PPARS: Transcription factors controlling lipid and lipoprotein metabolism

Annals of the New York Academy of Sciences

Volumn 967, Issue , 2002, Pages 7-18

  Bocher, Virginie ^a,b   Pineda Torra, Inés ^a,b   Fruchart, Jean Charles ^a,b   Staels, Bart ^a,b  

^a INSTITUT PASTEUR DE LILLE   (France)

^b UNIV LILLE   (France)

Author keywords

Fatty acids; Gene expression; Lipoprotein metabolism; Transcription factors

Indexed keywords

ABC TRANSPORTER; ACYL COENZYME A OXIDASE; ANTIDIABETIC AGENT; ANTILIPEMIC AGENT; APOLIPOPROTEIN A1; CCAAT ENHANCER BINDING PROTEIN; CD36 ANTIGEN; CELL NUCLEUS RECEPTOR; CHOLESTEROL; FATTY ACID BINDING PROTEIN; HYDROXYICOSATETRAENOIC ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LEUKOTRIENE B4; LIPID; LIPOPROTEIN; LONG CHAIN FATTY ACID COENZYME A LIGASE; OXIDIZED LOW DENSITY LIPOPROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; POLYUNSATURATED FATTY ACID; PROSTAGLANDIN; PROSTAGLANDIN J2 DERIVATIVE; RETINOID X RECEPTOR; STAT PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ATHEROSCLEROSIS; BILE ACID METABOLISM; CHOLESTEROL TRANSPORT; CONFERENCE PAPER; CORONARY ARTERY DISEASE; DIABETES MELLITUS; FOAM CELL; GENE EXPRESSION; GLUCOSE HOMEOSTASIS; HUMAN; LIGAND BINDING; LIPID METABOLISM; LIPOPROTEIN METABOLISM; RISK FACTOR; TISSUE DISTRIBUTION;

EID: 0036293873     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2002.tb04258.x     Document Type: Conference Paper

References (67)

