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Volumn 18, Issue 6, 1997, Pages 573-580

Abnormalities in Alzheimer's disease fibroblasts bearing the APP670/671 mutation

Author keywords

ketoglutarate dehydrogenase; Alzheimer's disease; Amyloid precursor protein; Bombesin; Bradykinin; Calcium; Fibroblasts; Signal transduction

Indexed keywords

AMYLOID PRECURSOR PROTEIN; BOMBESIN; BRADYKININ; CALCIUM; OXOGLUTARATE DEHYDROGENASE;

EID: 0031470172     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-4580(97)00149-8     Document Type: Article
Times cited : (48)

References (46)
  • 1
    • 0027988641 scopus 로고
    • A large Swedish family with Alzheimer's disease with a codon 670/671 amyloid precursor protein mutation: A clinical and genealogical investigation
    • Axelman K., Basun H., Winblad B., Lannfelt L. A large Swedish family with Alzheimer's disease with a codon 670/671 amyloid precursor protein mutation A clinical and genealogical investigation . Arch. Neurol. 51:1994;1193-1197.
    • (1994) Arch. Neurol. , vol.51 , pp. 1193-1197
    • Axelman, K.1    Basun, H.2    Winblad, B.3    Lannfelt, L.4
  • 2
    • 0344852277 scopus 로고    scopus 로고
    • Inherent abnormalities in oxidative metabolism in AD: Interaction with vascular abnormalities
    • In: de la Torre, J. C.; Hachinski, V. eds. New York: New York Academy of Sciences; (In press).
    • Blass, J. P.; Sheu, K. -F. R.; Piaciantini, S.; Sorbi, S. Inherent abnormalities in oxidative metabolism in AD: Interaction with vascular abnormalities. In: de la Torre, J. C.; Hachinski, V. eds. Cerebrovasular Pathology in Alzheimer's Disease. New York: New York Academy of Sciences; 1997 (In press).
    • (1997) Cerebrovasular Pathology in Alzheimer's Disease
    • Blass, J.P.1    Sheu, K.-F.R.2    Piaciantini, S.3    Sorbi, S.4
  • 5
    • 0000936455 scopus 로고
    • A standard procedure for cultivating human diploid fibroblast like cells to study cellular aging
    • Cristofalo V. J., Charpentier R. A standard procedure for cultivating human diploid fibroblast like cells to study cellular aging. J. Tiss. Cult. Meth. 3117-121.
    • (1980) J. Tiss. Cult. Meth. , vol.34 , pp. 117-121
    • Cristofalo, V.J.1    Charpentier, R.2
  • 8
    • 0028200649 scopus 로고
    • Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative
    • Gabuzda D., Busciglio J., Chen L. B., Matsudaira P., Yankner B. A. Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative. J. Biol. Chem. 269:1994;13623-13628.
    • (1994) J. Biol. Chem. , vol.269 , pp. 13623-13628
    • Gabuzda, D.1    Busciglio, J.2    Chen, L.B.3    Matsudaira, P.4    Yankner, B.A.5
  • 10
    • 0023732664 scopus 로고
    • Reduced activities of thiamine-dependent enzymes in brains and peripheral tissues of Alzheimer patients
    • Gibson G. E., Sheu K-F. R., Blass J. P., Baker A., Carlson K. C., Harding B., Perrino P. Reduced activities of thiamine-dependent enzymes in brains and peripheral tissues of Alzheimer patients. Arch. Neurol. 45:1988;836-840.
    • (1988) Arch. Neurol. , vol.45 , pp. 836-840
    • Gibson, G.E.1    Sheu K-F., R.2    Blass, J.P.3    Baker, A.4    Carlson, K.C.5    Harding, B.6    Perrino, P.7
  • 13
  • 14
    • 0030891662 scopus 로고    scopus 로고
    • Alzheimer' PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid β-peptide
    • Guo Q., Katsutosh F., Sopher B. L., Pham D. G., Robinson N., Martin G. M., Mattson M. P. Alzheimer' PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid β-peptide. NeuroReport. 8:1996;379-383.
    • (1996) NeuroReport , vol.8 , pp. 379-383
    • Guo, Q.1    Katsutosh, F.2    Sopher, B.L.3    Pham, D.G.4    Robinson, N.5    Martin, G.M.6    Mattson, M.P.7
  • 15
    • 0028866435 scopus 로고
    • The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway
