Characterization of phospholipase C activity at h5-HT2C compared with h5-HT2B receptors: Influence of novel ligands upon membrane-bound levels of [3H]phosphatidylinositols

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 365, Issue 3, 2002, Pages 242-252

  Cussac, Didier ^a   Newman Tancredi, Adrian ^a   Quentric, Yann ^a   Carpentier, Nathalie ^a   Poissonnet, Guillaume ^a   Parmentier, Jean Gilles ^a   Goldstein, Solo ^a   Millan, Mark J ^a  

^a INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

Author keywords

5 HT2B receptors; 5 HT2C receptors; Phosphatidylinositols; Phospholipase C; Receptor reserve

Indexed keywords

(3 CHLOROPHENYL)PIPERAZINE; (6 CHLORO 2,3,4,9 TETRAHYDRO 1H BETA CARBOLIN YL)PHENYL ACETIC ACID ETHYL ESTER; 1 (1 METHYL 5 INDOLYL) 3 (3 METHYL 5 ISOTHIAZOLYL)UREA; 1 (2 CHLORO 3,4 DIMETHOXYBENZYL) 6 METHYL 1,2,3,4 TETRAHYDRO 9H PYRIDO[3,4 B]INDOLE; 1 [5 (2 THIENYLMETHOXY) 3 INDOLYL] 2 PROPANAMINE; 1 METHY 2 (4,4,7 TRIMETHYL 1,4 DIHYDROINDENO[1,2]PYRROLO 1 YL)ETHYLAMINE FUMARATE; 1,2,3,5 TETRAHYDRO 5 METHYL 1 (3 PYRIDYLCARBAMOYL)PYRROLO[2,3 F]INDOLE; 2 (6 CHLORO 5 FLUORO 1 INDOLYL) 1 METHYLETHYLAMINE; 2 ETHOXY 1(2H) QUINOLINECARBOXYLIC ACID ETHYL ESTER; 4 IODO 2,5 DIMETHOXYAMPHETAMINE; 6 CHLORO 2 (1 PIPERAZINYL)PYRAZINE; 6 CHLORO 5 METHYL 1 [[2 [(2 METHYL 3 PYRIDYL)OXY] 5 PYRIDYL]CARBAMOYL]INDOLINE; 6 CHLORO 5 METHYL N [6 (2 METHYLPYRIDIN 3 YLOXY)PYRIDIN 3 YL]INDOLINE 1 CARBOXAMIDE; 8 [4 (5 AMINO 2,4 DIMETHOXYBENZOYL)BUTYL] 1,3,8 TRIAZASPIRO[4.5]DECANE 2,4 DIONE; LISURIDE; LY 266097; N [5 [5 (2,5 DIOXOSPIRO[IMIDAZOLIDINE 4,4' PIPERIDIN] 1' YL)PENTANOYL] 2,4 DIMETHOXYPHENYL] 4 (TRIFLUOROMETHYL)BENZENESULFONAMIDE; PHOSPHATIDYLINOSITOL; PHOSPHOLIPASE C; RECEPTOR RESERVE; RO 600332; RO 600869; S 33526; SEROTONIN; SEROTONIN 2B RECEPTOR; SEROTONIN 2C AGONIST; SEROTONIN 2C ANTAGONIST; SEROTONIN 2C RECEPTOR; SEROTONIN ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL CELL; ANION EXCHANGE CHROMATOGRAPHY; ARTICLE; BINDING AFFINITY; CHO CELL; CONTROLLED STUDY; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; ENZYME ACTIVITY; NONHUMAN; PROTEIN EXPRESSION;

ANIMALS; BINDING, COMPETITIVE; CHO CELLS; CRICETINAE; HUMANS; KINETICS; LIGANDS; PHOSPHATIDYLINOSITOLS; PHOSPHOLIPASE C; RECEPTOR, SEROTONIN, 5-HT2B; RECEPTOR, SEROTONIN, 5-HT2C; RECEPTORS, SEROTONIN; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS;

EID: 0036193721     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-001-0505-y     Document Type: Article

References (70)

