Germline and somatic mutation analyses in the DNA mismatch repair gene MLH3: Evidence for somatic mutation in colorectal cancers

Human Mutation

Volumn 17, Issue 5, 2001, Pages 389-396

  Lipkin, Steven M ^a,b,c,d   Wang, Victoria ^a,b   Stoler, Dan L ^a,b   Anderson, Garth R ^a,b   Kirsch, Ilan ^a,b,c   Hadley, Don ^a,b,c   Lynch, Henry T ^a,b   Collins, Francis S ^a  

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^b ROSWELL PARK CANCER INSTITUTE   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Colorectal cancer; DHPLC; HNPCC; Microsatellite instability; Mismatch repair; MLH3; MMR; MSI; SNP; Somatic mutation; Tumorigenesis

Indexed keywords

ARTICLE; BASE MISPAIRING; CANCER GROWTH; CANCER RISK; CANCER SCREENING; CANCER SUSCEPTIBILITY; CARCINOGENESIS; COLORECTAL CANCER; CONTROLLED STUDY; DNA REPAIR; GENE FREQUENCY; GENETIC RISK; HETEROZYGOSITY LOSS; HUMAN; MAJOR CLINICAL STUDY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SOMATIC MUTATION;

AGE OF ONSET; ALLELES; BASE PAIR MISMATCH; BASE SEQUENCE; CARRIER PROTEINS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMOSOMES, HUMAN, PAIR 14; CODON, NONSENSE; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; DISEASE PROGRESSION; DNA REPAIR; DNA-BINDING PROTEINS; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENETIC SCREENING; GERM-LINE MUTATION; HUMANS; LOSS OF HETEROZYGOSITY; MICROSATELLITE REPEATS; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MUTATION; MUTS HOMOLOG 2 PROTEIN; NEOPLASM PROTEINS; NUCLEAR PROTEINS; NUCLEIC ACID DENATURATION; POLYMORPHISM, GENETIC; PROTO-ONCOGENE PROTEINS; UNITED STATES;

EID: 0035039417     PISSN: 10597794     EISSN: None     Source Type: Journal    
DOI: 10.1002/humu.1114     Document Type: Article

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