    • Haass C., Lemere C. A., Capell A., Citron M., Seubert P., Schenk D., Lannfelt L., Selkoe D. J. The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway. Nature Med. 1:1995;1291-1296.
    • (1995) Nature Med. , vol.1 , pp. 1291-1296
    • Haass, C.1    Lemere, C.A.2    Capell, A.3    Citron, M.4    Seubert, P.5    Schenk, D.6    Lannfelt, L.7    Selkoe, D.J.8
  • 16
    • 0023884115 scopus 로고
    • Inhibitory effects of aminoglycosides on renal protein phosphorylation by protein kinase C
    • Hagiwara M., Inagaki M., Kanamura K., Ohta H., Hidaka H. Inhibitory effects of aminoglycosides on renal protein phosphorylation by protein kinase C. J. Pharmacol. Exp. Ther. 244:1988;355-360.
    • (1988) J. Pharmacol. Exp. Ther. , vol.244 , pp. 355-360
    • Hagiwara, M.1    Inagaki, M.2    Kanamura, K.3    Ohta, H.4    Hidaka, H.5
  • 17
    • 0021893597 scopus 로고
    • 2+ in pyruvate dehydrogenase interconversion in brain mitochondria and synaptosomes
    • 2+ in pyruvate dehydrogenase interconversion in brain mitochondria and synaptosomes. Biochem. J. 227:1985;129-136.
    • (1985) Biochem. J. , vol.227 , pp. 129-136
    • Hansford, R.G.1    Castro, F.2
  • 19
    • 0021219068 scopus 로고
    • Effect of aminoglycoside antibiotics on cellular functions of kidney epithelial cell line (LLC-PK1): A model system for aminoglycoside nephrotoxicity
    • Hori R., Yamamoto K., Saito H., Kohno M., Inui K. Effect of aminoglycoside antibiotics on cellular functions of kidney epithelial cell line (LLC-PK1) A model system for aminoglycoside nephrotoxicity . J. Pharmacol. Exp. Ther. 230:1984;724-728.
    • (1984) J. Pharmacol. Exp. Ther. , vol.230 , pp. 724-728
    • Hori, R.1    Yamamoto, K.2    Saito, H.3    Kohno, M.4    Inui, K.5
  • 20
    • 0029994529 scopus 로고    scopus 로고
    • Aminoglycoside antibiotics restore CFTR function by overcoming premature stop mutations
    • Howard M., Frizzell R. A., Bedwell D. M. Aminoglycoside antibiotics restore CFTR function by overcoming premature stop mutations. Nature Med. 2:1996;467-469.
    • (1996) Nature Med. , vol.2 , pp. 467-469
    • Howard, M.1    Frizzell, R.A.2    Bedwell, D.M.3
  • 21
    • 0027244664 scopus 로고
    • Altered β-adrenergic receptor stimulated cAMP formation in cultured skin fibroblasts from Alzheimer donors
    • Huang, H. -M.; Gibson, G. E. Altered β-adrenergic receptor stimulated cAMP formation in cultured skin fibroblasts from Alzheimer donors. J. Biol. Chem. 268:14616-1462; 1993.
    • (1993) J. Biol. Chem. , vol.268 , pp. 14616-14626
    • Huang, H.-M.1    Gibson, G.E.2
  • 22
    • 0028830626 scopus 로고
    • Increased insitol(1,4,5)trisphosphate accumulation correlates with an upregulation of bradykinin receptors in Alzheimer's disease
    • Huang H. -M., Lin T. A., Sun G. Y., Gibson G. E. Increased insitol(1,4,5)trisphosphate accumulation correlates with an upregulation of bradykinin receptors in Alzheimer's disease. J. Neurochem. 64:1995;761-766.
    • (1995) J. Neurochem. , vol.64 , pp. 761-766
    • Huang H., -M.1    Lin, T.A.2    Sun, G.Y.3    Gibson, G.E.4
  • 23
    • 0028661101 scopus 로고
    • The use of cultured fibroblasts in elucidating the pathophysiology and diagnosis of Alzheimer's disease
    • J.F. Disterhoft, W.H. Gispen, J. Traber, & Z.S. Khachaturian. New York: New York Academy of Science
    • Huang H. -M., Martins R., Gandy S., Etcheberrigaray R., Ito E., Alkon D. L., Blass J. P., Gibson G. E. The use of cultured fibroblasts in elucidating the pathophysiology and diagnosis of Alzheimer's disease. Disterhoft J. F., Gispen W. H., Traber J., Khachaturian Z. S. Calcium Hypothesis of Aging and Dementia. 1994;225-244 New York Academy of Science, New York.
    • (1994) Calcium Hypothesis of Aging and Dementia , pp. 225-244
