DHFR/MSH3 amplification in methotrexate-resistant cells alters the hMutSα/hMutSβ ratio and reduces the efficiency of base-base mismatch repair

Proceedings of the National Academy of Sciences of the United States of America

Volumn 94, Issue 19, 1997, Pages 10144-10149

  Drummond, James T ^a   Genschel, Jochen ^a   Wolf, Elisabeth ^a   Modrich, Paul ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Drug resistance; Genetic instability

Indexed keywords

DIHYDROFOLATE REDUCTASE; DINUCLEOTIDE; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; METHOTREXATE;

ARTICLE; BASE MISPAIRING; CELL STRAIN HL 60; CONTROLLED STUDY; DRUG RESISTANCE; GENE; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MUTATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL;

DNA REPAIR; DNA-BINDING PROTEINS; DRUG RESISTANCE, MICROBIAL; FUNGAL PROTEINS; GENE AMPLIFICATION; HL-60 CELLS; HUMANS; METHOTREXATE; MUTATION; NUCLEIC ACID HETERODUPLEXES; TETRAHYDROFOLATE DEHYDROGENASE;

EID: 0030885951     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.94.19.10144     Document Type: Article

References (41)

1. Huennekens, F. M. (1994) Adv. Enzyme Regul. 34, 397-419.
2. Bertino, J. R. (1993) J. Clin. Oncol. 11, 5-15.
3. Osborn, M. J., Freeman, M. & Huennekens, F. M. (1958) Proc. Soc. Exp. Biol. Med. 97, 429-431.
4. Blakley, R. L. (1984) in Folates and Pterins, eds. Blakley, R. L. & Benkovic, S. J. (Wiley, New York), Vol. 1, pp. 191-253.
5. Carman, M. D., Schomagel, J. H., Rivest, R. S., Srimatkandada, S., Portlock, C. S., Duffy, T. & Bertino, J. R. (1984) J. Clin. Oncol. 2, 16-20.
6. Curt, G. A., Carney, D. N., Cowan, R. H., Jolivet, J., Bailey, B. D., Drake, J. C., Kao-Shan, C. S., Minna, J. D. & Chabner, B. A. (1983) New Eng. J. Med. 308, 199-202.
7. Horns, R. C., Dower, W. J. & Schimke, R. T. (1984) J. Clin. Oncol. 2, 2-7.
8. Trent, J. M., Buick, R. N., Olson, S., Horns, R. C. & Schimke, R. T. (1984) J. Clin. Oncol. 2, 8-15.
9. Schimke, R. T., Kaufman, R. J., Alt, F. W. & Kellems, R. F. (1978) Science 102, 1051-1055.
10. Schimke, R. T. (1986) Cancer 57, 1912-1917.
11. Fujii, H. & Shimada, T. (1989) J. Biol. Chem. 264, 10057-10064.
12. Linton, J. P., Yen, J.-Y. J., Selby, E., Chen, Z., Chinsky, J. M., Liu, K., Kellems, R. E. & Crouse, G. F. (1989) Mol. Cell. Biol. 9, 3058-3072.
13. New, L., Liu, K. & Crouse, G. F. (1993) Mol. Gen. Genet. 239, 97-108.
14. Johnson, R. E., Kowali, G. K., Prakash, L. & Prakash, S. (1996) J. Biol. Chem. 271, 7285-7288.
15. Marsischky, G. T., Filosi, N., Kane, M. F. & Kolodner, R. (1996) Genes Dev. 10, 407-420.
16. Strand, M., Earley, M. C., Crouse, G. F. & Petes, T. D. (1995) Proc. Natl. Acad. Sci. USA 92, 10418-10421.
17. Habraken, Y., Sung, P., Prakash, L. & Prakash, S. (1996) Curr. Biol. 6, 1185-1187.
