Central Role Of The Adipocyte In Insulin Resistance

Journal of Basic and Clinical Physiology and Pharmacology

Volumn 9, Issue 2-4, 1998, Pages 205-222

  Bergman, Richard N ^a   Mittelman, Steven D ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

free fatty acids (FFA); liver glucose production; transendothelial transport (TET); type 2 diabetes mellitus

Indexed keywords

ALBUMIN; CYCLOHEXYLADENOSINE; FATTY ACID; GLUCOSE; GLUCOSE TRANSPORTER; INSULIN; INSULIN RECEPTOR; LIPOSYN; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3 KINASE;

ADIPOCYTE; CAPILLARY PERMEABILITY; GLUCONEOGENESIS; GLUCOSE METABOLISM; GLUCOSE TRANSPORT SYSTEM; HUMAN; INSULIN RESISTANCE; LIVER; MUSCLE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS; REVIEW;

ADIPOCYTES; CELLS, CULTURED; DIABETES MELLITUS, TYPE 2; FATTY ACIDS, NONESTERIFIED; GLUCOSE; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN RESISTANCE; ISLETS OF LANGERHANS; LIVER; MONOSACCHARIDE TRANSPORT PROTEINS; MUSCLE, SKELETAL; OBESITY; SIGNAL TRANSDUCTION;

EID: 0032456181     PISSN: 07926855     EISSN: 21910286     Source Type: Journal    
DOI: 10.1515/JBCPP.1998.9.2-4.205     Document Type: Article

References (40)