1. Receptor reserve masks partial agonist activity of drugs in a cloned rat 5-hydroxytryptamine1B receptor expression system
2. 2C receptors expressed in human embryonic kidney 293 cells
3. Occupancy-response relationships for β- and α2-adrenergic receptors exerting opposing effects on cAMP production
4. 2B receptors
5. 2B receptors
6. Effector pathway-dependent relative efficacy at serotonin type 2A and 2C receptors: Evidence for agonist-directed trafficking of receptor stimulus
7. 2C receptor systems
8. Inositol triphosphate and calcium signalling
9. 2C receptors. Synthesis and biological evaluation of substituted 2-(indol-1-yl)-1-methylethylamines and 2-(indeno(12-b)pyrrol-1-yl)-1-methylethylamines. Improved therapeutics for obsessive compulsive disorder
10. Syntheses of O-methylasparvenone-derived serotonin-receptor antagonists
11. 2C receptors
12. 2C receptor antagonist
13. 2A-adrenergic receptor signaling in Chinese hamster ovary cells: 1-isoproterenol selectively activates Gs
14. 2C receptor G-protein coupling by RNA editing
15. Pharmacology of muscarinic receptor subtypes constitutively activated by G protein
16. 2A receptor-mediated phosphoinositide (PI) turnover by clozapine in the rat: A comparison to other antipsychotics
17. (2C) receptors in choroid plexus epithelial cells
18. A unique serotonin receptor in choriod plexus is linked to phosphatidylinositol turnover
19. 3 receptors mediate mitogen-activated protein kinase activation via a phosphatidylinositol 3-kinase and an atypical protein kinase C-dependent mechanism
20. 2C receptors: A parallel phosphatidylinositol and calcium accumulation comparison with clozapine and haloperidol
21. 3H]phosphatidylinositol depletion
22. 2C receptor agonist RO 60-0175: A pharmacological analysis
23. Synergistic interactions between human transfected adenosine A1 receptors and endogenous cholecystokinin receptors in CHO cells
24. Evidence for expression of the 5-hydroxytryptamine-2B receptor protein in the rat central nervous system
25. 2B receptors in the medial amygdala causes anxiolysis in the social interaction test in the rat
26. 2C receptors
27. 2C receptors: Evidence favoring the ternary complex and two-state models of agonist action
28. 2B receptors in the cardiopathy associated with fenfluramine
29. Cloning and functional characterization of the rat stomach fundus serotonin receptor
30. 2C receptor antagonists in the treatment of Parkinson's disease?
31. Functional characteristics of heterologously expressed 5-HT receptors
32. 1B receptor on CHO cells: Functional responses in the absence of radioligand binding
33. 2B receptors
34. Serotonin2C receptors tonically suppress the activity of mesocortical dopaminergic and adrenergic but not serotonergic pathways: A combined dialysis and electrophysiological analysis in the rat
35. 2C receptor RNA editing alters receptor basal activity: Implications for serotonergic signal transduction
36. 5-HT receptor classification and nomenclature: Towards a harmonization with the human genome
37. 2C receptors in affective disorders
38. 2C receptor agonists and fluoxetine in a model of panic-like anxiety in rats
39. 2 receptor subtypes
40. 1C receptors
41. 2B receptor agonist BW 723C86 on three rat models of anxiety
42. 2B receptor antagonist with anxiolytic-like properties
43. 2B receptor agonist, causes hyperphagia and reduced grooming in rats
44. 2C receptor antagonist
45. 2B receptor mediated
46. 2B receptor antagonist in rats
47. 2F) from rat stomach fundus
48. 2B receptor
49. B from inhibition curves in functional experiments: Alternatives to the Cheng-Prusoff equation
50. 2 receptor sub-family
51. 2C receptor agonists: Pharmacological characteristics and therapeutic potential
52. The role of serotonin in antipsychotic drug action
53. 1A agonist properties. I. Receptorial and neurochemical profile in comparison with clozapine and haloperidol
54. Reciprocal autoreceptor and heteroreceptor control of serotonergic dopaminergic and noradrenergic transmission in the frontal cortex: Relevance to the actions of antidepressant agents
55. 2C receptors: A comparison with citalopram
56. 33and cGMP in HEK293 cells: Evidence for agonist directed trafficking
57. 2C receptors expressed in the human neuroblastoma cell line SH-SY5Y: Comparative stimulation by hallucinogenic drug
58. 2C receptors by N-ethoxycarbonyl-2-ethoxy-12-dihydroquinoline (EEDQ)
59. 2C receptor silences constitutive activity
60. 2C receptors in CHO-K1 cells
61. 2C receptor antagonist
62. The role of serotonin in schizophrenia
63. 2C): Where structure meets function
64. Serotonin receptors: Signal transduction pathways
65. 2C receptors
66. 2 receptor antagonists: Potential in the treatment of psychiatric disorders CNS
67. 2B receptor
68. 2C receptors
69. 2C receptors in functional studies
70. 125I-lysergic acid diethylamide binds to a novel serotonergic site on rat choroid plexus epithelial cells