18. Drummond, J. T., Li, G.-M., Longley, M. J. & Modrich, P. (1995) Science 268, 1909-1912.
19. Palombo, F., Iaccarino, I., Nakajima, E., Ikejima, M., Shimada, T. & Jiricny, J. (1996) Curr. Biol. 6, 1181-1184.
20. Acharya, S., Wilson, T., Gradia, S., Kane, M. F., Guerrette, S., Marsischky, G. T., Kolodner, R. & Fishel, R. (1996) Proc. Natl. Acad. Sci. USA 93, 13629-13634.
21. Risinger, J. I., Umar, A., Boyd, J., Berchuck, A., Kunkel, T. A. & Barrett, J. C. (1996) Nat. Genet. 14, 102-105.
22. Koiti, I., Ikejima, M., Watanabe, A., Nakajima, E., Orimo, H., Nomura, T. & Shimada, T. (1995) Biochem. Biophys. Res. Comm. 214, 171-179.
23. Holmes, J., Clark, S. & Modrich, P. (1990) Proc. Natl. Acad. Sci. USA 87, 5837-5841.
24. Parsons, R., Li, G. M., Longley, M. J., Fang, W. H., Papadopoulos, N., Jen, J., de la Chapelle, A., Kinzler, K. W., Vogelstein, B. & Modrich, P. (1993) Cell 75, 1227-1236.
25. Eshleman, J. R., Lang, E. Z., Bowerfind, G. K., Parsons, R., Vogelstein, B., Willson, J. K., Veigl, M. L., Sedwick, W. D. & Markowitz, S. D. (1995) Oncogene 10, 33-37.
26. Luria, S. E. & Delbrück, M. (1943) Genetics 28, 491-511.
27. Capizzi, R. L. & Jameson, J. W. (1973) Mutat. Res. 17, 147-148.
28. Umar, A., Boyer, J. C., Thomas, D. C., Nguyen, D. C., Risinger, J. I., Boyd, J., Ionov, Y., Perucho, M. & Kunkel, T. A. (1994) J. Biol. Chem. 269, 14367-14370.
29. Monnat, R. J. (1989) Cancer Res. 49, 81-87.
30. Aquilina, G., Hess, P., Fiumicino, S., Ceccotti, S. & Bignami, M. (1995) Cancer Res. 55, 2569-2575.
31. Caligo, M. A., Armstrong, W., Rossiter, B. J. & Meuth, M. (1990) Mol. Cell. Biol. 10, 6805-6808.
32. Streisinger, G., Okada, Y., Emrich, J., Newton, J., Tsugita, A., Terzaghi, E. & Inouye, M. (1966) Cold Spring Harbor Symp. Quant. Biol. 31, 77-84.
33. Papadopoulos, N., Nicolaides, N. C., Liu, B., Parsons, R., Lengauer, C., Palombo, F., D'Arrigo, A., Markowitz, S., Willson, J. K. V., Kinzler, K., Jiricny, J. & Vogelstein, B. (1995) Science 268, 1915-1917.
34. Bhattacharyya, N. P., Skandalis, A., Ganesh, A., Groden, J. & Meuth, M. (1994) Proc. Natl. Acad. Sci. USA 91, 6319-6323.
35. Kat, A., Thilly, W. G., Fang, W. H., Longley, M. J., Li, G. M. & Modrich, P. (1993) Proc. Natl. Acad. Sci. USA 90, 6424-6428.
36. Farnham, P. J. & Schimke, R. T. (1986) Mol. Cell Biol. 6, 365-371.
37. Schilling, L. J. & Farnham, P. J. (1995) Cell Growth Differ. 6, 541-548.
38. Blount, B. C., Mack, M. M., Wehr, C. M., MacGregor, J. T., Hiatt, R. A., Wang, G., Wickramasinghe, S. N., Everson, R. B. & Ames, B. N. (1997) Proc. Natl. Acad. Sci. USA 94, 3290-3295.
39. Modrich, P. (1997) J. Biol. Chem. 272, in press.
40. Duckett, D. R., Drummond, J. T., Murchie, A. I. H., Reardon, J. T., Sancar, A., Lilley, D. M. J. & Modrich, P. (1996) Proc. Natl. Acad. Sci. USA 93, 6443-6447.
41. Fang, W.-h. & Modrich, P. (1993) J. Biol. Chem. 268, 11838-11844.