    • Huang H., -M.1    Martins, R.2    Gandy, S.3    Etcheberrigaray, R.4    Ito, E.5    Alkon, D.L.6    Blass, J.P.7    Gibson, G.E.8
  • 25
    • 0028171524 scopus 로고
    • Increased beta-amyloid release and levels of amyloid precursor protein (APP) in fibroblast cell lines from family members with the Swedish Alzheimer's disease APP670/671 mutation
    • Johnston J. A., Cowburn R. F., Norgren S., Wiehager B., Venizelos N., Winblad B., Vigo-Pelfrey C., Schenk D., Lannfelt L., O'Neill C. Increased beta-amyloid release and levels of amyloid precursor protein (APP) in fibroblast cell lines from family members with the Swedish Alzheimer's disease APP670/671 mutation. FEBS Letters. 354:1994;274-278.
    • (1994) FEBS Letters , vol.354 , pp. 274-278
    • Johnston, J.A.1    Cowburn, R.F.2    Norgren, S.3    Wiehager, B.4    Venizelos, N.5    Winblad, B.6    Vigo-Pelfrey, C.7    Schenk, D.8    Lannfelt, L.9    O'Neill, C.10
  • 28
    • 0028245164 scopus 로고
    • Mitochondria from Alzheimer's fibroblasts show decreased uptake of calcium and increased sensitivity to free radicals
    • Kumar U., Dunlop D. M., Richardson J. S. Mitochondria from Alzheimer's fibroblasts show decreased uptake of calcium and increased sensitivity to free radicals. Life Science. 54:1994;1855-1860.
    • (1994) Life Science , vol.54 , pp. 1855-1860
    • Kumar, U.1    Dunlop, D.M.2    Richardson, J.S.3
  • 29
    • 0022972426 scopus 로고
    • Brain alpha-ketoglutarate dehydrogenase complex: Kinetic properties, regional distribution, and effects of inhibitors
    • Lai J. C., Cooper A. J. Brain alpha-ketoglutarate dehydrogenase complex Kinetic properties, regional distribution, and effects of inhibitors . J. Neurochem. 47:1986;11376-11386.
    • (1986) J. Neurochem. , vol.47 , pp. 11376-11386
    • Lai, J.C.1    Cooper, A.J.2
  • 33
    • 0028650421 scopus 로고
    • Calcium and neuronal injury in Alzheimer's disease Contributions of beta-amyloid precursor protein mismetabolism, free radicals, and metabolic compromise
    • Mattson M. P. Calcium and neuronal injury in Alzheimer's disease Contributions of beta-amyloid precursor protein mismetabolism, free radicals, and metabolic compromise. Ann. NY Acad. Sci. 747:1994;50-76.
    • (1994) Ann. NY Acad. Sci. , vol.747 , pp. 50-76
    • Mattson, M.P.1
  • 34
    • 0026907151 scopus 로고
    • A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid
    • Mullan M., Crawford F., Axelman K., Houlden H., Lilius L., Winblad B., Lannfelt L. A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid. Nature Genetics. 1:1992;345-347.
    • (1992) Nature Genetics , vol.1 , pp. 345-347
    • Mullan, M.1    Crawford, F.2    Axelman, K.3    Houlden, H.4    Lilius, L.5    Winblad, B.6    Lannfelt, L.7
  • 35
    • 0022001659 scopus 로고
    • Altered calcium uptake in cultured skin fibroblasts from patients with Alzheimer's disease
    • Peterson C., Gibson G. E., Blass J. P. Altered calcium uptake in cultured skin fibroblasts from patients with Alzheimer's disease. N. Engl. J. Med. 312:1985;1063-1064.
    • (1985) N. Engl. J. Med. , vol.312 , pp. 1063-1064
    • Peterson, C.1    Gibson, G.E.2    Blass, J.P.3
  • 36
    • 0343050763 scopus 로고
    • Alterations in calcium content and biochemical processes in cultured skin fibroblasts from aged and Alzheimer donors
    • Peterson C., Goldman J. Alterations in calcium content and biochemical processes in cultured skin fibroblasts from aged and Alzheimer donors. Proc. Natl. Acad. Sci. USA. 83:1986;2758-2762.
    • (1986) Proc. Natl. Acad. Sci. USA. , vol.83 , pp. 2758-2762
    • Peterson, C.1    Goldman, J.2
  • 37
    • 0025237291 scopus 로고
    • Alteration of intracellular fura-2 fluorescence by viscosity: A simple correction
