Down regulation of oxidative phosphorylation in Alzheimer disease: Loss of cytochrome oxidase subunit mRNA in the hippocampus and entorhinal cortex

Brain Research

Volumn 796, Issue 1-2, 1998, Pages 13-19

  Chandrasekaran, Krish ^a   Hatanpää, Kimmo ^a   Brady, Daniel R ^a   Stoll, James ^a   Rapoport, Stanley I ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Mitochondria; Mitochondrial DNA; Mutation; Neuritic plaque; Neurofibrillary tangles; Neuronal activity; Oxidative damage; Synapse

Indexed keywords

CYTOCHROME C OXIDASE; MESSENGER RNA;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; CONTROLLED STUDY; DENTATE GYRUS; ENTORHINAL CORTEX; ENZYME ACTIVITY; ENZYME SUBUNIT; FEMALE; GENE EXPRESSION; HIPPOCAMPUS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IN SITU HYBRIDIZATION; MALE; NEUROFIBRILLARY TANGLE; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; PRIORITY JOURNAL; SENILE PLAQUE; TISSUE DISTRIBUTION; GENETICS; IMMUNOHISTOCHEMISTRY; METABOLISM; MIDDLE AGED; PATHOLOGY; REFERENCE VALUE;

AGED; ALZHEIMER DISEASE; ELECTRON TRANSPORT COMPLEX IV; ENTORHINAL CORTEX; FEMALE; HIPPOCAMPUS; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MALE; MIDDLE AGED; OXIDATIVE PHOSPHORYLATION; REFERENCE VALUES; RNA, MESSENGER;

EID: 0032525344     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(98)00248-0     Document Type: Article

References (48)

