Mutator phenotype induced by aberrant replication

Molecular and Cellular Biology

Volumn 19, Issue 2, 1999, Pages 1126-1135

  Liu, Vivian F ^a   Bhaumik, Dipa ^a   Wang, Teresa S F ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA POLYMERASE; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; PROTEIN KINASE;

ARTICLE; DELETION MUTANT; DNA REPLICATION; GENE DUPLICATION; MUTATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SCHIZOSACCHAROMYCES POMBE; TEMPERATURE SENSITIVE MUTANT;

SCHIZOSACCHAROMYCES POMBE;

EID: 0032911884     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.19.2.1126     Document Type: Article

References (40)

1. Al-Khodairy, F., E. Fotou, K. S. Sheldrick, D. J. F. Griffiths, A. R. Lehmann, and A. M. Carr. 1994. Identification and characterization of new elements involved in checkpoint and feedback controls in fission yeast. Mol. Biol. Cell 5:147-160.
2. Bambara, R. A., R. S. Murante, and L. A. Henricksen. 1997. Enzymes and reactions at the eukaryotic DNA replication fork. J. Biol. Chem. 272:4647-4650.
3. Bhaumik, D., and T. S.-F. Wang. 1998. Mutational effect of fission yeast Po1α on cell cycle events. Mol. Biol. Cell 9:2107-2123.
4. Boddy, M. N., B. Furnari, O. Mondesert, and P. Russell. 1998. Replication checkpoint enforced by kinases Cds1 and Chk1. Science 280:909-912.
5. Canning, S., and T. P. Dryja. 1989. Short direct repeats at the breakpoints of deletions of the retinoblastoma gene. Proc. Natl. Acad. Sci. USA 86:5044-5048.
6. Chen, C., K. Umezu, and R. D. Kolodner. 1998. Chromosomal rearrangements occur in S. cerevisiae rfa1 mutator mutants due to mutagenic lesions processed by double-strand-break repair. Mol. Cell 2:9-22.
7. de Jong, P. J., A. J. Grosovsky, and B. W. Glickman. 1988. Spectrum of spontaneous mutation at the APRT locus of Chinese hamster ovary cells: an analysis at the DNA sequence level. Proc. Natl. Acad. Sci. USA 85:3499-3503.
8. Desany, B. A., A. A. Alcasabas, J. B. Bachant, and S. J. Elledge. 1998. Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway. Genes Dev. 12:2956-2970.
9. D'Urso, G., B. Grallert, and P. Nurse. 1995. DNA polymerase alpha, a component of the replication initiation complex, is essential for the checkpoint coupling S phase to mitosis in fission yeast. J. Cell Sci. 108:3109-3118.
10. Efstratiadis, A. 1980. The structure and evolution of the human β-globin gene family. Cell 21:653-668.
11. Francesconi, S., H. Park, and T. S.-F. Wang. 1993. Fission yeast with DNA polymerase delta temperature-sensitive alleles exhibits cell division cycle phenotype. Nucleic Acids Res. 21:3821-3828.
12. Gordenin, D. A., A. L. Malkova, A. Peterzen, V. N. Kulikov, Y. I. Pavlov, E. Perkins, and M. A. Resnick. 1992. Transposon Tn5 excision in yeast: influence of DNA polymerases α, δ, and ε and repair genes. Proc. Natl. Acad. Sci. USA 89:3785-3789.
13. Grallert, B., and P. Nurse. 1996. The ORC1 homolog orp1 in fission yeast plays a key role in regulating onset of S phase. Genes Dev. 10:2644-2654.
14. Grosovsky, A. J., J. G. de Boer, P. J. de Jong, E. A. Drobetsky, and B. W. Glickman. 1988. Base substitutions, frameshifts, and small deletions constitute ionizing radiation-induced point mutation in mammalian cells. Proc. Natl. Acad. Sci. USA 85:185-188.
15. Gutz, H., H. Heslot, U. Leupold, and N. Loprieno. 1974. Schizosaccharomyces pombe, p. 395-446. In R. C. King (ed.), Handbook of genetics 1, vol. 1. Plenum Press, New York, N.Y.
16. Harrington, J. J., and M. R. Leiber. 1994. The characterization of a mammalian DNA structure-specific endonuclease. EMBO J. 13:1235-1246.
17. Kokoska, R. J., L. Stefanovic, H. T. Tran, M. A. Resnick, D. A. Gordenin, and T. D. Petes. 1998. Destabilization of yeast micro- and minisatellite DNA sequences by mutations affecting a nuclease involved in Okazaki fragment processing (rad27) and DNA polymerase δ (pol3-t). Mol. Cell. Biol. 18:2779-2788.
