Peroxisome proliferator-activated receptor activators inhibit thrombin- induced endothelin-1 production in human vascular endothelial cells by inhibiting the activator protein-1 signaling pathway

Circulation Research

Volumn 85, Issue 5, 1999, Pages 394-402

  Delerive, Philippe ^a,b   Martin Nizard, Françoise ^a,b   Chinetti, Giulia ^a,b   Trottein, François ^a   Fruchart, Jean Charles ^a,b   Najib, Jamila ^a,b   Duriez, Patrick ^a,b   Staels, Bart ^a,b  

^a INSTITUT PASTEUR DE LILLE   (France)

^b UNIV LILLE   (France)

Author keywords

Atherosclerosis; Endothelin; Endothelium; Peroxisome proliferator activated receptor; Thrombin

Indexed keywords

ENDOTHELIN 1; PEROXISOME PROLIFERATOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; THROMBIN; TRANSCRIPTION FACTOR AP 1;

ANIMAL CELL; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; CORONARY ARTERY; ENDOTHELIUM CELL; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; NONHUMAN; ONCOGENE C FOS; ONCOGENE C JUN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSACTIVATION; VASCULAR ENDOTHELIUM;

EID: 0033520304     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.85.5.394     Document Type: Article

References (46)

1. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature. 1993;362:801-809.
2. Komuro I, Kurihara H, Sugiyama T, Takaku F, Yazaki Y. Endothelin stimulates c-fos and c-myc expression and proliferation of vascular smooth muscle cells. FEBS Lett. 1988;238:249-252.
3. Yanagisawa M, Kurihara H, Kimura S, Tomobe Y, Kobayashi M, Mitsui Y, Yazaki Y, Goto K, Masaki T. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature. 1988;323:411-415.
4. Achmad TH, Rao GS. Chemotaxis of human blood monocytes toward endothelin-1 and the influence of calcium channel blockers. Biochem Biophys Res Commun. 1992;189:994-1000.
5. McCarron RM, Wang L, Stanimirovic DB, Spatz M. Endothelin induction of adhesion molecule expression on human brain microvascular endothelial cells. Neurosci Lett. 1993;156:31-34.
6. Lerman A, Edwards BS, Hallett JW, Heublein DM, Sandberg SM, Burnett JC. Circulating and tissue endothelin immunoreactivity in advanced atherosclerosis. N Engl J Med. 1991;325:997-1001.
7. Jones GT, Van Rij AM, Solomon C, Thomson IA, Packer SGK. Endothelin-1 is increased overlying atherosclerotic plaques in human arteries. Atherosclerosis. 1996;124:25-35.
8. Zeiher AM, Ihling C, Pistorius K, Schächinger V, Schaefer HE. Increased tissue endothelin immunoreactivity in atherosclerotic lesions associated with acute coronary syndromes. Lancet. 1994;344:1405-1406.
9. Marsen TA, Simonson MS, Dunn MJ. Thrombin induces the preproendothelin-1 gene in endothelial cells by a protein tyrosine kinase-linked mechanism. Circ Res. 1995;76:987-995.
10. Kohno M, Yasunari K, Yokokawa K, Murakawa K, Horio T, Kanayama Y, Fuzisawa M, Inoue T, Takeda T. Thrombin stimulates the production of immunoreactive endothelin-1 in cultured umbilical vein endothelial cells. Metabolism. 1990;39:1003-1005.
11. Kohno M, Yokokawa K, Horie T, Yasunari K, Murahawa K, Ikeda M, Takeda T. Release mechanism of endothelin-1 and big endothelin-1 after stimulation with thrombin in cultured porcine endothelial cells. J Vasc Res. 1992;29:56-63.
12. Madden PA, Brenner BM. Transcriptional regulation of endothelin-1 by tumor necrosis-α. Am J Physiol. 1992; 262:854-861.
13. Lamas S, Michel T, Collins T, Brenner BM, Marsden PA. Effects of interferon-γ on nitric oxide synthase activity and endothelin-1 production by vascular endothelial cells. J Clin Invest. 1992;90:879-887.
14. Morey AK, Razandi M, Pedram A, Hu RM, Prins BA, Levin ER. Oestrogen and progesterone inhibit the stimulated production of endothelin-1. Biochem J. 1998;330:1097-1105.
15. Lee ME, Dhadly MS, Temizer DH, Clifford JA, Yoshizum, M, Quertermous T. Regulation of endothelin-1 gene expression by Fos and Jun. J Biol Chem. 1991;266:19034-19039.
16. Kawana M, Lee M-E, Quertermous EE, Quertermous T. Cooperative interaction of GATA-2 and API regulates transcription of endothelin-1 gene. Mol Cell Biol. 1995;15:4225-4231.
17. Schüle R, Rangarajan P, Yang N, Kliewer S, Ransone LJ, Bolado J, Verma IM, Evans RM. Retinoic acid is a negative of AP-1 responsive genes. Proc Natl Acad Sci U S A. 1991;88:6092-6096.
18. Jonat C, Ramhsdorf HJ, Park KK, Cato AC, Gebel S, Ponta H, Herrlich P. Antitumor promotion and antiinflammation: down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone. Cell. 1990;62:1189-1204.
19. Issemann I, Green S. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature. 1990;347.
20. Shoonjans K, Staels B, Auwerx J. The peroxisome proliferator activated receptors (PPARs) and their effects on lipid metabolism and adipocyte differentiation. Biochim Biophvs Acta. 1996;1302:93-109.