1. Abe K., Kawagoe J., Kogure K. Early disturbance of a mitochondrial DNA expression in gerbil hippocampus after transient forebrain ischemia. Neurosci. Lett. 153:1993;173-176.
2. Anderson S., Bankier A.T., Barrell B.G., de Bruijn M.H.L., Coulson A.R., Drouin J., Eperon I.C., Nierlich D.P., Roe B.A., Sanger F., Schreier P.H., Smith A.J.H., Staden R., Young I.G. Sequence and organization of the human mitochondrial genome. Nature. 290:1981;457-465.
3. Ball M.J., Nuttall K. Topography of neurofibrillary tangles and granulovacuoles in hippocampi of patients with Down's syndrome: quantitative comparison with normal aging and Alzheimer's disease. Neuropathol. Appl. Neurobiol. 7:1981;13-20.
4. Baudry M., Fuchs J., Kessler M., Arst D., Lynch G. Entorhinal cortex lesions induce a decreased calcium transport in hippocampal mitochondria. Science. 216:1982;411-413.
5. Borowsky I.W., Collins R.C. Metabolic anatomy of brain: a comparison of regional capillary density, glucose metabolism and enzyme activities. J. Comp. Neurol. 288:1989;401-413.
6. Borowsky I.W., Collins R.C. Histochemical changes in enzymes of energy metabolism in the dentate gyrus accompany deafferentation and synaptic reorganization. Neuroscience. 33:1989;253-262.
7. Brady D.R., Mufson E.J. Alz-50 immunoreactive neuropil differentiates hippocampal complex subfields in Alzheimer's disease. J. Comp. Neurol. 305:1991;489-507.
8. Capaldi R.A. Structure and function of cytochrome c oxidase. Annu. Rev. Biochem. 59:1990;569-596.
9. Chandrasekaran K., Stoll J., Giordano T., Atack J.R., Matocha M.F., Brady D.R., Rapoport S.I. Differential expression of cytochrome oxidase (COX) genes in different regions of monkey brain. J. Neurosci. Res. 32:1992;415-423.
10. Chandrasekaran K., Stoll J., Brady D.R., Rapoport S.I. Distribution of cytochrome oxidase (COX) activity and mRNA in monkey and human brain. COX mRNA distribution correlates with neurons vulnerable to Alzheimer pathology. Soc. Neurosci. 18:1992;557.
11. Chandrasekaran K., Stoll J., Brady D.R., Rapoport S.I. Localization of cytochrome oxidase (COX) activity and COX mRNA in the hippocampus and entorhinal cortex of the monkey brain: correlation with specific neuronal pathways. Brain Res. 579:1993;333-336.
12. Chandrasekaran K., Stoll J., Rapoport S.I., Brady D.R. Localization of cytochrome oxidase (COX) activity and COX mRNA in the perirhinal and superior temporal sulci of the monkey brain. Brain Res. 606:1993;213-219.
13. Chandrasekaran K., Giordano T., Brady D.R., Stoll J., Martin L.J., Rapoport S.I. Impairment in mitochondrial cytochrome oxidase gene expression in Alzheimer disease. Mol. Brain Res. 24:1994;336-340.
14. Chandrasekaran K., Hatanpää K., Brady D.R., Rapoport S.I. Evidence for physiological downregulation of brain oxidative phosphorylation in Alzheimer's disease. Exp. Neurol. 142:1996;80-88.
15. Chandrasekaran K., Hatanpää K., Rapoport S.I., Brady D.R. Decreased expression of nuclear and mitochondrial DNA-encoded genes of oxidative phosphorylation in association neocortex in Alzheimer disease. Mol. Brain Res. 44:1997;99-104.
16. Davis R.E., Miller S., Herrnstadt C., Ghosh S.S., Fahy E., Shinobu L.A., Galasko D., Thal L.J., Beal M.F., Howell N., Parker W.D. Jr. Mutations in mitochondrial cytochrome c oxidase genes segregate with late-onset Alzheimer disease. Proc. Natl. Acad. Sci. U.S.A. 94:1997;4526-4531.
17. DeKosky S.T., Scheff S.W. Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity. Ann. Neurol. 27:1990;457-464.
18. Frackowiak R.S., Herold S., Petty R.K.H., Morgan-Hughes J.A. The cerebral metabolism of glucose and oxygen measured with positron tomography in patients with mitochondrial diseases. Brain. 111:1988;1009-1024.
19. Frackowiak R.S.J., Pozzilli C., Legg N.J., Du Boulay G.H., Marshall J., Lenzi G.L., Jones T. Regional cerebral oxygen supply and utilization in dementia. A clinical and physiological study with oxygen-15 and positron tomography. Brain. 104:1981;753-778.
20. Fukuyama R., Hatanpää K., Rapoport S.I., Chandrasekaran K. Gene expression of ND4, a subunit of complex I of oxidative phosphorylation in mitochondria, is decreased in temporal cortex of brains of Alzheimer's disease patients. Brain Res. 713:1996;290-293.
21. Gomez-Isla T., Price J., McKeel D.W. Jr., Morris J.C., Growdon J.H., Hyman B.T. Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease. J. Neurosci. 16:1996;4491-4500.
22. Guntern R., Bouras C., Hof P.R., Vallet P.G. An improved thioflavine S method for staining neurofibrillary tangles and senile plaques in Alzheimer's disease. Experientia. 48:1992;8-10.
