The human PMS2L proteins do not interact with hMLH1, a major DNA mismatch repair protein

Journal of Biochemistry

Volumn 125, Issue 4, 1999, Pages 818-825

  Kondo, Emiko ^a   Horii, Akira ^a   Fukushige, Shinichi ^a  

^a TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Immunoprecipitation study; Mismatch repair; PMS2L; RT PCR; Yeast two hybrid assay

Indexed keywords

DNA; DNA BINDING PROTEIN; POLYDEOXYRIBONUCLEOTIDE SYNTHASE;

AMINO TERMINAL SEQUENCE; ARTICLE; ASSAY; BASE MISPAIRING; CARBOXY TERMINAL SEQUENCE; CELL MUTANT; CHROMOSOME 7P; CHROMOSOME 7Q; CONTROLLED STUDY; DNA REPAIR; GENE EXPRESSION; GENE ISOLATION; HEART; IMMUNOPRECIPITATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN PROTEIN INTERACTION; TISSUE DISTRIBUTION; YEAST;

BACTERIA (MICROORGANISMS);

EID: 0032960108     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.jbchem.a022354     Document Type: Article

References (15)

1. Modrich, P. (1996) Mismatch repair in replication fidelity, genetic recombination, and cancer biology. Annu. Rev. Biochem. 65, 101-133
2. Acharya, S., Wilson, T., Gradia, S., Kane, M.F., Guerrette, S., Marsischky, G.T., Kolodner, R., and Fishel, R. (1996) hMSH2 forms specific mispair-binding complexes with hMSHS and hMSH6. Proc. Natl. Acad. Sci. USA 93, 13629-13634
3. Li, G.-M. and Modrich, P. (1995) Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs. Proc. Nall. Acad. Sci. USA 92, 1950 1954
4. Horii, A., Han, H.-J., Sasaki, S., Shimada, M., and Nakamura, Y. (1994) Cloning, characterization and chromosomal assignment of the human genes homologous to yeast PMS1, a member of mismatch repair genes. Biochem. Biophys. Res. Commun. 204, 1257-1264
5. Nicolaides, N.C., Carter, K., Shell, B.K., Papadopoulos, N., Vogelstein, B., and Kinzler, K.W. (1995) Genomic organization of the human PMS2 gene family. Genomics 30, 195-206
6. Prolla, T.A., Christie, D.-M., and Liskay, R.M. (1994) Dual requirement in yeast DNA mismatch repair for MLH1 and PMS1, two homologs of the bacterial mutL gene. Mol. Cell. biol. 14, 407-415
7. Nicolaides, N.C., Littman, S.J., Modrich, P., Kinzler, K.W., and Vogelstein, B. (1998) A naturally occurring hPMS2 mutation can confer a dominant negative mutator phenotype. Mol. Cell. Biol. 18, 1635-1641
8. Liu, B., Nicolaides, N.C., Markowitz, S., Willson, J.K.V., Parsons, R.E., Jen, J., Papadopoulos, N., Peltomaki, P., de la Chapelle, A., Hamilton, S.R., Kinzler, K.W., and Vogelstein, B. (1995) Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability. Nat. Genet. 9, 48-55
9. Mori, Y., Shiwaku, H., Fukushige, S., Wakatsuki, S., Sato, M., Nukiwa, T., and Horii, A. (1997) Alternative splicing of hMSH2 in normal human tissues. Hum. Genet. 99, 590-595
10. Sambrook, J., Fritsch, E.F., and Maniatis, T. (1989) Molecular Cloning. A Laboratory Manual, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
11. Vojtek, A.B., Hollenberg, S.M., and Cooper, J.A. (1993) Mammalian Ras interacts directly with the serine/threonine kinase Raf. Cell 74, 205-214
12. Gietz, D., Jean, A.S., Woods, R.A., and Schiestl, R.H. (1992) Improved method for high efficiency transformation of intact yeast cells. Nucleic Acids Res. 20, 1425-1430
13. Staudinger, J., Perry, M., Elledge, S.J., and Olson, E.N. (1993) Interaction among vertebrate helix-loop-helix proteins in yeast two-hybrid system. J. Biol. Chem. 268, 4608-4611
14. Risinger, J.I., Umar, A., Barrett, J.C., and Kunkel, T.A. (1995) A hPMS2 mutant cell line is defective in strand-specific mismatch repair. J. Biol. Chem. 270, 18183-18186
15. Pang, Q., Prolla, T.A., and Liskay, R.M. (1997) Functional domains of the Saccharomyces cerevisiae Mlhlp and Pmslp DNA mismatch repair proteins and their relevance to human hereditary nonpolyposis colorectal cancer-associated mutations. Mol. Cell. Biol. 17, 4465-4473