18. Kolodner, R. 1996. Biochemistry and genetics of eukaryotic mismatch repair. Genes Dev. 10:1433-1442.
19. Krawczak, M., and D. N. Cooper. 1991. Gene deletions causing human genetic disease: mechanisms of mutagenesis and the role of the local DNA sequence environments. Hum. Genet. 86:425-441.
20. Krawczak, M., and D. N. Cooper. 1997. The human gene mutation database. Trends Genet. 13:121-122.
21. Lieber, M. R. 1997. The FEN-1 family of structure-specific nucleases in eukaryotic DNA replication, recombination and repair. Bioessays 19:233-240.
22. Lindsay, H. D., D. J. F. Griffiths, R. Edwards, J. M. Murray, P. U. Christensen, N. Walworth, and A. M. Carr. 1998. S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe. Genes Dev. 12:382-395.
23. Loeb, L. A. 1998. Cancer cells exhibit a mutator phenotype. Adv. Cancer Res. 72:25-56.
24. Loeb, L. A. 1994. Microsatellite instability: marker of a mutator phenotype in cancer. Cancer Res. 54:5059-5063.
25. Loeb, L. A. 1991. Mutator phenotype may be required for multi-stage carcinogenesis. Cancer Res. 51:3075-3079.
26. Marra, G., and C. R. Boland. 1995. Hereditary nonpolyposis colorectal cancer: the syndrome, the genes and historical perspectives. J. Natl. Cancer Inst. 87:1114-1125.
27. Meuth, M. 1989. Illegitimate recombination in mammalian cells. In D. E. Berg and M. M. Howe (ed.). Mobile DNA. American Society for Microbiology, Washington, D.C.
28. Moreno, S., A. Klar, and P. Nurse. 1991. Molecular genetic analysis of fission yeast Schizosaccharomyces pombe. Methods Enzymol. 94:795-823.
29. Murakami, H., and H. Okayama. 1995. A kinase from fission yeast responsible for blocking mitosis in S phase. Nature 374:817-819.
30. Murray, J. M., M. Tavassoli, R. Al-Harithy, K. S. Sheldrick, A. R. Lehmann, A. M. Carr, and F. Z. Watts. 1994. Structural and functional conservation of the human homolog of the Schizosaccharomyces pombe rad2 gene, which is required for chromosome segregation and recovery from DNA damage. Mol. Cell. Biol. 14:4878-4888.
31. Nalbantoglu, J., D. Hartley, G. Phear, G. Tear, and M. Meuth. 1986. Spontaneous deletion formation at the aprt locus of hamster cells: the presence of short sequence homologies and dyad symmetries at deletion termini. EMBO J. 5:1199-1204.
32. Nasmyth, K., and P. Nurse. 1981. Cell division cycle mutants altered in DNA replication and mitosis in the fission yeast Schizosaccharomyces pombe. Mol. Gen. Genet. 182:119-124.
33. Nurse, P., P. Thuriaux, and K. Nasmyth. 1976. Genetic control of the cell division cycle in the fission yeast Schizosaccharomyces pombe. Mol. Gen. Genet. 146:167-178.
34. Santocanale, S., and J. F. X. Diffley. 1998. A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication. Nature 395:615-618.
35. +, a fission yeast gene related to the Bloom's and Werner's syndrome genes, is required for reversible S-phase arrest. EMBO J. 16:2682-2692.
36. Tanaki, T., and K. Nasmyth. 1998. Association of RPA with chromosomal replication origins requires an Mcm protein, and is regulated by Rad53, and cyclin- and Dbf4-dependent kinases. EMBO J. 17:5182-5191.
37. Tishkoff, D. X., N. Filosi, G. M. Gaida, and R. D. Kolodner. 1997. A novel mutation avoidance mechanism dependent on S. cerevisiae RAD27 is distinct from DNA mismatch repair. Cell 88:253-263.
38. Tran, H. T., N. P. Degtyareva, N. N. Koloteva, A. Sugino, H. Masumoto, D. A. Gordenin, and M. A. Resnick. 1995. Replication slippage between distant short repeats in Saccharomyces cerevisiae depends on the direction of replication and the RAD50 and RAD52 genes. Mol. Cell. Biol. 15:5607-5617.
39. Waga, S., and B. Stillman. 1994. Anatomy of a DNA replication fork revealed by reconstitution of SV40 DNA replication in vitro. Nature 369:207-212.
40. Zeng, Y., K. C. Forbes, Z. Wu, S. Morena, H. Piwnica-Worms, and T. Enoch. 1998. Replication checkpoint requires phosphorylation of the phosphatase Cdc25 by Cds1 or Chk1. Nature 395:507-510.