23. Hatanpää K., Brady D.R., Stoll J., Rapoport S.I., Chandrasekaran K. Neuronal activity and early neurofibrillary tangles in Alzheimer disease. Ann. Neurol. 40:1996;411-420.
24. Hatefi Y. The mitochondrial electron transport and oxidative phosphorylation system. Annu. Rev. Biochem. 54:1985;1015-1069.
25. Heddi A., Lestienne P., Wallace D.C., Stepien G. Mitochondrial DNA expression in mitochondrial myopathies and coordinated expression of nuclear genes involved in ATP production. J. Biol. Chem. 268:1993;12156-12163.
26. Hevner R.F., Wong-Riley M.T.T. Neuronal expression of nuclear and mitochondrial genes for cytochrome oxidase (CO) subunits analyzed by in situ hybridization: comparison with CO activity and protein. J. Neurosci. 11:1991;1942-1958.
27. Hevner R.F., Wong-Riley M.T.T. Mitochondrial and nuclear gene expression for cytochrome oxidase subunits are disproportionally regulated by functional activity in neurons. J. Neurosci. 13:1993;1805-1819.
28. Hirano M., Shtilbans A., Mayeux R., Davidson M.M., DiMauro S., Knowles J.A., Schon E.A. Apparent mtDNA heteroplasmy in Alzheimer's disease patients and in normals due to PCR amplification of nucleus-embedded mtDNA pseudogenes. Proc. Natl. Acad. Sci. U.S.A. 94:1997;14894-14899.
29. Horton J.C., Hubel D.H. Regular patchy distribution of cytochrome oxidase staining in primary visual cortex of macaque monkey. Nature. 292:1981;762-764.
30. Hyman B.T., Van Hoesen G.W., Damasio A.R., Barnes C.L. Alzheimer's disease: cell-specific pathology isolates the hippocampal formation. Science. 225:1984;1168-1170.
31. Hyman B.T., Kromer L.J., Van Hoesen G.W. A direct demonstration of the perforant pathway terminal zone in Alzheimer's disease using the monoclonal antibody Alz-50. Brain Res. 450:1988;392-397.
32. Kadenbach B., Kunh-Nentwig L., Buge U. Evolution of a regulatory enzyme: cytochrome-c-oxidase (complex IV). Curr. Top. Bioenerg. 15:1987;113-161.
33. Kageyama G.H., Wong-Riley M.T.T. Histochemical localization of cytochrome oxidase in the hippocampus: correlation with specific neuronal types and afferent pathways. Neuroscience. 7:1982;2337-2361.
34. Khachaturian Z.S. Diagnosis of Alzheimer's disease. Arch. Neurol. 42:1985;1097-1105.
35. Mentis M.J., Horwitz B., Grady C.L., Alexander G.E., Vanmeter J.W., Maisog J.M., Pietrini P., Schapiro M.B., Rapoport S.I. Visual cortical dysfunction in Alzheimer's disease evaluated with a temporally graded 'stress test' during PET. Am. J. Psychiatry. 153:1996;32-40.
36. Rapoport S.I., Grady C.L. Parametric in vivo brain imaging during activation to examine pathological mechanisms of functional failure in Alzheimer disease. Int. J. Neurosci. 70:1993;39-56.
37. Rapoport S.I., Hatanpää K., Brady D.R., Chandrasekaran K. Brain energy metabolism, cognitive function, and down-regulated oxidative phosphorylation in Alzheimer disease. J. Neurodegeneration. 5:1997;473-476.
38. Scheff S.W., Sparks D.L., Price D.A. Quantitative assessment of synaptic density in the entorhinal cortex in Alzheimer's disease. Ann. Neurol. 34:1993;356-361.
39. Simonian N.A., Hyman B.T. Functional alterations in Alzheimer's disease: Diminution of cytochrome oxidase in the hippocampal formation. J. Neuropathol. Exp. Neurol. 52:1993;580-585.
40. Simonian N.A., Hyman B.T. Functional alterations in Alzheimer's disease: selective loss of mitochondrial-encoded cytochrome oxidase mRNA in the hippocampal formation. J. Neuropathol. Exp. Neurol. 53:1994;508-512.
41. Sze C.I., Troncoso J.C., Kawas C., Mouton P., Price D.L., Martin L.J. Loss of presynaptic vesicle protein synaptophysin in hippocampus correlates with cognitive decline in Alzheimer disease. J. Neuropathol. Exp. Neurol. 56:1997;933-944.
42. Vale R.D., Schnapp B.J., Reese T.S., Sheetz M.P. Movement of organelles along filaments dissociated from the axoplasm of the squid giant axon. Cell. 40:1985;449-454.
43. Van Hoesen G.W. The parahippocampal gyrus: new observations regarding its cortical connections in the monkey. Trends Neurosci. 5:1982;345-350.
44. Van Hoesen G.W., Hyman B.T., Damasio A.R. Entorhinal cortex pathology in Alzheimer's disease. Hippocampus. 1:1991;1-8.
45. Wolozin B.L., Pruchnicki A., Dickson D.W., Davies P.A. A neuronal antigen in the brains of Alzheimer patients. Science. 232:1986;648-650.
46. Wong-Riley M.T.T. Cytochrome oxidase: an endogenous metabolic marker for neuronal activity. Trends Neurosci. 12:1989;94-101.
47. Wong-Riley M.T.T., Merzenich M.M., Leake P.A. Changes in endogenous enzymatic reactivity to DAB induced by neuronal inactivity. Brain Res. 141:1978;185-192.
48. Yamamoto T., Hirano A.A. Comparative study of modified Bielschowsky, Bodian and thioflavin stains on Alzheimer's neurofibrillary tangles. Neuropath. Appl. Neurobiol. 12:1986;3-9.