1. Peroxisome proliferator-activated receptors: Nuclear control of metabolism
2. Peroxisome proliferator-activated receptor activators inhibit thrombin-induced endothelin-1 production in human vascular endothelial cells by inhibiting the activator protein-1 signaling pathway
3. Activation of human aortic smoothmuscle cells is inhibited by PPARα, but not by PPARγ activators
4. Activation of peroxisome proliferator-activated receptors α and γ induces apoptosis of human monocyte-derived macrophages
5. The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation
6. PPAR-γ agonists inhibit production of monocyte inflammatory cytokines
7. CLA-1/SR-BI is expressed in atherosclerotic lesion macrophages and regulated by activators of peroxisome proliferator-activated receptors
8. Macrophages in human atheroma contain PPARgamma: Differentiation-dependent peroxisomal proliferator-activated receptor gamma (PPARgamma) expression and reduction of MMP-9 activity through PPARgamma activation in mononuclear phagocytes in vitro
9. Peroxisome proliferator-activated receptor beta regulates acyl-CoA synthetase 2 in reaggregated rat brain cell cultures
10. A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport
11. Impaired skin wound healing in peroxisome proliferator-activated receptor (PPAR) alpha and PPAR beta mutant mice
12. Peroxisome-proliferator-activated receptor delta mediates the effects of long-chain fatty acids on post-confluent cell proliferation
13. Peroxisome proliferator-activated receptor delta (PPARdelta)-mediated regulation of preadipocyte proliferation and gene expression is dependent on cAMP signaling
14. Growth, adipose, brain, and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor beta(delta)
15. Induction of IkappaBalpha expression as a mechanism contributing to the anti-inflammatory activities of peroxisome proliferator-activated receptor-alpha activators
16. Negative regulation of human fibrinogen gene expression by peroxisome proliferator-activated receptor alpha agonists via inhibition of CCAAT box/enhancer-binding protein beta
17. Cross-talk between Janus kinase-signal transducer activator of transcription (JAK-STAT) and peroxisome proliferator-activated receptor α (PPARα) signaling pathways
18. Peroxisome proliferator-activated receptors: From transcriptional control to clinical practice
19. Albumin regulates induction of peroxisome proliferator-activated receptor-gamma (PPARgamma) by 15-deoxy-delta (12-14)-prostaglandin J(2) in vitro and may be an important regulator of PPARgamma function in vivo
20. Fatty acids and hypolipidemic drugs regulate peroxisome proliferator-activated receptors alpha- and gamma-mediated gene expression via liver fatty acid binding protein: A signaling path to the nucleus
21. Peroxisome proliferator-activated receptor agonists
22. PPAR: A key nuclear factor in nutrient/gene interactions
23. The PPARα-leukotriene B4 pathway to inflammation control
24. Oxidized phospholipids activate PPARα in a phospholipase A2-dependent manner
25. Oxidized LDL regulates macrophage gene expression through ligand activation of PPARγ
26. Binding of prostaglandins to human PPARgamma: Tool assessment and new natural ligands
27. Peroxisome proliferator-activated receptors α and γ are activated by indomethacin and other non-steroidal anti-inflammatory drugs
28. Fibrates downregulate apolipoprotein C-III expression independent of induction of peroxisomal acyl coenzyme A oxidase
29. The peroxisome proliferator activated receptors (PPARs) and their effects on lipid metabolism and adipocyte differentiation
30. Differential gene regulation in human versus rodent hepatocytes by peroxisome proliferator-activated receptor (PPAR) alpha: PPAR alpha fails to induce peroxisome proliferation-associated genes in human cells independently of the level of receptor expression
31. Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor alpha (PPARalpha)
32. Coordinate regulation of the expression of the fatty acid transport protein and acyl-CoA synthetase genes by PPARalpha and PPARgamma activators
33. Control of human muscle-type carnitine palmitoyltransferase I gene transcription by peroxisome proliferator-activated receptor
34. Fatty acids activate transcription of the muscle carnitine palmitoyltransferase I gene in cardiac myocytes via the peroxisome proliferator-activated receptor alpha
35. Co-regulation of tissue-specific alternative human carnitine palmitoyltransferase Ibeta gene promoters by fatty acid enzyme substrate
36. Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting
37. Differential involvement of peroxisome-proliferator-activated receptors alpha and delta in fibrate and fatty-acid-mediated inductions of the gene encoding liver fatty-acid-binding protein in the liver and the small intestine
38. PPARα and PPARγ activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene
39. Acyl-CoA synthetase mRNA expression is controlled by fibric-acid derivatives, feeding, and liver proliferation
40. Induction of the acyl-coenzyme A synthetase gene by fibrates and fatty acids is mediated by a peroxisome proliferator response element in the C promoter
41. Mechanism of action of fibrates on lipid and lipoprotein metabolism
42. Direct regulatory effect of fatty acids on macrophage lipoprotein lipase: Potential role of PPARs
43. PPARγ promotes monocyte/macrophage differentiation and uptake of oxidized LDL
44. The role of PPARγ in macrophage differentiation and cholesterol uptake
45. PPARγ dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation
46. Peroxisome proliferator-activated receptor γ ligands inhibit development of atherosclerosis in LDL receptor-deficient mice
47. Troglitazone inhibits formation of early atherosclerotic lesions in diabetic and nondiabetic low density lipoprotein receptor-deficient mice
48. Troglitazone inhibits atherosclerosis in apolipoprotein E-knockout mice: Pleiotropic effects on CD36 expression and HDL
49. The Tangier disease gene product ABC1 controls the cellular apolipoprotein-mediated lipid removal pathway
50. PPARCα and PPARγ activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway
51. Sterol-dependent transactivation of the human ABC1 promoter by LXR/RXR
52. Negative regulation of the human apolipoprotein A-I promoter by fibrates can be attenuated by the interaction of the peroxisome proliferator-activated receptor with its response element
53. The nuclear receptor peroxisome proliferator-activated receptors α and Rev-erbα mediate the species-specific regulation of apolipoprotein A-I expression by fibrates
54. Fibrates increase human apolipoprotein A-II expression through activation of the peroxisome proliferator-activated receptor
55. Activation of PPARdelta alters lipid metabolism in db/db mice
56. The peroxisome proliferator-activated receptor delta promotes lipid accumulation in human macrophages
57. Cross-talk between fatty acid and cholesterol metabolism mediated by liver X receptor-alpha
58. Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway
59. Regulation of cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRalpha)
60. Influence of bezafibrate on hepatic cholesterol metabolism in gallstone patients: Reduced activity of cholesterol 7alpha-hydroxylase
61. Effects of treatment with clofibrate, bezafibrate, and ciprofibrate on the metabolism of cholesterol in rat liver microsomes
62. Effects of different phenotypes of hyperlipoproteinemia and of treatment with fibric acid derivatives on the rates of cholesterol 7alpha-hydroxylation in humans
63. Peroxisome proliferator-activated receptor alpha (PPARalpha) and agonist inhibit cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription
64. The effect of peroxisome-proliferator-activated receptor-alpha on the activity of the cholesterol 7alpha-hydroxylase gene
65. The murine and human cholesterol 7alpha-hydroxylase gene promoters are differentially responsive to regulation by fatty acids mediated via peroxisome proliferator-activated receptor alpha
66. Fibrates suppress bile acid synthesis via peroxisome proliferator-activated receptor-alpha-mediated downregulation of cholesterol 7alpha-hydroxylase and sterol 27-hydroxylase expression
67. The peroxisome proliferator-activated receptor alpha (PPARalpha) regulates bile acid biosynthesis