DNA mismatch repair and mutation avoidance pathways

Journal of Cellular Physiology

Volumn 191, Issue 1, 2002, Pages 28-41

  Marti, Thomas M ^a   Kunz, Christophe ^a   Fleck, Oliver ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; DNA; DNA GLYCOSYLTRANSFERASE; DNA POLYMERASE; ENDONUCLEASE; HELICASE;

ANIMAL MODEL; COLORECTAL CANCER; DNA REPAIR; ENZYME ACTIVITY; ESCHERICHIA COLI; EXCISION REPAIR; FAMILIAL CANCER; GENE MUTATION; HUMAN; MISMATCH REPAIR; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REVIEW; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES POMBE; SEQUENCE HOMOLOGY;

ADENOSINE TRIPHOSPHATASES; ANIMALS; BACTERIAL PROTEINS; BASE PAIR MISMATCH; DNA REPAIR; DNA-BINDING PROTEINS; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; HUMANS; MUTATION; MUTS DNA MISMATCH-BINDING PROTEIN; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES;

ESCHERICHIA COLI; EUKARYOTA; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE; ZIZIPHUS MAURITIANA;

EID: 0036198664     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.10077     Document Type: Review

References (161)

1. hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6
2. The Saccharomyces cerevisiae Msh2 and Msh6 proteins form a complex that specifically binds to duplex oligonucleotides containing mismatched DNA base pairs
3. Genetic and biochemical analysis of Msh2p-Msh6p: Role of ATP hydrolysis and Msh2p-Msh6p subunit interactions in mismatch base pair recognition
4. Kinetic measurement of the step size of DNA unwinding by Escherichia coli UvrD helicase
5. MutS mediates heteroduplex loop formation by a translocation mechanism
6. Exo1-dependent mutator mutations: Model system for studying functional interactions in mismatch repair
7. Escherichia coli mutY gene product is required for specific A G to C G mismatch correction
8. Initiation of methyl-directed mismatch repair
9. Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis
10. Crystal structure and ATPase activity of MutL: Implications for DNA repair and mutagenesis
11. Structural basis for MutH activation in E. coli mismatch repair and relationship of MutH to restriction endonucleases
12. Transformation of MutL by ATP binding and hydrolysis: A switch in DNA mismatch repair
13. Role of MED1 (MBD4) gene in DNA repair and human cancer
14. MED1, a novel human methyl-CpG-binding endonuclease, interacts with DNA mismatch repair protein MLH1
15. Mutator phenotypes in human colorectal carcinoma cell lines
16. DNA mismatch repair catalyzed by extracts of mitotic, postmitotic, and senescent Drosophila tissues and involvement of mei-9 gene for full activity
17. Modulation of MutS ATP hydrolysis by DNA cofactors
18. Nucleotide-promoted release of hMutSα from heteroduplex DNA is consistent with an ATP-dependent translocation mechanism
19. hMYH cell cycle-dependent expression, subcellular localization and association with replication foci: Evidence suggesting replication-coupled repair of adenine:8-oxoguanine mispairs
20. A mutation in the MSH6 subunit of the Saccharomyces cerevisiae MSH2-MSH6 complex disrupts mismatch recognition
21. MSH-MLH complexes formed at a DNA mismatch are disrupted by the PCNA sliding clamp
22. In vivo requirement for RecJ, ExoVII, ExoI, and ExoX in methyl-directed mismatch repair
23. Mismatch repair, gene conversion, and crossing-over in two recombination-defective mutants of Drosophila melanogaster
24. Repair of heteroduplex DNA molecules with multibase loops in Escherichia coli
25. Exonuclease VII of Escherichia coli: Mechanism of action
26. Saccharomyces cerevisiae pol30 (proliferating cell nuclear antigen) mutations impair replication fidelity and mismatch repair
27. Purification and characterization of MSH1, a yeast mitochondrial protein that binds to DNA mismatches
28. Functional interaction of proliferating cell nuclear antigen with MSH2-MSH6 and MSH2-MSH3 complexes
29. Methyl-directed mismatch repair is bi-directional
30. Correction of large mispaired DNA loops by extracts of Saccharomyces cerevisiae
31. Efficient repair of large DNA loops in Saccharomyces cerevisiae
32. Evidence for short-patch mismatch repair in Saccharomyces cerevisiae
33. Arabidopsis MutS homologs-AtMSH2, AtMSH3, AtMSH6, and a novel AtMSH7-form three distinct protein heterodimers with different specificities for mismatched DNA