    • Poenie M. Alteration of intracellular fura-2 fluorescence by viscosity A simple correction . Cell Calcium. 11:1990;85-91.
    • (1990) Cell Calcium , vol.11 , pp. 85-91
    • Poenie, M.1
  • 38
    • 0027997404 scopus 로고
    • Decrease in calcium currents induced by aminoglycoside antibiotics in frog motor nerve endings
    • Redman R. S., Silinsky E. M. Decrease in calcium currents induced by aminoglycoside antibiotics in frog motor nerve endings. Br. J. Pharm. 113:1994;375-378.
    • (1994) Br. J. Pharm. , vol.113 , pp. 375-378
    • Redman, R.S.1    Silinsky, E.M.2
  • 39
    • 0028204224 scopus 로고
    • Calcium ionophore increases amyloid beta peptide production by cultured cells
    • Querfurth H. W., Selkoe D. J. Calcium ionophore increases amyloid beta peptide production by cultured cells. Biochem. 33:1994;4550-4561.
    • (1994) Biochem. , vol.33 , pp. 4550-4561
    • Querfurth, H.W.1    Selkoe, D.J.2
  • 40
    • 0028978471 scopus 로고
    • Beta APP mRNA transcription is increased in cultured fibroblasts from the familial Alzheimer's disease-1 family
    • Querfurth H. W., Wijsman E. M., St. George-Hyslop P. H., Selkoe D. J. Beta APP mRNA transcription is increased in cultured fibroblasts from the familial Alzheimer's disease-1 family. Mol. Brain Res. 28:1995;319-337.
    • (1995) Mol. Brain Res. , vol.28 , pp. 319-337
    • Querfurth, H.W.1    Wijsman, E.M.2    St. George-Hyslop, P.H.3    Selkoe, D.J.4
  • 42
    • 0028387219 scopus 로고
    • Abnormality of the α-ketaglutarate dehydrogenase complex in fibroblasts from familial Alzheimer's disease
    • Sheu K. -F. R., Cooper A. J. L., Koike K., Koike M., Linsday J. G., Blass J. P. Abnormality of the α-ketaglutarate dehydrogenase complex in fibroblasts from familial Alzheimer's disease. Ann. Neurol. 35:1994;312-318.
    • (1994) Ann. Neurol. , vol.35 , pp. 312-318
    • Sheu K. -F., R.1    Cooper, A.J.L.2    Koike, K.3    Koike, M.4    Linsday, J.G.5    Blass, J.P.6
  • 44
    • 0024467607 scopus 로고
    • Reduced protein kinase C immunoreactivity and altered protein phosphorylationin Alzheimer's disease fibroblasts
    • VanHuynh T., Cole G., Katzman R., Huang K. P., Saitoh T. Reduced protein kinase C immunoreactivity and altered protein phosphorylationin Alzheimer's disease fibroblasts. Arch. Neurol. 46:1989;1195-1199.
    • (1989) Arch. Neurol. , vol.46 , pp. 1195-1199
    • Vanhuynh, T.1    Cole, G.2    Katzman, R.3    Huang, K.P.4    Saitoh, T.5
  • 45
    • 0000670303 scopus 로고
    • Protein kinase C levels and activity in cultured skin fibroblasts from affected and nonaffected of the Swedish family with the amyloid precursor protein 670/671 mutation
    • Vestling, M.; Adem, A.; Lannfelt, L.; Cowburn, R. F. Protein kinase C levels and activity in cultured skin fibroblasts from affected and nonaffected of the Swedish family with the amyloid precursor protein 670/671 mutation. Soc. Neurosci. Abst. 25:744.14; 1995.
    • (1995) . Soc. Neurosci. Abst. , vol.25 , Issue.14 , pp. 744
    • Vestling, M.1    Adem, A.2    Lannfelt, L.3    Cowburn, R.F.4
  • 46
    • 0030848152 scopus 로고    scopus 로고
    • Differential regulation of adenylyl cyclase activity in fibroblasts from sporadic and familial Alzheimer's disease cases with PS-1 and Swedish APP mutations
    • Vestling M., Adem A., Racchi M., Govoni S., Lannfelt L., Gibson G. E., Cowburn R. F. Differential regulation of adenylyl cyclase activity in fibroblasts from sporadic and familial Alzheimer's disease cases with PS-1 and Swedish APP mutations. Neuroreport. 8:1997;2031-2035.
    • (1997) Neuroreport , vol.8 , pp. 2031-2035
    • Vestling, M.1    Adem, A.2    Racchi, M.3    Govoni, S.4    Lannfelt, L.5    Gibson, G.E.6    Cowburn, R.F.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.