1. Martin, BC., Warram, JH., Krolewski, AS., et al. Role of glucose and insulin resistance in development of type 2 diabetes mellitus: Results of a 25-year follow-up study. Lancet 1992; 340: 925–929.
2. Saad, MF. Knowler, WC. Pettitt, DJ. et al. The natural history of impaired glucose tolerance in the Pima Indians. N Engl J Med 1988; 319: 1500–1506.
3. Hollenbeck, C., Reaven, GM. Variations in insulin-stimulated glucose uptake in healthy individuals with normal glucose tolerance. J Clin Endocrinol Metab 1987; 64: 1169–1173.
4. Saad, MF., Anderson, RL., Laws, A., et al. Variations in insulin-stimulated glucose uptake in healthy individuals with normal glucose tolerance. Diabetes 1994; 43: 1114–1121.
5. Banerji, MA. Lebovitz, HE. Insulin-sensitive and insulin-resistant variants in NIDDM. Diabetes 1989; 38: 784–792.
6. Arner, P., Pollare, T., Lithell, H. Different aetiologies of type 2 (non-insulindependent) diabetes mellitus in obese and non-obese subjects. Diabetologia 1991; 34: 483–487.
7. Taniguchi, A., Nakai, Y. Fukushima, M., et al. Pathogenic factors responsible for glucose intolerance in patients with NIDDM. Diabetes 1992; 41: 1540–1546.
8. Bergman, RN., Watanabe, RM. Haffner, S., et al. Hyperbolic insulin secretion/sensitivity relation in 3 ethnic groups: Severe B-cell defect in those with impaired glucose tolerance. Diabetes 1998; under review.
9. Buchanan, TA., Xiang, A., Kjos, SL., et al. Gestational diabetes: Antepartum characteristics that predict postpartum glucose intolerance and type 2 diabetes in Latino women. Diabetes 1998; 47: 1302–1310.
10. Laakso, M., Edelman, SV., Brechtel, G., et al. Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. J Clin Invest 1990; 85: 1844–1852.
11. Utriainen, T., Nuutila, P., Takala, T., et al. Intact insulin stimulation of skeletal muscle blood flow, its heterogeneity and redistribution, but not of glucose uptake in non-insulin-dependent diabetes mellitus. J Clin Invest 1997; 100: 777–785.
12. Zeng, G., Quon, MJ. Insulin-stimulated production of nitric oxide is inhibited by wortmannin: Direct measurement in vascular endothelial cells. J Clin Invest 1996; 98: 894–898.
13. Ciaraldi, TP., Olefsky, JM. Kinetic relationships between insulin receptor binding and effects on glucose transport in isolated rat adipocytes. Biochemistry 1982; 21: 3475–3480.
14. Bradley, DC., Poulin, RA., Bergman, RN. Dynamics of hepatic and peripheral insulin effects suggest common rate-limiting step in vivo. Diabetes 1993; 42: 296–306.
15. Yang, YJ., Hope, ID., Ader, M., et al. Dose-response relationship between lymph insulin and glucose uptake reveals enhanced insulin sensitivity of peripheral tissues. Diabetes 1992; 41; 241–253.
16. Poulin, RA., Steil, GM., Moore, DM., et al. Dynamics of glucose production and uptake are more closely related to insulin in hindlimb lymph than in thoracic duct lymph. Diabetes 1994; 43: 180–190.
17. King, GL. Johnson, SM. Receptor-mediated transport of insulin across endothelial cells. Science 1985; 227: 1583–1586.
18. Baura, GD., Foster, DM., Porte, D. Jr, et al. Saturable transport of insulin from plasma into the central nervous system of dogs in vivo: A mechanism for regulated insulin delivery to the brain. J Clin Invest 1993; 92: 1824–1830.
19. Steil, GM., Ader, M., Moore, DM., et al. Transendothelial insulin transport is not saturable in vivo: No evidence for a receptor-mediated process. J Clin Invest 1996; 97: 1497–1503.
20. Hamilton-Wessler, M., Ader, M., Dea, MK., et al. Interstitial appearance of fatty acid acylated insulin, NN304, in dogs is independent of ambient insulin: Evidence for passive diffusion. J Clin Invest 1998; under review.
21. Ader, M., Richey, JM., Bergman, RN. Evidence for direct action of alloxan to induce insulin resistance at the cellular level. Diabetologia 1998; in press.
22. Miles, PD., Li, S., Hart, M., et al. Mechanisms of insulin resistance in experimental hyperinsulinemic dogs. J Clin Invest 1998; 101: 202–211.
23. 123I]Insulin metabolism in normal rats and humans: external detection by a scintillation camera. Science 1983; 219: 865–867.
24. Levine, R., Fritz, IB. The relation of insulin to liver metabolism. Diabetes 1956; 5: 209–219.
25. Ader, M., Bergman, RN. Peripheral effects of insulin dominate suppression of fasting hepatic glucose production. Am J Physiol 1990; 258: E1020-E1032.
26. Rebrin, K., Steil, GM., Getty, L., et al. Free fatty acid as a link in the regulation of hepatic glucose output by peripheral insulin. Diabetes 1995; 44: 1038–1045.
27. Rebrin, K., Steil, GM., Mittelman, SD., et al. Causal linkage between insulin suppression of lipolysis and suppression of liver glucose output in dogs. J Clin Invest 1996; 98: 741–749.
28. Mittelman, SD., Fu, YY. Sympathetic response uncouples free fatty acids from endogenous glucose output. Diabetes 1998; 47: A28 (abst).
29. Groop, LC., Saloranta, C., Shank, M., et al. The role of free fatty acid metabolism in the pathogenesis of insulin resistance in obesity and noninsulindependent diabetes mellitus. J Clin Endocrinol Metab 1991; 72: 96–107.
30. Boden, G., Jadali, F. Effects of lipid on basal carbohydrate metabolism in normal men. Diabetes 1991; 40: 686–692.
31. DeFronzo, RA. Lilly Lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM. [Review] [210 refs]. Diabetes 1988; 37: 667–687.
32. Stein, DT., Esser, V., Stevenson, BE., et al. Essentiality of circulating fatty acids for glucose-stimulated insulin secretion in the fasted rat. J Clin Invest 1996; 97: 2728–2735.
33. Randle, PJ., Hales, CN., Garland, PB., et al. The glucose fatty-acid cycle: its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1963; i: 785–789.
34. Randle, PJ., Priestman, DA., Mistry, SC., et al. Glucose fatty acid interactions and the regulation of glucose disposal. J Cell Biochem 1994; 55S: 1–11.
35. McGarry, JD. Disordered metabolism in diabetes: Have we underemphasized the fat component? J Cell Biochem 1994; 55S: 29–38.
36. Lillioja, S., Bogardus, C. Obesity and insulin resistance: lessons learned from the Pima Indians. Diabetes Metab Rev 1988; 4: 517–540.
37. O'Shaughnessy, IM., Myers, TJ., Stepniakowski, KT., et al. Glucose metabolism in abdominally obese hypertensive and normotensive subjects. Hypertension 1995; 26: 186–192.
38. Zavaroni, I., Bonini, L., Fantuzzi, M., et al. Hyperinsulinaemia, obesity, and syndrome X. J Intern Med 1994; 235: 51–56.
39. Golay, A., Chen, N., Chen, YD., et al. Effect of central obesity on regulation of carbohydrate metabolism in obese patients with varying degrees of glucose tolerance. J Clin Endocrinol Metab 1990; 71: 1299–1304.
40. Baier, LJ., Sacchettini, JC., Knowler, WC., et al. An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation, and insulin resistance. J Clin Invest 1995; 95: 1281–1287.