34. Evolutionary origin, diversification, and specialization of eukaryotic MutS homolog mismatch repair proteins
35. Mismatch-, MutS-, MutL-, and helicase II-dependent unwinding from the single-strand break of an incised heteroduplex
36. Mouse models for hereditary nonpolyposis colorectal cancer
37. HNPCC-like cancer predisposition in mice through simultaneous loss of Msh3 and Msh6 mismatch-repair protein functions
38. Human DNA mismatch repair in vitro operates independently of methylation status at CpG sites
39. Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells
40. DHFR/MSH3 amplification in methotrexate-resistant cells alters the hMutSα / hMutSβ ratio and reduces the efficiency of base-base mismatch repair
41. Mismatch recognition and DNA-dependent stimulation of the ATPase activity of hMutSα is abolished by a single mutation in the hMSH6 subunit
42. The DNA mismatch repair genes Msh3 and Msh6 cooperate in intestinal tumor suppression
43. Mismatch repair, molecular switches, and signal transduction
44. + gene of Schizosaccharomyces pombe encodes a homologue of mismatch repair enzymes
45. The high mobility group domain protein Cmb1 of Schizosaccharomyces pombe binds to cytosines in base mismatches and opposite chemically altered guanines
46. Involvement of nucleotide-excision repair in msh2 pms1-independent mismatch repair
47. Microsatellite instability in Drosophila spellchecker 1 (MutS homolog) mutants
48. The Saccharomyces cerevisiae MLH3 gene functions in MSH3-dependent suppression of frameshift mutations
49. Proliferating cell nuclear antigen and Msh2p-Msh6p interact to form an active mispair recognition complex
50. A DNA repair process in Escherichia coli corrects U:G and T:G mismatches to C:G at sites of cytosine methylation
51. Isolation of MutSβ from human cells and comparison of the mismatch repair specificities of MutSβ and MutSα
52. DNA binding and cleavage selectivity of the Escherichia coli DNA G:T-mismatch endonuclease (vsr protein)
53. The human mismatch recognition complex hMSH2-hMSH6 functions as a novel molecular switch
54. hMSH2-hMSH6 forms a hydrolysis-independent sliding clamp on mismatched DNA
55. Isolation and characterization of the Escherichia coli mutL gene product
56. Bidirectional excision in methyl-directed mismatch repair
57. ATP-dependent interaction of human mismatch repair proteins and dual role of PCNA in mismatch repair
58. Interactions of human hMSH2 with hMSH3 and hMSH2 with hMSH6: Examination of mutations found in hereditary nonpolyposis colorectal cancer
59. Binding of insertion/deletion DNA mismatches by the heterodimer of yeast mismatch repair proteins MSH2 and MSH3
60. Enhancement of MSH2-MSH3-mediated mismatch recognition by the yeast MLH1-PMS1 complex
61. ATP-dependent assembly of a ternary complex consisting of a DNA mismatch and the yeast MSH2-MSH6 and MLH1-PMS1 protein complexes
62. The Escherichia coli MutL protein physically interacts with MutH and stimulates the MutH-associated endonuclease activity
63. Evidence for a physical interaction between the Escherichia coli methyl-directed mismatch repair proteins MutL and UvrD
64. DNA mismatch repair and genetic instability
65. DNA polymerase ζ introduces multiple mutations when bypassing spontaneous DNA damage in Saccharomyces cerevisiae
66. Discrete in vivo roles for the MutL homologs Mlh2p and Mlh3p in the removal of frameshift intermediates in budding yeast
67. Mismatch repair in Escherichia coli cells lacking single-strand exonucleases ExoI, ExoVII, and RecJ
68. The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites
69. The vsr gene product of E. coli K-12 is a strand- and sequence-specific DNA mismatch endonuclease
70. Mouse models for colorectal cancer
71. Sliding clamps: A (tail)ored fit
72. Binding and repair of mismatched DNA mediated by Rhp 14, the fission yeast homologue of human XPA
73. MSH5, a novel MutS homolog, facilitates meiotic reciprocal recombination between homologs in Saccharomyces cerevisiae but not mismatch repair
74. Mth1 is unique among mismatch repair proteins in its ability to promote crossing-over during meiosis
75. The structure of guanosine-thymidine mismatches in B-DNA at 2.5-A resolution
76. hMSH2 and hMSH6 play distinct roles in mismatch binding and contribute differently to the ATPase activity of hMutSα
77. Mismatch repair defects in cancer
