The awesome power of multiple model systems: Interpreting the complex nature of spindle checkpoint signaling

Trends in Cell Biology

Volumn 12, Issue 5, 2002, Pages 205-209

  Millband, David N ^a   Campbell, Leigh ^a   Hardwick, Kevin G ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE; CENTROMERE; CYTOLOGY; HUMAN; MICROTUBULE; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; SISTER CHROMATID;

ANAPHASE; ANIMALS; HUMANS; KINETICS; METAPHASE; MICROTUBULES; MITOSIS; MITOTIC SPINDLE APPARATUS; MODELS, BIOLOGICAL; SIGNAL TRANSDUCTION; XENOPUS;

EID: 0036568815     PISSN: 09628924     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0962-8924(02)02276-6     Document Type: Review

References (41)

1. Waiting for anaphase: Mad2 and the spindle assembly checkpoint
2. The mitotic spindle checkpoint
3. Chromosome cohesion and segregation in mitosis and meiosis
4. The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores
5. Mammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochore-tension checkpoints
6. Kinetochore localisation and phosphorylation of the mitotic checkpoint components Bub1 and BubR1 are differentially regulated by spindle events in human cells
7. Mitotic forces control a cell-cycle checkpoint
8. How cells get the right chromosomes
9. Checkpoint signals in grasshopper meiosis are sensitive to microtubule attachment, but tension is still essential
10. Requirement of the spindle checkpoint for proper chromosome segregation in budding yeast meiosis
11. Lack of tension at kinetochores activates the spindle checkpoint in budding yeast
12. The budding yeast protein kinase Ipl1/Aurora allows the absence of tension to activate the spindle checkpoint
13. Evidence that the Ipl1-Sli15 (Aurora kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections
14. Spindle checkpoint protein Bub1 is required for kinetochore localization of Mad1, mad2, Bub3, and CENP-E, independently of its kinase activity
15. Cdc20 by the mitotic checkpoint protein BubR1
16. Mps1 is a kinetochore-associated kinase essential for the vertebrate mitotic checkpoint
17. Visualization of Mad2 dynamics at kinetochores, along spindle fibers, and at spindle poles in living cells
18. The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation
19. Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint
20. The mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either mad1 or cdc20
21. Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BubR1, Bub3, Cdc20, Mad2
22. The checkpoint protein BubRI acts synergistically with Mad2 to inhibit the anaphase promoting complex
23. Fission yeast Mad3p is required for Mad2p to inhibit the anaphase-promoting complex and localises to kinetochores in a Bub1p, Bub3p and Mph1p dependent manner
24. Bub3 interaction with Mad2, Mad3 and Cdc20 is mediated by WD40 repeats and does not require intact kinetochores
25. Role of the kinetochore protein Ndc10 in mitotic checkpoint activation in Saccharomyces cerevisiae
26. Inhibition of Cdh1-APC by the MAD2-related protein MAD2L2: A novel mechanism for regulating Cdh1
27. Cytoplasmic dynein/dynactin drives kinetochore protein transport to the spindle poles and has a role in mitotic spindle checkpoint inactivation
28. Spindle checkpoint protein Xmad1 recruits xmad2 to unattached kinetochores
29. Complex formation between Mad1p, Bub1p and Bub3p is crucial for spindle checkpoint function
30. Phosphorylation of human MAD1 by the BUB1 kinase in vitro
31. Mad1p, a phosphoprotein component of the spindle assembly checkpoint in budding yeast
32. MAD3 encodes a novel component of the spindle checkpoint which interacts with Bub3p, Cdc20p and Mad2p
33. Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20
34. Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2
35. MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells
36. The mitotic checkpoint protein hBUB3 and the mRNA export factor hRAE1 interact with GLEBS-containing proteins
37. Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC
38. CENP-E forms a link between attachment of spindle microtubules to kinetochores and the mitotic checkpoint
39. Bub3 gene disruption in mice reveals essential mitotic spindle checkpoint function during early embryogenesis
40. Activation of the budding yeast spindle assembly checkpoint without mitotic spindle disruption
41. The Saccharomyces cerevisiae spindle pole body duplication gene MPS1 is part of a mitotic checkpoint