagher SJ, Coleman SM, Loscalzo J, Dzau VJ. Impaired vasodilation of forearm resistant vessels in hypercholesterolemic humans. J Clin Invest 1990;86:228-34.
24. Vance JR, Anggard EE, Botting RM. Regulatory functions of the vascular endothelium. N Engl J Med 1990;323(1):27-36.
25. Moncada S, Higgs A. Mechanisms of disease: the L-arginine-nitric oxide pathway. N Engl J Med 1993;329:2002-12.
26. Loscalzo J, Welch G. Nitric oxide and its role in the cardiovascular system. Prog Cardiovasc Dis 1995;38:87-104.
27. Radomski MW, Palmer RMJ, Moncada S. The antiaggregating properties of vascular endothelium: interactions between prostacyclin and nitric oxide. Br J Pharmacol 1987;92:639-46.
28. Simon DI, Stamler JS, Loh E, Loscalzo J, Francis SA, Creager MA. Effect of nitric oxide synthase inhibition on bleeding time in humans. J Cardiovasc Pharmacol 1995;26:339-42.
29. Lamon-Fava S, Jimenez D, Christian JC, Fabsitz RR, Reed T, Carmelli D, Castelli WP, Ordovas MJ, Wilson PWF, Schaefer EJ. The NHLBI twin study: heritability of apoliprotein A-I, B, and low density lipoprotein subclasses and concordance for lipoprotein (a). Atherosclerosis 1991;91:97-106.
30. Lembo G, Rendina V, Iaccarino G, Lamenza F, Condorelli G, Rosiello G, Trimarco B. Insulin does not modulate reflex forearm sympathetic vasoconstriction in patients with essential hypertension. J Hypertens 1993;11:5272-3.
31. Steinberg D. Role of oxidized LDL and antioxidants in atherosclerosis. Adv Exp Med Biol 1995;369:39-48.
32. Baron AD, Brechtel G, Johonson A, Fineberg N, Henry DP, Steinberg HO. Interactions between insulin and norepinephrine on blood pressure and insulin sensitivity. Studies in lean and obese men. J Clin Invest 1994;93:2453-62.