78. Mismatch-containing oligonucleotide duplexes bound by the E. coli mutS-encoded protein
79. Requirement of the yeast RTH1 5′ to 3′ exonuclease for the stability of simple repetitive DNA
80. Evidence for involvement of yeast proliferating cell nuclear antigen in DNA mismatch repair
81. Requirement of the yeast MSH3 and MSH6 genes for MSH2-dependent genomic stability
82. Repair of a mismatch is influenced by the base composition of the surrounding nucleotide sequence
83. Composite active site of an ABC ATPase: MutS uses ATP to verify mismatch recognition and authorize DNA repair
84. Specificity of mutations in the PMS2-deficient human tumor cell line HEC-1-A
85. Repair of DNA loops involves DNA-mismatch and nucleotide-excision repair proteins
86. hMSH3 and hMSH6 interact with PCNA and colocalize with it to replication foci
87. Second pathway for completion of human DNA base excision-repair: Reconstitution with purified proteins and requirement for DNase IV (FEN1)
88. The human PMS2L proteins do not interact with hMLH1, a major DNA mismatch repair protein
89. The interacting domains of three MutL heterodimers in man: hMLH1 interacts with 36 homologous amino acid residues within hMLH3, hPMS1 and hPMS2
90. Heteroduplex DNA correction in Saccharomyces cerevisiae is mismatch specific and requires functional PMS genes
91. Cloning and nucleotide sequence of DNA mismatch repair gene PMS1 from Saccharomyces cerevisiae: Homology of PMS1 to procaryotic MutL and HexB
92. Base excision repair of DNA in mammalian cells
93. Role of the DNA repair nucleases Rad13, Rad2, and Uve1 of Schizosaccharomyces pombe in mismatch correction
94. The crystal structure of DNA mismatch repair protein MutS binding to a G T mismatch
95. The deoxyribonucleases of Escherichia coli.V. On the specificity of exonuctease I (phosphodiesterase)
96. Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs
97. Bacterial mutL, mutS, and dcm participate in repair of mismatches at 5-methylcytosine sites
98. The FEN-1 family of structure-specific nucleases in eukaryotic DNA replication, recombination and repair
99. MLH3: A DNA mismatch repair gene associated with mammalian microsatellite instability
100. Germline and somatic mutation analyses in the DNA mismatch repair gene MLH3: Evidence for somatic mutation in colorectal cancers
101. Repair of large insertion/ deletion heterologies in human nuclear extracts is directed by a 5′ single-strand break and is independent of the mismatch repair system
102. Mutator phenotype induced by aberrant replication
103. DNA polymerase δ is required for human mismatch repair in vitro
104. Germline and somatic mutation analysis of MLH3 in MSI-positive colorectal cancer
105. Identification and purification of a single-stranded-DNA-specific exonuclease encoded by the recJ gene of Escherichia coli
106. Interaction of the β sliding clamp with MutS, tigase, and DNA polymerase I
107. Frameshift mismatch recognition by the human MutS alpha complex
108. Photocross-linking of the NH2-terminal region of Taq MutS protein to the major groove of a heteroduplex DNA
109. Control of GT repeat stability in Schizosaccharomyces pombe by mismatch repair factors
110. Mismatch repair deficiency associated with overexpression of the MSH3 gene
111. Biochemical characterization of the interaction between the Saccharomvces cerevisiae MSH2-MSH6 complex and mispaired bases in DNA
112. Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair
113. Escherichia coli helicase II (uvrD gene product) translocates unidirectionally in a 3′ to 5′ direction
114. Characterization of a mammalian homolog of the Escherichia coli MutY mismatch repair protein
115. Escherichia coli MutL loads DNA helicase II onto DNA
116. Mechanisms and biological effects of mismatch repair
117. Mismatch repair in replication fidelity, genetic recombination, and cancer biology
118. Identification of proteins of Escherichia coli and Saccharomyces cerevisiae that specifically bind to C/C mismatches in DNA
119. Crystal structures of mismatch repair protein MutS and its complex with a substrate DNA
120. GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells
121. Functional domains of the Saccharomyces cerevisiae Mlh1p and Pms1p DNA mismatch repair proteins and their relevance to human hereditary nonpolyposis colorectal cancer-associated mutations
122. Mutations predisposing to hereditary nonpolyposis colorectal cancer: Database and results of a collaborative study