21. Forman BM, Chen J, Evans RM. Hypolipidemic drugs, polyunsaurated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ. Proc Natl Acad Sci U S A. 1997;94:4312-4317.
22. 4 pathway to inflammation control. Nature. 1996: 384: 39-43.
23. Kliewer SA, Lenhard JM, Wilson TM, Patel I, Morris DC, Lehmann JM. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation. Cell. 1995;83: 803-812.
24. Lehmann JM, Moore LB, Smith-Oliver TA, Wilkison WO, Willson TM, Kliewer SA. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPARγ). J Biol Chem. 1995;270:12953-12956.
25. Tugwood JD, Issemann I, Anderson RG, Bundell KR, McPheat WL, Green S. The mouse peroxisome proliferator-activated receptor recognizes a response element in the 5′ flanking sequence of the rat acyl coA oxidase gene. EMBO J. 1992;11:433-439.
26. Staels B, Koenig W, Habib A, Merval R, Lebret M, Pineda-Torra I, Delerive P, Fadel A, Chinetti G, Fruchart JC, Najib J, Maclouf J, Tedgui A. Activation of human aortic smooth-muscle cells is inhibited by PPARα but not by PPARγ activators. Nature. 1998;393:790-793.
27. Ricote M, Li AC, Willson TM, Kelly CJ, Glass CK. The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation. Nature. 1998;391:79-82.
28. Jiang C, Ting AT, Seed B. PPAR-γ agonists inhibit production of monocyte inflammatory cytokines. Nature. 1998;391:82-86.
29. Gospodarowicz D, Moran J, Braun DJ, Birdwell C. Clonal growth of bovine vascular endothelial cells: fibroblast growth factor as a survival agent. Proc Natl Acad Sci U S A. 1976;73:4120-4124.
30. Ades EW, Candal FJ, Swerlick RA, George VG, Summers S, Bosse DC, Lawley TJ. HMEC-1: establishment of an immortalized human microvascular endothelial cell line. J Invest Dermatol. 1992;99:683-690.
31. Chinetti G, Griglio S, Antonucci M, Pineda Torra I, Delerive P, Majd Z, Fruchart JC, Chapman J, Najib J, Staels B. Activation of peroxisome proliferator activated receptors α and γ induces apoptosis of human monocyte-derived macrophages. J Biol Chem. 1998;273:25573-25580.
32. Chomczynski P, Sacchi N. Single step method for RNA isolation by acid guanidinium-thiocyanate-phenol-chloroform extraction. Anal Biochem. 1987;162:156-159.
33. Itoh Y, Yanagisawa M, Ohkubo S, Kimura C, Kosaka T, Inoue A, Ishida N, Mitsui Y, Onda H, Fujino M, Masaki T. Cloning and sequence analysis of cDNA encoding the precursor of human endothelium-derived vasoconstrictor peptide, endothelin: identity of human and porcine endothelin. FEBS Lett. 1988;231:440-444.
34. Dignam JP, Lebowitz RM, Roeder RG. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 1983;11:1475-1489.
35. Trejo J, Chambard JC, Karin M, Brown JH. Biphasic Increase in c-jun mRNA is required for induction of AP-1 mediated gene transcription: differential effects of muscarinic and thrombin receptor activation. Mol Cell Biol. 1992;12:4742-4750.
36. Inoue I, Shino K, Noji S, Awata T, Katayama S. Expression of peroxisome proliferator-activated receptor α (PPARα) in primary cultures of human vascular endothelial cells. Biochem Biophys Res Commun. 1998; 246:370-374.
37. Marx N, Bourcier T, Sukhova GK, Libby P, Plutzky J. PPARγ activation in human endothelial cells increases plasminogen activator inhibitor type-1 expression. Arterioscler Thromb Vasc Biol. 1999;19:546-551.
38. Marx N, Schönbeck U, Lazar MA, Libby P, Plutzky J. Peroxisome proliferator-activated receptor gamma activators inhibit gene expression and migration in human vascular smooth muscle cells. Circ Res. 1998; 83:1097-1103.
39. Tontonoz P, Nagy L, Alvarez JGA, Thomazy VA, Evans RM. PPARγ promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell. 1998;93:241-252.
40. Marx N, Sukhova G, Murphy C, Libby P, Plutzky J. Macrophages in human atheroma contain PPARγ. Am J Pathol. 1998;153:1-7.
41. Ricote M, Huang J, Fajas L, Li A, Welch J, Najib J, Witztum JL, Auwerx J, Palinski W, Glass CK. Expression of the peroxisome proliferator-activated receptor γ (PPARγ) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoproteins. Proc Natl Acad Sci U S A. 1998;95:7614-7619.
42. Boulanger C, Lüscher T. Release of endothelin from the porcine aorta. J Clin Invest. 1990;85:587-590.
43. Balfour JA, McTavish D, Heel RC. Fenofibrate, a review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in dyslipidaemia. Drugs. 1990;40:260-290.
44. Sakai M, Matsushima-Hibiya Y, Nishizawa M, Nishi S. Suppression of rat glutathione transferase P expression by peroxisome proliferators: interaction between Jun and peroxisome proliferator-activated receptor α. Cancer Res. 1995;53:5370-5376.
45. Hsu JY, Pfahl M. ET-1 expression and growth inhibition of prostate cancer cells: a retinoid target with novel specificity. Cancer Res. 1998; 58:4817-4822.
46. Caelles C, Gonzalez-Sancho JM, Munoz A. Nuclear hormone receptor antagonism with AP-1 by inhibition of the JNK pathway. Genes Dev. 1997;11:3351-3364.