Eicosapentaenoic acid as an adjuvant to dieting strategies that disinhibit hepatic fatty acid oxidation

Medical Hypotheses

Volumn 50, Issue 1, 1998, Pages 37-38

  Mccarty, M F ^a  

^a Nutrition 21 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADJUVANT; FISH OIL; ICOSAPENTAENOIC ACID;

DIET; DIET SUPPLEMENTATION; EDITORIAL; FATTY ACID METABOLISM; FATTY ACID OXIDATION; HUMAN; LIVER METABOLISM; PRIORITY JOURNAL;

EID: 0031974819     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-9877(98)90174-8     Document Type: Article

References (20)

1. McCarty M F. Promotion of hepatic lipid oxidation and gluconeogenesis as a strategy for appetite control. Med Hypotheses 1994; 42: 215-225.
2. Marsh J B, Topping D L, Nestel P J. Comparative effects of dietary fish oil and carbohydrate on plasma lipids and hepatic activities of phosphatidate phosphohydrolase, diacylglycerol acyltransferase and neutral lipase activities in the rat. Biochim Biophys Acta 1987; 922: 239-243.
3. Wong S-H, Marsh J B. Inhibition of apolipoprotein secretion and phosphatidate phosphohydrolase activity by eicosapentaenoic and docosahexaenoic acids in the perfused rat liver. Metabolism 1988; 37: 1177-1181.
4. Halminski M A, Marsh J B, Harrison E H. Differential effects of fish oil, safflower oil and palm oil on fatty acid oxidation and glycerolipid synthesis in rat liver. J Nutr 1991; 121: 1554-1561.
5. Surette M E, Whelan J, Broughton K S, Kinsella J E. Evidence for mechanisms of the hypotriglyceridemic effect of n-3 polyunsaturated fatty acids. Biochim Biophys Acta 1992; 1126: 199-205.
6. Wong S H, Nestel P J, Trimble R P et al. The adaptive effects of dietary fish and safflower oil on lipid and lipoprotein metabolism in perfused rat liver. Biochim Biophys Acta 1984; 792: 103-109.
7. Yamazaki R K, Shen T, Schade G B. A diet rich in (n-3) fatty acids increases peroxisomal β-oxidation activity and lowers plasma triacylglycerols without inhibiting glutathione-dependent detoxication activities in the rat liver. Biochim Biophys Acta 1987; 920: 62-67.
8. Willumsen N, Skorve J, Hexeberg S et al. The hypotriglyceridemic effect of eicosapentaenoic acid in rats is reflected in increased mitochondrial fatty acid oxidation followed by diminished lipogenesis. Lipids 1993; 28: 683-690.
9. Willumsen N, Vaagenes H, Lie ø et al. Eicosapentaenoic acid, but not docosahexaenoic acid, increases mitochondrial fatty acid oxidation and upregulates 2,4-dienoyl-CoA reductase gene expression in rats. Lipids 1996; 31: 579-592.
10. McGarry J D, Foster D W. In support of the roles of malonylcoA and carnitine acyltransferase I in the regulation of hepatic fatty acid oxidation and ketogenesis. J Biol Chem 1979; 254: 8163-8168.
11. Delarue J, Couet C, Cohen R et al. Effects of fish oil on metabolic responses to oral fructose and glucose loads in healthy humans. Am J Physiol 1996; 270: E353-E362.
12. Hirai A, Terano T, Makuta H et al. Effect of oral admini-stration of highly purified eicosapentaenoic acid and docosahexaenoic acid on platelet function and serum lipids in hyperlipidemic patients. Adv Prost Thromb Leuk Res 1989; 19: 627-630.
13. Willumsen N, Hexeberg S, Skorve J et al. Docosahexaenoic acid shows no triglyceride-lowering effects but increases the peroxisomal fatty acid oxidation in liver of rats. J Lipid Res 1993; 34: 13-22.
14. IKeda I, Wakamatsu K, Inayoshi A et al. Alpha-linolenic, eicosapentaenoic and docosahexaenoic acids affect lipid metabolism differently in rats. J Nutr 1994; 124: 1098-1096.
15. Kobatake Y, Kuroda K, Jinnouchi H et al. Differential effects of dietary eicosapentaenoic and docosahexaenoic fatty acids on lowering of triglyceride and cholesterol levels in the serum of rats on hypercholesterolemic diet. J Nutr Sci Vitaminol 1984; 30: 357-372.
16. Zhang Z J, Wilcox M B, Elam L W et al. Metabolism of n-3 polyunsaturated fatty acids by the isolated perfused rat liver. Lipids 1991; 26: 504-511.
17. Harris WS. Eicosapentaenoic acid is responsible for the hypotriglyceridemic effect of fish oils in humans. 2nd International Congress of the ISSFAL International Society for the Study of Fatty Acids and Lipids, ISSFAL, Washington DC, Plenary Session 4.
18. Cunnane S C, McAdoo K R, Horrobin D F. n-3 Essential fatty acids decrease weight gain in genetically obese mice. Br J Nutr 1986; 56: 87-95.
19. Belzung F, Raclot T, Groscolas R. Fish oil n-3 fatty acids selectively limit the hypertrophy of abdominal fat depots in growing rats fed high-fat diets. Am J Physiol 1993; 264: R1111-R1118.
20. McCarty M F. Inhibition of citrate lyase may aid aerobic endurance. Med Hypotheses 1995; 45: 247-254.