123. Nucleotide excision repair: From E. coli to man
124. Dual requirement in yeast DNA mismatch repair for MLH1 and PMS1, two homotogs of the bacterial mutL gene
125. MLH1, PMS1, and MSH2 interactions during the initiation of DNA mismatch repair in yeast
126. Tumour susceptibility and spontaneous mutation in mice deficient in Mlhl, Pmsl, and Pms2 DNA mismatch repair
127. Human exonuclease 1 functionally complements its yeast homologues in DNA recombination, RNA primer removal, and mutation avoidance
128. Characterization of insertion mutations in the Saccharomyces cerevisiae MSH1 and MSH2 genes: Evidence for separate mitochondrial and nuclear functions
129. Spontaneous intestinal carcinomas and skin neoplasms in Msh2-deficient mice
130. Mutation of MSH3 in endometrial cancer and evidence for its functional role in heteroduplex repair
131. Mutation of a meiosis-specific MutS homolog decreases crossing over but not mismatch correction
132. Schizosaccharomyces pombe exo1 is involved in the same mismatch repair pathway as msh2 and pms1
133. The rash2 gene of Schizosaccharomyces pombe is involved in mismatch repair, mating-type switching, and meiotic chromosome organization
134. Cleavage of substrates with mismatched nucleotides by flap endonuclease-1. Implications for mammalian Okazaki fragment processing
135. Identification of hMutLβ, a heterodimer of hMLH1 and hPMS1
136. Requirement of mismatch repair genes MSH2 and MSH3 in the RAD1-RAD10 pathway of mitotic recombination in Saccharomyces cerevisiae
137. The interaction of DNA mismatch repair proteins with human exonuclease I
138. Marker effects of G to C transversions on intragenic recombination and mismatch repair in Schizosaccharomyces pombe
139. Mismatch repair in Schizosaccharomyces pombe requires the mutL homologous gene pms1: Molecular cloning and functional analysis
140. Microsatellite instability in yeast: Dependence on repeat unit size and DNA mismatch repair genes
141. Analysis of microsatellite mutations in the mitochondrial DNA of Saccharomyces cerevisiae
142. The MutL ATPase is required for mismatch repair
143. Saccharomyces cerevisiae Msh2p and Msh6p ATPase activities are both required during mismatch repair
144. A role for exonuclease I from S. pombe in mutation avoidance and mismatch correction
145. Identification and characterization of Saccharomyces cerevisiae EXO1, a gene encoding an exonuclease that interacts with MSH2
146. A novel mutation avoidance mechanism dependent on S. cerevisiae RAD27 is distinct from DNA mismatch repair
147. Identification of a human gene encoding a homologue of Saccharomyces cerevisiae EXO1, an exonuclease implicated in mismatch repair and recombination
148. Requirement for Msh6, but not for Swi4 (Msh3), in Msh2-dependent repair of base-base mismatches and mononucleotide loops in Schizosaccharomyces pombe
149. The 3′→5′ exonucleases of DNA polymerases δ and ε and the 5′→3′ exonuclease Exo1 have major roles in postreplication mutation avoidance in Saccharomyces cerevisiae
150. Functional studies on the candidate ATPase domains of Saccharomyces cerevisiae MutLα
151. Interactions of Exo1p with components of MutLα in Saccharomyces cerevisiae
152. Recognition of a TG mismatch: The crystal structure of very short patch repair endonuclease in complex with a DNA duplex
153. Requirement for PCNA in DNA mismatch repair at a step preceding DNA resynthesis
154. Single-strand DNA-specific exonucleases in Escherichia coli: Roles in repair and mutation avoidance
155. Exonuclease X of Escherichia coli. A novel 3′-5′ DNase and Dnaq superfamily member involved in DNA repair
156. Redundant exonuclease involvement in Escherichia coli methyl-directed mismatch repair
157. Functional specificity of MutL homologs in yeast: Evidence for three Mlh1-based heterocomplexes with distinct roles during meiosis in recombination and mismatch correction
158. Meiotic gene conversion mutants in Saccharomyces cerevisiae. Isolation and characterization of pms1-1 and pms1-2
159. A role for MLH3 in hereditary nonpolyposis colorectal cancer
160. Identification of rad27 mutations that confer differential defects in mutation avoidance, repeat tract instability, and flap cleavage
161. DNA mismatch-repair in Escherichia coli counteracting the hydrolytic deamination of 5-methyl-cytosine residues